LOCUS       NM_032110               3080 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens DMRT like family A2 (DMRTA2), mRNA.
ACCESSION   NM_032110 XM_027162 XM_941606
VERSION     NM_032110.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3080)
  AUTHORS   Maleszewska,M., Wojnicki,K., Mieczkowski,J., Krol,S.K., Jacek,K.,
            Smiech,M., Kocyk,M., Ciechomska,I.A., Bujko,M., Siedlecki,J.,
            Kotulska,K., Grajkowska,W., Zawadzka,M. and Kaminska,B.
  TITLE     DMRTA2 supports glioma stem-cell mediated neovascularization in
            glioblastoma
  JOURNAL   Cell Death Dis 15 (3), 228 (2024)
   PUBMED   38509074
  REMARK    GeneRIF: DMRTA2 supports glioma stem-cell mediated
            neovascularization in glioblastoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3080)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   3  (bases 1 to 3080)
  AUTHORS   Urquhart,J.E., Beaman,G., Byers,H., Roberts,N.A., Chervinsky,E.,
            O'Sullivan,J., Pilz,D., Fry,A., Williams,S.G., Bhaskar,S.S.,
            Khayat,M., Simanovsky,N., Shachar,I.B., Shalev,S.A. and Newman,W.G.
  TITLE     DMRTA2 (DMRT5) is mutated in a novel cortical brain malformation
  JOURNAL   Clin Genet 89 (6), 724-727 (2016)
   PUBMED   26757254
  REMARK    GeneRIF: Data suggest that loss of function of doublesex and
            mab-3-related transcription factor a2 (DMRTA2) leads to disorder of
            cortical development.
REFERENCE   4  (bases 1 to 3080)
  AUTHORS   Poulain,M., Frydman,N., Tourpin,S., Muczynski,V., Souquet,B.,
            Benachi,A., Habert,R., Rouiller-Fabre,V. and Livera,G.
  TITLE     Involvement of doublesex and mab-3-related transcription factors in
            human female germ cell development demonstrated by xenograft and
            interference RNA strategies
  JOURNAL   Mol Hum Reprod 20 (10), 960-971 (2014)
   PUBMED   25082981
  REMARK    GeneRIF: This study reveals, for the first time, the requirement of
            DMRTA2 for normal human female embryonic germ cell development.
            Erratum:[Mol Hum Reprod. 2015 Jul;21(7):615. doi:
            10.1093/molehr/gav029.. Mucsynski, Vincent [Corrected to Muczynski,
            Vincent]. PMID: 26134375]
REFERENCE   5  (bases 1 to 3080)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 3080)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BQ941189.1, AJ301580.1, AL049637.44, BM675521.1 and CF242912.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032110.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC143800.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404795.4/ ENSP00000383909.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               BQ941189.1         5-506
            503-1523            AJ301580.1         1-1021
            1524-2072           AL049637.44        103092-103640
            2073-2497           BM675521.1         6-430               c
            2498-3079           CF242912.1         1-582               c
            3080-3080           AL049637.44        104648-104648
FEATURES             Location/Qualifiers
     source          1..3080
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..3080
                     /gene="DMRTA2"
                     /note="DMRT like family A2"
                     /db_xref="GeneID:63950"
                     /db_xref="HGNC:HGNC:13908"
                     /db_xref="MIM:614804"
     exon            1..328
                     /gene="DMRTA2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..895
                     /gene="DMRTA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             337..1965
                     /gene="DMRTA2"
                     /note="doublesex- and mab-3-related transcription factor
                     5"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor A2"
                     /protein_id="NP_115486.1"
                     /db_xref="CCDS:CCDS44141.1"
                     /db_xref="GeneID:63950"
                     /db_xref="HGNC:HGNC:13908"
                     /db_xref="MIM:614804"
                     /translation="MELRSELPSVPGAATAAAATATGPPVASVASVAAAAAAAASLPV
                     SVAGGLLRGPPLLLRAAEKYPRTPKCARCRNHGVVSALKGHKRYCRWKDCLCAKCTLI
                     AERQRVMAAQVALRRQQAQEENEARELQLLYGTAEGLALAAANGIIPPRPAYEVFGSV
                     CAADGGGPGAGAPAGTGGGAAGAGGSEAKLQKFDLFPKTLLQAGRPGSPLPPPVKPLS
                     PDGADSGPGTSSPEVRPGSGSENGDGESFSGSPLARASKEAGGSCPGSAGPGGGGEED
                     SPGSASPLGSESGSEADKEEGEAAPAPGLGGGSGPRQRTPLDILTRVFPGHRRGVLEL
                     VLQGCGGDVVQAIEQVLNHHRGGLAAGLGPAAPPDKAAVGAAAAADDAWPSRVDAAAA
                     AAAAAGGPGLPAPLQAGPAAPPHHRPLLAGAMAPGALGSLSSRSAFSPLQPNASHFGA
                     DAGAYPLGAPLGLSPLRLAYSAAAAHSRGLAFMAPYSTAGLVPTLGFRPPMDYAFSDL
                     MRDRSAAAAAAVHKEPTYGGGLYGPMVNGAPEKQ"
     exon            896..3080
                     /gene="DMRTA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3054..3059
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTA2"
                     /note="hexamer: AATAAA"
     polyA_site      3080
                     /gene="DMRTA2"
                     /note="major polyA site"
ORIGIN      
        1 attgagagtc tggcagcgcc gggcaactgg gccccggctg cgcgcagcgt ccggcgcgca
       61 ccgcgagggg acccggcacg gcgagagtca ggtcgcgggt tccaaccacg cggcccgcag
      121 acgagcctcc gacccggatt tctgaaggga gggttggact gcgctgcgtt ctgaggggtc
      181 cggaagttcg gacatggtga ctgaaggagg gtgacgtggt cagataaggg gccgggggca
      241 aagggaagcg gccaagagct ccagcgtcgc cagtggagcc gggaggcgcg tgcagcgcca
      301 gcggaggagg aggatcccgg agcccaaggt cctgtcatgg agctgcgctc ggagctgccc
      361 agcgtgcccg gcgcggcgac ggcggcggcg gcaacagcga cggggccgcc tgtggcgtcg
      421 gtggcgtcgg tggcggcagc cgcggcggcc gctgcatcgc taccggtgag cgtggcaggc
      481 ggcttgctgc gggggccgcc actgttgctg cgggcagccg agaagtaccc gcggaccccc
      541 aagtgcgcgc gctgtcgcaa ccatggcgtg gtgtcggccc tcaagggcca caaacgctac
      601 tgtcgctgga aggactgcct gtgcgccaag tgcacgctca tcgcggagcg ccagcgtgtc
      661 atggcggcgc aggtggcgct gcgcaggcag caggcgcagg aggagaacga ggcgcgcgag
      721 ctgcagctgc tctacggcac tgccgagggg ctggcgctgg ccgccgccaa cggcatcatc
      781 cccccgaggc ccgcctacga ggtcttcggt tcagtgtgcg ccgccgacgg cgggggacct
      841 ggagcgggag cgcccgcggg gaccggaggc ggagcagctg gcgcaggggg ctcagaggcc
      901 aagttgcaga agtttgacct gtttcctaag acgctgctgc aggcaggccg cccgggcagc
      961 ccgctgccgc cgccggtgaa gcccttatca cccgacggcg cagactcggg gcccgggacg
     1021 tcgtccccag aggtgcggcc cggctcaggc tcggagaacg gcgatggcga gtccttttct
     1081 ggttcgcccc tagctcgggc ctccaaagag gcaggtggca gctgcccagg cagcgctggc
     1141 cctggcggcg gcggcgagga ggacagcccg ggctccgcta gccctctggg ctctgaatcc
     1201 ggttcagagg ctgacaaaga agagggtgag gccgcgccgg cgccagggct gggcggaggc
     1261 tcgggtccac ggcagcggac gccgctggat atcttgacac gcgtgttccc aggccaccgg
     1321 cgaggcgtcc tggagctggt gttgcagggc tgcggcggcg acgtggtgca ggccatcgag
     1381 caggtgctga accaccaccg tgggggcctg gcggccggcc tgggccctgc ggcgccccca
     1441 gataaggccg ccgtgggtgc tgcagcagct gcagacgacg cgtggcccag ccgcgtcgac
     1501 gccgccgccg ccgccgccgc cgccgccggg gggcctgggc tgcctgcgcc gctgcaggcg
     1561 gggcccgccg cacctccgca ccacagaccc ttgctggccg gcgccatggc gcctggggcg
     1621 ctgggctcgc tgagcagccg ctcggccttc tcgccgctgc agcccaacgc cagtcacttc
     1681 ggtgccgacg cgggcgccta cccgctgggc gcgccgctcg gcctcagccc cctgcgcctg
     1741 gcctactccg cggcggcggc gcacagccgc ggtctggcct tcatggcgcc ctactccact
     1801 gccggcttgg tgcccacgct cggcttccgc ccacccatgg actacgcctt tagcgatctc
     1861 atgcgtgacc gctcggccgc cgctgctgcg gcggtgcaca aggagccgac ctacggcggc
     1921 ggcctgtacg ggcctatggt caacggcgct ccggagaagc agtagggcga ggggcctggc
     1981 agccggccgg tccccaaaca ggaaccccag ccctgttccc gcgggccatc gacccctctt
     2041 cgcccagcgc tctctctgcg ccctggctgg gcgtcttctc actctaaggt ggtttttggg
     2101 ttttgtttag gagggtgggt ggggaaggct gagcaaaggg ggagcagcta cagacaggtg
     2161 caggtgttct cggagggggt gcgcggcctg ggtcctcatc tcctacctcc ggatccctct
     2221 tccagcctca cccggccccc tttccaaaag gctgggaatt catgagaatt cagaggctgc
     2281 gacagcagcg caggctcctg cggctcctta gctgtgctca tccggctctc agtggatggc
     2341 aggataatcc gagagtcttt tctgtgtctc cccagccctc acttttaaaa aatttaaata
     2401 ttcgctctaa caaatataaa tttaggatgt ataaatctct tggcactgag tctttgggac
     2461 acacatatat atcgatacaa ttgtaaaaaa aaaaaaagga aacaagtttt aaggtgcact
     2521 ttcctcgttg cggtatttgt cgctctcttt gttgcttatg ccgataagca tgggtttcct
     2581 tggtgcagtg tgtttttata tatgtataaa tctatatata atctatacat atatatatac
     2641 aagccagtgt ataatgttat aaaatggaat tctaagttat taattgtaat ctgtaggtga
     2701 cctcggtatt aacgtgaaaa acattcaaaa caagcaaaaa aagggacaaa atggaaaaaa
     2761 attagactat gcgcgcattg tacttatcag gtttagagat taaatatatt ggaaactcgg
     2821 gatgaatcct gcccacctgc ccctcttgcc tgcggctggt ctgtccctaa ggagccgtca
     2881 aggtgcgcac tgaagcagga acagagcgac gtgtgactga gccagaaccg cccgctcgcg
     2941 ggcccatcct cgcctcccgg gactcgccaa acgccctgac tgaagggccc gcagcggaaa
     3001 acgctgctgc agagcagcac tttgtgcttt cctttgcata gatatgagct agaaataaat
     3061 gttattttct aagaaaacaa
//
