LOCUS       NM_033067               1910 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens DMRT like family B with proline rich C-terminal 1
            (DMRTB1), mRNA.
ACCESSION   NM_033067
VERSION     NM_033067.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Hilbold,E., Bergmann,M., Fietz,D., Kliesch,S., Weidner,W.,
            Langeheine,M., Rode,K. and Brehm,R.
  TITLE     Immunolocalization of DMRTB1 in human testis with normal and
            impaired spermatogenesis
  JOURNAL   Andrology 7 (4), 428-440 (2019)
   PUBMED   30920770
  REMARK    GeneRIF: role in the entry of spermatogonia into meiosis
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1910)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   5  (bases 1 to 1910)
  AUTHORS   Barber,M.J., Mangravite,L.M., Hyde,C.L., Chasman,D.I., Smith,J.D.,
            McCarty,C.A., Li,X., Wilke,R.A., Rieder,M.J., Williams,P.T.,
            Ridker,P.M., Chatterjee,A., Rotter,J.I., Nickerson,D.A.,
            Stephens,M. and Krauss,R.M.
  TITLE     Genome-wide association of lipid-lowering response to statins in
            combined study populations
  JOURNAL   PLoS One 5 (3), e9763 (2010)
   PUBMED   20339536
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1910)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 1910)
  AUTHORS   Lim,J., Hao,T., Shaw,C., Patel,A.J., Szabo,G., Rual,J.F.,
            Fisk,C.J., Li,N., Smolyar,A., Hill,D.E., Barabasi,A.L., Vidal,M.
            and Zoghbi,H.Y.
  TITLE     A protein-protein interaction network for human inherited ataxias
            and disorders of Purkinje cell degeneration
  JOURNAL   Cell 125 (4), 801-814 (2006)
   PUBMED   16713569
REFERENCE   8  (bases 1 to 1910)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK057273.1 and BC029566.1.
            
            On Feb 27, 2020 this sequence version replaced NM_033067.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK057273.1, BC029566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371445.3/ ENSP00000360500.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1146              AK057273.1         1-1146
            1147-1910           BC029566.1         663-1426
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1910
                     /gene="DMRTB1"
                     /note="DMRT like family B with proline rich C-terminal 1"
                     /db_xref="GeneID:63948"
                     /db_xref="HGNC:HGNC:13913"
                     /db_xref="MIM:614805"
     exon            1..632
                     /gene="DMRTB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1084
                     /gene="DMRTB1"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor B1"
                     /protein_id="NP_149056.1"
                     /db_xref="CCDS:CCDS581.1"
                     /db_xref="GeneID:63948"
                     /db_xref="HGNC:HGNC:13913"
                     /db_xref="MIM:614805"
                     /translation="MADKMVRTPKCSRCRNHGFLVPVKGHAGKCRWKQCLCEKCYLIS
                     ERQKIMAAQKVLKTQAAEEEQEAALCAQGPKQASGAAAAAPAPVPVPAASLRPLSPGT
                     PSGDADPGPEGRAAACFFEQPPRGRNPGPRALQPVLGGRSHVEPSERAAVAMPSLAGP
                     PFGAEAAGSGYPGPLDLRRPMRTVPGPLFTDFVRPLNINPDRALGPEYPGGSSMHPYC
                     PFPLGYLDAPPGVPLQQGFRHVSRSQYQGGGLVSEPGGDFQPSYYLPPPPPPLPPLPP
                     LPPQPQFLPPGYLSALHFLPPPPPPPPPSSFSLTVLFDTDKENTDDQDAEVLSGEPSQ
                     PSSQEQSD"
     exon            633..805
                     /gene="DMRTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1016
                     /gene="DMRTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1910
                     /gene="DMRTB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1891..1896
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTB1"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="DMRTB1"
                     /note="major polyA site"
ORIGIN      
        1 acttgctctg cagctcccag aggtggtggt tgtgttacga aggctgaccc tgccaatggc
       61 cgacaaaatg gtgcgcaccc ccaagtgctc gagatgcagg aaccatggct tcctggtgcc
      121 cgtcaaggga cacgcgggca aatgccgctg gaagcagtgc ctctgcgaga agtgctacct
      181 gatctccgag cgccagaaga tcatggccgc gcagaaggtg ctcaagacgc aggccgccga
      241 ggaggagcag gaggcggccc tgtgtgcgca ggggcccaag caggcctccg gggctgcggc
      301 cgccgccccc gcccccgtcc ccgtcccggc cgcgagcctc cgcccgctgt ccccggggac
      361 tccctccgga gacgccgacc cgggacccga gggccgcgcg gccgcttgct tcttcgagca
      421 gcccccgcgg ggccggaacc ccggcccgag agccctccag ccggttctgg gcggccgcag
      481 ccacgtggag ccgagcgagc gagccgccgt ggcgatgccc agccttgcgg gacccccttt
      541 tggggcggag gccgcaggca gtggctaccc tggcccccta gacctgcgca ggccgatgcg
      601 gaccgtgccc ggcccactgt tcaccgactt tgtgcgccct ctgaacatca acccggaccg
      661 tgcactgggc cctgagtacc ctggtggctc cagcatgcac ccctactgcc cgttcccgct
      721 gggctacctg gacgcccctc ctggcgtccc cctgcagcag ggcttccggc atgtgtcccg
      781 cagccagtac caaggcggag gcttggtgtc agaaccagga ggagacttcc agccaagcta
      841 ctacctgccg ccgccgccgc cgccactgcc gccccttcca ccgcttccac cgcagcccca
      901 gttcctcccg ccaggctacc tctctgcgct ccacttcctc cccccgccac cgccaccacc
      961 acctccatca tctttctcac tgaccgtcct gtttgatact gacaaggaga acactgatga
     1021 ccaggatgca gaggtactgt cgggtgagcc cagccagcca tcgtctcagg agcagtccga
     1081 ctaggcccca ggcccgccct cctggccagc agagtggggc actggggggc aacagcaaca
     1141 gttttcttgt cttcattcag tgatatgtag ggaggaagga ggttgatagc atagatggca
     1201 actgattccc agtttaagat aggaggaagg agagcaattt ctaagtttca atcctgcgct
     1261 gtacagttga agaagagtgt ggaggaagct attaccaggg gagggccagg gctctgagga
     1321 gtgggcgctg ggagaagctc ccatttagga atgaatttaa ctgtccttgg gttacactac
     1381 catttattgg aacaagcccc agaggcagta tttgatttcc tcaggcccca ctctaggaca
     1441 ggaggcacca tctatttcag ccttctgctg cctttgcctg gtcctccagg ttgctggggg
     1501 caccacagac atcaagattc cagttcatcc aggtggctgg agccagcagc caggaccagg
     1561 gtcgttgaca gcaggttctg cagcatcctg ccttgctgct ctgtccccca catcttcctg
     1621 gccacagccc cttgcccctc ctctaagggg ttttactagc aagcatcctg gctgctgggg
     1681 ctacttcatt ccccctccat aaagtttcag ccattatggg cactggtttt aaaaaattta
     1741 ttagtttgac tatttgatgt ttttatagtg attgccaact ttaaaaagta ggctgttcat
     1801 aagcactgat gcagtcccta gggaatagaa tggtgcttct gatcacctgt gacatgaaca
     1861 gtttcttctg tgaggacagt tggctattga aataaaatga gcaatggaaa
//
