LOCUS       NM_005618               3779 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens delta like canonical Notch ligand 1 (DLL1), mRNA.
ACCESSION   NM_005618
VERSION     NM_005618.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3779)
  AUTHORS   Xu,Y., Qiu,Z., Chen,J., Huang,L., Zhang,J. and Lin,J.
  TITLE     LINC00460 promotes neuroblastoma tumorigenesis and cisplatin
            resistance by targeting miR-149-5p/DLL1 axis and activating Notch
            pathway in vitro and in vivo
  JOURNAL   Drug Deliv Transl Res 14 (7), 2003-2018 (2024)
   PUBMED   38161194
  REMARK    GeneRIF: LINC00460 promotes neuroblastoma tumorigenesis and
            cisplatin resistance by targeting miR-149-5p/DLL1 axis and
            activating Notch pathway in vitro and in vivo.
REFERENCE   2  (bases 1 to 3779)
  AUTHORS   Engwerda,A., Kerstjens-Frederikse,W.S., Corsten-Janssen,N.,
            Dijkhuizen,T. and van Ravenswaaij-Arts,C.M.A.
  TITLE     The phenotypic spectrum of terminal 6q deletions based on a large
            cohort derived from social media and literature: a prominent role
            for DLL1
  JOURNAL   Orphanet J Rare Dis 18 (1), 59 (2023)
   PUBMED   36935482
  REMARK    GeneRIF: The phenotypic spectrum of terminal 6q deletions based on
            a large cohort derived from social media and literature: a
            prominent role for DLL1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3779)
  AUTHORS   Chen,L., Lu,H., Peng,D., Cao,L.L., Ballout,F., Srirmajayam,K.,
            Chen,Z., Bhat,A., Wang,T.C., Capobianco,A., Que,J., McDonald,O.G.,
            Zaika,A., Zhang,S. and El-Rifai,W.
  TITLE     Activation of NOTCH signaling via DLL1 is mediated by
            APE1-redox-dependent NF-kappaB activation in oesophageal
            adenocarcinoma
  JOURNAL   Gut 72 (3), 421-432 (2023)
   PUBMED   35750470
  REMARK    GeneRIF: Activation of NOTCH signaling via DLL1 is mediated by
            APE1-redox-dependent NF-kappaB activation in oesophageal
            adenocarcinoma.
REFERENCE   4  (bases 1 to 3779)
  AUTHORS   Hildebrand,D., Nurjadi,D., Hoan,N.X., Linh,M.T.H., Sang,V.V.,
            Bang,M.H., Pallerla,S.R., Kremsner,P.G., Heeg,K., Song,L.H. and
            Velavan,T.P.
  TITLE     Association Between Soluble Notch Ligand Delta-like Ligand 1 and
            Bleeding Complications in Patients With Dengue Fever Infection
  JOURNAL   J Infect Dis 225 (3), 476-480 (2022)
   PUBMED   34375432
  REMARK    GeneRIF: Association Between Soluble Notch Ligand Delta-like Ligand
            1 and Bleeding Complications in Patients With Dengue Fever
            Infection.
REFERENCE   5  (bases 1 to 3779)
  AUTHORS   Lesieur-Sebellin,M., Till,M., Khau Van Kien,P., Herve,B.,
            Bourgon,N., Dupont,C., Tabet,A.C., Barrois,M., Coussement,A.,
            Loeuillet,L., Mousty,E., Ea,V., El Assal,A., Mary,L., Jaillard,S.,
            Beneteau,C., Le Vaillant,C., Coutton,C., Devillard,F., Goumy,C.,
            Delabaere,A., Redon,S., Laurent,Y., Lamouroux,A., Massardier,J.,
            Turleau,C., Sanlaville,D., Cantagrel,V., Sonigo,P., Vialard,F.,
            Salomon,L.J. and Malan,V.
  TITLE     Terminal 6q deletions cause brain malformations, a phenotype
            mimicking heterozygous DLL1 pathogenic variants: A multicenter
            retrospective case series
  JOURNAL   Prenat Diagn 42 (1), 118-135 (2022)
   PUBMED   34894355
  REMARK    GeneRIF: Terminal 6q deletions cause brain malformations, a
            phenotype mimicking heterozygous DLL1 pathogenic variants: A
            multicenter retrospective case series.
REFERENCE   6  (bases 1 to 3779)
  AUTHORS   Beckers,J., Clark,A., Wunsch,K., Hrabe De Angelis,M. and Gossler,A.
  TITLE     Expression of the mouse Delta1 gene during organogenesis and fetal
            development
  JOURNAL   Mech Dev 84 (1-2), 165-168 (1999)
   PUBMED   10473134
REFERENCE   7  (bases 1 to 3779)
  AUTHORS   Gray,G.E., Mann,R.S., Mitsiadis,E., Henrique,D., Carcangiu,M.L.,
            Banks,A., Leiman,J., Ward,D., Ish-Horowitz,D. and
            Artavanis-Tsakonas,S.
  TITLE     Human ligands of the Notch receptor
  JOURNAL   Am J Pathol 154 (3), 785-794 (1999)
   PUBMED   10079256
REFERENCE   8  (bases 1 to 3779)
  AUTHORS   Mitsiadis,T.A., Hirsinger,E., Lendahl,U. and Goridis,C.
  TITLE     Delta-notch signaling in odontogenesis: correlation with
            cytodifferentiation and evidence for feedback regulation
  JOURNAL   Dev Biol 204 (2), 420-431 (1998)
   PUBMED   9882480
REFERENCE   9  (bases 1 to 3779)
  AUTHORS   Lewis,A.K., Frantz,G.D., Carpenter,D.A., de Sauvage,F.J. and
            Gao,W.Q.
  TITLE     Distinct expression patterns of notch family receptors and ligands
            during development of the mammalian inner ear
  JOURNAL   Mech Dev 78 (1-2), 159-163 (1998)
   PUBMED   9858718
REFERENCE   10 (bases 1 to 3779)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL078605.30, DA243552.1,
            DR000029.1 and AY358892.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005618.3.
            
            Summary:  DLL1 is a human homolog of the Notch Delta ligand and is
            a member of the delta/serrate/jagged family.  It plays a role in
            mediating cell fate decisions during hematopoiesis. It may play a
            role in cell-to-cell communication. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358892.1, SRR1803611.188174.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366756.4/ ENSP00000355718.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-469               AL078605.30        101148-101616
            470-1044            DA243552.1         1-575
            1045-1068           DR000029.1         195-218
            1069-3779           AY358892.1         167-2877
FEATURES             Location/Qualifiers
     source          1..3779
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..3779
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /note="delta like canonical Notch ligand 1"
                     /db_xref="GeneID:28514"
                     /db_xref="HGNC:HGNC:2908"
                     /db_xref="MIM:606582"
     exon            1..993
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             940..3111
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /note="delta-like protein 1; H-Delta-1; drosophila Delta
                     homolog 1; epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="delta-like protein 1 precursor"
                     /protein_id="NP_005609.3"
                     /db_xref="CCDS:CCDS5313.1"
                     /db_xref="GeneID:28514"
                     /db_xref="HGNC:HGNC:2908"
                     /db_xref="MIM:606582"
                     /translation="MGSRCALALAVLSALLCQVWSSGVFELKLQEFVNKKGLLGNRNC
                     CRGGAGPPPCACRTFFRVCLKHYQASVSPEPPCTYGSAVTPVLGVDSFSLPDGGGADS
                     AFSNPIRFPFGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWS
                     QDLHSSGRTDLKYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKG
                     PYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNC
                     QEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDP
                     SPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGYSCR
                     CPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASS
                     PCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECA
                     RGYGGPNCQFLLPELPPGPAVVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVV
                     VCVRLRLQKHRPPADPCRGETETMNNLANCQREKDISVSIIGATQIKNTNKKADFHGD
                     HSADKNGFKARYPAVDYNLVQDLKGDDTAVRDAHSKRDTKCQPQGSSGEEKGTPTTLR
                     GGEASERKRPDSGCSTSKDTKYQSVYVISEEKDECVIATEV"
     exon            994..1290
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1351
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1609
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1670
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1801
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1971
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            1972..2188
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2189..2987
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            2988..3105
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     exon            3106..3779
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3759..3764
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /note="hexamer: AATAAA"
     polyA_site      3779
                     /gene="DLL1"
                     /gene_synonym="Delta; DELTA1; DL1; NEDBAS"
                     /note="major polyA site"
ORIGIN      
        1 actgaccatt tggcgatcca ttgagaggag ggtttggaaa agtggctcct ttgtgacagc
       61 tctcgccaga ttggggggct gctgatttgc atctcattag ccatgcgggc ggccggctga
      121 atataagggc ggcaggcgcc ggcgagagcc agatcctctg cgcgcacccg cggagacccg
      181 acccggccga gggcagagcg caggggaacc cgggcagccg cggcgcagag cctcctccca
      241 cggcccggcc cctccggtcc tgcgcgtgtg tactggatgg cattggctgg attcatcgga
      301 aagacgcgga tctttgctgt gacaccggag atcggagccc ggagtgctcc cggaacgacc
      361 gccgccgccg agtgacaccg ggccgcgatc cgcaggggcc gccgcgcaca cccgccgccg
      421 ccgaccgtcc cctcagcgcg cgccgctggc cccggattat cgccttgccc gtgggatttc
      481 cagaccgcgg ctttctaatc ggctcgggag gaagctctgc agctctcttg ggaattaagc
      541 tcaatctctg gactctctct ctttctcttt ctccccctcc ctctcctgcg aagaagctca
      601 agacaaaacc aggaagccgg cgaccctcac ctcctcgggg gctgggagga aggaggaaaa
      661 cgaaagtcgc cgccgccgcg ctgtcccccg agagctgcct ttcctcgggc atccctgggg
      721 ctgccgcggg acctcgcagg gcggatataa agaaccgcgg ccttgggaag aggcggagac
      781 cggcttttaa agaaagaagt cctgggtcct gcggtctggg gcgaggcaag ggcgcttttc
      841 tgcccacgct ccccgtggcc catcgatccc ccgcgcgtcc gccgctgttc taaggagaga
      901 agtgggggcc ccccaggctc gcgcgtggag cgaagcagca tgggcagtcg gtgcgcgctg
      961 gccctggcgg tgctctcggc cttgctgtgt caggtctgga gctctggggt gttcgaactg
     1021 aagctgcagg agttcgtcaa caagaagggg ctgctgggga accgcaactg ctgccgcggg
     1081 ggcgcggggc caccgccgtg cgcctgccgg accttcttcc gcgtgtgcct caagcactac
     1141 caggccagcg tgtcccccga gccgccctgc acctacggca gcgccgtcac ccccgtgctg
     1201 ggcgtcgact ccttcagtct gcccgacggc gggggcgccg actccgcgtt cagcaacccc
     1261 atccgcttcc ccttcggctt cacctggccg ggcaccttct ctctgattat tgaagctctc
     1321 cacacagatt ctcctgatga cctcgcaaca gaaaacccag aaagactcat cagccgcctg
     1381 gccacccaga ggcacctgac ggtgggcgag gagtggtccc aggacctgca cagcagcggc
     1441 cgcacggacc tcaagtactc ctaccgcttc gtgtgtgacg aacactacta cggagagggc
     1501 tgctccgttt tctgccgtcc ccgggacgat gccttcggcc acttcacctg tggggagcgt
     1561 ggggagaaag tgtgcaaccc tggctggaaa gggccctact gcacagagcc gatctgcctg
     1621 cctggatgtg atgagcagca tggattttgt gacaaaccag gggaatgcaa gtgcagagtg
     1681 ggctggcagg gccggtactg tgacgagtgt atccgctatc caggctgtct ccatggcacc
     1741 tgccagcagc cctggcagtg caactgccag gaaggctggg ggggcctttt ctgcaaccag
     1801 gacctgaact actgcacaca ccataagccc tgcaagaatg gagccacctg caccaacacg
     1861 ggccagggga gctacacttg ctcttgccgg cctgggtaca caggtgccac ctgcgagctg
     1921 gggattgacg agtgtgaccc cagcccttgt aagaacggag ggagctgcac ggatctcgag
     1981 aacagctact cctgtacctg cccacccggc ttctacggca aaatctgtga attgagtgcc
     2041 atgacctgtg cggacggccc ttgctttaac gggggtcggt gctcagacag ccccgatgga
     2101 gggtacagct gccgctgccc cgtgggctac tccggcttca actgtgagaa gaaaattgac
     2161 tactgcagct cttcaccctg ttctaatggt gccaagtgtg tggacctcgg tgatgcctac
     2221 ctgtgccgct gccaggccgg cttctcgggg aggcactgtg acgacaacgt ggacgactgc
     2281 gcctcctccc cgtgcgccaa cgggggcacc tgccgggatg gcgtgaacga cttctcctgc
     2341 acctgcccgc ctggctacac gggcaggaac tgcagtgccc ccgtcagcag gtgcgagcac
     2401 gcaccctgcc acaatggggc cacctgccac gagaggggcc accgctatgt gtgcgagtgt
     2461 gcccgaggct acgggggtcc caactgccag ttcctgctcc ccgagctgcc cccgggccca
     2521 gcggtggtgg acctcactga gaagctagag ggccagggcg ggccattccc ctgggtggcc
     2581 gtgtgcgccg gggtcatcct tgtcctcatg ctgctgctgg gctgtgccgc tgtggtggtc
     2641 tgcgtccggc tgaggctgca gaagcaccgg cccccagccg acccctgccg gggggagacg
     2701 gagaccatga acaacctggc caactgccag cgtgagaagg acatctcagt cagcatcatc
     2761 ggggccacgc agatcaagaa caccaacaag aaggcggact tccacgggga ccacagcgcc
     2821 gacaagaatg gcttcaaggc ccgctaccca gcggtggact ataacctcgt gcaggacctc
     2881 aagggtgacg acaccgccgt cagggacgcg cacagcaagc gtgacaccaa gtgccagccc
     2941 cagggctcct caggggagga gaaggggacc ccgaccacac tcaggggtgg agaagcatct
     3001 gaaagaaaaa ggccggactc gggctgttca acttcaaaag acaccaagta ccagtcggtg
     3061 tacgtcatat ccgaggagaa ggatgagtgc gtcatagcaa ctgaggtgta aaatggaagt
     3121 gagatggcaa gactcccgtt tctcttaaaa taagtaaaat tccaaggata tatgccccaa
     3181 cgaatgctgc tgaagaggag ggaggcctcg tggactgctg ctgagaaacc gagttcagac
     3241 cgagcaggtt ctcctcctga ggtcctcgac gcctgccgac agcctgtcgc ggcccggccg
     3301 cctgcggcac tgccttccgt gacgtcgccg ttgcactatg gacagttgct cttaagagaa
     3361 tatatattta aatgggtgaa ctgaattacg cataagaagc atgcactgcc tgagtgtata
     3421 ttttggattc ttatgagcca gtcttttctt gaattagaaa cacaaacact gcctttattg
     3481 tcctttttga tacgaagatg tgctttttct agatggaaaa gatgtgtgtt attttttgga
     3541 tttgtaaaaa tatttttcat gatatctgta aagcttgagt attttgtgat gttcgttttt
     3601 tataatttaa attttggtaa atatgtacaa aggcacttcg ggtctatgtg actatatttt
     3661 tttgtatata aatgtattta tggaatattg tgcaaatgtt atttgagttt tttactgttt
     3721 tgttaatgaa gaaattcctt tttaaaatat ttttccaaaa taaattttat gaatgacaa
//
