LOCUS       NM_022160               5586 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DMRT like family A1 (DMRTA1), mRNA.
ACCESSION   NM_022160 XM_291311
VERSION     NM_022160.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5586)
  AUTHORS   Zhang,R., Zhou,P., Ou,X., Zhao,P., Guo,X., Xi,M. and Qing,C.
  TITLE     The DMRTA1-SOX2 positive feedback loop promotes progression and
            chemotherapy resistance of esophageal squamous cell carcinoma
  JOURNAL   Oncol Res 31 (6), 887-897 (2023)
   PUBMED   37744275
  REMARK    GeneRIF: The DMRTA1-SOX2 positive feedback loop promotes
            progression and chemotherapy resistance of esophageal squamous cell
            carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5586)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5586)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   4  (bases 1 to 5586)
  AUTHORS   Schaarschmidt,H., Ellinghaus,D., Rodriguez,E., Kretschmer,A.,
            Baurecht,H., Lipinski,S., Meyer-Hoffert,U., Harder,J., Lieb,W.,
            Novak,N., Folster-Holst,R., Esparza-Gordillo,J., Marenholz,I.,
            Ruschendorf,F., Hubner,N., Reischl,E., Waldenberger,M., Gieger,C.,
            Illig,T., Kabesch,M., Zhang,X.J., Xiao,F.L., Lee,Y.A., Franke,A.
            and Weidinger,S.
  TITLE     A genome-wide association study reveals 2 new susceptibility loci
            for atopic dermatitis
  JOURNAL   J Allergy Clin Immunol 136 (3), 802-806 (2015)
   PUBMED   25865352
  REMARK    GeneRIF: A genome-wide association study reveals 2 new
            susceptibility loci for atopic dermatitis, XIRP2 and DMRTA1.
REFERENCE   5  (bases 1 to 5586)
  AUTHORS   Chimusa,E.R., Zaitlen,N., Daya,M., Moller,M., van Helden,P.D.,
            Mulder,N.J., Price,A.L. and Hoal,E.G.
  TITLE     Genome-wide association study of ancestry-specific TB risk in the
            South African Coloured population
  JOURNAL   Hum Mol Genet 23 (3), 796-809 (2014)
   PUBMED   24057671
REFERENCE   6  (bases 1 to 5586)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 5586)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 5586)
  AUTHORS   Ottolenghi,C., Fellous,M., Barbieri,M. and McElreavey,K.
  TITLE     Novel paralogy relations among human chromosomes support a link
            between the phylogeny of doublesex-related genes and the evolution
            of sex determination
  JOURNAL   Genomics 79 (3), 333-343 (2002)
   PUBMED   11863363
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL161730.9, AK096011.1 and BC130435.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022160.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK096011.1, BC130435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325870.3/ ENSP00000319651.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AL161730.9         127294-127310
            18-700              AK096011.1         1-683
            701-1898            BC130435.1         663-1860
            1899-2319           AL161730.9         132523-132943
            2320-5586           AL161730.9         132944-136210
FEATURES             Location/Qualifiers
     source          1..5586
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..5586
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /note="DMRT like family A1"
                     /db_xref="GeneID:63951"
                     /db_xref="HGNC:HGNC:13826"
                     /db_xref="MIM:614803"
     exon            1..909
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..1757
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /codon_start=1
                     /product="doublesex- and mab-3-related transcription
                     factor A1"
                     /protein_id="NP_071443.2"
                     /db_xref="CCDS:CCDS6514.1"
                     /db_xref="GeneID:63951"
                     /db_xref="HGNC:HGNC:13826"
                     /db_xref="MIM:614803"
                     /translation="MERSQCGSRDRGVSGRPHLAPGLVVAAPPPPSPALPVPSGMQVP
                     PAFLRPPSLFLRAAAAAAAAAAATSGSGGCPPAPGLESGVGAVGCGYPRTPKCARCRN
                     HGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEESEARGLQRLL
                     CSGLSWPPGGRASGGGGRAENPQSTGGPAAGAALGLGALRQASGSATPAFEVFQQDYP
                     EEKQEQKESKCESCQNGQEELISKSHQLYLGSSSRSNGVIGKQSIGSSISEYSNKPDS
                     ILSPHPGEQSGGEESPRSLSSSDLESGNESEWVKDLTATKASLPTVSSRPRDPLDILT
                     KIFPNYRRSRLEGILRFCKGDVVQAIEQVLNGKEHKPDNRNLANSEELENTAFQRASS
                     FSLAGIGFGTLGNKSAFSPLQTTSASYGGDSSLYGVNPRVGISPLRLAYSSAGRGLSG
                     FMSPYLTPGLVPTLPFRPALDYAFSGMIRDSSYLSSKDSITCGRLYFRPNQDNP"
     exon            910..5586
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2298..2303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /note="hexamer: AATAAA"
     polyA_site      2325
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /note="major polyA site"
     regulatory      5568..5573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /note="hexamer: AATAAA"
     polyA_site      5577
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
     polyA_site      5586
                     /gene="DMRTA1"
                     /gene_synonym="DMO; DMRT4"
                     /note="major polyA site"
ORIGIN      
        1 aacttagcgc ccggggtctc tgccaggctc acgggacagc tgcacctctc agcgtctcca
       61 gctccaggac gcggtcgtcc caactccttc cgagtggaaa gagtgtaaaa cttttgtccg
      121 tgcgcgggtg gagctcagta ggaccacggc gcgtcctgcc ccggcttccc cagcctccca
      181 gcagggttag ctgcggtcag cgcactttcc acttgggact cccggccaga aatttctcgg
      241 gaatggagcg gtcacagtgt ggcagcagag accgaggcgt tagcggccga cctcacttgg
      301 cccctgggct agtggtggct gcccctccgc ccccgtcccc ggcgttgccg gtaccatcgg
      361 ggatgcaggt tcccccagcg ttcctgcggc cgcccagcct ctttctgcga gcagcggccg
      421 cggccgccgc cgccgctgcc gccacctcgg gaagcggagg ctgcccgccg gctcccgggc
      481 tggagagcgg ggtaggcgcg gtgggctgcg gctacccgcg gacgcccaag tgcgcccgct
      541 gtcgtaacca tggtgtggtg tcagcgctca agggccacaa gcgcttctgc cgctggcggg
      601 actgcgcgtg tgccaagtgc accctgatcg ccgagcgcca gcgcgtcatg gccgcccagg
      661 tggcgctgcg caggcagcag gcgcaggagg agagcgaagc ccgggggcta cagaggctcc
      721 tgtgctcggg gctctcctgg ccccccggtg gtcgggcatc cgggggcggc ggcagagccg
      781 agaatccaca gtccacgggc ggccctgcgg cgggggctgc gctgggactg ggtgccttga
      841 gacaggccag tggttccgcg acccccgctt tcgaagtttt ccagcaagat tatcctgagg
      901 aaaaacaaga acaaaaagag agtaaatgtg agtcatgcca gaatggacaa gaagaactga
      961 tctccaaatc ccatcagctt tacctaggat catcttctag gtctaatggt gtcattggga
     1021 aacaaagtat cgggtcatct atttcagaat actccaacaa gcctgatagt atcctgtctc
     1081 ctcatcctgg agagcaatca ggaggtgaag agagtcccag gtccttatca tcctctgatc
     1141 tggaatcagg aaatgaaagt gaatgggtca aagacttgac tgcgaccaag gcaagccttc
     1201 cgacagtgtc ctcaagacca agagatcctc ttgatatcct tactaagatt ttcccaaatt
     1261 acaggcgcag ccggctagaa ggcattctac ggttctgcaa aggggatgtg gtccaagcca
     1321 ttgaacaggt tttaaatggc aaagaacaca agccagacaa caggaaccta gcaaactcag
     1381 aagaactgga aaacacagcc tttcagagag cttcaagttt tagtcttgct ggaattggtt
     1441 ttggaactct aggtaataaa tcagctttct ctcctcttca aactacttct gcttcttatg
     1501 gaggtgattc aagtctctac ggcgtaaatc ctagagtagg tatcagtcca ttaaggctgg
     1561 catattcttc tgcaggaaga gggttatctg gttttatgtc accctaccta acacctgggt
     1621 tagtaccaac cttacctttt cggccagctt tggattatgc cttttcaggg atgattagag
     1681 attcttccta cctttccagt aaagactcaa taacttgtgg cagactgtac ttcagaccaa
     1741 atcaggacaa tccgtaatgt atatgcccat tctctctttc tggagttttt ccagcataca
     1801 atacatgcac gtgcacacac atacacacac atccattaat atacttcagt aagtatgtga
     1861 gtggattatg aggtcttaaa atgctgggtt tttttttttt caagcaatat aataggtctt
     1921 agatctgaaa actcttcatt aggatttatc aagtgaaaga agtaaatctg aacattatat
     1981 gtgccttgaa taaagctatt tcaggaaata tttaatgaat tttctcccta aattatcatt
     2041 tgtaaacatt tttattttaa aactagtttt tattttattg aaaagtggaa tttttagtga
     2101 taaaatacat ttgtaagtgt aaagcaatac agcataatag aatagaatat aaaccgaaag
     2161 gaagaactga acaattaagg caattctaaa taattaccat ttcaaaactg tttcttctat
     2221 tcctggttca taggaaagaa aaaagttatt caaagtattt ttaaagcatt tgatttgcag
     2281 atgggtgatt cgtaataaat aaaacatttg agcattttga atttatattt cctgagtatt
     2341 ttatttttca atcttagctt ccatgagtga aaacaagtgc cattaaaaaa catttctctt
     2401 taaagttgac actgtgtcta tgaagtaaat tttaggaaat aagactgcgc catctcctgg
     2461 ccactatcgc caattgcaac tgagctctgt agagtatatg aattagaaac attgattccg
     2521 gagaataacc attttttttt caaatagtca ttttggatta tactacatta aaatttccat
     2581 actgtaaagt gcacatctac tgtggatgag agttgcagtc tttaagtgtg cttatgtctg
     2641 tatctgggga aatatcctta aaagtttggg acaagaatat atggcagcca ttctcaaagg
     2701 taagaataat tttattcaga aaactaaaat agctgctcaa ataaatattt attaactgca
     2761 gatagttgat gcttaatgca ctgaggagag atataagatt tccaaagggg aaaaactgcc
     2821 atgaagtttc agaggtattc ttgcaatttt aaaaataatt tttgtcctcc ctctggcgca
     2881 tttgaaaact atttatttca gtcagtggaa agtccctgag gaaactgctt acaaaacagt
     2941 ttctaggaca ttttctttgt atgtcatcat ttttcttttt tgaaggacag tagcttcatt
     3001 gttattatta ggaataaatg gaagcccact ggtggtaaaa gatagttgat gaattagaga
     3061 ttgtttaaac tatttaagca gcatgactca ctaaagattt tttaaattat atgtatatac
     3121 gtatgtgtgt atgcatctat atgcacatat ataagtctat gtagacatac attaaacccc
     3181 tataggttat attatcatgg aggcgttttt catgaagcca gtaagaatgt atttccaagg
     3241 aatattttgc cagcaaatgt gatattaaat tacttcagag tatctgatgc tgatttagga
     3301 tgtaaatgtg tttattaggt tatgcattaa ttttaatggt gtgaatataa gaaagcagat
     3361 cttgaaaaat ttcgatgtac tcaatattca tttattataa aaaagtttta tattctaagc
     3421 ctaaaccgta gtacaatgtc tagcaagtag ttgaaattca attcatatat actgagtaag
     3481 aaactcttat atataataga tctctttgag actctgataa aactgaagaa ctctacaaaa
     3541 tggcgtacag acacacagtt ttgcatacaa tttcactggg ttcttgaatc tcctaaatgg
     3601 tattcaggtt agattccttg gtgattcttc agttgtttct attgcattaa tccacttatt
     3661 gaatgctatt tttctgaaaa gtgctagatc ctgtagagga tactgaatgt aaaatattgt
     3721 gctctaaagg aagttacatt atacaataga gatatggttt aaaaaaaaat cctagagtta
     3781 ctgcattatg tatgtggttt tataatgatg tgcttgtatc tgagaaactg aattgctttt
     3841 gaccttggga gaacatccat tttgggcagt attcgaattt ataaaatagt tttataatca
     3901 taaaacttaa tttatataat gccttacaca ttccatactc tttataataa tttaaggact
     3961 taatcttatc aaataggtca tttgtctaac aactcagtag tatatgagga aattggggct
     4021 cagcagtagg gttttttctc cctaaggtta gtaatatgag tcatctgcag tggaattact
     4081 gtgctcactt cagcaatttc agactccaat gtctgaggaa ggattcatgt ctgttttttt
     4141 cattcatggc cttgaacagt gtctgatata ggttctcaac ctatacacta gatttccact
     4201 gactgaaaaa aaataaaagc aagtattagc ttaataattt cttcattcaa cacctattta
     4261 atatttttaa taatctattt gtgccatgca ctgtgttaga cacaagagat aaagaaatga
     4321 ttaagataca agactttgcc tcaagttgct cacggtctat attgtgtgta caaaaacaac
     4381 caatcaacca atgttggtat tatttgacag tgttggtaca tcaatgagtt ctttgtaatc
     4441 ttgatattta tatccatgga tgctgcttga agcctgaact cctaagccac taattagtgg
     4501 tgggaagaaa gagggggtaa atgctttaag agctagcata taacaaaaat gaattgggtt
     4561 tattctgtat catatagagg gcctaagagg caaacatttc atagagtatt cagaagaaca
     4621 taaggaatga cttttttcac agttaacagc tgtccaagag tgtagtggct gcctcgtatg
     4681 ataaagcatc tggaactcat tgaaaaatgc atgtagaaaa taccaatcag agcctgattg
     4741 atgggatttt taattactgc tttaatattg ggactgaatc attttgtagc tcattagaaa
     4801 catggaaagt atttgttaaa taaataagtc atggaatttc aattctaagg ccatgaaaat
     4861 taaaacaccc taccattatt tatcaataaa acacagtgca gttttgctca tcagaatttt
     4921 gcctatgtga tagcctcctg agagtaggca gaaaagaaag acatagaacg cagtgcgtga
     4981 cttacaaggg aataaaactg acagaggtta gtgtaaggta tataggcatg agtggggctt
     5041 aaagaggata tgggagaaca ctgaagacaa atattagtac aattcctata aggtaaatac
     5101 caatatgtct ttctagaaga agcaattgtt ttggaattga ggaaacctag aatggattta
     5161 tctatatgac ttggacaggt tacttatact ctttggacat ttatttcttc tcagcaaaac
     5221 aagggtaata atatttaact tgcaagattc gtggagataa aagcttaaat aaacggcaga
     5281 gtacagtaat gcttatatac gggatgctaa ataaataact ctcactgtta ttactttgta
     5341 ttaagatatt atctttgccc cctcgtggca gtctctcaac aaagagtact gtaattgcat
     5401 ttaatccact tagtggatgt ggagcccaaa gggcagccat cactagagca gcgtacaggc
     5461 ttagttccag acttcgtgtt tggttgttca tttcataggc gagccacgtg ttttgtaaca
     5521 tattctcgta tatgttattt ggattatttt cagggctttc tgaagaaaat aaacatcgaa
     5581 atcata
//
