LOCUS       NM_001382507            2944 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens distal membrane arm assembly component 2 like
            (DMAC2L), transcript variant 5, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001382507 XM_011536653
VERSION     NM_001382507.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2944)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2944)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2944)
  AUTHORS   Wen,F., Li,B., Huang,C., Wei,Z., Zhou,Y., Liu,J. and Zhang,H.
  TITLE     MiR-34a is Involved in the Decrease of ATP Contents Induced by
            Resistin Through Target on ATP5S in HepG2 Cells
  JOURNAL   Biochem Genet 53 (11-12), 301-309 (2015)
   PUBMED   26385595
  REMARK    GeneRIF: The study is the first to show that ATP5S is one of the
            target genes of miR-34a.
REFERENCE   4  (bases 1 to 2944)
  AUTHORS   Shaffer,J.R., Polk,D.E., Wang,X., Feingold,E., Weeks,D.E.,
            Lee,M.K., Cuenco,K.T., Weyant,R.J., Crout,R.J., McNeil,D.W. and
            Marazita,M.L.
  TITLE     Genome-wide association study of periodontal health measured by
            probing depth in adults ages 18-49 years
  JOURNAL   G3 (Bethesda) 4 (2), 307-314 (2014)
   PUBMED   24347629
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2944)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2944)
  AUTHORS   Belogrudov,G.I. and Hatefi,Y.
  TITLE     Factor B and the mitochondrial ATP synthase complex
  JOURNAL   J Biol Chem 277 (8), 6097-6103 (2002)
   PUBMED   11744738
REFERENCE   7  (bases 1 to 2944)
  AUTHORS   Kinosita,K. Jr., Yasuda,R. and Noji,H.
  TITLE     F1-ATPase: a highly efficient rotary ATP machine
  JOURNAL   Essays Biochem 35, 3-18 (2000)
   PUBMED   12471886
  REMARK    Review article
REFERENCE   8  (bases 1 to 2944)
  AUTHORS   Wang,H. and Oster,G.
  TITLE     Energy transduction in the F1 motor of ATP synthase
  JOURNAL   Nature 396 (6708), 279-282 (1998)
   PUBMED   9834036
REFERENCE   9  (bases 1 to 2944)
  AUTHORS   Elston,T., Wang,H. and Oster,G.
  TITLE     Energy transduction in ATP synthase
  JOURNAL   Nature 391 (6666), 510-513 (1998)
   PUBMED   9461222
REFERENCE   10 (bases 1 to 2944)
  AUTHORS   Sanadi,D.R., Pringle,M., Kantham,L., Hughes,J.B. and Srivastava,A.
  TITLE     Evidence for the involvement of coupling factor B in the H+ channel
            of the mitochondrial H+-ATPase
  JOURNAL   Proc Natl Acad Sci U S A 81 (5), 1371-1374 (1984)
   PUBMED   6143319
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359397.3.
            
            On May 13, 2020 this sequence version replaced XM_011536653.3.
            
            Summary: This gene encodes a subunit of mitochondrial ATP synthase.
            Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an
            electrochemical gradient of protons across the inner membrane
            during oxidative phosphorylation. ATP synthase is composed of two
            linked multi-subunit complexes: the soluble catalytic core, F1, and
            the membrane-spanning component, Fo, comprising the proton channel.
            This gene encodes the subunit s, also known as factor B, of the
            proton channel. This subunit is necessary for the energy
            transduction activity of the ATP synthase complexes. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3183375.1,
                                           SRR14038195.1836573.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000557421.7/
                                                  ENSP00000506374.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AL359397.3         61551-61616
            67-102              AL359397.3         63818-63853
            103-214             AL359397.3         70710-70821
            215-423             AL359397.3         71738-71946
            424-595             AL359397.3         73172-73343
            596-2944            AL359397.3         74836-77184
FEATURES             Location/Qualifiers
     source          1..2944
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..2944
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="distal membrane arm assembly component 2 like"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
     exon            1..66
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /inference="alignment:Splign:2.1.0"
     exon            67..102
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /inference="alignment:Splign:2.1.0"
     exon            103..214
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..710
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /EC_number="3.6.1.14"
                     /note="isoform a precursor is encoded by transcript
                     variant 5; ATP synthase, H+ transporting, mitochondrial F0
                     complex, subunit s (factor B); distal membrane arm
                     assembly complex 2-like protein; distal membrane arm
                     assembly complex 2 like; ATP synthase, H+ transporting,
                     mitochondrial Fo complex subunit s (factor B);
                     mitochondrial ATP synthase regulatory component factor B;
                     ATP synthase coupling factor B, mitochondrial; ATP
                     synthase coupling factor B-like 1; ATP synthase subunit s,
                     mitochondrial; ATP synthase-coupling factor B"
                     /codon_start=1
                     /product="ATP synthase subunit s, mitochondrial isoform a
                     precursor"
                     /protein_id="NP_001369436.1"
                     /db_xref="CCDS:CCDS32075.2"
                     /db_xref="GeneID:27109"
                     /db_xref="HGNC:HGNC:18799"
                     /db_xref="MIM:618579"
                     /translation="MMPFGKISQQLCGVKKLPWSCDSRYFWGWLNAVFNKVDYDRIRD
                     VGPDRAASEWLLRCGAMVRYHGQERWQKDYNHLPTGPLDKYKIQAIDATDSCIMSIGF
                     DHMEGLEHVEKIRLCKCHYIEDDCLLRLSQLENLQKTILEMEIISCGNITDKGIIALR
                     HLRNLKYLLLSDLPGVREKENLVQAFKTALPSLELKLQLK"
     exon            215..423
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /inference="alignment:Splign:2.1.0"
     exon            424..595
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /inference="alignment:Splign:2.1.0"
     exon            596..2944
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /inference="alignment:Splign:2.1.0"
     regulatory      852..857
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="hexamer: AATAAA"
     polyA_site      883
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="major polyA site"
     regulatory      1680..1685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="hexamer: AATAAA"
     polyA_site      1702
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="major polyA site"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="hexamer: TATAAA"
     polyA_site      2909
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
     regulatory      2915..2920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
                     /note="hexamer: AATAAA"
     polyA_site      2944
                     /gene="DMAC2L"
                     /gene_synonym="ATP5S; ATPW; FB; HSU79253"
ORIGIN      
        1 gggccggcca gggtgccgca gacgcgggga cgctggctcg ctccctccct ccctccctcc
       61 gacgctgata agtgcccaag agtacaattg ctgggtcata tgatcaaatg atgccgtttg
      121 gaaaaatttc ccagcagttg tgtggcgtaa agaaactccc atggtcatgt gactccagat
      181 acttctgggg ctggttgaat gcagtgttta ataaggtgga ttatgatcgc atcagggatg
      241 ttggccctga cagggcggca tccgagtggt tgctgcgctg tggggccatg gtgcgctacc
      301 atggccagga gaggtggcag aaggactaca accaccttcc aacaggccct ctggacaaat
      361 acaagattca ggcgatcgac gccaccgact cttgtatcat gagcattgga tttgatcaca
      421 tggagggcct agagcatgtt gaaaaaataa ggctgtgcaa gtgtcattat atcgaggatg
      481 actgtttgct gagacttagt caacttgaaa atttacaaaa aaccatattg gaaatggaaa
      541 taatatcctg tgggaatatc acagacaaag gcatcattgc tttgcgtcat ttaagaaacc
      601 tcaaatattt gttgttaagt gatcttcctg gagtaagaga aaaagaaaat cttgtccaag
      661 cctttaagac agcactgcct tctctggaac taaaattaca attgaagtaa aataatgtgt
      721 cttatttcag tataaaggat catttgaaac tgttgattcc aaacatcaac taatattata
      781 tagtcatcag tagaattata aggatgccat atcatgacat tttagaagtg gagagtgcat
      841 catatgtaga aaataaatat tcagacgtgg ctcattaatg ttactaagtt ggaagtgaga
      901 atttatgaac attaattcat tttaagaaaa gtgcagccag gcgcagtggc tcatgcctgt
      961 aatcctagca ctttgggagg ccaaagcggg cagatcacct gaggtcagga gttcaagacc
     1021 aaccatggcc aacatggtga aaccccatct ctactaaaaa aacaaaatta gctgaatgtg
     1081 gtggtgcacg cctttaatcc cagctactct ggaggctgag gcaggagaat cacttgactt
     1141 gggaggtgga ggttgcaggg acccgagatt gtgccactgc actccagcct gggtgacaga
     1201 gcgagactgt ctcaaaaaaa aaaaaaaaag aaaaatgtaa actaggtaac attttaattc
     1261 taatatattc atttaatatg taaatctata gatatctctt gatgtagata tttagaatcc
     1321 tttaaagtta tttgtacaac agatgttttt attataacag taatttacat ttaactttaa
     1381 agttagtgaa gcatactacc ataaatgcac aattatgaaa aattagaagc taaattacag
     1441 attcattgat ggagtcaatt atgcaaagtg gtcagtggtt gttgaagcat gcattgcttc
     1501 aacaggattt gcgtgcattt cccatgatcc tgcattcttg tgttcttgat agcatacaga
     1561 cttactcaga atcaacagtt gctgcttaat ttgtctattt tgtaagctta ggctactatt
     1621 ttattaaaac tggacataga tacttggctg aatacaaata gttttgcaga ttgcaatata
     1681 ataaaggaaa cagtaaaaac tagtgggcta tgcttaggtt tttcttgaaa cctaacattg
     1741 ctttaggctg ggtgccgtgg ctcgtgcctg taatcccagt gctttgggag gctgaggtgg
     1801 gaggatcact tgagaccagg agtttgagac caatttgggc aacacagtga gaccccatct
     1861 ctaaaaaaat tttaaaaatt aggcaggcat ggtggtgcat acctgtaatc tcagatactt
     1921 gggaggttga ggtggtagga ttgcttgagc tcaggagttt gaggctgcag taagctatga
     1981 tcacggccac tgcacaccag cctggtagcc tgggtgaaag ggggagaccc tgtctcttaa
     2041 aaaaaagggc tggcctgtaa tcccagcact tttgaaggcc aaggcaggca gatcatttga
     2101 gcccaggagt tcaggacgag cctgggcaac atggcaaaac cctgtctcta ccaaaaaatt
     2161 aaaaaataaa aaatagctgg gtgtagtggc acatgcctgt agtcccaact actcaggagt
     2221 ctgaggtagg aggatcagtt gagcccggga agtcgaggct gcagtgagcc atgttggcac
     2281 cactgcactc cagcctgggc aacagattaa gaccctgtct caaaaaaaaa aaaaaaagtg
     2341 aaaaatagat aaaacaggtc ttcattgtta cctgtgagaa atggccctga ttctattact
     2401 cttatatgcc agtttgttta tagatttctg tgtgtttgat ttgaactttt tttttttttt
     2461 tttttttttt gagacagact ctcactctgt tgcccaggtt ggagtgcagt ggtgtgatct
     2521 cagttcactg caacctctgc ctcccgggtt caagcagttc tctgtcgcag cgtcccaggt
     2581 agctgggatt acaggcgccc accaccacgc ccagctaatt tttgtacttt tagtagagac
     2641 agggtttcac catcttggcc agactggtct tgaactccta acctcaggat ccacccgcct
     2701 cggcctccca aagtgctggg agccaccgcg cccagcctgg tttgaacatt attaagctgt
     2761 tgaatataaa cttgaaaata attttctatg atacagcttt caggtagaaa aatgaatttt
     2821 cgttgtgttt aacaatgttg tgtttaacag cttatacaaa taacacagta taaatggtaa
     2881 ttgccactgt cattttaaaa atcagaaaat agtaaataaa aggatgtgga agagtctcat
     2941 gtga
//
