LOCUS       NM_005222               2300 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens distal-less homeobox 6 (DLX6), mRNA.
ACCESSION   NM_005222 XM_376652 XM_379892
VERSION     NM_005222.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2300)
  AUTHORS   Liang,J., Liu,J., Deng,Z., Liu,Z. and Liang,L.
  TITLE     DLX6 promotes cell proliferation and survival in oral squamous cell
            carcinoma
  JOURNAL   Oral Dis 28 (1), 87-96 (2022)
   PUBMED   33215805
  REMARK    GeneRIF: DLX6 promotes cell proliferation and survival in oral
            squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2300)
  AUTHORS   Luo,Y., Ge,P., Wang,M., Chen,H., Liu,J., Wei,T., Jiang,Y., Qu,J.
            and Chen,H.
  TITLE     Research progress of DLX6-AS1 in human cancers
  JOURNAL   Hum Cell 34 (6), 1642-1652 (2021)
   PUBMED   34508305
  REMARK    GeneRIF: Research progress of DLX6-AS1 in human cancers.
            Review article
REFERENCE   3  (bases 1 to 2300)
  AUTHORS   Qian,Y., Song,W., Wu,X., Hou,G., Wang,H., Hang,X. and Xia,T.
  TITLE     DLX6 Antisense RNA 1 Modulates Glucose Metabolism and Cell Growth
            in Gastric Cancer by Targeting microRNA-4290
  JOURNAL   Dig Dis Sci 66 (2), 460-473 (2021)
   PUBMED   32239379
  REMARK    GeneRIF: DLX6 Antisense RNA 1 Modulates Glucose Metabolism and Cell
            Growth in Gastric Cancer by Targeting microRNA-4290.
REFERENCE   4  (bases 1 to 2300)
  AUTHORS   Zhao,H. and Xu,Q.
  TITLE     Long non-coding RNA DLX6-AS1 mediates proliferation, invasion and
            apoptosis of endometrial cancer cells by recruiting p300/E2F1 in
            DLX6 promoter region
  JOURNAL   J Cell Mol Med 24 (21), 12572-12584 (2020)
   PUBMED   32951317
  REMARK    GeneRIF: Long non-coding RNA DLX6-AS1 mediates proliferation,
            invasion and apoptosis of endometrial cancer cells by recruiting
            p300/E2F1 in DLX6 promoter region.
REFERENCE   5  (bases 1 to 2300)
  AUTHORS   Zhang,J.J., Xu,W.R., Chen,B., Wang,Y.Y., Yang,N., Wang,L.J. and
            Zhang,Y.L.
  TITLE     The up-regulated lncRNA DLX6-AS1 in colorectal cancer promotes cell
            proliferation, invasion and migration via modulating PI3K/AKT/mTOR
            pathway
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (19), 8321-8331 (2019)
   PUBMED   31646562
  REMARK    GeneRIF: The up-regulated lncRNA DLX6-AS1 in colorectal cancer
            promotes cell proliferation, invasion and migration via modulating
            PI3K/AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 2300)
  AUTHORS   Depew,M.J., Lufkin,T. and Rubenstein,J.L.
  TITLE     Specification of jaw subdivisions by Dlx genes
  JOURNAL   Science 298 (5592), 381-385 (2002)
   PUBMED   12193642
  REMARK    GeneRIF: In mice, deletion of Dlx5 and Dlx6 results in skull
            repatterning, including a homeotic transformation of the lower jaw
            into an upper jaw, and supports a model of patterning within
            branchial arches that relies on a nested pattern of Dlx gene
            expression.
REFERENCE   7  (bases 1 to 2300)
  AUTHORS   Charite,J., McFadden,D.G., Merlo,G., Levi,G., Clouthier,D.E.,
            Yanagisawa,M., Richardson,J.A. and Olson,E.N.
  TITLE     Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND
            branchial arch enhancer
  JOURNAL   Genes Dev 15 (22), 3039-3049 (2001)
   PUBMED   11711438
  REMARK    GeneRIF: In mice, Dlx6 acts as an intermediary between endothelin-1
            signaling and transcription of the basic helix-loop-helix
            transcription factor dHAND during craniofacial morphogenesis.
REFERENCE   8  (bases 1 to 2300)
  AUTHORS   Crackower,M.A., Scherer,S.W., Rommens,J.M., Hui,C.C., Poorkaj,P.,
            Soder,S., Cobben,J.M., Hudgins,L., Evans,J.P. and Tsui,L.C.
  TITLE     Characterization of the split hand/split foot malformation locus
            SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its
            expression during limb development
  JOURNAL   Hum Mol Genet 5 (5), 571-579 (1996)
   PUBMED   8733122
REFERENCE   9  (bases 1 to 2300)
  AUTHORS   Simeone,A., Acampora,D., Pannese,M., D'Esposito,M., Stornaiuolo,A.,
            Gulisano,M., Mallamaci,A., Kastury,K., Druck,T., Huebner,K. et al.
  TITLE     Cloning and characterization of two members of the vertebrate Dlx
            gene family
  JOURNAL   Proc Natl Acad Sci U S A 91 (6), 2250-2254 (1994)
   PUBMED   7907794
REFERENCE   10 (bases 1 to 2300)
  AUTHORS   Cross,S.H., Charlton,J.A., Nan,X. and Bird,A.P.
  TITLE     Purification of CpG islands using a methylated DNA binding column
  JOURNAL   Nat Genet 6 (3), 236-244 (1994)
   PUBMED   8012384
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004774.1, AK094086.1 and
            BU616500.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005222.3.
            
            Summary: This gene encodes a member of a homeobox transcription
            factor gene family similiar to the Drosophila distal-less gene.
            This family is comprised of at least 6 different members that
            encode proteins with roles in forebrain and craniofacial
            development. This gene is in a tail-to-tail configuration with
            another member of the family on the long arm of chromosome 7.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.234367.1,
                                           SRR1803615.220668.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518156.3/ ENSP00000428480.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-644               AC004774.1         111446-112089
            645-1420            AK094086.1         31-806
            1421-2062           AC004774.1         116054-116695
            2063-2300           BU616500.1         18-255              c
FEATURES             Location/Qualifiers
     source          1..2300
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q21.3"
     gene            1..2300
                     /gene="DLX6"
                     /note="distal-less homeobox 6"
                     /db_xref="GeneID:1750"
                     /db_xref="HGNC:HGNC:2919"
                     /db_xref="MIM:600030"
     exon            1..861
                     /gene="DLX6"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..1307
                     /gene="DLX6"
                     /note="distal-less homeo box 6"
                     /codon_start=1
                     /product="homeobox protein DLX-6"
                     /protein_id="NP_005213.3"
                     /db_xref="CCDS:CCDS47647.2"
                     /db_xref="GeneID:1750"
                     /db_xref="HGNC:HGNC:2919"
                     /db_xref="MIM:600030"
                     /translation="MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQQQQ
                     PPPPPPPPPQPHSQQSSPAMAGAHYPLHCLHSAAAAAAAGSHHHHHHQHHHHGSPYAS
                     GGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRF
                     NGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNK
                     RSKFKKLLKQGSNPHESDPLQGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYS
                     HWYSSPHQDTMQRPQMM"
     exon            862..1055
                     /gene="DLX6"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..2300
                     /gene="DLX6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2279..2284
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLX6"
                     /note="hexamer: AGTAAA"
     polyA_site      2300
                     /gene="DLX6"
                     /note="major polyA site"
ORIGIN      
        1 attcgactcg tggcgtctgc atcaagtctg aaagcagacg cgcaactttc gcagaatcca
       61 ccttaaaatc tctgccttaa actgcaccag cccccaaaaa atccaagggg ggaaagcagg
      121 cggggggaga gcagattccc ccctccccct ctcctctccc atccctcctc cttcctcctc
      181 cctttgagtt aacaaggccc cgctcactat atctctttat attaaatata tatatatatt
      241 agagaagagc gagggagagg gagaaccacc tccacccccc tctttaaatt cttttttttt
      301 tttttttttt tttttgcaag gatccaaaga gctaaggtgg ctgcagaggg gagagcggcg
      361 cgagccaagt gggggagggt ggaggaaacc cgggagaagg ctttctccag cccccaaagt
      421 ttttgatgat gaccatgact acgatggctg acggcttgga aggccaggac tcgtccaaat
      481 ccgccttcat ggagttcggg cagcagcagc agcagcagca gcaacagcag cagcagcagc
      541 agcagcaaca gcaacagccg ccgccgccgc cgccgccgcc gccgcagccg cactcgcagc
      601 agagctcccc ggccatggca ggcgcgcact accctctgca ctgcctgcac tcggcggcgg
      661 cggcggcagc ggccggctcg caccaccacc accaccacca gcaccaccac cacggctcgc
      721 cctacgcgtc gggcggaggg aactcctaca accaccgctc gctcgccgcc tacccctaca
      781 tgagccactc gcagcacagc ccttacctcc agtcctacca caacagcagc gcagccgccc
      841 agacgcgagg ggacgacaca gatcaacaaa aaactacagt gattgaaaac ggggaaatca
      901 ggttcaatgg aaaagggaaa aagattcgga agcctcggac catttattcc agcctgcagc
      961 tccaggcttt aaaccatcgc tttcagcaga cacagtatct ggcccttcca gagagagccg
     1021 aactggcagc ttccttagga ctgacacaaa cacaggtgaa gatatggttt cagaacaaac
     1081 gctctaagtt taagaaactg ctgaagcagg gcagtaatcc tcatgagagc gaccccctcc
     1141 agggctcggc ggccctgtcg ccacgctcgc cagcgctgcc tccagtctgg gacgtttctg
     1201 cctcggccaa gggtgtcagt atgcccccca acagctacat gcctggctat tctcactggt
     1261 actcctctcc acaccaggac acgatgcaga gaccacagat gatgtgagtt gcccaaggga
     1321 acaccctagg gaaacgtctg aacaaggaaa agaggatccg ggacctgctt gtatctgcga
     1381 aaaggagcca aaggagcagg cttaggagag ctcataagtg tggcaagaag ccgactaggc
     1441 tcattctctc tccctctctc tctctctccc tctcctttct ttttacttct tcctttcctc
     1501 cattccttct ttctttcctt ttcctttcta cctttctttt ctttttgcct ttcacctttt
     1561 ttctcattta ccttctctct tgagcaacgt cagtaattga tcttgcatct cagagagaga
     1621 gaaagagcat gtgtgagaga gaaactggtt tctatgccag cactcctgaa accccttact
     1681 gtaaggatat tttctcttac cccttgggat ccaggctctg agtctcttct ctttgggagt
     1741 atccatcaaa atgacttttt ttaaaaacag attttccccc aaccagaaga atctgcacaa
     1801 acttggcagc gtttttactt gtttaatgag tttaagacat tacatggtga aagagaagca
     1861 ttttggactc ctgcattttt atttaccatt cccagactga cgagaaaaag aaaattcctc
     1921 acataacagc ccttctctaa agaaaaagga aaaagtggct gtaagattag aacattgcta
     1981 caaagggaat gctgcatgtt ttatcaaaat gcaatgacca ggaatgatgg ttgattaaaa
     2041 aaaaacaaaa caaaaaccac tctttcccca ccccaccccc ccaaaccctg aactggaatc
     2101 aggaaagacg gaggaaacaa tcaaaatcac cattctattg ctttgacacc tttactaggt
     2161 gaattggtgg cattcacaaa gctaataggg acgtttatat caagaaacat ttctgtatat
     2221 attgttgaat tttagttgta catatacttt gtatgttttt gtcttctttc atatatggag
     2281 taaaagccac aaaacgctga
//
