LOCUS       NM_004407               2705 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens dentin matrix acidic phosphoprotein 1 (DMP1),
            transcript variant 1, mRNA.
ACCESSION   NM_004407
VERSION     NM_004407.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2705)
  AUTHORS   Bastida,G., Ramirez,F., Exeni,G., Costa,M. and Avila,S.A.
  TITLE     First report in Argentina of a pathogenic DMP1 variant associated
            with autosomal recessive hypophosphatemic rickets
  JOURNAL   Arch Argent Pediatr 121 (2), e202202682 (2023)
   PUBMED   36315908
  REMARK    GeneRIF: First report in Argentina of a pathogenic DMP1 variant
            associated with autosomal recessive hypophosphatemic rickets.
REFERENCE   2  (bases 1 to 2705)
  AUTHORS   Tavana,N., Ting,T.H., Lai,K., Kennerson,M.L. and Thilakavathy,K.
  TITLE     Whole exome sequencing identifies two novel variants in PHEX and
            DMP1 in Malaysian children with hypophosphatemic rickets
  JOURNAL   Ital J Pediatr 48 (1), 193 (2022)
   PUBMED   36482408
  REMARK    GeneRIF: Whole exome sequencing identifies two novel variants in
            PHEX and DMP1 in Malaysian children with hypophosphatemic rickets.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2705)
  AUTHORS   He,Y., Wang,W., Luo,P., Wang,Y., He,Z., Dong,W., Jia,M., Yu,X.,
            Yang,B. and Wang,J.
  TITLE     Mettl3 regulates hypertrophic differentiation of chondrocytes
            through modulating Dmp1 mRNA via Ythdf1-mediated m6A modification
  JOURNAL   Bone 164, 116522 (2022)
   PUBMED   35981698
  REMARK    GeneRIF: Mettl3 regulates hypertrophic differentiation of
            chondrocytes through modulating Dmp1 mRNA via Ythdf1-mediated m(6)A
            modification.
REFERENCE   4  (bases 1 to 2705)
  AUTHORS   Suzuki,S., Yuan,H., Hirata-Tsuchiya,S., Yoshida,K., Sato,A.,
            Nemoto,E., Shiba,H. and Yamada,S.
  TITLE     DMP-1 promoter-associated antisense strand non-coding RNA,
            panRNA-DMP-1, physically associates with EGFR to repress
            EGF-induced squamous cell carcinoma migration
  JOURNAL   Mol Cell Biochem 476 (4), 1673-1690 (2021)
   PUBMED   33420898
  REMARK    GeneRIF: DMP-1 promoter-associated antisense strand non-coding RNA,
            panRNA-DMP-1, physically associates with EGFR to repress
            EGF-induced squamous cell carcinoma migration.
REFERENCE   5  (bases 1 to 2705)
  AUTHORS   Porebska,A., Rozycka,M., Holubowicz,R., Szewczuk,Z., Ozyhar,A. and
            Dobryszycki,P.
  TITLE     Functional derivatives of human dentin matrix protein 1 modulate
            morphology of calcium carbonate crystals
  JOURNAL   FASEB J 34 (5), 6147-6165 (2020)
   PUBMED   32190922
REFERENCE   6  (bases 1 to 2705)
  AUTHORS   Narayanan,K., Ramachandran,A., Hao,J., He,G., Park,K.W., Cho,M. and
            George,A.
  TITLE     Dual functional roles of dentin matrix protein 1. Implications in
            biomineralization and gene transcription by activation of
            intracellular Ca2+ store
  JOURNAL   J Biol Chem 278 (19), 17500-17508 (2003)
   PUBMED   12615915
REFERENCE   7  (bases 1 to 2705)
  AUTHORS   Jain,A., Karadag,A., Fohr,B., Fisher,L.W. and Fedarko,N.S.
  TITLE     Three SIBLINGs (small integrin-binding ligand, N-linked
            glycoproteins) enhance factor H's cofactor activity enabling
            MCP-like cellular evasion of complement-mediated attack
  JOURNAL   J Biol Chem 277 (16), 13700-13708 (2002)
   PUBMED   11825898
  REMARK    GeneRIF: Three SIBLINGs (small integrin-binding ligand, N-linked
            glycoproteins) enhance factor H's cofactor activity enabling
            MCP-like cellular evasion of complement-mediated attack.
REFERENCE   8  (bases 1 to 2705)
  AUTHORS   Kulkarni,G.V., Chen,B., Malone,J.P., Narayanan,A.S. and George,A.
  TITLE     Promotion of selective cell attachment by the RGD sequence in
            dentine matrix protein 1
  JOURNAL   Arch Oral Biol 45 (6), 475-484 (2000)
   PUBMED   10775676
REFERENCE   9  (bases 1 to 2705)
  AUTHORS   Hirst,K.L., Simmons,D., Feng,J., Aplin,H., Dixon,M.J. and
            MacDougall,M.
  TITLE     Elucidation of the sequence and the genomic organization of the
            human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion
            of the locus from a causative role in the pathogenesis of
            dentinogenesis imperfecta type II
  JOURNAL   Genomics 42 (1), 38-45 (1997)
   PUBMED   9177774
REFERENCE   10 (bases 1 to 2705)
  AUTHORS   Aplin,H.M., Hirst,K.L., Crosby,A.H. and Dixon,M.J.
  TITLE     Mapping of the human dentin matrix acidic phosphoprotein gene
            (DMP1) to the dentinogenesis imperfecta type II critical region at
            chromosome 4q21
  JOURNAL   Genomics 30 (2), 347-349 (1995)
   PUBMED   8586437
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093895.3, U89012.1 and
            AI371158.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004407.3.
            
            Summary: Dentin matrix acidic phosphoprotein is an extracellular
            matrix protein and a member of the small integrin binding ligand
            N-linked glycoprotein family. This protein, which is critical for
            proper mineralization of bone and dentin, is present in diverse
            cells of bone and tooth tissues. The protein contains a large
            number of acidic domains, multiple phosphorylation sites, a
            functional arg-gly-asp cell attachment sequence, and a DNA binding
            domain. In undifferentiated osteoblasts it is primarily a nuclear
            protein that regulates the expression of osteoblast-specific genes.
            During osteoblast maturation the protein becomes phosphorylated and
            is exported to the extracellular matrix, where it orchestrates
            mineralized matrix formation. Mutations in the gene are known to
            cause autosomal recessive hypophosphatemia, a disease that
            manifests as rickets and osteomalacia. The gene structure is
            conserved in mammals. Two transcript variants encoding different
            isoforms have been described for this gene. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments and data in PMID:15108359.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89012.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2148874 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339673.11/ ENSP00000340935.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                AC093895.3         52970-52991
            23-27               AC093895.3         52992-52996
            28-1870             U89012.1           1-1843
            1871-2573           AC093895.3         66213-66915
            2574-2705           AI371158.1         11-142              c
FEATURES             Location/Qualifiers
     source          1..2705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..2705
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /note="dentin matrix acidic phosphoprotein 1"
                     /db_xref="GeneID:1758"
                     /db_xref="HGNC:HGNC:2932"
                     /db_xref="MIM:600980"
     exon            1..105
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            106..180
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..1668
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; dentin matrix protein 1"
                     /codon_start=1
                     /product="dentin matrix acidic phosphoprotein 1 isoform 1
                     precursor"
                     /protein_id="NP_004398.1"
                     /db_xref="CCDS:CCDS3623.1"
                     /db_xref="GeneID:1758"
                     /db_xref="HGNC:HGNC:2932"
                     /db_xref="MIM:600980"
                     /translation="MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPP
                     LESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDK
                     DDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQD
                     TTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSD
                     DPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEE
                     DDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVD
                     GPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTL
                     SHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSE
                     EDDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAYHNKPIGDQDDND
                     CQDGY"
     exon            181..228
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..261
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            262..309
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..2705
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2683..2688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /note="hexamer: AATAAA"
     polyA_site      2705
                     /gene="DMP1"
                     /gene_synonym="ARHP; ARHR; DMP-1"
                     /note="major polyA site"
ORIGIN      
        1 agaatatcaa cacaagagtg gcttcattgg gcatagattt cctctttgag aacatcaacc
       61 tgatttttga gactttttga aaaaattctt tgtgaactac ggagggtaga ggtatcacac
      121 ccaactatga agatcagcat cctgctcatg ttcctttggg gattatcctg tgctctccca
      181 gtaaccaggt atcaaaataa tgaatctgag gattctgaag aatggaaggg tcatttggct
      241 caggcaccaa caccaccctt ggagagcagt gagtcatcag aaggcagtaa agttagctca
      301 gaggaacagg caaatgaaga ccccagtgac agcactcagt cagaggaggg cctgggctct
      361 gatgatcatc aatacattta taggctagct ggtggcttct ccaggagcac aggaaaagga
      421 ggagatgata aagatgacga tgaagatgac agtggagatg acacctttgg tgacgatgac
      481 agtggcccag ggcccaaaga cagacaagaa ggaggaaact ccagactggg aagtgatgag
      541 gactctgatg acaccataca agccagtgaa gagagtgccc cacaagggca agacagtgcc
      601 caagatacca ccagtgagag cagggaactt gacaatgagg accgggtgga cagcaagcct
      661 gagggaggtg actccactca agagagtgag agtgaagagc actgggtggg aggtggcagt
      721 gatggggaga gcagccatgg agacggctcc gagttggacg atgagggaat gcagagtgat
      781 gacccagaga gcatcaggag tgaaagggga aactccagaa tgaacagtgc aggcatgaaa
      841 tcaaaagaat ctggagaaaa cagtgagcaa gcaaacactc aagattcagg tggcagccaa
      901 ttgctggagc atcccagtag gaaaattttt aggaagtctc gcatctcaga ggaagatgac
      961 agaagcgagc ttgatgacaa caacacaatg gaagaagtca agagtgactc tacagaaaac
     1021 agcaactcca gagacactgg cctcagccaa cccaggagag acagcaaggg tgactctcaa
     1081 gaagacagca aggagaatct gtcccaggaa gagagccaaa acgtagatgg tcccagcagt
     1141 gagtccagcc aagaggccaa cctgtcatct caagagaaca gcagtgagtc tcaggaagag
     1201 gtggtgagtg agtccagggg agataacccc gaccccacaa ctagttatgt agaagaccag
     1261 gaagacagtg actccagcga ggaggacagc tcgcacacac tctcccactc aaaaagtgaa
     1321 tccagagagg agcaagcaga cagcgaatcc agtgagagcc tcaacttctc agaggaaagc
     1381 ccggagtccc ctgaggatga gaacagctcc agccaggagg gcctccagtc tcacagcagc
     1441 tcagcagaga gtcagagcga ggaaagccat tctgaggaag acgacagtga ctctcaagac
     1501 agcagcagat ccaaagaaga tagcaactcc acggagagca aatcaagcag tgaggaagat
     1561 ggccagttga aaaacattga gatagagagc cggaaattaa cagttgatgc ctatcacaac
     1621 aaacccattg gggaccaaga tgacaatgac tgccaagacg gctattagca tcagctgtcc
     1681 taagaagcag ttgtcacata aaggagtctt agggacttga aaatgtatca tgataactat
     1741 aatttattga tgttttgatc aaaagaataa ccagatgcca tatttttcct gaaaggaatt
     1801 gctggacatt acacttgttt ttagggtgtc atcatttcac agaggtttaa atactgtgga
     1861 gtgacaccag aacacagcca aagaggctag aagcaagaaa ggatctgcat gataactttg
     1921 cagctgagat agttcctaat tcatcaacgt aacaaacaaa gctattgggt gtccatgata
     1981 taccaggcac tatgctaggt gttgagaatg taaagcaggt taagacttgt ttcttgctcc
     2041 tgaggagcgt atagaaggac ccacaaagct acagagttaa agagggatat gtataagaga
     2101 aacaagaatt gttacaaccc agtatggtga gtgccaagac agagagctat gaacacgata
     2161 tctatctggg aacactgaga agggtgacca atgcgttgga gaacgaggga gggcttcata
     2221 gcagaagaca ttggagttgg aaggttgcat agggtttcct cattggagac cgggaaattc
     2281 tattcttggg ataaataata gtaaattcta taggattcaa tacttagttt gcaaaagcac
     2341 tttgaaatta tggcacagtg agttgttttg gataagaaaa tctttttctc ccaattaatt
     2401 taccaattca tcattttttt ttttttgtag aactcccata aacatcacct tactaatcac
     2461 tggtgatgat aagaaggatt gggtcaggaa gagtgggaga aagaaattcc tctttacgta
     2521 gatacttttt agctttattt tttctaaaat cagtttgcgt gcaatgctag aaaaaaactg
     2581 ttctctgagt cctttacaga gcaaaattct gtatgtaaga ttcaattgat ttttgacaaa
     2641 taccatttga aatattacct caacataaaa tacttgtttt gtaataaaga ttataatacc
     2701 cagaa
//
