LOCUS       NM_007068               2269 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DNA meiotic recombinase 1 (DMC1), transcript variant
            1, mRNA.
ACCESSION   NM_007068
VERSION     NM_007068.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2269)
  AUTHORS   Ito,M., Fujita,Y. and Shinohara,A.
  TITLE     Positive and negative regulators of RAD51/DMC1 in homologous
            recombination and DNA replication
  JOURNAL   DNA Repair (Amst) 134, 103613 (2024)
   PUBMED   38142595
  REMARK    GeneRIF: Positive and negative regulators of RAD51/DMC1 in
            homologous recombination and DNA replication.
            Review article
REFERENCE   2  (bases 1 to 2269)
  AUTHORS   Ito,M., Furukohri,A., Matsuzaki,K., Fujita,Y., Toyoda,A. and
            Shinohara,A.
  TITLE     FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic
            DNA replication and meiotic recombination
  JOURNAL   Nat Commun 14 (1), 6857 (2023)
   PUBMED   37891173
  REMARK    GeneRIF: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in
            pre-meiotic DNA replication and meiotic recombination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2269)
  AUTHORS   Sun,D., Shang,D., Miao,P., Jiang,Z., Chen,Y. and Gao,J.
  TITLE     MiR-4284 inhibits sensitivity to paclitaxel in human ovarian
            carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1
  JOURNAL   Anticancer Drugs 33 (8), 701-709 (2022)
   PUBMED   35946537
  REMARK    GeneRIF: MiR-4284 inhibits sensitivity to paclitaxel in human
            ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.
REFERENCE   4  (bases 1 to 2269)
  AUTHORS   Guo,Y.X., Yan,S.P. and Wang,Y.X.
  TITLE     Recent advances in functional conservation and divergence of
            recombinase RAD51 and DMC1
  JOURNAL   Yi Chuan 44 (5), 398-413 (2022)
   PUBMED   35729697
  REMARK    GeneRIF: Recent advances in functional conservation and divergence
            of recombinase RAD51 and DMC1.
            Review article
REFERENCE   5  (bases 1 to 2269)
  AUTHORS   Habu,T., Wakabayashi,N., Yoshida,K., Yomogida,K., Nishimune,Y. and
            Morita,T.
  TITLE     p53 Protein interacts specifically with the meiosis-specific
            mammalian RecA-like protein DMC1 in meiosis
  JOURNAL   Carcinogenesis 25 (6), 889-893 (2004)
   PUBMED   14764457
  REMARK    GeneRIF: p53 might be involved in homologous recombination and/or
            checkpoint function by directly binding to DMC1 protein to repress
            genomic instability in meiotic germ cells
REFERENCE   6  (bases 1 to 2269)
  AUTHORS   Kinebuchi,T., Kagawa,W., Enomoto,R., Tanaka,K., Miyagawa,K.,
            Shibata,T., Kurumizaka,H. and Yokoyama,S.
  TITLE     Structural basis for octameric ring formation and DNA interaction
            of the human homologous-pairing protein Dmc1
  JOURNAL   Mol Cell 14 (3), 363-374 (2004)
   PUBMED   15125839
  REMARK    GeneRIF: The monomeric structure of the Dmc1 protein closely
            resembled those of the human and archaeal Rad51 proteins. We found
            another hydrogen bonding interaction at the polymer interface.
REFERENCE   7  (bases 1 to 2269)
  AUTHORS   Masson,J.Y., Davies,A.A., Hajibagheri,N., Van Dyck,E., Benson,F.E.,
            Stasiak,A.Z., Stasiak,A. and West,S.C.
  TITLE     The meiosis-specific recombinase hDmc1 forms ring structures and
            interacts with hRad51
  JOURNAL   EMBO J 18 (22), 6552-6560 (1999)
   PUBMED   10562567
REFERENCE   8  (bases 1 to 2269)
  AUTHORS   Golub,E.I., Gupta,R.C., Haaf,T., Wold,M.S. and Radding,C.M.
  TITLE     Interaction of human rad51 recombination protein with
            single-stranded DNA binding protein, RPA
  JOURNAL   Nucleic Acids Res 26 (23), 5388-5393 (1998)
   PUBMED   9826763
REFERENCE   9  (bases 1 to 2269)
  AUTHORS   Habu,T., Taki,T., West,A., Nishimune,Y. and Morita,T.
  TITLE     The mouse and human homologs of DMC1, the yeast meiosis-specific
            homologous recombination gene, have a common unique form of
            exon-skipped transcript in meiosis
  JOURNAL   Nucleic Acids Res 24 (3), 470-477 (1996)
   PUBMED   8602360
REFERENCE   10 (bases 1 to 2269)
  AUTHORS   Sato,S., Seki,N., Hotta,Y. and Tabata,S.
  TITLE     Expression profiles of a human gene identified as a structural
            homologue of meiosis-specific recA-like genes
  JOURNAL   DNA Res 2 (4), 183-186 (1995)
   PUBMED   8590282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292617.1, DB517711.2 and
            AL022320.23.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007068.3.
            
            Summary: This gene encodes a member of the superfamily of
            recombinases (also called DNA strand-exchange proteins).
            Recombinases are important for repairing double-strand DNA breaks
            during mitosis and meiosis. This protein, which is evolutionarily
            conserved, is reported to be essential for meiotic homologous
            recombination and may thus play an important role in generating
            diversity of genetic information. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D64108.1, AK292617.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216024.7/ ENSP00000216024.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2137              AK292617.1         14-2150
            2138-2268           DB517711.2         530-660
            2269-2269           AL022320.23        5245-5245           c
FEATURES             Location/Qualifiers
     source          1..2269
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2269
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="DNA meiotic recombinase 1"
                     /db_xref="GeneID:11144"
                     /db_xref="HGNC:HGNC:2927"
                     /db_xref="MIM:602721"
     exon            1..141
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            142..225
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1197
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="isoform 1 is encoded by transcript variant 1;
                     disrupted meiotic cDNA1, yeast, homolog of; meiotic
                     recombination protein DMC1/LIM15 homolog; DMC1 dosage
                     suppressor of mck1 homolog, meiosis-specific homologous
                     recombination"
                     /codon_start=1
                     /product="meiotic recombination protein DMC1/LIM15 homolog
                     isoform 1"
                     /protein_id="NP_008999.2"
                     /db_xref="CCDS:CCDS13973.1"
                     /db_xref="GeneID:11144"
                     /db_xref="HGNC:HGNC:2927"
                     /db_xref="MIM:602721"
                     /translation="MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVG
                     ICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHIT
                     TGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFID
                     TENTFRPDRLRDIADRFNVDHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFK
                     LLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGA
                     TMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGG
                     IGDAKE"
     exon            226..270
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            271..417
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            418..500
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            501..553
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            554..595
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            596..668
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            669..760
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            761..834
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            835..949
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1010
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1127
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..2269
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2245..2250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="major polyA site"
ORIGIN      
        1 gccaaaccct gtggtcaacg gcgcgcgggt ctccaggctc cgtgttctag gcccgagtta
       61 gaatcctgtc agctgaggag gtcgggcggg gcagaggggc ttcaccttga aaatctcggg
      121 gagactgtgg gtacgagggg gaagtgatta tttttctgtt gcccactttt caatatgaag
      181 gaggatcaag ttgtggcgga agaaccagga ttccaagatg aagaggaatc tttgtttcaa
      241 gatattgacc tgttacagaa acatggaatt aacgtggctg acattaagaa actgaaatca
      301 gtaggaatct gtaccatcaa aggtatacag atgacaacaa gaagagctct atgcaatgtc
      361 aaaggactct cagaagccaa agtagacaag attaaagagg cagcgaacaa actaattgaa
      421 ccaggattct tgactgcatt tgagtatagt gaaaagagga aaatggtttt ccatatcacc
      481 accgggagcc aggaatttga taagttacta ggaggtggaa ttgaaagtat ggcaattaca
      541 gaagcttttg gagaatttcg tactggaaaa acccagcttt ctcataccct ctgtgtgaca
      601 gctcaacttc caggagctgg tggctaccca ggaggaaaga ttatcttcat tgatacagaa
      661 aatactttcc gtccagatcg ccttagggac attgctgatc gctttaatgt agaccatgat
      721 gcagtactgg acaacgtact ttatgcacgt gcatatacta gtgaacatca gatggagcta
      781 cttgattatg tagcagcaaa gttccatgaa gaagctggca tcttcaagct attgattatc
      841 gattcaataa tggcactttt tcgagtggat ttcagtggcc gtggggagtt ggccgaacgg
      901 cagcaaaaat tggcccagat gttgtcacga ctccaaaaaa tctcagaaga atataacgtg
      961 gctgtttttg tgaccaatca aatgactgcc gatccaggag caactatgac ctttcaggca
     1021 gatcccaaaa aacccattgg gggacacatt ctggctcatg cttcaacaac aagaataagc
     1081 ttgcgaaagg gaagaggaga gctcagaatt gccaagattt atgacagtcc tgagatgcct
     1141 gaaaatgaag ccaccttcgc aataactgct ggaggaattg gggatgccaa ggagtaggtg
     1201 gtgaattgat gcaaattgct tcttagtgct tattaggagc tgaagaaatg gaaaagcagt
     1261 ctccaatttc acatcttgaa atagaggttt tttcccacat gttactaaag aaaagtcagc
     1321 aaagagattt aaatcttata tttatcttaa aagtccctga tttatgataa ctatacattg
     1381 tatgtaaatt cagggatatg tatatgtatg tttgtgtgtg tgtgtgtttg tgtgtgtata
     1441 cctgacatat atagtagata tatataccta ttgaaattct ctcactctgt gtatgtatat
     1501 atacctatgg aaaactagtt gttgggaaag gagtacgtga ttccctccct ttcacttttc
     1561 aaagtgagcc actaaacaga aagtctaaga gttcagaaat gtcccattct cctaaggact
     1621 ttcccttcac catttttcta gggtatagtg ccactgactt acatagctag atgtttttcc
     1681 acaagaggat ttaagggagg aatgtttata ggacacacac acaaaagctc tttctattta
     1741 taatatcaaa ctgcatattc acctttatag caacagaaaa cagacattaa attaagccaa
     1801 attttaaatc atttgacttt gacaagcaga aattactttt aaaaaatgta tttatggctg
     1861 ggcgtggtgg ctcacacctg taatcccagc actttgggag gccgaggcag gtggatcact
     1921 tgaggtcagg agttcaagac cagcctggcc aacatggaga aaccccatct ctactaaaaa
     1981 tacaaaaatt agccaagtgc agtggcatgt gcttgtaatc ccagctactc tggaggctga
     2041 ggcaggagaa ttgcttgaac ccaggaggca gagattgcgg tgagccaaga tggcaccact
     2101 gcactccagc ctaggtgaca gagtgagact ccgtctcaaa aaaaaaaaaa aaactttttt
     2161 aaaatgttaa aattaattta aatgtaaaat ttctgaatac taatcttaga aatgtgtaaa
     2221 agatattatt ttgattgtta aacaaataaa atcctgtttt caaaatgca
//
