LOCUS       NM_033317               1924 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens dermokine (DMKN), transcript variant 2, mRNA.
ACCESSION   NM_033317
VERSION     NM_033317.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1924)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1924)
  AUTHORS   Huang,C., Xiang,Y., Chen,S., Yu,H., Wen,Z., Ye,T., Sun,H., Kong,H.,
            Li,D., Yu,D., Chen,B. and Zhou,M.
  TITLE     Dermokine contributes to epithelial-mesenchymal transition through
            increased activation of signal transducer and activator of
            transcription 3 in pancreatic cancer
  JOURNAL   Cancer Sci 108 (11), 2130-2141 (2017)
   PUBMED   28795470
  REMARK    GeneRIF: we showed that DMKN loss of function in Patu-8988 and
            PANC-1 pancreatic cancer cell lines resulted in reduced
            phosphorylation of STAT3.these data suggested that DMKN could be a
            potential prognostic biomarker and therapeutic target in pancreatic
            cancer.
REFERENCE   3  (bases 1 to 1924)
  AUTHORS   Hasegawa,M., Higashi,K., Matsushita,T., Hamaguchi,Y., Saito,K.,
            Fujimoto,M. and Takehara,K.
  TITLE     Dermokine inhibits ELR(+)CXC chemokine expression and delays early
            skin wound healing
  JOURNAL   J Dermatol Sci 70 (1), 34-41 (2013)
   PUBMED   23428944
  REMARK    GeneRIF: These results suggest that dermokine-beta delays early
            cutaneous wound healing in part by inhibiting expression of CXC
            chemokines containing the ERL-sequence motif.
REFERENCE   4  (bases 1 to 1924)
  AUTHORS   Watanabe,K., Oochiai,T., Kikuchi,S., Kumano,T., Matsui,T.,
            Morimoto,K., Yasukawa,S., Nakamori,S., Sasako,M., Yanagisawa,A. and
            Otsuji,E.
  TITLE     Dermokine expression in intraductal papillary-mucinous neoplasm and
            invasive pancreatic carcinoma
  JOURNAL   Anticancer Res 32 (10), 4405-4412 (2012)
   PUBMED   23060565
  REMARK    GeneRIF: Serum DK is a potential biomarker in intraductal papillary
            mucinous neoplasm and invasive ductal carcinoma, when used in
            combination with conventional biomarkers.
            Erratum:[Anticancer Res. 2012 Nov;32(11):5137]
REFERENCE   5  (bases 1 to 1924)
  AUTHORS   Higashi,K., Hasegawa,M., Yokoyama,C., Tachibana,T., Mitsui,S. and
            Saito,K.
  TITLE     Dermokine-beta impairs ERK signaling through direct binding to
            GRP78
  JOURNAL   FEBS Lett 586 (16), 2300-2305 (2012)
   PUBMED   22735594
  REMARK    GeneRIF: Dermokine-beta impairs ERK signaling through direct
            binding to GRP78
REFERENCE   6  (bases 1 to 1924)
  AUTHORS   Leclerc,E.A., Gazeilles,L., Serre,G., Guerrin,M. and Jonca,N.
  TITLE     The ubiquitous dermokine delta activates Rab5 function in the early
            endocytic pathway
  JOURNAL   PLoS One 6 (3), e17816 (2011)
   PUBMED   21423773
  REMARK    GeneRIF: Dmkndelta activates Rab5 function and thus is involved in
            the early endosomal trafficking.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1924)
  AUTHORS   Naso,M.F., Liang,B., Huang,C.C., Song,X.Y., Shahied-Arruda,L.,
            Belkowski,S.M., D'Andrea,M.R., Polkovitch,D.A., Lawrence,D.R.,
            Griswold,D.E., Sweet,R.W. and Amegadzie,B.Y.
  TITLE     Dermokine: an extensively differentially spliced gene expressed in
            epithelial cells
  JOURNAL   J Invest Dermatol 127 (7), 1622-1631 (2007)
   PUBMED   17380110
  REMARK    GeneRIF: Dermokine gene is expressed in epithelial tissues other
            than the skin and this expression is transcriptionally and
            posttranscriptionally complex.
REFERENCE   8  (bases 1 to 1924)
  AUTHORS   Toulza,E., Galliano,M.F., Jonca,N., Gallinaro,H., Mechin,M.C.,
            Ishida-Yamamoto,A., Serre,G. and Guerrin,M.
  TITLE     The human dermokine gene: description of novel isoforms with
            different tissue-specific expression and subcellular location
  JOURNAL   J Invest Dermatol 126 (2), 503-506 (2006)
   PUBMED   16374476
  REMARK    GeneRIF: Analysis of alternative spliced transcripts produced from
            the dermokine gene.
REFERENCE   9  (bases 1 to 1924)
  AUTHORS   Matsui,T., Hayashi-Kisumi,F., Kinoshita,Y., Katahira,S., Morita,K.,
            Miyachi,Y., Ono,Y., Imai,T., Tanigawa,Y., Komiya,T. and Tsukita,S.
  TITLE     Identification of novel keratinocyte-secreted peptides
            dermokine-alpha/-beta and a new stratified epithelium-secreted
            protein gene complex on human chromosome 19q13.1
  JOURNAL   Genomics 84 (2), 384-397 (2004)
   PUBMED   15234001
REFERENCE   10 (bases 1 to 1924)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC138125.1 and AD001502.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033317.4.
            
            Summary: This gene is upregulated in inflammatory diseases, and it
            was first observed as expressed in the differentiated layers of
            skin. The most interesting aspect of this gene is the differential
            use of promoters and terminators to generate isoforms with unique
            cellular distributions and domain components. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified for this gene. [provided by RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) represents the longest
            transcript and encodes the longest isoform (2, also referred to as
            isoform beta).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035311.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339686.8/ ENSP00000342012.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               AC138125.1         5420-6019           c
            601-801             AC138125.1         4960-5160           c
            802-858             AC138125.1         4791-4847           c
            859-909             AC138125.1         4133-4183           c
            910-1092            AC138125.1         3781-3963           c
            1093-1161           AD001502.1         44313-44381         c
            1162-1212           AD001502.1         44040-44090         c
            1213-1260           AD001502.1         40068-40115         c
            1261-1308           AD001502.1         39847-39894         c
            1309-1365           AD001502.1         36959-37015         c
            1366-1413           AD001502.1         36265-36312         c
            1414-1461           AD001502.1         34662-34709         c
            1462-1533           AD001502.1         34087-34158         c
            1534-1557           AD001502.1         33003-33026         c
            1558-1605           AD001502.1         32845-32892         c
            1606-1924           AD001502.1         31349-31667         c
FEATURES             Location/Qualifiers
     source          1..1924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..1924
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /note="dermokine"
                     /db_xref="GeneID:93099"
                     /db_xref="HGNC:HGNC:25063"
                     /db_xref="MIM:617211"
     exon            1..600
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1605
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; epidermis-specific secreted protein SK30/SK89"
                     /codon_start=1
                     /product="dermokine isoform 2 precursor"
                     /protein_id="NP_201574.4"
                     /db_xref="CCDS:CCDS12463.1"
                     /db_xref="GeneID:93099"
                     /db_xref="HGNC:HGNC:25063"
                     /db_xref="MIM:617211"
                     /translation="MKFQGPLACLLLALCLGSGEAGPLQSGEESTGTNIGEALGHGLG
                     DALSEGVGKAIGKEAGGAAGSKVSEALGQGTREAVGTGVRQVPGFGVADALGNRVGEA
                     AHALGNTGHEIGRQAEDVIRHGADAVRGSWQGVPGHNGAWETSGGHGIFGSQGGLGGQ
                     GQGNPGGLGTPWVHGYPGNSAGSFGMNPQGAPWGQGGNGGPPNFGTNTQGAVAQPGYG
                     SVRASNQNEGCTNPPPSGSGGGSSNSGGGSGSQSGSSGSGSNGDNNNGSSSGGSSSGS
                     SSGGSSGGSSGGSSGNSGGSRGDSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPG
                     NEARGSGESGIQNSETSPGMFNFDTFWKNFKSKLGFINWDAINKNQVPPPSTRALLYF
                     SRLWEDFKQNTPFLNWKAIIEGADASSLQKRAGRDDQNYNYNQHAYPTAYGGKYSVKT
                     PAKGGVSPSSSASRVQPGLLQWVKFW"
     exon            601..801
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            802..858
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            859..909
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1092
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1161
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1212
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1260
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1308
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1365
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1413
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1461
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1533
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1557
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1605
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1924
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1899..1904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /note="hexamer: AATAAA"
     polyA_site      1924
                     /gene="DMKN"
                     /gene_synonym="UNQ729; ZD52F10"
                     /note="major polyA site"
ORIGIN      
        1 gagaagccca ggcagttgag gacaggagag agaaggctgc agacccagag ggagggagga
       61 cagggagtcg gaaggaggag gacagaggag ggcacagaga cgcagagcaa gggcggcaag
      121 gaggagaccc tggtgggagg aagacactct ggagagagag ggggctgggc agagatgaag
      181 ttccaggggc ccctggcctg cctcctgctg gccctctgcc tgggcagtgg ggaggctggc
      241 cccctgcaga gcggagagga aagcactggg acaaatattg gggaggccct tggacatggc
      301 ctgggagacg ccctgagcga aggggtggga aaggccattg gcaaagaggc cggaggggca
      361 gctggctcta aagtcagtga ggcccttggc caagggacca gagaagcagt tggcactgga
      421 gtcaggcagg ttccaggctt tggcgtagca gatgctttgg gcaacagggt cggggaagca
      481 gcccatgctc tgggaaacac tgggcacgag attggcagac aggcagaaga tgtcattcga
      541 cacggagcag atgctgtccg cggctcctgg cagggggtgc ctggccacaa tggtgcttgg
      601 gaaacttctg gaggccatgg catctttggc tctcaaggtg gccttggagg ccagggccag
      661 ggcaatcctg gaggtctggg gactccgtgg gtccacggat accccggaaa ctcagcaggc
      721 agctttggaa tgaatcctca gggagctccc tggggtcaag gaggcaatgg agggccacca
      781 aactttggga ccaacactca gggagctgtg gcccagcctg gctatggttc agtgagagcc
      841 agcaaccaga atgaagggtg cacgaatccc ccaccatctg gctcaggtgg aggctccagc
      901 aactctgggg gaggcagcgg ctcacagtcg ggcagcagtg gcagtggcag caatggtgac
      961 aacaacaatg gcagcagcag tggtggcagc agcagtggca gcagcagtgg cggcagcagt
     1021 ggcggcagca gtggtggcag cagtggcaac agtggtggca gcagaggtga cagcggcagt
     1081 gagtcctcct ggggatccag caccggctcc tcctccggca accacggtgg gagcggcgga
     1141 ggaaatggac ataaacccgg gtgtgaaaag ccagggaatg aagcccgcgg gagcggggaa
     1201 tctgggattc agaactctga gacgtctcct gggatgttta actttgacac tttctggaag
     1261 aattttaaat ccaagctggg tttcatcaac tgggatgcca taaacaagaa ccaggtcccg
     1321 ccccccagca cccgagccct cctctacttc agccgactct gggaggattt caaacagaac
     1381 actcctttcc tcaactggaa agcaattatt gagggtgcgg acgcgtcatc actgcagaaa
     1441 cgtgcaggca gagacgatca gaactacaat tacaaccagc atgcgtatcc cactgcctat
     1501 ggtgggaagt actcagtcaa gacccctgca aaggggggag tctcaccttc ttcctcggct
     1561 tcccgggtgc aacctggcct gctgcagtgg gtgaagtttt ggtaggcaat ttcttgcaac
     1621 caccaccgag gccccgaaaa gcactggtcg tcagggagct cctccccttg gcccccagcc
     1681 tgtgccagcc ctggcccggc tgccacacct ctgtttccta ggctggggac ccagcttgtc
     1741 tctccttgtt tcttcccact gcactgtggt gcttcagtgg ccaccagcct cgtcacatac
     1801 accagcatct ttctgtacct cctccctttg gtgacctgaa gtcactgtga cagttctcca
     1861 ggaaggagga gcttcctact tttgagtttc tctgtggaaa taaaacatga atcttgtttc
     1921 ccta
//
