LOCUS       NM_019074               3426 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens delta like canonical Notch ligand 4 (DLL4), mRNA.
ACCESSION   NM_019074
VERSION     NM_019074.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3426)
  AUTHORS   Mora,P., Laisne,M., Bourguignon,C., Rouault,P., Jaspard-Vinassa,B.,
            Maitre,M., Gadeau,A.P., Renault,M.A., Horng,S., Couffinhal,T. and
            Chapouly,C.
  TITLE     Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation
            via the IL-6-STAT3 axis
  JOURNAL   J Neuroinflammation 21 (1), 258 (2024)
   PUBMED   39390606
  REMARK    GeneRIF: Astrocytic DLL4-NOTCH1 signaling pathway promotes
            neuroinflammation via the IL-6-STAT3 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3426)
  AUTHORS   Yang,S., Xiong,L., Yang,G., Xiang,J., Li,L., Kang,L. and Liang,Z.
  TITLE     KLF13 restrains Dll4-muscular Notch2 axis to improve the muscle
            atrophy
  JOURNAL   J Cachexia Sarcopenia Muscle 15 (5), 1869-1882 (2024)
   PUBMED   38973459
  REMARK    GeneRIF: KLF13 restrains Dll4-muscular Notch2 axis to improve the
            muscle atrophy.
REFERENCE   3  (bases 1 to 3426)
  AUTHORS   Cong,L., Zhao,L., Shi,Y., Bai,Y. and Guo,Z.
  TITLE     Circ_0006476 modulates macrophage apoptosis through the
            miR-3074-5p/DLL4 axis: implications for Notch signalling pathway
            regulation in cardiovascular disease
  JOURNAL   Aging (Albany NY) 16 (16), 11857-11876 (2024)
   PUBMED   39167432
  REMARK    GeneRIF: Circ_0006476 modulates macrophage apoptosis through the
            miR-3074-5p/DLL4 axis: implications for Notch signalling pathway
            regulation in cardiovascular disease.
REFERENCE   4  (bases 1 to 3426)
  AUTHORS   Wang,X., Zhu,L., Liu,J., Ma,Y., Qiu,C., Liu,C., Gong,Y., Yuwen,Y.,
            Guan,G., Zhang,Y., Pan,S., Wang,J. and Liu,Z.
  TITLE     Palmitic acid in type 2 diabetes mellitus promotes atherosclerotic
            plaque vulnerability via macrophage Dll4 signaling
  JOURNAL   Nat Commun 15 (1), 1281 (2024)
   PUBMED   38346959
  REMARK    GeneRIF: Palmitic acid in type 2 diabetes mellitus promotes
            atherosclerotic plaque vulnerability via macrophage Dll4 signaling.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3426)
  AUTHORS   Alve,S., Gramolelli,S., Jukonen,J., Juteau,S., Pink,A.,
            Manninen,A.A., Hanninen,S., Monto,E., Lackman,M.H., Carpen,O.,
            Saharinen,P., Karaman,S., Vaahtomeri,K. and Ojala,P.M.
  TITLE     DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic
            crosstalk between melanoma and lymphatic endothelial cells
  JOURNAL   JCI Insight 9 (1), e171821 (2024)
   PUBMED   37971882
  REMARK    GeneRIF: DLL4/Notch3/WNT5B axis mediates bidirectional
            prometastatic crosstalk between melanoma and lymphatic endothelial
            cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3426)
  AUTHORS   Yan,X.Q., Sarmiento,U., Sun,Y., Huang,G., Guo,J., Juan,T., Van,G.,
            Qi,M.Y., Scully,S., Senaldi,G. and Fletcher,F.A.
  TITLE     A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when
            overexpressed in mice by retroviral-mediated gene transfer
  JOURNAL   Blood 98 (13), 3793-3799 (2001)
   PUBMED   11739188
REFERENCE   7  (bases 1 to 3426)
  AUTHORS   Mailhos,C., Modlich,U., Lewis,J., Harris,A., Bicknell,R. and
            Ish-Horowicz,D.
  TITLE     Delta4, an endothelial specific notch ligand expressed at sites of
            physiological and tumor angiogenesis
  JOURNAL   Differentiation 69 (2-3), 135-144 (2001)
   PUBMED   11798067
REFERENCE   8  (bases 1 to 3426)
  AUTHORS   Yoneya,T., Tahara,T., Nagao,K., Yamada,Y., Yamamoto,T., Osawa,M.,
            Miyatani,S. and Nishikawa,M.
  TITLE     Molecular cloning of delta-4, a new mouse and human Notch ligand
  JOURNAL   J Biochem 129 (1), 27-34 (2001)
   PUBMED   11134954
REFERENCE   9  (bases 1 to 3426)
  AUTHORS   Shutter,J.R., Scully,S., Fan,W., Richards,W.G., Kitajewski,J.,
            Deblandre,G.A., Kintner,C.R. and Stark,K.L.
  TITLE     Dll4, a novel Notch ligand expressed in arterial endothelium
  JOURNAL   Genes Dev 14 (11), 1313-1318 (2000)
   PUBMED   10837024
REFERENCE   10 (bases 1 to 3426)
  AUTHORS   Lehman,A., Wuyts,W. and Patel,M.S.
  TITLE     Adams-Oliver Syndrome - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   27077170
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA089757.1, BC106950.2,
            AB036931.1, AI478830.1 and HY291308.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2018 this sequence version replaced NM_019074.3.
            
            Summary: This gene is a homolog of the Drosophila delta gene. The
            delta gene family encodes Notch ligands that are characterized by a
            DSL domain, EGF repeats, and a transmembrane domain. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.104185.1,
                                           SRR1660805.112319.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249749.7/ ENSP00000249749.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-193               DA089757.1         8-200
            194-2871            BC106950.2         1-2678
            2872-3392           AB036931.1         2819-3339
            3393-3413           AI478830.1         213-233
            3414-3426           HY291308.1         32-44               c
FEATURES             Location/Qualifiers
     source          1..3426
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..3426
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /note="delta like canonical Notch ligand 4"
                     /db_xref="GeneID:54567"
                     /db_xref="HGNC:HGNC:2910"
                     /db_xref="MIM:605185"
     exon            1..395
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..2387
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /note="delta 4; delta ligand 4; notch ligand delta-2;
                     notch ligand DLL4; delta-like protein 4; delta-like 4
                     protein; drosophila Delta homolog 4; delta-like 4 homolog"
                     /codon_start=1
                     /product="delta-like protein 4 precursor"
                     /protein_id="NP_061947.1"
                     /db_xref="CCDS:CCDS45232.1"
                     /db_xref="GeneID:54567"
                     /db_xref="HGNC:HGNC:2910"
                     /db_xref="MIM:605185"
                     /translation="MAAASRSASGWALLLLVALWQQRAAGSGVFQLQLQEFINERGVL
                     ASGRPCEPGCRTFFRVCLKHFQAVVSPGPCTFGTVSTPVLGTNSFAVRDDSSGGGRNP
                     LQLPFNFTWPGTFSLIIEAWHAPGDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQ
                     TSTLTRLRYSYRVICSDNYYGDNCSRLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQ
                     QPICLSGCHEQNGYCSKPAECLCRPGWQGRLCNECIPHNGCRHGTCSTPWQCTCDEGW
                     GGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCR
                     NGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPP
                     NFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRMCRCRPGFTGTYCELHVSDCARNPCA
                     HGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNC
                     PYGFVGSRCEFPVGLPPSFPWVAVSLGVGLAVLLVLLGMVAVAVRQLRLRRPDDGSRE
                     AMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKQQNHTLDYNLAPGPLGR
                     GTMPGKFPHSDKSLGEKAPLRLHSEKPECRISAICSPRDSMYQSVCLISEERNECVIA
                     TEV"
     exon            396..665
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            666..723
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..987
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1048
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1179
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1349
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1569
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            1570..2272
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2381
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     exon            2382..3426
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3421
                     /gene="DLL4"
                     /gene_synonym="AOS6; delta4; hdelta2"
                     /note="major polyA site"
ORIGIN      
        1 agtagcggcg ctgcgcgcag gccgggaaca cgaggccaag agccgcagcc ccagccgcct
       61 tggtgcagcg tacaccggca ctagcccgct tgcagcccca ggattagaca gaagacgcgt
      121 cctcggcgcg gtcgccgccc agccgtagtc acctggatta cctacagcgg cagctgcagc
      181 ggagccagcg agaaggccaa aggggagcag cgtcccgaga ggagcgcctc ttttcaggga
      241 ccccgccggc tggcggacgc gcgggaaagc ggcgtcgcga acagagccag attgagggcc
      301 cgcgggtgga gagagcgacg cccgagggga tggcggcagc gtcccggagc gcctctggct
      361 gggcgctact gctgctggtg gcactttggc agcagcgcgc ggccggctcc ggcgtcttcc
      421 agctgcagct gcaggagttc atcaacgagc gcggcgtact ggccagtggg cggccttgcg
      481 agcccggctg ccggactttc ttccgcgtct gccttaagca cttccaggcg gtcgtctcgc
      541 ccggaccctg caccttcggg accgtctcca cgccggtatt gggcaccaac tccttcgctg
      601 tccgggacga cagtagcggc ggggggcgca accctctcca actgcccttc aatttcacct
      661 ggccgggtac cttctcgctc atcatcgaag cttggcacgc gccaggagac gacctgcggc
      721 cagaggcctt gccaccagat gcactcatca gcaagatcgc catccagggc tccctagctg
      781 tgggtcagaa ctggttattg gatgagcaaa ccagcaccct cacaaggctg cgctactctt
      841 accgggtcat ctgcagtgac aactactatg gagacaactg ctcccgcctg tgcaagaagc
      901 gcaatgacca cttcggccac tatgtgtgcc agccagatgg caacttgtcc tgcctgcccg
      961 gttggactgg ggaatattgc caacagccta tctgtctttc gggctgtcat gaacagaatg
     1021 gctactgcag caagccagca gagtgcctct gccgcccagg ctggcagggc cggctgtgta
     1081 acgaatgcat cccccacaat ggctgtcgcc acggcacctg cagcactccc tggcaatgta
     1141 cttgtgatga gggctgggga ggcctgtttt gtgaccaaga tctcaactac tgcacccacc
     1201 actccccatg caagaatggg gcaacgtgct ccaacagtgg gcagcgaagc tacacctgca
     1261 cctgtcgccc aggctacact ggtgtggact gtgagctgga gctcagcgag tgtgacagca
     1321 acccctgtcg caatggaggc agctgtaagg accaggagga tggctaccac tgcctgtgtc
     1381 ctccgggcta ctatggcctg cattgtgaac acagcacctt gagctgcgcc gactccccct
     1441 gcttcaatgg gggctcctgc cgggagcgca accagggggc caactatgct tgtgaatgtc
     1501 cccccaactt caccggctcc aactgcgaga agaaagtgga caggtgcacc agcaacccct
     1561 gtgccaacgg gggacagtgc ctgaaccgag gtccaagccg catgtgccgc tgccgtcctg
     1621 gattcacggg cacctactgt gaactccacg tcagcgactg tgcccgtaac ccttgcgccc
     1681 acggtggcac ttgccatgac ctggagaatg ggctcatgtg cacctgccct gccggcttct
     1741 ctggccgacg ctgtgaggtg cggacatcca tcgatgcctg tgcctcgagt ccctgcttca
     1801 acagggccac ctgctacacc gacctctcca cagacacctt tgtgtgcaac tgcccttatg
     1861 gctttgtggg cagccgctgc gagttccccg tgggcttgcc gcccagcttc ccctgggtgg
     1921 ccgtctcgct gggtgtgggg ctggcagtgc tgctggtact gctgggcatg gtggcagtgg
     1981 ctgtgcggca gctgcggctt cgacggccgg acgacggcag cagggaagcc atgaacaact
     2041 tgtcggactt ccagaaggac aacctgattc ctgccgccca gcttaaaaac acaaaccaga
     2101 agaaggagct ggaagtggac tgtggcctgg acaagtccaa ctgtggcaaa cagcaaaacc
     2161 acacattgga ctataatctg gccccagggc ccctggggcg ggggaccatg ccaggaaagt
     2221 ttccccacag tgacaagagc ttaggagaga aggcgccact gcggttacac agtgaaaagc
     2281 cagagtgtcg gatatcagcg atatgctccc ccagggactc catgtaccag tctgtgtgtt
     2341 tgatatcaga ggagaggaat gaatgtgtca ttgccacgga ggtataaggc aggagcctac
     2401 ctggacatcc ctgctcagcc ccgcggctgg accttccttc tgcattgttt acattgcatc
     2461 ctggatggga cgtttttcat atgcaacgtg ctgctctcag gaggaggagg gaatggcagg
     2521 aaccggacag actgtgaact tgccaagaga tgcaataccc ttccacacct ttgggtgtct
     2581 gtctggcatc agattggcag ctgcaccaac cagaggaaca gaagagaaga gagatgccac
     2641 tgggcactgc cctgccagta gtggccttca gggggctcct tccggggctc cggcctgttt
     2701 tccagagaga gtggcagtag ccccatgggg cccggagctg ctgtggcctc cactggcatc
     2761 cgtgtttcca aaagtgcctt tggcccaggc tccacggcga cagttgggcc caaatcagaa
     2821 aggagagagg gggccaatga gggcagggcc tcctgtgggc tggaaaacca ctgggtgcgt
     2881 ctcttgctgg ggtttgccct ggaggtgagg tgagtgctcg agggagggga gtgctttctg
     2941 ccccatgcct ccaactactg tatgcaggcc tggctctctg gtctaggccc tttgggcaag
     3001 aatgtccgtc tacccggctt ccaccaccct ctggccctgg gcttctgtaa gcagacaggc
     3061 agagggcctg cccctcccac cagccaaggg tgccaggcct aactggggca ctcagggcag
     3121 tgtgttggaa attccactga gggggaaatc aggtgctgcg gccgcctggg ccctttcctc
     3181 cctcaagccc atctccacaa cctcgagcct gggctctggt ccactactgc cccagaccac
     3241 cctcaaagct ggtcttcaga aatcaataat atgagttttt attttgtttt tttttttttt
     3301 tttgtagttt attttggagt ctagtatttc aataatttaa gaatcagaag cactgacctt
     3361 tctacatttt ataacattat tttgtatata atgtgtattt ataatatgaa acagatgtgt
     3421 acagga
//
