LOCUS       NM_001363017            2104 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens DNA meiotic recombinase 1 (DMC1), transcript variant
            4, mRNA.
ACCESSION   NM_001363017 XM_006724112
VERSION     NM_001363017.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2104)
  AUTHORS   Ito,M., Fujita,Y. and Shinohara,A.
  TITLE     Positive and negative regulators of RAD51/DMC1 in homologous
            recombination and DNA replication
  JOURNAL   DNA Repair (Amst) 134, 103613 (2024)
   PUBMED   38142595
  REMARK    GeneRIF: Positive and negative regulators of RAD51/DMC1 in
            homologous recombination and DNA replication.
            Review article
REFERENCE   2  (bases 1 to 2104)
  AUTHORS   Ito,M., Furukohri,A., Matsuzaki,K., Fujita,Y., Toyoda,A. and
            Shinohara,A.
  TITLE     FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic
            DNA replication and meiotic recombination
  JOURNAL   Nat Commun 14 (1), 6857 (2023)
   PUBMED   37891173
  REMARK    GeneRIF: FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in
            pre-meiotic DNA replication and meiotic recombination.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2104)
  AUTHORS   Sun,D., Shang,D., Miao,P., Jiang,Z., Chen,Y. and Gao,J.
  TITLE     MiR-4284 inhibits sensitivity to paclitaxel in human ovarian
            carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1
  JOURNAL   Anticancer Drugs 33 (8), 701-709 (2022)
   PUBMED   35946537
  REMARK    GeneRIF: MiR-4284 inhibits sensitivity to paclitaxel in human
            ovarian carcinoma SKOV3ip1 and HeyA8 cells by targeting DMC1.
REFERENCE   4  (bases 1 to 2104)
  AUTHORS   Guo,Y.X., Yan,S.P. and Wang,Y.X.
  TITLE     Recent advances in functional conservation and divergence of
            recombinase RAD51 and DMC1
  JOURNAL   Yi Chuan 44 (5), 398-413 (2022)
   PUBMED   35729697
  REMARK    GeneRIF: Recent advances in functional conservation and divergence
            of recombinase RAD51 and DMC1.
            Review article
REFERENCE   5  (bases 1 to 2104)
  AUTHORS   Habu,T., Wakabayashi,N., Yoshida,K., Yomogida,K., Nishimune,Y. and
            Morita,T.
  TITLE     p53 Protein interacts specifically with the meiosis-specific
            mammalian RecA-like protein DMC1 in meiosis
  JOURNAL   Carcinogenesis 25 (6), 889-893 (2004)
   PUBMED   14764457
  REMARK    GeneRIF: p53 might be involved in homologous recombination and/or
            checkpoint function by directly binding to DMC1 protein to repress
            genomic instability in meiotic germ cells
REFERENCE   6  (bases 1 to 2104)
  AUTHORS   Kinebuchi,T., Kagawa,W., Enomoto,R., Tanaka,K., Miyagawa,K.,
            Shibata,T., Kurumizaka,H. and Yokoyama,S.
  TITLE     Structural basis for octameric ring formation and DNA interaction
            of the human homologous-pairing protein Dmc1
  JOURNAL   Mol Cell 14 (3), 363-374 (2004)
   PUBMED   15125839
  REMARK    GeneRIF: The monomeric structure of the Dmc1 protein closely
            resembled those of the human and archaeal Rad51 proteins. We found
            another hydrogen bonding interaction at the polymer interface.
REFERENCE   7  (bases 1 to 2104)
  AUTHORS   Masson,J.Y., Davies,A.A., Hajibagheri,N., Van Dyck,E., Benson,F.E.,
            Stasiak,A.Z., Stasiak,A. and West,S.C.
  TITLE     The meiosis-specific recombinase hDmc1 forms ring structures and
            interacts with hRad51
  JOURNAL   EMBO J 18 (22), 6552-6560 (1999)
   PUBMED   10562567
REFERENCE   8  (bases 1 to 2104)
  AUTHORS   Golub,E.I., Gupta,R.C., Haaf,T., Wold,M.S. and Radding,C.M.
  TITLE     Interaction of human rad51 recombination protein with
            single-stranded DNA binding protein, RPA
  JOURNAL   Nucleic Acids Res 26 (23), 5388-5393 (1998)
   PUBMED   9826763
REFERENCE   9  (bases 1 to 2104)
  AUTHORS   Habu,T., Taki,T., West,A., Nishimune,Y. and Morita,T.
  TITLE     The mouse and human homologs of DMC1, the yeast meiosis-specific
            homologous recombination gene, have a common unique form of
            exon-skipped transcript in meiosis
  JOURNAL   Nucleic Acids Res 24 (3), 470-477 (1996)
   PUBMED   8602360
REFERENCE   10 (bases 1 to 2104)
  AUTHORS   Sato,S., Seki,N., Hotta,Y. and Tabata,S.
  TITLE     Expression profiles of a human gene identified as a structural
            homologue of meiosis-specific recA-like genes
  JOURNAL   DNA Res 2 (4), 183-186 (1995)
   PUBMED   8590282
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022320.23.
            
            On May 31, 2019 this sequence version replaced NM_001363017.1.
            
            Summary: This gene encodes a member of the superfamily of
            recombinases (also called DNA strand-exchange proteins).
            Recombinases are important for repairing double-strand DNA breaks
            during mitosis and meiosis. This protein, which is evolutionarily
            conserved, is reported to be essential for meiotic homologous
            recombination and may thus play an important role in generating
            diversity of genetic information. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, May 2013].
            
            Transcript Variant: This variant (4) lacks two alternate in-frame
            exons in the coding region compared to variant 1. The resulting
            protein (isoform 2) lacks an internal portion compared to isoform
            1. Variants 2 and 4 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.166393.1,
                                           SRR1163657.229575.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AL022320.23        56340-56480         c
            142-225             AL022320.23        54503-54586         c
            226-270             AL022320.23        53880-53924         c
            271-417             AL022320.23        52887-53033         c
            418-500             AL022320.23        48584-48666         c
            501-553             AL022320.23        41654-41706         c
            554-595             AL022320.23        38963-39004         c
            596-669             AL022320.23        24836-24909         c
            670-784             AL022320.23        24592-24706         c
            785-845             AL022320.23        23889-23949         c
            846-962             AL022320.23        7905-8021           c
            963-2104            AL022320.23        5245-6386           c
FEATURES             Location/Qualifiers
     source          1..2104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.1"
     gene            1..2104
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="DNA meiotic recombinase 1"
                     /db_xref="GeneID:11144"
                     /db_xref="HGNC:HGNC:2927"
                     /db_xref="MIM:602721"
     exon            1..141
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            142..225
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..1032
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="isoform 2 is encoded by transcript variant 4;
                     disrupted meiotic cDNA1, yeast, homolog of; meiotic
                     recombination protein DMC1/LIM15 homolog; DMC1 dosage
                     suppressor of mck1 homolog, meiosis-specific homologous
                     recombination"
                     /codon_start=1
                     /product="meiotic recombination protein DMC1/LIM15 homolog
                     isoform 2"
                     /protein_id="NP_001349946.1"
                     /db_xref="CCDS:CCDS63477.1"
                     /db_xref="GeneID:11144"
                     /db_xref="HGNC:HGNC:2927"
                     /db_xref="MIM:602721"
                     /translation="MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVG
                     ICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHIT
                     TGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCGEHQMELLDYVAAKFHEEAG
                     IFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTAD
                     PGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAIT
                     AGGIGDAKE"
     exon            226..270
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            271..417
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            418..500
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            501..553
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            554..595
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            596..669
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            670..784
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            785..845
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            846..962
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     exon            963..2104
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="hexamer: AATAAA"
     polyA_site      2104
                     /gene="DMC1"
                     /gene_synonym="dJ199H16.1; DMC1H; LIM15"
                     /note="major polyA site"
ORIGIN      
        1 gccaaaccct gtggtcaacg gcgcgcgggt ctccaggctc cgtgttctag gcccgagtta
       61 gaatcctgtc agctgaggag gtcgggcggg gcagaggggc ttcaccttga aaatctcggg
      121 gagactgtgg gtacgagggg gaagtgatta tttttctgtt gcccactttt caatatgaag
      181 gaggatcaag ttgtggcgga agaaccagga ttccaagatg aagaggaatc tttgtttcaa
      241 gatattgacc tgttacagaa acatggaatt aacgtggctg acattaagaa actgaaatca
      301 gtaggaatct gtaccatcaa aggtatacag atgacaacaa gaagagctct atgcaatgtc
      361 aaaggactct cagaagccaa agtagacaag attaaagagg cagcgaacaa actaattgaa
      421 ccaggattct tgactgcatt tgagtatagt gaaaagagga aaatggtttt ccatatcacc
      481 accgggagcc aggaatttga taagttacta ggaggtggaa ttgaaagtat ggcaattaca
      541 gaagcttttg gagaatttcg tactggaaaa acccagcttt ctcataccct ctgtggtgaa
      601 catcagatgg agctacttga ttatgtagca gcaaagttcc atgaagaagc tggcatcttc
      661 aagctattga ttatcgattc aataatggca ctttttcgag tggatttcag tggccgtggg
      721 gagttggccg aacggcagca aaaattggcc cagatgttgt cacgactcca aaaaatctca
      781 gaagaatata acgtggctgt ttttgtgacc aatcaaatga ctgccgatcc aggagcaact
      841 atgacctttc aggcagatcc caaaaaaccc attgggggac acattctggc tcatgcttca
      901 acaacaagaa taagcttgcg aaagggaaga ggagagctca gaattgccaa gatttatgac
      961 agtcctgaga tgcctgaaaa tgaagccacc ttcgcaataa ctgctggagg aattggggat
     1021 gccaaggagt aggtggtgaa ttgatgcaaa ttgcttctta gtgcttatta ggagctgaag
     1081 aaatggaaaa gcagtctcca atttcacatc ttgaaataga ggttttttcc cacatgttac
     1141 taaagaaaag tcagcaaaga gatttaaatc ttatatttat cttaaaagtc cctgatttat
     1201 gataactata cattgtatgt aaattcaggg atatgtatat gtatgtttgt gtgtgtgtgt
     1261 gtttgtgtgt gtatacctga catatatagt agatatatat acctattgaa attctctcac
     1321 tctgtgtatg tatatatacc tatggaaaac tagttgttgg gaaaggagta cgtgattccc
     1381 tccctttcac ttttcaaagt gagccactaa acagaaagtc taagagttca gaaatgtccc
     1441 attctcctaa ggactttccc ttcaccattt ttctagggta tagtgccact gacttacata
     1501 gctagatgtt tttccacaag aggatttaag ggaggaatgt ttataggaca cacacacaaa
     1561 agctctttct atttataata tcaaactgca tattcacctt tatagcaaca gaaaacagac
     1621 attaaattaa gccaaatttt aaatcatttg actttgacaa gcagaaatta cttttaaaaa
     1681 atgtatttat ggctgggcgt ggtggctcac acctgtaatc ccagcacttt gggaggccga
     1741 ggcaggtgga tcacttgagg tcaggagttc aagaccagcc tggccaacat ggagaaaccc
     1801 catctctact aaaaatacaa aaattagcca agtgcagtgg catgtgcttg taatcccagc
     1861 tactctggag gctgaggcag gagaattgct tgaacccagg aggcagagat tgcggtgagc
     1921 caagatggca ccactgcact ccagcctagg tgacagagtg agactccgtc tcaaaaaaaa
     1981 aaaaaaaact tttttaaaat gttaaaatta atttaaatgt aaaatttctg aatactaatc
     2041 ttagaaatgt gtaaaagata ttattttgat tgttaaacaa ataaaatcct gttttcaaaa
     2101 tgca
//
