LOCUS       NM_019100               1742 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens DNA methyltransferase 1 associated protein 1 (DMAP1),
            transcript variant 1, mRNA.
ACCESSION   NM_019100
VERSION     NM_019100.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Li,J., Hu,B., Wang,T., Huang,W., Ma,C., Zhao,Q., Zhuo,L., Zhang,T.
            and Jiang,Y.
  TITLE     C-Src confers resistance to mitotic stress through inhibition
            DMAP1/Bub3 complex formation in pancreatic cancer
  JOURNAL   Mol Cancer 17 (1), 174 (2018)
   PUBMED   30553276
  REMARK    GeneRIF: Findings reveal a regulatory role of Bub3 in
            DMAP1-mediated DNA methylation upon mitotic stress.
            Erratum:[Mol Cancer. 2019 Nov 29;18(1):172. doi:
            10.1186/s12943-019-1067-2.. PMID: 31783872]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Wang,K., Liang,Q., Li,X., Tsoi,H., Zhang,J., Wang,H., Go,M.Y.,
            Chiu,P.W., Ng,E.K., Sung,J.J. and Yu,J.
  TITLE     MDGA2 is a novel tumour suppressor cooperating with DMAP1 in
            gastric cancer and is associated with disease outcome
  JOURNAL   Gut 65 (10), 1619-1631 (2016)
   PUBMED   26206665
  REMARK    GeneRIF: A novel tumour suppressor gene, MDGA2, which is frequently
            inactivated by promoter methylation in Gastric cancer, exerts a
            tumour suppressive function by cooperating with DMAP1 to activate
            the p53/p21 signalling cascade.
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Jacquet,K., Fradet-Turcotte,A., Avvakumov,N., Lambert,J.P.,
            Roques,C., Pandita,R.K., Paquet,E., Herst,P., Gingras,A.C.,
            Pandita,T.K., Legube,G., Doyon,Y., Durocher,D. and Cote,J.
  TITLE     The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1
            through Direct H4K20me Binding and H2AK15 Acetylation
  JOURNAL   Mol Cell 62 (3), 409-421 (2016)
   PUBMED   27153538
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Liu,Z. and Fisher,R.A.
  TITLE     RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1
            transcriptional repressor activity
  JOURNAL   J Biol Chem 279 (14), 14120-14128 (2004)
   PUBMED   14734556
  REMARK    GeneRIF: RGS6 inhibited the transcriptional repressor activity of
            DMAP1.
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Xin,H., Yoon,H.G., Singh,P.B., Wong,J. and Qin,J.
  TITLE     Components of a pathway maintaining histone modification and
            heterochromatin protein 1 binding at the pericentric
            heterochromatin in Mammalian cells
  JOURNAL   J Biol Chem 279 (10), 9539-9546 (2004)
   PUBMED   14665632
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Yang,C.S. and Weiner,H.
  TITLE     Yeast two-hybrid screening identifies binding partners of human
            Tom34 that have ATPase activity and form a complex with Tom34 in
            the cytosol
  JOURNAL   Arch Biochem Biophys 400 (1), 105-110 (2002)
   PUBMED   11913976
REFERENCE   10 (bases 1 to 1742)
  AUTHORS   Rountree,M.R., Bachman,K.E. and Baylin,S.B.
  TITLE     DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex
            at replication foci
  JOURNAL   Nat Genet 25 (3), 269-277 (2000)
   PUBMED   10888872
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB123593.1, BC008053.2 and
            BU616029.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019100.4.
            
            Summary: This gene encodes a subunit of several, distinct complexes
            involved in the repression or activation of transcription. The
            encoded protein can independently repress transcription and is
            targeted to replication foci throughout S phase by interacting
            directly with the N-terminus of DNA methyltransferase 1. During
            late S phase, histone deacetylase 2 is added to this complex,
            providing a means to deacetylate histones in transcriptionally
            inactive heterochromatin following replication. The encoded protein
            is also a component of the nucleosome acetyltransferase of H4
            complex and interacts with the transcriptional corepressor tumor
            susceptibility gene 101 and the pro-apoptotic death-associated
            protein 6, among others. Alternatively spliced transcript variants
            encoding the same protein have been described. [provided by RefSeq,
            Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1086660.1,
                                           SRR3476690.1166588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372289.7/ ENSP00000361363.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                CB123593.1         8-27
            21-1718             BC008053.2         1-1698
            1719-1742           BU616029.1         25-48               c
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.1"
     gene            1..1742
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /note="DNA methyltransferase 1 associated protein 1"
                     /db_xref="GeneID:55929"
                     /db_xref="HGNC:HGNC:18291"
                     /db_xref="MIM:605077"
     exon            1..388
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..1687
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /note="DNMT1 associated protein 1"
                     /codon_start=1
                     /product="DNA methyltransferase 1-associated protein 1"
                     /protein_id="NP_061973.1"
                     /db_xref="CCDS:CCDS509.1"
                     /db_xref="GeneID:55929"
                     /db_xref="HGNC:HGNC:18291"
                     /db_xref="MIM:605077"
                     /translation="MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSET
                     LTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTN
                     PARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHL
                     FDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVF
                     DAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAAD
                     TTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVG
                     QKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLR
                     HRHEALARAGVLGGPATPASGPGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRK
                     RRESASSSSSVKKAKKP"
     exon            389..480
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            481..676
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            677..835
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1003
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1189
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1261
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1334
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1627
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1742
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1723..1728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /note="hexamer: AATAGA"
     polyA_site      1742
                     /gene="DMAP1"
                     /gene_synonym="DNMAP1; DNMTAP1; EAF2; MEAF2; SWC4"
                     /note="major polyA site"
ORIGIN      
        1 gccgcggctt tgcggggacg ggggagtggt agtgggggct gcagctgccg gacccaggtg
       61 cggaagtgcg agggcccagg tggctgaagg ggccgttagg aacatccaag cggtggggca
      121 caggcagatc cccgacctga cctggaccac ccttctcctc ttggcccgcc ccttcaactc
      181 gcctccgctt aggtctggat tggccccgcc ccctgacctg agcctggtcc ttcttcaggc
      241 actgaccctt gacctccggt ggctccccca tctctcaggc gcgatggcta cgggcgcgga
      301 tgtacgggac attctagaac tcgggggtcc agaaggggat gcagcctctg ggaccatcag
      361 caagaaggac attatcaacc cggacaagaa aaaatccaag aagtcctctg agacactgac
      421 tttcaagagg cccgagggca tgcaccggga agtctatgcc ttgctctact ctgacaagaa
      481 ggatgcaccc ccactgctac ccagtgacac tggccaggga taccgtacag tgaaggccaa
      541 gttgggctcc aagaaggtgc ggccttggaa gtggatgcca ttcaccaacc cggcccgcaa
      601 ggacggagca atgttcttcc actggcgacg tgcagcggag gagggcaagg actacccctt
      661 tgccaggttc aataagactg tgcaggtgcc tgtgtactcg gagcaggagt accagcttta
      721 tctccacgat gatgcttgga ctaaggcaga aactgaccac ctctttgacc tcagccgccg
      781 ctttgacctg cgttttgttg ttatccatga ccggtatgac caccagcagt tcaagaagcg
      841 ttctgtggaa gacctgaagg agcggtacta ccacatctgt gctaagcttg ccaacgtgcg
      901 ggctgtgcca ggcacagacc ttaagatacc agtatttgat gctgggcacg aacgacggcg
      961 gaaggaacag cttgagcgtc tctacaaccg gaccccagag caggtggcag aggaggagta
     1021 cctgctacag gagctgcgca agattgaggc ccggaagaag gagcgggaga aacgcagcca
     1081 ggacctgcag aagctgatca cagcggcaga caccactgca gagcagcggc gcacggaacg
     1141 caaggccccc aaaaagaagc taccccagaa aaaggaggct gagaagccgg ctgttcctga
     1201 gactgcaggc atcaagtttc cagacttcaa gtctgcaggt gtcacgctgc ggagccaacg
     1261 gatgaagctg ccaagctctg tgggacagaa gaagatcaag gccctggaac agatgctgct
     1321 ggagcttggt gtggagctga gcccgacacc tacggaggag ctggtgcaca tgttcaatga
     1381 gctgcgaagc gacctggtgc tgctctacga gctcaagcag gcctgtgcca actgcgagta
     1441 tgagctgcag atgctgcggc accgtcatga ggcactggcc cgggctggtg tgctaggggg
     1501 ccctgccaca ccagcatcag gcccaggccc ggcctctgct gagccggcag tgactgaacc
     1561 cggacttggt cctgacccca aggacaccat cattgatgtg gtgggcgcac ccctcacgcc
     1621 caattcgaga aagcgacggg agtcggcctc cagctcatct tccgtgaaga aagccaagaa
     1681 gccgtgagag gccccacggg gtgtgggcga cgctgttatg taaatagagc tgctgagttg
     1741 ga
//
