LOCUS       NM_004006              13992 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens dystrophin (DMD), transcript variant Dp427m, mRNA.
ACCESSION   NM_004006
VERSION     NM_004006.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 13992)
  AUTHORS   Chen,L., Luo,X., Wang,H., Tian,Y. and Liu,Y.
  TITLE     Identifying inversions with breakpoints in the Dystrophin gene
            through long-read sequencing: report of two cases
  JOURNAL   BMC Med Genomics 17 (1), 227 (2024)
   PUBMED   39251998
  REMARK    GeneRIF: Identifying inversions with breakpoints in the Dystrophin
            gene through long-read sequencing: report of two cases.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 13992)
  AUTHORS   Chen,J., Jia,Y., Zhong,J., Zhang,K., Dai,H., He,G., Li,F., Zeng,L.,
            Fan,C. and Xu,H.
  TITLE     Novel mutation leading to splice donor loss in a conserved site of
            DMD gene causes Duchenne muscular dystrophy with cryptorchidism
  JOURNAL   J Med Genet 61 (8), 741-749 (2024)
   PUBMED   38621993
  REMARK    GeneRIF: Novel mutation leading to splice donor loss in a conserved
            site of DMD gene causes Duchenne muscular dystrophy with
            cryptorchidism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 13992)
  AUTHORS   Davies,K.E. and Vogt,J.
  TITLE     Long-term clinical follow-up of a family with Becker muscular
            dystrophy associated with a large deletion in the DMD gene
  JOURNAL   Neuromuscul Disord 39, 5-9 (2024)
   PUBMED   38653179
  REMARK    GeneRIF: Long-term clinical follow-up of a family with Becker
            muscular dystrophy associated with a large deletion in the DMD
            gene.
            Erratum:[Neuromuscul Disord. 2024 Jun;39:54. doi:
            10.1016/j.nmd.2024.05.010. PMID: 38801812]
REFERENCE   4  (bases 1 to 13992)
  AUTHORS   Achermann,J.C. and Vilain,E.J.
  TITLE     NR0B1-Related Adrenal Hypoplasia Congenita
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301604
REFERENCE   5  (bases 1 to 13992)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
REFERENCE   6  (bases 1 to 13992)
  AUTHORS   Darras,B.T., Urion,D.K. and Ghosh,P.S.
  TITLE     Dystrophinopathies
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301298
REFERENCE   7  (bases 1 to 13992)
  AUTHORS   Nigro,V., Politano,L., Nigro,G., Romano,S.C., Molinari,A.M. and
            Puca,G.A.
  TITLE     Detection of a nonsense mutation in the dystrophin gene by multiple
            SSCP
  JOURNAL   Hum Mol Genet 1 (7), 517-520 (1992)
   PUBMED   1307253
REFERENCE   8  (bases 1 to 13992)
  AUTHORS   Gorecki,D.C., Monaco,A.P., Derry,J.M., Walker,A.P., Barnard,E.A.
            and Barnard,P.J.
  TITLE     Expression of four alternative dystrophin transcripts in brain
            regions regulated by different promoters
  JOURNAL   Hum Mol Genet 1 (7), 505-510 (1992)
   PUBMED   1307251
REFERENCE   9  (bases 1 to 13992)
  AUTHORS   Lederfein,D., Levy,Z., Augier,N., Mornet,D., Morris,G., Fuchs,O.,
            Yaffe,D. and Nudel,U.
  TITLE     A 71-kilodalton protein is a major product of the Duchenne muscular
            dystrophy gene in brain and other nonmuscle tissues
  JOURNAL   Proc Natl Acad Sci U S A 89 (12), 5346-5350 (1992)
   PUBMED   1319059
REFERENCE   10 (bases 1 to 13992)
  AUTHORS   Koenig,M., Monaco,A.P. and Kunkel,L.M.
  TITLE     The complete sequence of dystrophin predicts a rod-shaped
            cytoskeletal protein
  JOURNAL   Cell 53 (2), 219-228 (1988)
   PUBMED   3282674
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031643.1, M18533.1,
            AL031542.1, AL109609.5, AC079864.22, AC079177.21 and BC028720.1.
            
            On Dec 27, 2019 this sequence version replaced NM_004006.2.
            
            Summary: This gene spans a genomic range of greater than 2 Mb and
            encodes a large protein containing an N-terminal actin-binding
            domain and multiple spectrin repeats. The encoded protein forms a
            component of the dystrophin-glycoprotein complex (DGC), which
            bridges the inner cytoskeleton and the extracellular matrix.
            Deletions, duplications, and point mutations at this gene locus may
            cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy
            (BMD), or cardiomyopathy. Alternative promoter usage and
            alternative splicing result in numerous distinct transcript
            variants and protein isoforms for this gene. [provided by RefSeq,
            Dec 2016].
            
            Transcript Variant: transcript Dp427m encodes the main dystrophin
            protein found in muscle. As a result of alternative promoter use,
            exon 1 encodes a unique N-terminal MLWWEEVEDCY aa sequence.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18533.1, X14298.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357033.9/ ENSP00000354923.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-37                AL031643.1         20726-20762         c
            38-2881             M18533.1           9-2852
            2882-2882           AL031542.1         65972-65972         c
            2883-4642           M18533.1           2854-4613
            4643-4643           AL109609.5         79506-79506         c
            4644-5766           M18533.1           4615-5737
            5767-5767           AL109609.5         35892-35892         c
            5768-7332           M18533.1           5739-7303
            7333-7333           AC079864.22        141601-141601       c
            7334-9046           M18533.1           7305-9017
            9047-9047           AC079177.21        132735-132735       c
            9048-12741          M18533.1           9019-12712
            12742-13992         BC028720.1         3398-4648
FEATURES             Location/Qualifiers
     source          1..13992
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp21.2-p21.1"
     gene            1..13992
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /note="dystrophin"
                     /db_xref="GeneID:1756"
                     /db_xref="HGNC:HGNC:2928"
                     /db_xref="MIM:300377"
     exon            1..268
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..11295
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /note="isoform Dp427m is encoded by transcript variant
                     Dp427m; mutant dystrophin"
                     /codon_start=1
                     /product="dystrophin isoform Dp427m"
                     /protein_id="NP_003997.2"
                     /db_xref="CCDS:CCDS14233.1"
                     /db_xref="GeneID:1756"
                     /db_xref="HGNC:HGNC:2928"
                     /db_xref="MIM:300377"
                     /translation="MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDL
                     QDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDG
                     NHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFT
                     TSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDV
                     DTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQ
                     QITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSL
                     MESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAH
                     QGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLM
                     DLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVN
                     SLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTE
                     EQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLK
                     QDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVM
                     ETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEA
                     VLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNA
                     DSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQ
                     PTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAF
                     TNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDY
                     EIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWK
                     KLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQL
                     KQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVY
                     ARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAK
                     EEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLE
                     EVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNP
                     NQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKS
                     LHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEA
                     AQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVE
                     QEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHY
                     NELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSE
                     VAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAE
                     EWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELND
                     IRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELE
                     QFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDER
                     KREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKL
                     ASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWRE
                     IESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQ
                     LLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKL
                     QEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQI
                     PENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNL
                     RWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKE
                     KLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVS
                     RALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFD
                     VKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRA
                     KQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWT
                     ELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLK
                     NKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVL
                     GQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSAD
                     DTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTA
                     NVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSD
                     DAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDEL
                     SRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQ
                     EPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLRELQEATD
                     ELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQL
                     TTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGP
                     WERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKA
                     LCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVD
                     MCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRL
                     GLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSM
                     VWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGH
                     KMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMET
                     PVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESID
                     DEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEY
                     DRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDH
                     NKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSM
                     GEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM"
     exon            269..330
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            331..423
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            424..501
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            502..594
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            595..767
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            768..886
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            887..1068
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1197
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1386
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1568
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1719
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1839
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1941
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2049
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            2050..2229
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2405
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            2406..2529
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2617
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2859
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            2860..3040
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3186
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            3187..3399
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3513
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3669
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            3670..3840
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            3841..4023
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4024..4158
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4159..4308
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4309..4470
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4581
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4582..4755
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4756..4911
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            4912..5082
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5083..5262
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..5391
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5392..5562
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5563..5685
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5686..5823
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5824..5976
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            5977..6159
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            6160..6354
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            6355..6527
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            6528..6675
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            6676..6851
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            6852..6999
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7000..7149
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7150..7335
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7336..7437
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7438..7546
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7547..7779
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7780..7897
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            7898..8109
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            8110..8264
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            8265..8454
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            8455..8627
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            8628..8784
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            8785..8905
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            8906..9174
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9175..9321
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9322..9400
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9401..9461
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9462..9523
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9524..9598
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9599..9800
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9801..9886
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            9887..10044
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10045..10211
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10212..10323
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10324..10460
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10461..10499
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10500..10565
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10566..10631
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10632..10790
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            10791..11034
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            11035..11158
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            11159..11251
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            11252..11283
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     exon            11284..13992
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13964..13969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /note="hexamer: AATAAA"
     polyA_site      13992
                     /gene="DMD"
                     /gene_synonym="BMD; CMD3B; DXS142; DXS164; DXS206; DXS230;
                     DXS239; DXS268; DXS269; DXS270; DXS272; MRX85"
                     /note="major polyA site"
ORIGIN      
        1 atcagttact gtgttgactc actcagtgtt gggatcactc actttccccc tacaggactc
       61 agatctggga ggcaattacc ttcggagaaa aacgaatagg aaaaactgaa gtgttacttt
      121 ttttaaagct gctgaagttt gttggtttct cattgttttt aagcctactg gagcaataaa
      181 gtttgaagaa cttttaccag gtttttttta tcgctgcctt gatatacact tttcaaaatg
      241 ctttggtggg aagaagtaga ggactgttat gaaagagaag atgttcaaaa gaaaacattc
      301 acaaaatggg taaatgcaca attttctaag tttgggaagc agcatattga gaacctcttc
      361 agtgacctac aggatgggag gcgcctccta gacctcctcg aaggcctgac agggcaaaaa
      421 ctgccaaaag aaaaaggatc cacaagagtt catgccctga acaatgtcaa caaggcactg
      481 cgggttttgc agaacaataa tgttgattta gtgaatattg gaagtactga catcgtagat
      541 ggaaatcata aactgactct tggtttgatt tggaatataa tcctccactg gcaggtcaaa
      601 aatgtaatga aaaatatcat ggctggattg caacaaacca acagtgaaaa gattctcctg
      661 agctgggtcc gacaatcaac tcgtaattat ccacaggtta atgtaatcaa cttcaccacc
      721 agctggtctg atggcctggc tttgaatgct ctcatccata gtcataggcc agacctattt
      781 gactggaata gtgtggtttg ccagcagtca gccacacaac gactggaaca tgcattcaac
      841 atcgccagat atcaattagg catagagaaa ctactcgatc ctgaagatgt tgataccacc
      901 tatccagata agaagtccat cttaatgtac atcacatcac tcttccaagt tttgcctcaa
      961 caagtgagca ttgaagccat ccaggaagtg gaaatgttgc caaggccacc taaagtgact
     1021 aaagaagaac attttcagtt acatcatcaa atgcactatt ctcaacagat cacggtcagt
     1081 ctagcacagg gatatgagag aacttcttcc cctaagcctc gattcaagag ctatgcctac
     1141 acacaggctg cttatgtcac cacctctgac cctacacgga gcccatttcc ttcacagcat
     1201 ttggaagctc ctgaagacaa gtcatttggc agttcattga tggagagtga agtaaacctg
     1261 gaccgttatc aaacagcttt agaagaagta ttatcgtggc ttctttctgc tgaggacaca
     1321 ttgcaagcac aaggagagat ttctaatgat gtggaagtgg tgaaagacca gtttcatact
     1381 catgaggggt acatgatgga tttgacagcc catcagggcc gggttggtaa tattctacaa
     1441 ttgggaagta agctgattgg aacaggaaaa ttatcagaag atgaagaaac tgaagtacaa
     1501 gagcagatga atctcctaaa ttcaagatgg gaatgcctca gggtagctag catggaaaaa
     1561 caaagcaatt tacatagagt tttaatggat ctccagaatc agaaactgaa agagttgaat
     1621 gactggctaa caaaaacaga agaaagaaca aggaaaatgg aggaagagcc tcttggacct
     1681 gatcttgaag acctaaaacg ccaagtacaa caacataagg tgcttcaaga agatctagaa
     1741 caagaacaag tcagggtcaa ttctctcact cacatggtgg tggtagttga tgaatctagt
     1801 ggagatcacg caactgctgc tttggaagaa caacttaagg tattgggaga tcgatgggca
     1861 aacatctgta gatggacaga agaccgctgg gttcttttac aagacatcct tctcaaatgg
     1921 caacgtctta ctgaagaaca gtgccttttt agtgcatggc tttcagaaaa agaagatgca
     1981 gtgaacaaga ttcacacaac tggctttaaa gatcaaaatg aaatgttatc aagtcttcaa
     2041 aaactggccg ttttaaaagc ggatctagaa aagaaaaagc aatccatggg caaactgtat
     2101 tcactcaaac aagatcttct ttcaacactg aagaataagt cagtgaccca gaagacggaa
     2161 gcatggctgg ataactttgc ccggtgttgg gataatttag tccaaaaact tgaaaagagt
     2221 acagcacaga tttcacaggc tgtcaccacc actcagccat cactaacaca gacaactgta
     2281 atggaaacag taactacggt gaccacaagg gaacagatcc tggtaaagca tgctcaagag
     2341 gaacttccac caccacctcc ccaaaagaag aggcagatta ctgtggattc tgaaattagg
     2401 aaaaggttgg atgttgatat aactgaactt cacagctgga ttactcgctc agaagctgtg
     2461 ttgcagagtc ctgaatttgc aatctttcgg aaggaaggca acttctcaga cttaaaagaa
     2521 aaagtcaatg ccatagagcg agaaaaagct gagaagttca gaaaactgca agatgccagc
     2581 agatcagctc aggccctggt ggaacagatg gtgaatgagg gtgttaatgc agatagcatc
     2641 aaacaagcct cagaacaact gaacagccgg tggatcgaat tctgccagtt gctaagtgag
     2701 agacttaact ggctggagta tcagaacaac atcatcgctt tctataatca gctacaacaa
     2761 ttggagcaga tgacaactac tgctgaaaac tggttgaaaa tccaacccac caccccatca
     2821 gagccaacag caattaaaag tcagttaaaa atttgtaagg atgaagtcaa ccggctatca
     2881 gatcttcaac ctcaaattga acgattaaaa attcaaagca tagccctgaa agagaaagga
     2941 caaggaccca tgttcctgga tgcagacttt gtggccttta caaatcattt taagcaagtc
     3001 ttttctgatg tgcaggccag agagaaagag ctacagacaa tttttgacac tttgccacca
     3061 atgcgctatc aggagaccat gagtgccatc aggacatggg tccagcagtc agaaaccaaa
     3121 ctctccatac ctcaacttag tgtcaccgac tatgaaatca tggagcagag actcggggaa
     3181 ttgcaggctt tacaaagttc tctgcaagag caacaaagtg gcctatacta tctcagcacc
     3241 actgtgaaag agatgtcgaa gaaagcgccc tctgaaatta gccggaaata tcaatcagaa
     3301 tttgaagaaa ttgagggacg ctggaagaag ctctcctccc agctggttga gcattgtcaa
     3361 aagctagagg agcaaatgaa taaactccga aaaattcaga atcacataca aaccctgaag
     3421 aaatggatgg ctgaagttga tgtttttctg aaggaggaat ggcctgccct tggggattca
     3481 gaaattctaa aaaagcagct gaaacagtgc agacttttag tcagtgatat tcagacaatt
     3541 cagcccagtc taaacagtgt caatgaaggt gggcagaaga taaagaatga agcagagcca
     3601 gagtttgctt cgagacttga gacagaactc aaagaactta acactcagtg ggatcacatg
     3661 tgccaacagg tctatgccag aaaggaggcc ttgaagggag gtttggagaa aactgtaagc
     3721 ctccagaaag atctatcaga gatgcacgaa tggatgacac aagctgaaga agagtatctt
     3781 gagagagatt ttgaatataa aactccagat gaattacaga aagcagttga agagatgaag
     3841 agagctaaag aagaggccca acaaaaagaa gcgaaagtga aactccttac tgagtctgta
     3901 aatagtgtca tagctcaagc tccacctgta gcacaagagg ccttaaaaaa ggaacttgaa
     3961 actctaacca ccaactacca gtggctctgc actaggctga atgggaaatg caagactttg
     4021 gaagaagttt gggcatgttg gcatgagtta ttgtcatact tggagaaagc aaacaagtgg
     4081 ctaaatgaag tagaatttaa acttaaaacc actgaaaaca ttcctggcgg agctgaggaa
     4141 atctctgagg tgctagattc acttgaaaat ttgatgcgac attcagagga taacccaaat
     4201 cagattcgca tattggcaca gaccctaaca gatggcggag tcatggatga gctaatcaat
     4261 gaggaacttg agacatttaa ttctcgttgg agggaactac atgaagaggc tgtaaggagg
     4321 caaaagttgc ttgaacagag catccagtct gcccaggaga ctgaaaaatc cttacactta
     4381 atccaggagt ccctcacatt cattgacaag cagttggcag cttatattgc agacaaggtg
     4441 gacgcagctc aaatgcctca ggaagcccag aaaatccaat ctgatttgac aagtcatgag
     4501 atcagtttag aagaaatgaa gaaacataat caggggaagg aggctgccca aagagtcctg
     4561 tctcagattg atgttgcaca gaaaaaatta caagatgtct ccatgaagtt tcgattattc
     4621 cagaaaccag ccaattttga gcagcgtcta caagaaagta agatgatttt agatgaagtg
     4681 aagatgcact tgcctgcatt ggaaacaaag agtgtggaac aggaagtagt acagtcacag
     4741 ctaaatcatt gtgtgaactt gtataaaagt ctgagtgaag tgaagtctga agtggaaatg
     4801 gtgataaaga ctggacgtca gattgtacag aaaaagcaga cggaaaatcc caaagaactt
     4861 gatgaaagag taacagcttt gaaattgcat tataatgagc tgggagcaaa ggtaacagaa
     4921 agaaagcaac agttggagaa atgcttgaaa ttgtcccgta agatgcgaaa ggaaatgaat
     4981 gtcttgacag aatggctggc agctacagat atggaattga caaagagatc agcagttgaa
     5041 ggaatgccta gtaatttgga ttctgaagtt gcctggggaa aggctactca aaaagagatt
     5101 gagaaacaga aggtgcacct gaagagtatc acagaggtag gagaggcctt gaaaacagtt
     5161 ttgggcaaga aggagacgtt ggtggaagat aaactcagtc ttctgaatag taactggata
     5221 gctgtcacct cccgagcaga agagtggtta aatcttttgt tggaatacca gaaacacatg
     5281 gaaacttttg accagaatgt ggaccacatc acaaagtgga tcattcaggc tgacacactt
     5341 ttggatgaat cagagaaaaa gaaaccccag caaaaagaag acgtgcttaa gcgtttaaag
     5401 gcagaactga atgacatacg cccaaaggtg gactctacac gtgaccaagc agcaaacttg
     5461 atggcaaacc gcggtgacca ctgcaggaaa ttagtagagc cccaaatctc agagctcaac
     5521 catcgatttg cagccatttc acacagaatt aagactggaa aggcctccat tcctttgaag
     5581 gaattggagc agtttaactc agatatacaa aaattgcttg aaccactgga ggctgaaatt
     5641 cagcaggggg tgaatctgaa agaggaagac ttcaataaag atatgaatga agacaatgag
     5701 ggtactgtaa aagaattgtt gcaaagagga gacaacttac aacaaagaat cacagatgag
     5761 agaaagcgag aggaaataaa gataaaacag cagctgttac agacaaaaca taatgctctc
     5821 aaggatttga ggtctcaaag aagaaaaaag gctctagaaa tttctcatca gtggtatcag
     5881 tacaagaggc aggctgatga tctcctgaaa tgcttggatg acattgaaaa aaaattagcc
     5941 agcctacctg agcccagaga tgaaaggaaa ataaaggaaa ttgatcggga attgcagaag
     6001 aagaaagagg agctgaatgc agtgcgtagg caagctgagg gcttgtctga ggatggggcc
     6061 gcaatggcag tggagccaac tcagatccag ctcagcaagc gctggcggga aattgagagc
     6121 aaatttgctc agtttcgaag actcaacttt gcacaaattc acactgtccg tgaagaaacg
     6181 atgatggtga tgactgaaga catgcctttg gaaatttctt atgtgccttc tacttatttg
     6241 actgaaatca ctcatgtctc acaagcccta ttagaagtgg aacaacttct caatgctcct
     6301 gacctctgtg ctaaggactt tgaagatctc tttaagcaag aggagtctct gaagaatata
     6361 aaagatagtc tacaacaaag ctcaggtcgg attgacatta ttcatagcaa gaagacagca
     6421 gcattgcaaa gtgcaacgcc tgtggaaagg gtgaagctac aggaagctct ctcccagctt
     6481 gatttccaat gggaaaaagt taacaaaatg tacaaggacc gacaagggcg atttgacaga
     6541 tctgttgaga aatggcggcg ttttcattat gatataaaga tatttaatca gtggctaaca
     6601 gaagctgaac agtttctcag aaagacacaa attcctgaga attgggaaca tgctaaatac
     6661 aaatggtatc ttaaggaact ccaggatggc attgggcagc ggcaaactgt tgtcagaaca
     6721 ttgaatgcaa ctggggaaga aataattcag caatcctcaa aaacagatgc cagtattcta
     6781 caggaaaaat tgggaagcct gaatctgcgg tggcaggagg tctgcaaaca gctgtcagac
     6841 agaaaaaaga ggctagaaga acaaaagaat atcttgtcag aatttcaaag agatttaaat
     6901 gaatttgttt tatggttgga ggaagcagat aacattgcta gtatcccact tgaacctgga
     6961 aaagagcagc aactaaaaga aaagcttgag caagtcaagt tactggtgga agagttgccc
     7021 ctgcgccagg gaattctcaa acaattaaat gaaactggag gacccgtgct tgtaagtgct
     7081 cccataagcc cagaagagca agataaactt gaaaataagc tcaagcagac aaatctccag
     7141 tggataaagg tttccagagc tttacctgag aaacaaggag aaattgaagc tcaaataaaa
     7201 gaccttgggc agcttgaaaa aaagcttgaa gaccttgaag agcagttaaa tcatctgctg
     7261 ctgtggttat ctcctattag gaatcagttg gaaatttata accaaccaaa ccaagaagga
     7321 ccatttgacg ttaaggaaac tgaaatagca gttcaagcta aacaaccgga tgtggaagag
     7381 attttgtcta aagggcagca tttgtacaag gaaaaaccag ccactcagcc agtgaagagg
     7441 aagttagaag atctgagctc tgagtggaag gcggtaaacc gtttacttca agagctgagg
     7501 gcaaagcagc ctgacctagc tcctggactg accactattg gagcctctcc tactcagact
     7561 gttactctgg tgacacaacc tgtggttact aaggaaactg ccatctccaa actagaaatg
     7621 ccatcttcct tgatgttgga ggtacctgct ctggcagatt tcaaccgggc ttggacagaa
     7681 cttaccgact ggctttctct gcttgatcaa gttataaaat cacagagggt gatggtgggt
     7741 gaccttgagg atatcaacga gatgatcatc aagcagaagg caacaatgca ggatttggaa
     7801 cagaggcgtc cccagttgga agaactcatt accgctgccc aaaatttgaa aaacaagacc
     7861 agcaatcaag aggctagaac aatcattacg gatcgaattg aaagaattca gaatcagtgg
     7921 gatgaagtac aagaacacct tcagaaccgg aggcaacagt tgaatgaaat gttaaaggat
     7981 tcaacacaat ggctggaagc taaggaagaa gctgagcagg tcttaggaca ggccagagcc
     8041 aagcttgagt catggaagga gggtccctat acagtagatg caatccaaaa gaaaatcaca
     8101 gaaaccaagc agttggccaa agacctccgc cagtggcaga caaatgtaga tgtggcaaat
     8161 gacttggccc tgaaacttct ccgggattat tctgcagatg ataccagaaa agtccacatg
     8221 ataacagaga atatcaatgc ctcttggaga agcattcata aaagggtgag tgagcgagag
     8281 gctgctttgg aagaaactca tagattactg caacagttcc ccctggacct ggaaaagttt
     8341 cttgcctggc ttacagaagc tgaaacaact gccaatgtcc tacaggatgc tacccgtaag
     8401 gaaaggctcc tagaagactc caagggagta aaagagctga tgaaacaatg gcaagacctc
     8461 caaggtgaaa ttgaagctca cacagatgtt tatcacaacc tggatgaaaa cagccaaaaa
     8521 atcctgagat ccctggaagg ttccgatgat gcagtcctgt tacaaagacg tttggataac
     8581 atgaacttca agtggagtga acttcggaaa aagtctctca acattaggtc ccatttggaa
     8641 gccagttctg accagtggaa gcgtctgcac ctttctctgc aggaacttct ggtgtggcta
     8701 cagctgaaag atgatgaatt aagccggcag gcacctattg gaggcgactt tccagcagtt
     8761 cagaagcaga acgatgtaca tagggccttc aagagggaat tgaaaactaa agaacctgta
     8821 atcatgagta ctcttgagac tgtacgaata tttctgacag agcagccttt ggaaggacta
     8881 gagaaactct accaggagcc cagagagctg cctcctgagg agagagccca gaatgtcact
     8941 cggcttctac gaaagcaggc tgaggaggtc aatactgagt gggaaaaatt gaacctgcac
     9001 tccgctgact ggcagagaaa aatagatgag acccttgaaa gactccggga acttcaagag
     9061 gccacggatg agctggacct caagctgcgc caagctgagg tgatcaaggg atcctggcag
     9121 cccgtgggcg atctcctcat tgactctctc caagatcacc tcgagaaagt caaggcactt
     9181 cgaggagaaa ttgcgcctct gaaagagaac gtgagccacg tcaatgacct tgctcgccag
     9241 cttaccactt tgggcattca gctctcaccg tataacctca gcactctgga agacctgaac
     9301 accagatgga agcttctgca ggtggccgtc gaggaccgag tcaggcagct gcatgaagcc
     9361 cacagggact ttggtccagc atctcagcac tttctttcca cgtctgtcca gggtccctgg
     9421 gagagagcca tctcgccaaa caaagtgccc tactatatca accacgagac tcaaacaact
     9481 tgctgggacc atcccaaaat gacagagctc taccagtctt tagctgacct gaataatgtc
     9541 agattctcag cttataggac tgccatgaaa ctccgaagac tgcagaaggc cctttgcttg
     9601 gatctcttga gcctgtcagc tgcatgtgat gccttggacc agcacaacct caagcaaaat
     9661 gaccagccca tggatatcct gcagattatt aattgtttga ccactattta tgaccgcctg
     9721 gagcaagagc acaacaattt ggtcaacgtc cctctctgcg tggatatgtg tctgaactgg
     9781 ctgctgaatg tttatgatac gggacgaaca gggaggatcc gtgtcctgtc ttttaaaact
     9841 ggcatcattt ccctgtgtaa agcacatttg gaagacaagt acagatacct tttcaagcaa
     9901 gtggcaagtt caacaggatt ttgtgaccag cgcaggctgg gcctccttct gcatgattct
     9961 atccaaattc caagacagtt gggtgaagtt gcatcctttg ggggcagtaa cattgagcca
    10021 agtgtccgga gctgcttcca atttgctaat aataagccag agatcgaagc ggccctcttc
    10081 ctagactgga tgagactgga accccagtcc atggtgtggc tgcccgtcct gcacagagtg
    10141 gctgctgcag aaactgccaa gcatcaggcc aaatgtaaca tctgcaaaga gtgtccaatc
    10201 attggattca ggtacaggag tctaaagcac tttaattatg acatctgcca aagctgcttt
    10261 ttttctggtc gagttgcaaa aggccataaa atgcactatc ccatggtgga atattgcact
    10321 ccgactacat caggagaaga tgttcgagac tttgccaagg tactaaaaaa caaatttcga
    10381 accaaaaggt attttgcgaa gcatccccga atgggctacc tgccagtgca gactgtctta
    10441 gagggggaca acatggaaac tcccgttact ctgatcaact tctggccagt agattctgcg
    10501 cctgcctcgt cccctcagct ttcacacgat gatactcatt cacgcattga acattatgct
    10561 agcaggctag cagaaatgga aaacagcaat ggatcttatc taaatgatag catctctcct
    10621 aatgagagca tagatgatga acatttgtta atccagcatt actgccaaag tttgaaccag
    10681 gactcccccc tgagccagcc tcgtagtcct gcccagatct tgatttcctt agagagtgag
    10741 gaaagagggg agctagagag aatcctagca gatcttgagg aagaaaacag gaatctgcaa
    10801 gcagaatatg accgtctaaa gcagcagcac gaacataaag gcctgtcccc actgccgtcc
    10861 cctcctgaaa tgatgcccac ctctccccag agtccccggg atgctgagct cattgctgag
    10921 gccaagctac tgcgtcaaca caaaggccgc ctggaagcca ggatgcaaat cctggaagac
    10981 cacaataaac agctggagtc acagttacac aggctaaggc agctgctgga gcaaccccag
    11041 gcagaggcca aagtgaatgg cacaacggtg tcctctcctt ctacctctct acagaggtcc
    11101 gacagcagtc agcctatgct gctccgagtg gttggcagtc aaacttcgga ctccatgggt
    11161 gaggaagatc ttctcagtcc tccccaggac acaagcacag ggttagagga ggtgatggag
    11221 caactcaaca actccttccc tagttcaaga ggaagaaata cccctggaaa gccaatgaga
    11281 gaggacacaa tgtaggaagt cttttccaca tggcagatga tttgggcaga gcgatggagt
    11341 ccttagtatc agtcatgaca gatgaagaag gagcagaata aatgttttac aactcctgat
    11401 tcccgcatgg tttttataat attcatacaa caaagaggat tagacagtaa gagtttacaa
    11461 gaaataaatc tatatttttg tgaagggtag tggtattata ctgtagattt cagtagtttc
    11521 taagtctgtt attgttttgt taacaatggc aggttttaca cgtctatgca attgtacaaa
    11581 aaagttataa gaaaactaca tgtaaaatct tgatagctaa ataacttgcc atttctttat
    11641 atggaacgca ttttgggttg tttaaaaatt tataacagtt ataaagaaag attgtaaact
    11701 aaagtgtgct ttataaaaaa aagttgttta taaaaacccc taaaaacaaa acaaacacac
    11761 acacacacac atacacacac acacacaaaa ctttgaggca gcgcattgtt ttgcatcctt
    11821 ttggcgtgat atccatatga aattcatggc tttttctttt tttgcatatt aaagataaga
    11881 cttcctctac caccacacca aatgactact acacactgct catttgagaa ctgtcagctg
    11941 agtggggcag gcttgagttt tcatttcata tatctatatg tctataagta tataaatact
    12001 atagttatat agataaagag atacgaattt ctatagactg actttttcca ttttttaaat
    12061 gttcatgtca catcctaata gaaagaaatt acttctagtc agtcatccag gcttacctgc
    12121 ttggtctaga atggattttt cccggagccg gaagccagga ggaaactaca ccacactaaa
    12181 acattgtcta cagctccaga tgtttctcat tttaaacaac tttccactga caacgaaagt
    12241 aaagtaaagt attggatttt tttaaaggga acatgtgaat gaatacacag gacttattat
    12301 atcagagtga gtaatcggtt ggttggttga ttgattgatt gattgataca ttcagcttcc
    12361 tgctgctagc aatgccacga tttagattta atgatgcttc agtggaaatc aatcagaagg
    12421 tattctgacc ttgtgaacat cagaaggtat tttttaactc ccaagcagta gcaggacgat
    12481 gatagggctg gagggctatg gattcccagc ccatccctgt gaaggagtag gccactcttt
    12541 aagtgaagga ttggatgatt gttcataata cataaagttc tctgtaatta caactaaatt
    12601 attatgccct cttctcacag tcaaaaggaa ctgggtggtt tggtttttgt tgctttttta
    12661 gatttattgt cccatgtggg atgagttttt aaatgccaca agacataatt taaaataaat
    12721 aaactttggg aaaaggtgta aaacagtagc cccatcacat ttgtgatact gacaggtatc
    12781 aacccagaag cccatgaact gtgtttccat cctttgcatt tctctgcgag tagttccaca
    12841 caggtttgta agtaagtaag aaagaaggca aattgattca aatgttacaa aaaaaccctt
    12901 cttggtggat tagacaggtt aaatatataa acaaacaaac aaaaattgct caaaaaagag
    12961 gagaaaagct caagaggaaa agctaaggac tggtaggaaa aagctttact ctttcatgcc
    13021 attttatttc tttttgattt ttaaatcatt cattcaatag ataccaccgt gtgacctata
    13081 attttgcaaa tctgttacct ctgacatcaa gtgtaattag cttttggaga gtgggctgac
    13141 atcaagtgta attagctttt ggagagtggg ttttgtccat tattaataat taattaatta
    13201 acatcaaaca cggcttctca tgctatttct acctcacttt ggttttgggg tgttcctgat
    13261 aattgtgcac acctgagttc acagcttcac cacttgtcca ttgcgttatt ttctttttcc
    13321 tttataattc tttctttttc cttcataatt ttcaaaagaa aacccaaagc tctaaggtaa
    13381 caaattacca aattacatga agatttggtt tttgtcttgc atttttttcc tttatgtgac
    13441 gctggacctt ttctttaccc aaggattttt aaaactcaga tttaaaacaa ggggttactt
    13501 tacatcctac taagaagttt aagtaagtaa gtttcattct aaaatcagag gtaaatagag
    13561 tgcataaata attttgtttt aatctttttg tttttctttt agacacatta gctctggagt
    13621 gagtctgtca taatatttga acaaaaattg agagctttat tgctgcattt taagcataat
    13681 taatttggac attatttcgt gttgtgttct ttataaccac caagtattaa actgtaaatc
    13741 ataatgtaac tgaagcataa acatcacatg gcatgttttg tcattgtttt caggtactga
    13801 gttcttactt gagtatcata atatattgtg ttttaacacc aacactgtaa catttacgaa
    13861 ttattttttt aaacttcagt tttactgcat tttcacaaca tatcagactt caccaaatat
    13921 atgccttact attgtattat agtactgctt tactgtgtat ctcaataaag cacgcagtta
    13981 tgttacaaaa aa
//
