LOCUS       NM_033053               1363 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens DMRT like family C1 (DMRTC1), transcript variant 1,
            mRNA.
ACCESSION   NM_033053 XM_005262287 XM_301088
VERSION     NM_033053.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1363)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   2  (bases 1 to 1363)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   3  (bases 1 to 1363)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC234776.4.
            
            On or before Sep 16, 2020 this sequence version replaced
            XM_005262287.4, NM_033053.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.104130.1,
                                           SRR14372080.151997.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615063.2/ ENSP00000484718.2
            RefSeq Select criteria :: based on manual assertion, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC234776.4         98279-98541
            264-421             AC234776.4         166328-166485
            422-480             AC234776.4         166785-166843
            481-614             AC234776.4         167158-167291
            615-675             AC234776.4         168174-168234
            676-823             AC234776.4         168419-168566
            824-1363            AC234776.4         169552-170091
FEATURES             Location/Qualifiers
     source          1..1363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1363
                     /gene="DMRTC1"
                     /note="DMRT like family C1"
                     /db_xref="GeneID:63947"
                     /db_xref="HGNC:HGNC:13910"
                     /db_xref="MIM:300878"
     exon            1..263
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..421
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..936
                     /gene="DMRTC1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     doublesex- and mab-3-related transcription factor C1;
                     doublesex-mab-3"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor C1 isoform 1"
                     /protein_id="NP_149042.2"
                     /db_xref="CCDS:CCDS35333.2"
                     /db_xref="GeneID:63947"
                     /db_xref="HGNC:HGNC:13910"
                     /db_xref="MIM:300878"
                     /translation="MAAPPKAPIRVRNLTIRAGALTGKENNMLQPETHIFTAPEEGSS
                     QGALLLGQAPEPLSLPCTPVTLEQQLVSPSGDPHRAPALPSICSTLILQPCATLDPLL
                     LQPQVPKVSDQALVSAHSEWQRKLEAAEALLTLRNSAQAPPDSISLHQPCNPPAPAGD
                     KGFQPPSPSLRPRPASSISLPIGHLGCISLLS"
     exon            422..480
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            481..614
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            615..675
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            676..823
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     exon            824..1363
                     /gene="DMRTC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1339..1344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTC1"
                     /note="hexamer: AATAAA"
     polyA_site      1363
                     /gene="DMRTC1"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcctcc tcctcctgct cctcctcctc ctgctcctcc tcctcctcct cctcctcctc
       61 ctccttctcc tcctcctccc ggtctgaggg cggcggtctc cgactcaaga ccctggggct
      121 ccgggtcttc ttagcagccg ccgcagcagc cgcggcgacg tcactgtcct ctcggcctgg
      181 cacacagcgc tccggccgcc gaatgcccgt ggacgcgcat ctcttcccag agttcctgct
      241 tcctgggcca gccaaagccg cagagaacgc ctcagggtct tgcctgctgt gagtgccttg
      301 aagagggagc agcgggcacg atcaaagaga cacctggctc aaggaccaat aaggagtatg
      361 gctgcccctc ccaaagctcc catccgtgtc aggaatttga ccatcagagc aggagccctc
      421 actgggaagg agaacaacat gctgcagccc gagacccaca tcttcacagc ccccgaggag
      481 gggagctccc aaggggctct gctgcttggc caggccccag aacctttgtc tctgccctgt
      541 actccagtga ccttggagca gcaactggtt tctccttctg gggatcccca cagggcccct
      601 gccctgccca gcatatgctc aactctgatc ctccagccct gtgccaccct tgaccctctt
      661 ctactgcagc cacaggtccc caaagtctct gaccaggctt tggtttctgc ccactcagag
      721 tggcagcgga agctggaggc cgctgaggct ctgctgactc tgagaaactc tgcccaggcc
      781 cctcctgact ccatctccct gcaccagcct tgcaacccac cagctcctgc tggagataaa
      841 ggattccagc ctcccagccc ctctctccgc cccaggccag ccagctccat ctcgctgcct
      901 attggacatc tgggatgcat ctccctcttg agctaggaac ccagaggagg aggcctcaat
      961 agagcactgc ctatttggta tccagtttct gaatgtgcaa aatggttaac gtccaaaacg
     1021 cttaacgtct ttttttaaag ccttcaggtg ttttataagc tttttattat atggggcaac
     1081 tccttggctg agggtggata ttcttgtacc tctgtccctt actcttttgg atgctggggc
     1141 ctttttctgt ctcataaaga caggattgtg caatctaagt tgatcagtct ctcagtgggg
     1201 ttctgtgtga gttcatatgc cagagttttt attcgtcttg tgattgctga catacctgtg
     1261 cactcatgtg tatacccctg catgtggaaa catgaagatg ttttcacttt gtgtctaggt
     1321 ttatgtacgt gaacaaataa taaaccgttg ttgttataag gca
//
