LOCUS       NM_003836               4657 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens delta like non-canonical Notch ligand 1 (DLK1),
            transcript variant 1, mRNA.
ACCESSION   NM_003836
VERSION     NM_003836.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4657)
  AUTHORS   Smith,C.M., Catchpoole,D. and Hutvagner,G.
  TITLE     MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster contribute
            to glioblastoma tumor heterogeneity
  JOURNAL   Sci Rep 14 (1), 8570 (2024)
   PUBMED   38609422
  REMARK    GeneRIF: MiRNAs from the Dlk1-Dio3 locus and miR-224/452 cluster
            contribute to glioblastoma tumor heterogeneity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4657)
  AUTHORS   Jensen,C.H., Johnsen,R.H., Eskildsen,T., Baun,C., Ellman,D.G.,
            Fang,S., Bak,S.T., Hvidsten,S., Larsen,L.A., Rosager,A.M.,
            Riber,L.P., Schneider,M., De Mey,J., Thomassen,M., Burton,M.,
            Uchida,S., Laborda,J. and Andersen,D.C.
  TITLE     Pericardial delta like non-canonical NOTCH ligand 1 (Dlk1) augments
            fibrosis in the heart through epithelial to mesenchymal transition
  JOURNAL   Clin Transl Med 14 (2), e1565 (2024)
   PUBMED   38328889
  REMARK    GeneRIF: Pericardial delta like non-canonical NOTCH ligand 1 (Dlk1)
            augments fibrosis in the heart through epithelial to mesenchymal
            transition.
REFERENCE   3  (bases 1 to 4657)
  AUTHORS   Wermter,A.K., Scherag,A., Meyre,D., Reichwald,K., Durand,E.,
            Nguyen,T.T., Koberwitz,K., Lichtner,P., Meitinger,T., Schafer,H.,
            Hinney,A., Froguel,P., Hebebrand,J. and Bronner,G.
  TITLE     Preferential reciprocal transfer of paternal/maternal DLK1 alleles
            to obese children: first evidence of polar overdominance in humans
  JOURNAL   Eur J Hum Genet 16 (9), 1126-1134 (2008)
   PUBMED   18398438
  REMARK    GeneRIF: Associated with extreme early-onset obesity.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 4657)
  AUTHORS   Charlier,C., Segers,K., Wagenaar,D., Karim,L., Berghmans,S.,
            Jaillon,O., Shay,T., Weissenbach,J., Cockett,N., Gyapay,G. and
            Georges,M.
  TITLE     Human-ovine comparative sequencing of a 250-kb imprinted domain
            encompassing the callipyge (clpg) locus and identification of six
            imprinted transcripts: DLK1, DAT, GTL2, PEG11, antiPEG11, and MEG8
  JOURNAL   Genome Res 11 (5), 850-862 (2001)
   PUBMED   11337479
REFERENCE   5  (bases 1 to 4657)
  AUTHORS   Wylie,A.A., Murphy,S.K., Orton,T.C. and Jirtle,R.L.
  TITLE     Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains
            motifs that mimic those implicated in IGF2/H19 regulation
  JOURNAL   Genome Res 10 (11), 1711-1718 (2000)
   PUBMED   11076856
  REMARK    GeneRIF: DLK1 gene is imprinted, with preferential expression from
            the paternal allele.
REFERENCE   6  (bases 1 to 4657)
  AUTHORS   Lee,Y.L., Helman,L., Hoffman,T. and Laborda,J.
  TITLE     dlk, pG2 and Pref-1 mRNAs encode similar proteins belonging to the
            EGF-like superfamily. Identification of polymorphic variants of
            this RNA
  JOURNAL   Biochim Biophys Acta 1261 (2), 223-232 (1995)
   PUBMED   7711066
REFERENCE   7  (bases 1 to 4657)
  AUTHORS   Jensen,C.H., Krogh,T.N., Hojrup,P., Clausen,P.P., Skjodt,K.,
            Larsson,L.I., Enghild,J.J. and Teisner,B.
  TITLE     Protein structure of fetal antigen 1 (FA1). A novel circulating
            human epidermal-growth-factor-like protein expressed in
            neuroendocrine tumors and its relation to the gene products of dlk
            and pG2
  JOURNAL   Eur J Biochem 225 (1), 83-92 (1994)
   PUBMED   7925474
REFERENCE   8  (bases 1 to 4657)
  AUTHORS   Jensen,C.H., Teisner,B., Hojrup,P., Rasmussen,H.B., Madsen,O.D.,
            Nielsen,B. and Skjodt,K.
  TITLE     Studies on the isolation, structural analysis and tissue
            localization of fetal antigen 1 and its relation to a human
            adrenal-specific cDNA, pG2
  JOURNAL   Hum Reprod 8 (4), 635-641 (1993)
   PUBMED   8501199
REFERENCE   9  (bases 1 to 4657)
  AUTHORS   Laborda,J., Sausville,E.A., Hoffman,T. and Notario,V.
  TITLE     dlk, a putative mammalian homeotic gene differentially expressed in
            small cell lung carcinoma and neuroendocrine tumor cell line
  JOURNAL   J Biol Chem 268 (6), 3817-3820 (1993)
   PUBMED   8095043
REFERENCE   10 (bases 1 to 4657)
  AUTHORS   Helman,L.J., Sack,N., Plon,S.E. and Israel,M.A.
  TITLE     The sequence of an adrenal specific human cDNA, pG2
  JOURNAL   Nucleic Acids Res 18 (3), 685 (1990)
   PUBMED   2308864
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132711.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_003836.6.
            
            Summary: This gene encodes a transmembrane protein that contains
            multiple epidermal growth factor repeats that functions as a
            regulator of cell growth. The encoded protein is involved in the
            differentiation of several cell types including adipocytes. This
            gene is located in a region of chromosome 14 frequently showing
            unparental disomy, and is imprinted and expressed from the paternal
            allele. A single nucleotide variant in this gene is associated with
            child and adolescent obesity and shows polar overdominance, where
            heterozygotes carrying an active paternal allele express the
            phenotype, while mutant homozygotes are normal. [provided by
            RefSeq, Nov 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.2826506.1,
                                           SRR14038194.1357065.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 11076856
            MANE Ensembl match     :: ENST00000341267.9/ ENSP00000340292.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AL132711.5         142382-142625
            245-308             AL132711.5         143886-143949
            309-439             AL132711.5         144426-144556
            440-581             AL132711.5         147532-147673
            582-4657            AL132711.5         149639-153714
FEATURES             Location/Qualifiers
     source          1..4657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..4657
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /note="delta like non-canonical Notch ligand 1"
                     /db_xref="GeneID:8788"
                     /db_xref="HGNC:HGNC:2907"
                     /db_xref="MIM:176290"
     exon            1..244
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1329
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; protein delta homolog 1; preadipocyte factor 1;
                     fetal antigen 1; secredeltin; delta-like 1 homolog"
                     /codon_start=1
                     /product="protein delta homolog 1 isoform 1 preproprotein"
                     /protein_id="NP_003827.4"
                     /db_xref="CCDS:CCDS9963.1"
                     /db_xref="GeneID:8788"
                     /db_xref="HGNC:HGNC:2907"
                     /db_xref="MIM:176290"
                     /translation="MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCR
                     CQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNRT
                     CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPP
                     GFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ
                     NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELP
                     VQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWV
                     SNLRYNHMLRKKKNLLLQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI"
     exon            245..308
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     exon            309..439
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     exon            440..581
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     exon            582..4657
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /note="hexamer: AATAAG"
     polyA_site      1559
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /note="major polyA site"
     regulatory      4638..4643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
                     /note="hexamer: AATAAA"
     polyA_site      4657
                     /gene="DLK1"
                     /gene_synonym="Delta1; DLK; DLK-1; FA1; pG2; Pref-1;
                     PREF1; ZOG"
ORIGIN      
        1 ggcagctccc cggcagcggc ggtggagagc gcagcgcgca gcccggtgca gccctggctt
       61 tcccctcgct gcgcgcccgc gccccctttc gcgtccgcaa ccagaagccc agtgcggcgc
      121 caggagccgg acccgcgccc gcaccgctcc cgggaccgcg accccggccg cccagagatg
      181 accgcgaccg aagccctcct gcgcgtcctc ttgctcctgc tggctttcgg ccacagcacc
      241 tatggggctg aatgcttccc ggcctgcaac ccccaaaatg gattctgcga ggatgacaat
      301 gtttgcaggt gccagcctgg ctggcagggt cccctttgtg accagtgcgt gacctctccc
      361 ggctgccttc acggactctg tggagaaccc gggcagtgca tttgcaccga cggctgggac
      421 ggggagctct gtgatagaga tgttcgggcc tgctcctcgg ccccctgtgc caacaacagg
      481 acctgcgtga gcctggacga tggcctctat gaatgctcct gtgcccccgg gtactcggga
      541 aaggactgcc agaaaaagga cgggccctgt gtgatcaacg gctccccctg ccagcacgga
      601 ggcacctgcg tggatgatga gggccgggcc tcccatgcct cctgcctgtg cccccctggc
      661 ttctcaggca atttctgcga gatcgtggcc aacagctgca cccccaaccc atgcgagaac
      721 gacggcgtct gcactgacat tgggggcgac ttccgctgcc ggtgcccagc cggcttcatc
      781 gacaagacct gcagccgccc ggtgaccaac tgcgccagca gcccgtgcca gaacgggggc
      841 acctgcctgc agcacaccca ggtgagctac gagtgtctgt gcaagcccga gttcacaggt
      901 ctcacctgtg tcaagaagcg cgcgctgagc ccccagcagg tcacccgtct gcccagcggc
      961 tatgggctgg cctaccgcct gacccctggg gtgcacgagc tgccggtgca gcagccggag
     1021 caccgcatcc tgaaggtgtc catgaaagag ctcaacaaga aaacccctct cctcaccgag
     1081 ggccaggcca tctgcttcac catcctgggc gtgctcacca gcctggtggt gctgggcact
     1141 gtgggtatcg tcttcctcaa caagtgcgag acctgggtgt ccaacctgcg ctacaaccac
     1201 atgctgcgga agaagaagaa cctgctgctt cagtacaaca gcggggagga cctggccgtc
     1261 aacatcatct tccccgagaa gatcgacatg accaccttca gcaaggaggc cggcgacgag
     1321 gagatctaag cagcgttccc acagccccct ctagattctt ggagttccgc agagcttact
     1381 atacgcggtc tgtcctaatc tttgtggtgt tcgctatctc ttgtgtcaaa tctggtgaac
     1441 gctacgctta catatattgt ctttgtgctg ctgtgtgaca aacgcaatgc aaaaacaatc
     1501 ctctttctct ctcttaatgc atgatacaga ataataataa gaatttcatc tttaaatgag
     1561 taagagaaat aagtatgtta ttctaaaatc taaactcaaa tgaaatttca aaaaagacca
     1621 aaaaaaaaca aggcaacaga accagggctc agtgccgacg cccctaccct gggggtctcg
     1681 gccacatggt cctcgtgaaa ccgttacgag tgctgtacat gaccacccac tgtgcaaaga
     1741 gctacgattg ctttcgttcg ttaattctca cacaccacat ccgactcgca ctcacatcca
     1801 gctcaacatc gctaccttta gatctttccg attgatttga gatttagcgg agtgcagcgg
     1861 ctgtgtgtca gtcagagaga gccccaggtt ggctgctggg gggccgggcc tctgtgccag
     1921 ccctgccact aactcgctgt gtgatccttg gcgagtccct atcccaatcc tgggcccact
     1981 ttctcgcccc tctcgaggga ggggtttgaa caccgaccac catggtcctc tctggctcta
     2041 aaactctgaa ttaggaacga gggggtatga accaaaacac ttcctgaccc caacaattgg
     2101 gatctgatga agacgaattc tcatcctggg atccgaaagg ttttggccta tcctggatga
     2161 acgcttgatg ttgaaattta tcctaactgt gtttctcaaa gtggggagcc tcctggccca
     2221 cttccctttt gggaaaaaat agcccctttg agtcataatg tgccatctgg agttgccact
     2281 taggcagcca gccctccccc acccctcttt gcccacccag aaccccaaca ctatacctgc
     2341 ctctacccta tagagacatc ccttgagact tgaatgtact ttgagccgca agtgcccctg
     2401 gcagaatctg agcagcaaca cagccctcac caaggttttc acagggatta gtggaaattg
     2461 tcacttgtgg ggcgcttact agttttgtgg caaatgtggt ccaagacctg gcccacacag
     2521 ccatgggttt acatttgtgt tgctgagtta ataatcctca gatctcaaaa gacctagcca
     2581 gcttctgaat tttgaatttg actttttttt tttttttaac aaagagcatc tatctttttt
     2641 gcaaaaatag aaagaaatgg gacagagctc tgtttagctt ttcagctttt ggggttggac
     2701 agctaaacag cccttgggta ccagatagga atattttgct tcttagatta tttggataag
     2761 aatctatact cttagcttta ttgagcattg cctgccgtgt ttaccttgct ccaggtgttt
     2821 atttctaagt catcatcacc ttcgtcatct acagtcagtc acatcagtca cccacacaca
     2881 actcacagtc acccatccat tggtcacctg cgccatcgtc atgacacaat atcgacctca
     2941 tcacctcatc gtcctccagc cactacccaa gccccctcat cctgactcaa agcccgacca
     3001 gcatctgccc aaactcccaa caccccactc tccccaccaa gccattggtc tcctcactcc
     3061 cggtcctttg tcatcctgat tccaagcccc gccccaccct caccgcctcc tccgcatcat
     3121 ctgcactctg cagagcccct cctacccgcc tctgtcccca ccaggcccct ccctaccgtc
     3181 agccctgagt cccacagcac gcgtccccag cccctcccag cctcacccca aaaaccctgt
     3241 caccccaccg accaccatca tcactggcaa gccccttccc cttctccagc tcccgtcccc
     3301 actacccctc ccgtccccca atccttcccc tcctgttagc ccacccctcc tttcctatca
     3361 cccccacctt tcccttccca ttctccccac ccttcccctc cgatcccacc acccttccct
     3421 tccgatcccc gtcatccttc ccctctgatc ccccaccctt cccctcctgt cctccccagc
     3481 cctcccttcc tatcaccctc acccttcccc tcccgttctc cccacccttc ccctcctgtc
     3541 tccaccagcc ctcccttcct atcaccccca cccttctcct cccttccctc accccaaacc
     3601 cctgggtcct ccaccccaat ctctgacaac cgccccaagt ccctcttcct tccccacgaa
     3661 gtcattcata agtcaccatc tcatctcatt ttgagtttgt tttaagaaat aaaaaaatta
     3721 aaaagacaaa aaaaagaatt gttggcatgt gtcaggcggg cgtctggtac cctgcctggc
     3781 ctctctcagc gtgagacctg gactgagcct gctaacgatt ctgttcctca gtttccccaa
     3841 atagaaaatt ctaagattgg tcagatgatc aaattatcta tgttttcgat cttgatgcta
     3901 tagagaacag ccatgttccc ctgataacaa gaaaaagacg tcccacggtc gaggtatcct
     3961 tgaccaactc cccatccatt catttgttca ccgtccacaa cccatctgat caggaagcat
     4021 ttccaggcac ctgcggagca ctaggcagtg tgcggaagct gcagggcagg caggacgagg
     4081 gggcagtctg gaggggggtg gacacacagc tgtccccagg gagcccagcg cggtgccggt
     4141 cacatgccgt gggagtggag ggtcttgagc agacgcctcc cttggagaag agccaccatc
     4201 tcaccttccc acgcaacaaa ttatctatta ccagcacccg atgaggccgt ccctcccaaa
     4261 ttccacagtg cccaccactc gcactacccc ccccgtgcca cagaagcagt gtcagcagcc
     4321 tcgccacggt cttcacgtca tgcagaaatg gtcattccat gttctatggc caccagattc
     4381 tgctgagagt gtcgggatcc ttgactgccc agccacacct tgtgtgtgtc tggtgtagtg
     4441 tgtagtttac gaaacaaacg gaaaagctca aagacagcga tccaagacat gatcagcaat
     4501 ttggtcccaa attaggagag gaggaagagg agtatcaatt ttgtcaccaa aatgttaaaa
     4561 aaaatgtcct tggcgctctt tttagctttc ccgtttacta ccagtccaga catgcaaaaa
     4621 aaccttgttt attgaaaaat aaacaacaag ggctaga
//
