LOCUS       NM_014750               2881 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens DLG associated protein 5 (DLGAP5), transcript variant
            1, mRNA.
ACCESSION   NM_014750
VERSION     NM_014750.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2881)
  AUTHORS   Chen,M., Zhang,S., Wang,F., He,J., Jiang,W. and Zhang,L.
  TITLE     DLGAP5 promotes lung adenocarcinoma growth via upregulating PLK1
            and serves as a therapeutic target
  JOURNAL   J Transl Med 22 (1), 209 (2024)
   PUBMED   38414025
  REMARK    GeneRIF: DLGAP5 promotes lung adenocarcinoma growth via
            upregulating PLK1 and serves as a therapeutic target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2881)
  AUTHORS   Zhou,F., Deng,Z., Shen,D., Lu,M., Li,M., Yu,J., Xiao,Y., Wang,G.,
            Qian,K., Ju,L. and Wang,X.
  TITLE     DLGAP5 triggers proliferation and metastasis of bladder cancer by
            stabilizing E2F1 via USP11
  JOURNAL   Oncogene 43 (8), 594-607 (2024)
   PUBMED   38182895
  REMARK    GeneRIF: DLGAP5 triggers proliferation and metastasis of bladder
            cancer by stabilizing E2F1 via USP11.
REFERENCE   3  (bases 1 to 2881)
  AUTHORS   Huang,J., Zheng,M., Li,Y., Xu,D. and Tian,D.
  TITLE     DLGAP5 promotes gallbladder cancer migration and tumor-associated
            macrophage M2 polarization by activating cAMP
  JOURNAL   Cancer Immunol Immunother 72 (10), 3203-3216 (2023)
   PUBMED   37421434
  REMARK    GeneRIF: DLGAP5 promotes gallbladder cancer migration and
            tumor-associated macrophage M2 polarization by activating cAMP.
REFERENCE   4  (bases 1 to 2881)
  AUTHORS   Gudmundsson,K.O., Thorsteinsson,L., Sigurjonsson,O.E., Keller,J.R.,
            Olafsson,K., Egeland,T., Gudmundsson,S. and Rafnar,T.
  TITLE     Gene expression analysis of hematopoietic progenitor cells
            identifies Dlg7 as a potential stem cell gene
  JOURNAL   Stem Cells 25 (6), 1498-1506 (2007)
   PUBMED   17322106
  REMARK    GeneRIF: Dlg7 has a role in stem cell survival, in maintaining stem
            cell properties, and in carcinogenesis.
REFERENCE   5  (bases 1 to 2881)
  AUTHORS   Wong,J. and Fang,G.
  TITLE     HURP controls spindle dynamics to promote proper interkinetochore
            tension and efficient kinetochore capture
  JOURNAL   J Cell Biol 173 (6), 879-891 (2006)
   PUBMED   16769820
  REMARK    GeneRIF: HURP controls spindle stability and dynamics to achieve
            efficient kinetochore capture at prometaphase, timely chromosome
            congression to the metaphase plate, and proper interkinetochore
            tension for anaphase initiation.
REFERENCE   6  (bases 1 to 2881)
  AUTHORS   Yu,C.T., Hsu,J.M., Lee,Y.C., Tsou,A.P., Chou,C.K. and Huang,C.Y.
  TITLE     Phosphorylation and stabilization of HURP by Aurora-A: implication
            of HURP as a transforming target of Aurora-A
  JOURNAL   Mol Cell Biol 25 (14), 5789-5800 (2005)
   PUBMED   15987997
  REMARK    GeneRIF: HURP is a potential oncogenic target of Aurora-A.
REFERENCE   7  (bases 1 to 2881)
  AUTHORS   Zhao,L., Qin,L.X., Ye,Q.H., Zhu,X.Q., Zhang,H., Wu,X., Chen,J.,
            Liu,Y.K. and Tang,Z.Y.
  TITLE     KIAA0008 gene is associated with invasive phenotype of human
            hepatocellular carcinoma--a functional analysis
  JOURNAL   J Cancer Res Clin Oncol 130 (12), 719-727 (2004)
   PUBMED   15340842
  REMARK    GeneRIF: KIAA0008 expression is associated with invasiveness of
            HCC; overexpression of KIAA0008 leads to a more invasive phenotype
            of HCC cell lines.
REFERENCE   8  (bases 1 to 2881)
  AUTHORS   Hsu,J.M., Lee,Y.C., Yu,C.T. and Huang,C.Y.
  TITLE     Fbx7 functions in the SCF complex regulating Cdk1-cyclin
            B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis
            by a proline-rich region
  JOURNAL   J Biol Chem 279 (31), 32592-32602 (2004)
   PUBMED   15145941
  REMARK    GeneRIF: Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein
            (HURP) proteolysis is regulated by Fbx7 and the SCF complex
REFERENCE   9  (bases 1 to 2881)
  AUTHORS   Tsou,A.P., Yang,C.W., Huang,C.Y., Yu,R.C., Lee,Y.C., Chang,C.W.,
            Chen,B.R., Chung,Y.F., Fann,M.J., Chi,C.W., Chiu,J.H. and Chou,C.K.
  TITLE     Identification of a novel cell cycle regulated gene, HURP,
            overexpressed in human hepatocellular carcinoma
  JOURNAL   Oncogene 22 (2), 298-307 (2003)
   PUBMED   12527899
  REMARK    GeneRIF: results strongly suggest that HURP is a potential novel
            cell cycle regulator that may play a role in the carcinogenesis of
            human cancer cells
REFERENCE   10 (bases 1 to 2881)
  AUTHORS   Bassal,S., Nomura,N., Venter,D., Brand,K., McKay,M.J. and van der
            Spek,P.J.
  TITLE     Characterization of a novel human cell-cycle-regulated homologue of
            Drosophila dlg1
  JOURNAL   Genomics 77 (1-2), 5-7 (2001)
   PUBMED   11543626
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB076695.1 and BC010658.1.
            
            On Nov 24, 2018 this sequence version replaced NM_014750.4.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript but encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010658.1, AK291847.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247191.7/ ENSP00000247191.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AB076695.1         94-422
            330-2881            BC010658.1         315-2866
FEATURES             Location/Qualifiers
     source          1..2881
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q22.3"
     gene            1..2881
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /note="DLG associated protein 5"
                     /db_xref="GeneID:9787"
                     /db_xref="HGNC:HGNC:16864"
                     /db_xref="MIM:617859"
     exon            1..123
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            124..362
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2665
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /note="isoform a is encoded by transcript variant 1;
                     hepatoma up-regulated protein; disks large-associated
                     protein 5; DAP-5; disks large-associated protein DLG7;
                     discs, large homolog 7; discs large homolog associated
                     protein 5"
                     /codon_start=1
                     /product="disks large-associated protein 5 isoform a"
                     /protein_id="NP_055565.3"
                     /db_xref="CCDS:CCDS9723.1"
                     /db_xref="GeneID:9787"
                     /db_xref="HGNC:HGNC:16864"
                     /db_xref="MIM:617859"
                     /translation="MSSSHFASRHRKDISTEMIRTKIAHRKSLSQKENRHKEYERNRH
                     FGLKDVNIPTLEGRILVELDETSQGLVPEKTNVKPRAMKTILGDQRKQMLQKYKEEKQ
                     LQKLKEQREKAKRGIFKVGRYRPDMPCFLLSNQNAVKAEPKKAIPSSVRITRSKAKDQ
                     MEQTKIDNESDVRAIRPGPRQTSEKKVSDKEKKVVQPVMPTSLRMTRSATQAAKQVPR
                     TVSSTTARKPVTRAANENEPEGKVPSKGRPAKNVETKPDKGISCKVDSEENTLNSQTN
                     ATSGMNPDGVLSKMENLPEINTAKIKGKNSFAPKDFMFQPLDGLKTYQVTPMTPRSAN
                     AFLTPSYTWTPLKTEVDESQATKEILAQKCKTYSTKTIQQDSNKLPCPLGPLTVWHEE
                     HVLNKNEATTKNLNGLPIKEVPSLERNEGRIAQPHHGVPYFRNILQSETEKLTSHCFE
                     WDRKLELDIPDDAKDLIRTAVGQTRLLMKERFKQFEGLVDDCEYKRGIKETTCTDLDG
                     FWDMVSFQIEDVIHKFNNLIKLEESGWQVNNNMNHNMNKNVFRKKVVSGIASKPKQDD
                     AGRIAARNRLAAIKNAMRERIRQEECAETAVSVIPKEVDKIVFDAGFFRVESPVKLFS
                     GLSVSSEGPSQRLGTPKSVNKAVSQSRNEMGIPQQTTSPENAGPQNTKSEHVKKTLFL
                     SIPESRSSIEDAQCPGLPDLIEENHVVNKTDLKVDCLSSERMSLPLLAGGVADDINTN
                     KKEGISDVVEGMELNSSITSQDVLMSSPEKNTASQNSILEEGETKISQSELFDNKSLT
                     TECHLLDSPGLNCSNPFTQLERRHQEHARHISFGGNLITFSPLQPGEF"
     exon            363..556
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            557..619
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            620..704
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            705..827
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            828..898
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1173
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1298
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1425
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1511
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1672
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1777
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1997
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2187
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2245
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            2246..2492
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            2493..2542
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2881
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2864..2869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /note="hexamer: AATAAA"
     polyA_site      2881
                     /gene="DLGAP5"
                     /gene_synonym="DLG7; HURP"
                     /note="major polyA site"
ORIGIN      
        1 aagtttgaat ttcgtggagg ctcgggttgt gagggttcct gcttcggagt cggcggtggt
       61 cgtccagacc gagtgttctt tactttttgt ttggttgagg tttcacgcta gaaggtggct
      121 caggatgtct tcatcacatt ttgccagtcg acacaggaag gatataagta ctgaaatgat
      181 tagaactaaa attgctcata ggaaatcact gtctcagaaa gaaaatagac ataaggaata
      241 cgaacgaaat agacactttg gtttgaaaga tgtaaacatt ccaaccttgg aaggtagaat
      301 tcttgttgaa ttagatgaga catctcaagg gcttgttcca gaaaagacca atgttaagcc
      361 aagggcaatg aaaactattc taggtgatca acgaaaacag atgctccaaa aatacaaaga
      421 agaaaagcaa cttcaaaaat tgaaagagca gagagagaaa gctaaacgag gaatatttaa
      481 agtgggtcgt tatagacctg atatgccttg ttttctttta tcaaaccaga atgctgtgaa
      541 agctgagcca aaaaaggcta ttccatcttc tgtacggatt acaaggtcaa aggccaaaga
      601 ccaaatggag cagactaaga ttgataacga gagtgatgtt cgagcaatcc gacctggtcc
      661 aagacaaact tctgaaaaga aagtgtcaga caaagagaaa aaagttgtgc agcctgtaat
      721 gcccacgtcg ttgagaatga ctcgatcagc tactcaagca gcaaagcagg ttcccagaac
      781 agtctcatct accacagcaa gaaagccagt cacaagagct gctaatgaaa acgaaccaga
      841 aggaaaggtg ccaagtaaag gaagacctgc caaaaatgta gaaacaaaac ccgacaaggg
      901 tatttcttgt aaagtcgata gtgaagaaaa tactttgaat tcacaaacta atgcaacaag
      961 tggaatgaat ccagatggag tcttatcaaa aatggaaaac ttacctgaga taaatactgc
     1021 aaaaataaaa gggaagaatt cctttgcacc taaggatttt atgtttcagc cactggatgg
     1081 tctgaagacc tatcaagtaa cacctatgac tcccagaagt gccaatgctt ttttgacacc
     1141 cagttacacc tggactcctt taaaaacaga agttgatgag tctcaagcaa caaaagaaat
     1201 tttggcacaa aaatgtaaaa cttactctac caagacaata cagcaagatt caaataaatt
     1261 gccatgtcct ttgggtcctc taactgtttg gcatgaagaa catgttttaa ataaaaatga
     1321 agctactact aaaaatttaa atggccttcc aataaaagaa gtcccatcac ttgaaagaaa
     1381 tgaaggtcga attgctcagc cccaccatgg tgtgccatat ttcagaaata tcctccagtc
     1441 agaaactgag aaattaactt cacattgctt cgagtgggac aggaaacttg aattggacat
     1501 tccagatgat gctaaagatc ttattcgcac agcagttggt caaacaagac tccttatgaa
     1561 ggaaaggttt aaacagtttg aaggactggt tgatgattgt gaatataaac gaggtataaa
     1621 ggagactacc tgtacagatc tggatggatt ttgggatatg gttagttttc agatagaaga
     1681 tgtaatccac aaattcaaca atctgatcaa acttgaggaa tctgggtggc aagtcaataa
     1741 taatatgaat cataatatga acaaaaatgt ctttaggaaa aaagttgtct caggtatagc
     1801 aagtaaacca aaacaggatg atgctggaag aattgcagcg agaaatcgcc tagctgccat
     1861 aaaaaatgca atgagagaga gaattaggca ggaagaatgt gctgaaacag cagtttctgt
     1921 gataccaaag gaagttgata aaatagtgtt cgatgctgga tttttcagag ttgaaagtcc
     1981 tgttaaatta ttctcaggac tttctgtctc ttctgaaggc ccttctcaaa gacttggaac
     2041 acctaagtct gtcaacaaag ctgtatctca gagtagaaat gagatgggca ttccacaaca
     2101 aactacatca ccagaaaatg ccggtcctca gaatacgaaa agtgaacatg tgaagaagac
     2161 tttgtttttg agtattcctg aaagcaggag cagcatagaa gatgctcagt gtcctggatt
     2221 accagattta attgaagaaa atcatgttgt aaataagaca gacttgaagg tggattgttt
     2281 atccagtgag agaatgagtt tgcctcttct tgctggtgga gtagcagatg atattaatac
     2341 taacaaaaaa gaaggaattt cagatgttgt ggaaggaatg gaactgaatt cttcaattac
     2401 atcacaggat gttttgatga gtagccctga aaaaaataca gcttcacaaa atagcatctt
     2461 agaagaaggg gaaactaaaa tttctcagtc agaactattt gataataaaa gtctcactac
     2521 tgaatgccac cttcttgatt caccaggtct aaactgcagt aatccattta ctcagctgga
     2581 gaggagacat caagaacatg ccagacacat ttcttttggt ggtaacctga ttactttttc
     2641 acctctacaa ccaggagaat tttgaattta aaaataaatc caaacatttt ccttcatatt
     2701 atcaatgctt atatattcct tagactattg aaattttgga gaaaatgtat ttgtgttcac
     2761 ttctatagca tataatgttt taatattctg tgttcatcaa agtgtatttt agatatactc
     2821 tttctcaagg gaagtgggga tattttgtac attttcaaca cagaataaaa aatgtactgt
     2881 g
//
