LOCUS       NM_001365621            5058 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DLG associated protein 4 (DLGAP4), transcript variant
            4, mRNA.
ACCESSION   NM_001365621 XM_011528688
VERSION     NM_001365621.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5058)
  AUTHORS   Bao,H., Zhang,Q., Li,Y. and Nie,C.
  TITLE     CircDLGAP4 overexpression ameliorates neuronal injury in
            Parkinson's disease by binding to EIF4A3 and increasing HMGA2
            expression
  JOURNAL   J Biochem Mol Toxicol 38 (1), e23530 (2024)
   PUBMED   37822284
  REMARK    GeneRIF: CircDLGAP4 overexpression ameliorates neuronal injury in
            Parkinson's disease by binding to EIF4A3 and increasing HMGA2
            expression.
REFERENCE   2  (bases 1 to 5058)
  AUTHORS   Xiong,Y., Huang,H., Chen,F. and Tang,Y.
  TITLE     CircDLGAP4 induces autophagy and improves endothelial cell
            dysfunction in atherosclerosis by targeting PTPN4 with miR-134-5p
  JOURNAL   Environ Toxicol 38 (12), 2952-2966 (2023)
   PUBMED   37615249
  REMARK    GeneRIF: CircDLGAP4 induces autophagy and improves endothelial cell
            dysfunction in atherosclerosis by targeting PTPN4 with miR-134-5p.
REFERENCE   3  (bases 1 to 5058)
  AUTHORS   Dong,C., Huang,S., Sun,L., Yao,J., Yan,J. and Yin,X.
  TITLE     DLGAP4 acts as an effective prognostic predictor for hepatocellular
            carcinoma and is closely related to tumour progression
  JOURNAL   Sci Rep 12 (1), 19775 (2022)
   PUBMED   36396671
  REMARK    GeneRIF: DLGAP4 acts as an effective prognostic predictor for
            hepatocellular carcinoma and is closely related to tumour
            progression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5058)
  AUTHORS   Bai,S., Xiong,X., Tang,B., Ji,T., Li,X., Qu,X. and Li,W.
  TITLE     Exosomal circ_DLGAP4 promotes diabetic kidney disease progression
            by sponging miR-143 and targeting ERBB3/NF-kappaB/MMP-2 axis
  JOURNAL   Cell Death Dis 11 (11), 1008 (2020)
   PUBMED   33230102
  REMARK    GeneRIF: Exosomal circ_DLGAP4 promotes diabetic kidney disease
            progression by sponging miR-143 and targeting ERBB3/NF-kappaB/MMP-2
            axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5058)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 5058)
  AUTHORS   Minocherhomji,S., Seemann,S., Mang,Y., El-Schich,Z., Bak,M.,
            Hansen,C., Papadopoulos,N., Josefsen,K., Nielsen,H., Gorodkin,J.,
            Tommerup,N. and Silahtaroglu,A.
  TITLE     Sequence and expression analysis of gaps in human chromosome 20
  JOURNAL   Nucleic Acids Res 40 (14), 6660-6672 (2012)
   PUBMED   22510267
REFERENCE   7  (bases 1 to 5058)
  AUTHORS   Verstraelen,S., Nelissen,I., Hooyberghs,J., Witters,H.,
            Schoeters,G., Van Cauwenberge,P. and Van Den Heuvel,R.
  TITLE     Gene profiles of a human bronchial epithelial cell line after in
            vitro exposure to respiratory (non-)sensitizing chemicals:
            identification of discriminating genetic markers and pathway
            analysis
  JOURNAL   Toxicology 255 (3), 151-159 (2009)
   PUBMED   19041681
REFERENCE   8  (bases 1 to 5058)
  AUTHORS   Grelle,G., Kostka,S., Otto,A., Kersten,B., Genser,K.F.,
            Muller,E.C., Walter,S., Boddrich,A., Stelzl,U., Hanig,C.,
            Volkmer-Engert,R., Landgraf,C., Alberti,S., Hohfeld,J.,
            Strodicke,M. and Wanker,E.E.
  TITLE     Identification of VCP/p97, carboxyl terminus of Hsp70-interacting
            protein (CHIP), and amphiphysin II interaction partners using
            membrane-based human proteome arrays
  JOURNAL   Mol Cell Proteomics 5 (2), 234-244 (2006)
   PUBMED   16275660
REFERENCE   9  (bases 1 to 5058)
  AUTHORS   Kawabe,H., Hata,Y., Takeuchi,M., Ide,N., Mizoguchi,A. and Takai,Y.
  TITLE     nArgBP2, a novel neural member of ponsin/ArgBP2/vinexin family that
            interacts with synapse-associated protein 90/postsynaptic
            density-95-associated protein (SAPAP)
  JOURNAL   J Biol Chem 274 (43), 30914-30918 (1999)
   PUBMED   10521485
  REMARK    GeneRIF: Shows that an homologous rat protein can interact with
            nArgBP2, a novel neural member of the ponsin/ArgB/vinexin family.
REFERENCE   10 (bases 1 to 5058)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
  REMARK    GeneRIF: Includes the identification and characterization of an
            homologous protein in rat.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512784.6, AL445705.8,
            AL390374.16 and AL050318.13.
            
            On Aug 13, 2020 this sequence version replaced NM_001365621.1.
            
            Summary: The product of this gene is a membrane-associated
            guanylate kinase found at the postsynaptic density in neuronal
            cells. It is a signaling molecule that can interact with potassium
            channels and receptors, as well as other signaling molecules. The
            protein encoded by this gene can interact with PSD-95 through its
            guanylate kinase domain and may be involved in clustering PSD-95 in
            the postsynaptic density region. The encoded protein is one of at
            least four similar proteins that have been found. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.1367781.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339266.10/ ENSP00000341633.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL512784.6         11101-11274
            175-405             AL445705.8         1324-1554
            406-1476            AL390374.16        8095-9165
            1477-1718           AL390374.16        12558-12799
            1719-1833           AL390374.16        16203-16317
            1834-1884           AL390374.16        19176-19226
            1885-2125           AL390374.16        23146-23386
            2126-2487           AL050318.13        7423-7784
            2488-2576           AL050318.13        10306-10394
            2577-2989           AL050318.13        10917-11329
            2990-3081           AL050318.13        34968-35059
            3082-3237           AL050318.13        36569-36724
            3238-5058           AL050318.13        37531-39351
FEATURES             Location/Qualifiers
     source          1..5058
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..5058
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /note="DLG associated protein 4"
                     /db_xref="GeneID:22839"
                     /db_xref="HGNC:HGNC:24476"
                     /db_xref="MIM:616191"
     exon            1..174
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            175..405
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            406..1476
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             478..3456
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /note="isoform d is encoded by transcript variant 4; disks
                     large-associated protein 4; PSD-95/SAP90-binding protein
                     4; SAP90/PSD-95-associated protein 4; discs large homolog
                     associated protein 4"
                     /codon_start=1
                     /product="disks large-associated protein 4 isoform d"
                     /protein_id="NP_001352550.1"
                     /db_xref="CCDS:CCDS93034.1"
                     /db_xref="GeneID:22839"
                     /db_xref="HGNC:HGNC:24476"
                     /db_xref="MIM:616191"
                     /translation="MKGLGDSRPRHLSDSLDPPHEPLFAGTDRNPYLLSPTEAFAREA
                     RFPGQNTLPGDGLFPLNNQLPPPSSTFPRIHYNSHFEVPEESPFPSHAQATKINRLPA
                     NLLDQFEKQLPIHRDGFSTLQFPRGEAKARGESPGRIRHLVHSVQRLFFTKAPSLEGT
                     AGKVGGNGSKKGGMEDGKGRRAKSKERAKAGEPKRRSRSNISGWWSSDDNLDGEAGAF
                     RSSGPASGLMTLGRQAERSQPRYFMHAYNTISGHMLKTTKNNTTELTAPPPPPAPPAT
                     CPSLGVGTDTNYVKRGSWSTLTLSHAHEVCQKTSATLDKSLLKSKSCHQGLAYHYLQV
                     PGGGGEWSTTLLSPRETDAAAEGPIPCRRMRSGSYIKAMGDEDSDESGGSPKPSPKTA
                     ARRQSYLRATQQSLGEQSNPRRSLDRLDSVDMLLPSKCPSWEEDYTPVSDSLNDSSCI
                     SQIFGQASLIPQLFGHEQQVREAELSDQYEAACESACSEAESTAAETLDLPLPSYFRS
                     RSHSYLRAIQAGCSQEEDSVSLQSLSPPPSTGSLSNSRTLPSSSCLVAYKKTPPPVPP
                     RTTSKPFISVTVQSSTESAQDTYLDSQDHKSEVTSQSGLSNSSDSLDSSTRPPSVTRG
                     GVAPAPEAPEPPPKHAALKSEQGTLTSSESHPEAAPKRKLSSIGIQVDCIQPVPKEEP
                     SPATKFQSIGVQVEDDWRSSVPSHSMSSRRDTDSDTQDANDSSCKSSERSLPDCTPHP
                     NSISIDAGPRQAPKIAQIKRNLSYGDNSDPALEASSLPPPDPWLETSSSSPAEPAQPG
                     ACRRDGYWFLKLLQAETERLEGWCCQMDKETKENNLSEEVLGKVLSAVGSAQLLMSQK
                     FQQFRGLCEQNLNPDANPRPTAQDLAGFWDLLQLSIEDISMKFDELYHLKANSWQLVE
                     TPEKRKEEKKPPPPVPKKPAKSKPAVSRDKASDASDKQRQEARKRLLAAKRAASVRQN
                     SATESADSIEIYVPEAQTRL"
     exon            1477..1718
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..1833
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1884
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2125
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2487
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2488..2576
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2989
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            2990..3081
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3237
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     exon            3238..5058
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3490..3495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /note="hexamer: ATTAAA"
     polyA_site      3521
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
     regulatory      5039..5044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /note="hexamer: AATAAA"
     polyA_site      5058
                     /gene="DLGAP4"
                     /gene_synonym="DAP-4; DAP4; DLP4; SAPAP-4; SAPAP4"
                     /note="major polyA site"
ORIGIN      
        1 gcagccgcat ctggggcgcc gcgccggccg gaggagaggc atggggcgcc cgcgggccgg
       61 agccggggcg ggggccgggg cctaggcgcg cggacctgcg agcggacccg agaggcggcg
      121 gcggcgcagc ggaacggcag agcgggccgg aggcggccga ggcgcccggc gcaggcaccc
      181 gtgcctcccc tctgccagga accttggggc cttgtgtgtg accaggacct ggtggccccc
      241 gggcggtggc agagcccctg tcccaagctg cttcctgccg gcacctctga tcaagtgcct
      301 agagggatgt gtgtgccagc cctcggtcca gtgcccgctc ctgagctgac tcctgctggg
      361 ccccgacagc ttgccgtgtt tcctgtgcct gtagctccct ggttggatag ctgccgcccg
      421 ggagaggtga cccgggcgcc ctgctagggt gaaggcccct gccctcggcc cgggatcatg
      481 aaaggcctcg gtgacagccg cccccgccac ctctccgaca gcctagaccc accccacgag
      541 cccctgtttg cagggaccga ccgcaacccc tacctgctgt cgcccacgga ggccttcgcc
      601 cgcgaggccc gcttccccgg gcagaacacc ctgccaggag atggcctctt tcccctcaac
      661 aaccagctgc ccccgcccag cagcaccttt ccccgcatcc actacaactc ccacttcgag
      721 gtgccagagg agagcccctt ccccagccat gcccaagcca ccaagatcaa ccggctgccc
      781 gccaacctcc tggaccagtt tgagaagcag ctgcccatcc accgtgatgg cttcagcacc
      841 ctccaatttc cccgtggcga ggccaaggcc cgtggtgaga gccctggccg catccgccac
      901 ctggtccact cagtccagcg gcttttcttc accaaggcac cctcactgga gggcacagcg
      961 ggcaaggtcg gtggcaatgg cagcaagaag ggtggcatgg aggacggcaa gggccggagg
     1021 gccaaaagca aggagcgggc caaggctggg gagcccaaac ggcgcagccg ctccaacatc
     1081 tcaggctggt ggagctccga tgacaacttg gacggcgagg ccggcgcctt ccgcagcagt
     1141 ggcccagcct ctgggctgat gacactaggc cgccaggcag aacgcagcca gccacgctac
     1201 ttcatgcacg cctacaacac catcagtggg cacatgctca aaaccaccaa gaacaacact
     1261 actgagctga ctgccccacc acccccgccc gcacccccag ccacctgccc cagccttggg
     1321 gtgggcactg acaccaacta cgtcaaacgg ggctcctggt ccactctgac cctcagccac
     1381 gcccacgagg tctgccagaa gacctcagcc accttggata agagcctgct caagtccaaa
     1441 tcctgccacc agggtctagc ctaccattac ctgcaggtgc ccggcggcgg cggcgagtgg
     1501 agcaccacgc tgctgtcccc acgcgagacg gatgccgcgg ccgagggccc tatcccgtgc
     1561 cggcgcatgc gcagcggcag ctacatcaag gccatgggcg acgaggacag cgacgagtcc
     1621 ggcggcagcc ccaagccctc acccaagacc gcggcgcggc gccagagcta tctgagggcc
     1681 acgcagcagt cgctgggaga gcagagcaac ccccgcagga gtctggaccg cctggattca
     1741 gtggacatgc tgctgccctc caagtgtccg agctgggaag aggactacac ccccgtcagc
     1801 gacagcctca acgactccag ctgcatcagc cagatttttg gacaggcctc cctgatcccc
     1861 cagttgtttg gccatgagca gcaggtacgg gaggcagagc tgagtgacca gtatgaggcg
     1921 gcctgcgagt cagcctgcag tgaagcggag tccacagcgg cagagacgct tgacttgcca
     1981 ctgcccagct acttccgctc ccgcagccac agctacctgc gtgccatcca ggcaggctgc
     2041 tcgcaggagg aggacagtgt ctccctgcag tccctctccc caccgcccag taccggcagc
     2101 ctcagcaata gtcgcacgct tccgagttca tcatgcctag tggcgtataa gaagaccccg
     2161 ccaccggtcc ctccacgcac cacttcaaag ccgttcatct cagtcacagt ccagagcagt
     2221 actgagtctg cccaggacac ctacctggac agccaggacc acaagagcga ggtgactagc
     2281 cagtcgggcc tgagcaactc gtcggacagc ctggacagca gtacccgacc gcccagcgtg
     2341 acacggggtg gagtcgcccc agcccctgag gccccagagc cacccccaaa acatgcagct
     2401 ctgaaaagtg aacaagggac gctgaccagc tctgagtccc accccgaggc cgcccccaaa
     2461 aggaaactgt catcgatagg aatacaagtt gactgcattc agccagtgcc aaaagaggag
     2521 cccagtcccg ctaccaaatt ccagtccatc ggggttcagg tagaggacga ctggcgaagc
     2581 agcgtcccct ctcacagtat gtcctcccga cgggacacag actcggatac ccaggatgcc
     2641 aatgactcaa gctgtaagtc atctgagagg agcctcccgg actgtacccc tcaccccaac
     2701 tccatcagca tcgatgccgg tccccggcag gcccccaaga ttgcccagat caagcgcaac
     2761 ctctcctatg gagacaacag cgaccctgcc ctagaggcgt cctcgctgcc cccacccgac
     2821 ccctggctcg agacctcctc cagctcccca gcagagccgg cacagccagg ggcctgccgc
     2881 cgagacggct actggttcct aaagctactg caggcagaaa cagagcggct ggaaggctgg
     2941 tgctgccaga tggacaagga gaccaaagag aacaacctct ctgaagaagt cttaggaaaa
     3001 gtcctcagtg ctgtgggcag tgcccagcta ctgatgtccc agaaattcca gcagttccgg
     3061 ggcctctgtg agcaaaactt gaaccctgat gccaacccac gccccacagc ccaggacctg
     3121 gcagggttct gggacctgct acagctgtcc atcgaggata tcagcatgaa gttcgatgaa
     3181 ctctaccacc tcaaggccaa cagctggcag ctggtggaga cccccgagaa gaggaaggaa
     3241 gagaagaaac caccccctcc ggtcccaaag aagccagcca aatccaagcc ggcagtgagc
     3301 cgcgacaagg cctcagacgc cagcgacaag cagcgccagg aggcccgcaa gagactcctg
     3361 gcggccaagc gggcagcttc tgtgcggcag aactcagcca ccgagagcgc agacagcatc
     3421 gagatttatg tcccggaggc ccagaccagg ctctgagacc atgcaggagg aaagaaacga
     3481 ttttaaatca ttaaaaacac aaaaactaag tgcgaacgga acagagtttt ctcaaccttt
     3541 gctatggtta ttctgtctag agaccctgag ccaactttca aattgacgca tacaagggct
     3601 cacaatttgg cttttttggg tccctcccag ctttaggtta tgaagatttt actcacaaaa
     3661 aaaatcaaca aaaatcacga aactagaaaa cttttttttt cctcttgctg gccgtggtgg
     3721 actagataga tggacgtcgg caactcccgg cccagcctcc atactgcggt ctttttactc
     3781 gttctatctg atgagaactc acactagctt gtttacaaga tgacgacagt ccaagggcag
     3841 ccttgggcac ctgccatgtc cctcctttcc ccagctatcc ccgctctgac cttgattttc
     3901 attcttatgt ttttctcttt tcccttcaga gctcacacag tggtcaccat tgtggcaagc
     3961 ggctttctgg gtctcagccc tctctgcggt tgagggccca gaggacagag agatggacat
     4021 gcgtcccctc cctccccccg ccaagtgctc acacacaacc tcacgcgcac acacacacac
     4081 gcagatggag gcgcctcact gggaggtgcc ccgccagccc tgggcagtgt caggcaggac
     4141 tcactcaccg ctgagcagat gagggaagtt ttagtcttgg cgggtggaaa tgagacgaag
     4201 ccacagttat cacactccag actcctgccc ttttattttc tccagcccct tcttccttca
     4261 gcaaaatcta ggactcccga gtggcttcca gggggccgtc agtcctcagc cgcgcctgtg
     4321 tccggtgccc gaggggcggg cggcggtgtc tgtatgtatg tgtacatatg cacatagacc
     4381 ttagagtgta tagttaacaa acgcccatct gctcacccat gcccacccag cgccgccgcc
     4441 gctggctctc ggggcacctg gcaggaggcg ggtgtgtgaa tagcatatat ttttacatgt
     4501 actatatcta ggtgtgtgta caagtgtgtg taaaaatata taccttgtgt gtaagcagcc
     4561 cttttttttt ttggtctcca cccccctccc cccgccccgc actcctaagg gcccatctgc
     4621 ccagcctctg agttttctgt tctatttttt ttttaacccc aattatcctt ctctctctcc
     4681 tgcccccgca tcccactccc agggtgtcac gagccctgag ctgcaatggc ccgggcctgc
     4741 agggcggggt aggggagggc aggggctgag ccccgaagcc agctcagtac ctgaggggct
     4801 gctctatgct gtgtatgcgc ctctctggca tccgagacat cctcttggct ggcgcttgct
     4861 gcaggggggg accccccccc gtccccaggt gaaccaaggg tctgctccgg ggcccatttc
     4921 cagcttggcc gccgtctgtg accttgggca agtcacttga cctctgtgtg cctcaacttc
     4981 ctcctctgta aaacggggac agtccctgcc cctccctacc tcacaggcat gttgtgagaa
     5041 taaatgaggt aacgtgta
//
