LOCUS       NM_178120               2356 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1,
            mRNA.
ACCESSION   NM_178120
VERSION     NM_178120.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Du,Y., Li,H., Wang,Y., He,Y. and Li,G.
  TITLE     DLX1 acts as a novel prognostic biomarker involved in immune cell
            infiltration and tumor progression in lung adenocarcinoma
  JOURNAL   PeerJ 12, e16823 (2024)
   PUBMED   38317839
  REMARK    GeneRIF: DLX1 acts as a novel prognostic biomarker involved in
            immune cell infiltration and tumor progression in lung
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Li,Q., Xu,K., Tian,J., Lu,Z. and Pu,J.
  TITLE     MiR-129-5p/DLX1 signalling axis mediates functions of prostate
            cancer during malignant progression
  JOURNAL   Andrologia 53 (11), e14230 (2021)
   PUBMED   34472106
  REMARK    GeneRIF: MiR-129-5p/DLX1 signalling axis mediates functions of
            prostate cancer during malignant progression.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Goel,S., Bhatia,V., Kundu,S., Biswas,T., Carskadon,S., Gupta,N.,
            Asim,M., Morrissey,C., Palanisamy,N. and Ateeq,B.
  TITLE     Transcriptional network involving ERG and AR orchestrates
            Distal-less homeobox-1 mediated prostate cancer progression
  JOURNAL   Nat Commun 12 (1), 5325 (2021)
   PUBMED   34493733
  REMARK    GeneRIF: Transcriptional network involving ERG and AR orchestrates
            Distal-less homeobox-1 mediated prostate cancer progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Busetto,G.M., Del Giudice,F., Maggi,M., De Marco,F., Porreca,A.,
            Sperduti,I., Magliocca,F.M., Salciccia,S., Chung,B.I., De
            Berardinis,E. and Sciarra,A.
  TITLE     Prospective assessment of two-gene urinary test with
            multiparametric magnetic resonance imaging of the prostate for men
            undergoing primary prostate biopsy
  JOURNAL   World J Urol 39 (6), 1869-1877 (2021)
   PUBMED   32681273
  REMARK    GeneRIF: Prospective assessment of two-gene urinary test with
            multiparametric magnetic resonance imaging of the prostate for men
            undergoing primary prostate biopsy.
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Haese,A., Trooskens,G., Steyaert,S., Hessels,D., Brawer,M.,
            Vlaeminck-Guillem,V., Ruffion,A., Tilki,D., Schalken,J.,
            Groskopf,J. and Van Criekinge,W.
  TITLE     Multicenter Optimization and Validation of a 2-Gene mRNA Urine Test
            for Detection of Clinically Significant Prostate Cancer before
            Initial Prostate Biopsy
  JOURNAL   J Urol 202 (2), 256-263 (2019)
   PUBMED   31026217
  REMARK    GeneRIF: Urinary DLX1 mRNA levels were quantified and RNA results
            were then combined with other risk factors in a clinical model
            optimized to detect International Society of Urological Pathology
            Grade Group 2 or greater prostate cancer in men with prostate
            specific antigen less than 10 ng/ml.
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Hamilton,S.P., Woo,J.M., Carlson,E.J., Ghanem,N., Ekker,M. and
            Rubenstein,J.L.
  TITLE     Analysis of four DLX homeobox genes in autistic probands
  JOURNAL   BMC Genet 6, 52 (2005)
   PUBMED   16266434
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Zhou,Q.P., Le,T.N., Qiu,X., Spencer,V., de Melo,J., Du,G.,
            Plews,M., Fonseca,M., Sun,J.M., Davie,J.R. and Eisenstat,D.D.
  TITLE     Identification of a direct Dlx homeodomain target in the developing
            mouse forebrain and retina by optimization of chromatin
            immunoprecipitation
  JOURNAL   Nucleic Acids Res 32 (3), 884-892 (2004)
   PUBMED   14769946
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Chiba,S., Takeshita,K., Imai,Y., Kumano,K., Kurokawa,M., Masuda,S.,
            Shimizu,K., Nakamura,S., Ruddle,F.H. and Hirai,H.
  TITLE     Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling
            pathway from activin A in hematopoietic cells
  JOURNAL   Proc Natl Acad Sci U S A 100 (26), 15577-15582 (2003)
   PUBMED   14671321
  REMARK    GeneRIF: DLX1 may function as a regulator of multiple signals from
            TGF-beta superfamily members in broad biological contexts during
            blood production
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Letinic,K., Zoncu,R. and Rakic,P.
  TITLE     Origin of GABAergic neurons in the human neocortex
  JOURNAL   Nature 417 (6889), 645-649 (2002)
   PUBMED   12050665
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Simeone,A., Acampora,D., Pannese,M., D'Esposito,M., Stornaiuolo,A.,
            Gulisano,M., Mallamaci,A., Kastury,K., Druck,T., Huebner,K. et al.
  TITLE     Cloning and characterization of two members of the vertebrate Dlx
            gene family
  JOURNAL   Proc Natl Acad Sci U S A 91 (6), 2250-2254 (1994)
   PUBMED   7907794
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY257976.1, BC036189.1 and
            BC053351.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_178120.4.
            
            Summary: This gene encodes a member of a homeobox transcription
            factor gene family similiar to the Drosophila distal-less gene. The
            encoded protein is localized to the nucleus where it may function
            as a transcriptional regulator of signals from multiple TGF-{beta}
            superfamily members. The encoded protein may play a role in the
            control of craniofacial patterning and the differentiation and
            survival of inhibitory neurons in the forebrain. This gene is
            located in a tail-to-tail configuration with another member of the
            family on the long arm of chromosome 2. Alternatively spliced
            transcript variants encoding different isoforms have been
            described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.59592.1, BC036189.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361725.5/ ENSP00000354478.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AY257976.1         28-145
            119-577             BC036189.1         112-570
            578-1014            AY257976.1         605-1041
            1015-2356           BC053351.1         719-2060
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q31.1"
     gene            1..2356
                     /gene="DLX1"
                     /note="distal-less homeobox 1"
                     /db_xref="GeneID:1745"
                     /db_xref="HGNC:HGNC:2914"
                     /db_xref="MIM:600029"
     exon            1..484
                     /gene="DLX1"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..939
                     /gene="DLX1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     distal-less homeo box 1; homeobox protein DLX-1"
                     /codon_start=1
                     /product="homeobox protein DLX-1 isoform 1"
                     /protein_id="NP_835221.2"
                     /db_xref="CCDS:CCDS2247.2"
                     /db_xref="GeneID:1745"
                     /db_xref="HGNC:HGNC:2914"
                     /db_xref="MIM:600029"
                     /translation="MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHC
                     LHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLE
                     DPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAE
                     LAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNP
                     NSSSGKGSGGNAGSYIPSYTSWYPSAHQEAMQQPQLM"
     exon            485..684
                     /gene="DLX1"
                     /inference="alignment:Splign:2.1.0"
     exon            685..2356
                     /gene="DLX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2334..2339
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLX1"
                     /note="hexamer: AGTAAA"
     polyA_site      2356
                     /gene="DLX1"
                     /note="major polyA site"
ORIGIN      
        1 agcagcatca tgcttagact tttcaaagag acaaactcca ttttcttatg aatggaaagt
       61 gaaaacccct gttccgctta aattgggttc cttcctgtcc tgagaaacat agagaccccc
      121 aaaagggaag cagaggagag aaagtcccac acccagaccc cgcgagaaga gatgaccatg
      181 accaccatgc cagaaagtct caacagcccc gtgtcgggca aggcggtgtt tatggagttt
      241 gggccgccca accagcaaat gtctccttct cccatgtccc acgggcacta ctccatgcac
      301 tgtttacact cggcgggcca ttcgcagccc gacggcgcct acagctcagc ctcgtccttc
      361 tcccgaccgc tgggctaccc ctacgtcaac tcggtcagca gccacgcatc cagcccctac
      421 atcagttcgg tgcagtccta cccgggcagc gccagcctcg cccagagccg cctggaggac
      481 ccaggggcgg actcggagaa gagcacggtg gtggaaggcg gtgaagtgcg cttcaatggc
      541 aagggaaaaa agatccgtaa acccaggacg atttattcca gtttgcagtt gcaggctttg
      601 aaccggaggt tccagcaaac tcagtaccta gctctgccgg agagggcgga gctcgcggcc
      661 tctttgggac tcacacagac tcaggtcaag atctggttcc aaaacaagcg atccaagttc
      721 aagaagctga tgaagcaggg tggggcggct ctggagggta gtgcgttggc caacggtcgg
      781 gccctgtctg ctggctcccc acccgtgccg cccggctgga accctaactc ttcatccggg
      841 aagggctcag gaggaaacgc gggctcctat atccccagct acacatcgtg gtacccttca
      901 gcgcaccaag aagctatgca gcaaccccaa cttatgtgag gttgcccgcc cgtctccttc
      961 ttgtctcccc ggcccaggtc cctcccgcct ccaggtccat ccatcccgtc cggaaaagaa
     1021 ggacccagag ggaagaagga acagtggagg cgggacgccc tccatctcct cggagccccg
     1081 cgaggtccgg cccagcaact tcccggcatc cgcgctctag cctgaaccct ggcctgggcc
     1141 gagcagtggc agcagagagt ggcctcggag ggaagccact gccacctgag acagcccaag
     1201 cagcaagata aacccgctcc acccgacccg ccgaccttca gctttgtggg actatcagga
     1261 aaaaacaaaa caaaaacaaa atgtagaaaa agcaaaagct cttttctgtc ctgtcagtct
     1321 cctgtctcct tttgctctgt ctgtgcgctg gtaaagtcca ggtcctcatc cgtccgctgt
     1381 cctcattctg cggcctcagc aaaaagccac aaggtctgag cggcccgggt cctgccgggc
     1441 tgaccatctc cggatcctgg gacactctgc ctgaccatct gtgtagctgg tgtgggaatc
     1501 tgggggcatt ggagggaggg ggttttattt attgagaaat ggacttcgcc tgaggctgtt
     1561 tgccaattca gggttctgct gggcgcaagg aacgcactgt tcaaacgcac tgtttacttt
     1621 aagcgcacgg ggagaaacga ataaggagga cgtggtgatt tttaatttat acagtaactt
     1681 ttgtacttct ctggtatgga gagtttggag ccgaatgatt tgcatttttt acatgtccga
     1741 cattatttaa taaataattt ttaaaagaaa agaacgataa atgaagccaa catgattttc
     1801 tcatttcggg aggaactctg ttgcttcgcc tggacaagaa ggaaaatgct gatttcctcc
     1861 ttgggtagaa agagggagcg agggcaaatg gggagtagag agaaaacagg cgagaacaag
     1921 cactctaatt ccagtgggct ttaaaataag acaaaatcag ctttacaaca atccctagag
     1981 gctcgaccac agaataatgc cagtcaccac cctgaacgca caatctccag tgcaggatct
     2041 aatgactgta catattattg ttattattat tattgttatt attgttgttc tgtaaacatg
     2101 ttgcacaagc ttagcctttt tgcgttctgt tgtgtgtggc tgtaaaaccc catgctttgt
     2161 gaaatgagaa tcttgacatt tttcttgtga aatttggaaa atgtgatcaa ttgaaatcaa
     2221 ctgtgttttg tgttctctat gtcaaagttt agttttatat tgagaatgtt aacttattgc
     2281 tttgtatctt gggaaaaaaa ctttgtaaat aagttataaa gtttctttga gacagtaaaa
     2341 ttatgatttc ttgaaa
//
