LOCUS       NM_001346810           10418 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens DLG associated protein 2 (DLGAP2), transcript variant
            3, mRNA.
ACCESSION   NM_001346810
VERSION     NM_001346810.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10418)
  AUTHORS   Johnson,R.K., Ireton,A.J., Carry,P.M., Vanderlinden,L.A., Dong,F.,
            Romero,A., Johnson,D.R., Ghosh,D., Yang,F., Frohnert,B., Yang,I.V.,
            Kechris,K., Rewers,M. and Norris,J.M.
  TITLE     DNA Methylation Near DLGAP2 May Mediate the Relationship between
            Family History of Type 1 Diabetes and Type 1 Diabetes Risk
  JOURNAL   Pediatr Diabetes 2023 (2023)
   PUBMED   38765731
  REMARK    GeneRIF: DNA Methylation Near DLGAP2 May Mediate the Relationship
            between Family History of Type 1 Diabetes and Type 1 Diabetes Risk.
REFERENCE   2  (bases 1 to 10418)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 10418)
  AUTHORS   Ouellette,A.R., Neuner,S.M., Dumitrescu,L., Anderson,L.C.,
            Gatti,D.M., Mahoney,E.R., Bubier,J.A., Churchill,G., Peters,L.,
            Huentelman,M.J., Herskowitz,J.H., Yang,H.S., Smith,A.N., Reitz,C.,
            Kunkle,B.W., White,C.C., De Jager,P.L., Schneider,J.A.,
            Bennett,D.A., Seyfried,N.T., Chesler,E.J., Hadad,N., Hohman,T.J.
            and Kaczorowski,C.C.
  CONSRTM   Alzheimer's Disease Genetics Consortium
  TITLE     Cross-Species Analyses Identify Dlgap2 as a Regulator of
            Age-Related Cognitive Decline and Alzheimer's Dementia
  JOURNAL   Cell Rep 32 (9), 108091 (2020)
   PUBMED   32877673
  REMARK    GeneRIF: Cross-Species Analyses Identify Dlgap2 as a Regulator of
            Age-Related Cognitive Decline and Alzheimer's Dementia.
REFERENCE   4  (bases 1 to 10418)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 10418)
  AUTHORS   Luedi,P.P., Dietrich,F.S., Weidman,J.R., Bosko,J.M., Jirtle,R.L.
            and Hartemink,A.J.
  TITLE     Computational and experimental identification of novel human
            imprinted genes
  JOURNAL   Genome Res 17 (12), 1723-1730 (2007)
   PUBMED   18055845
  REMARK    GeneRIF: DLGAP2 gene is imprinted, with preferential expression
            from the paternal allele in testis.
REFERENCE   6  (bases 1 to 10418)
  AUTHORS   Verhoeven,K., De Jonghe,P., Van de Putte,T., Nelis,E., Zwijsen,A.,
            Verpoorten,N., De Vriendt,E., Jacobs,A., Van Gerwen,V., Francis,A.,
            Ceuterick,C., Huylebroeck,D. and Timmerman,V.
  TITLE     Slowed conduction and thin myelination of peripheral nerves
            associated with mutant rho Guanine-nucleotide exchange factor 10
  JOURNAL   Am J Hum Genet 73 (4), 926-932 (2003)
   PUBMED   14508709
REFERENCE   7  (bases 1 to 10418)
  AUTHORS   Ranta,S., Zhang,Y., Ross,B., Takkunen,E., Hirvasniemi,A., de la
            Chapelle,A., Gilliam,T.C. and Lehesjoki,A.E.
  TITLE     Positional cloning and characterisation of the human DLGAP2 gene
            and its exclusion in progressive epilepsy with mental retardation
  JOURNAL   Eur J Hum Genet 8 (5), 381-384 (2000)
   PUBMED   10854099
REFERENCE   8  (bases 1 to 10418)
  AUTHORS   Ranta,S., Lehesjoki,A.E., de Fatima Bonaldo,M., Knowles,J.A.,
            Hirvasniemi,A., Ross,B., de Jong,P.J., Soares,M.B., de la
            Chapelle,A. and Gilliam,T.C.
  TITLE     High-resolution mapping and transcript identification at the
            progressive epilepsy with mental retardation locus on chromosome 8p
  JOURNAL   Genome Res 7 (9), 887-896 (1997)
   PUBMED   9314494
REFERENCE   9  (bases 1 to 10418)
  AUTHORS   Satoh,K., Yanai,H., Senda,T., Kohu,K., Nakamura,T., Okumura,N.,
            Matsumine,A., Kobayashi,S., Toyoshima,K. and Akiyama,T.
  TITLE     DAP-1, a novel protein that interacts with the guanylate
            kinase-like domains of hDLG and PSD-95
  JOURNAL   Genes Cells 2 (6), 415-424 (1997)
   PUBMED   9286858
REFERENCE   10 (bases 1 to 10418)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100797.4, AC026950.16,
            AC110288.10, AC005010.2, AC126333.7 and AW195368.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001346810.1.
            
            Summary: The product of this gene is a membrane-associated protein
            that may play a role in synapse organization and signalling in
            neuronal cells. This gene is biallelically expressed in the brain,
            however, only the paternal allele is expressed in the testis
            (PMID:18055845). Alternatively spliced transcript variants encoding
            different isoforms have been identified. [provided by RefSeq, Jun
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874,
                              SAMEA2151119 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene            :: PMID: 18055845
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000637795.2/ ENSP00000489774.1
            RefSeq Select criteria    :: based on single protein-coding
                                         transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC100797.4         76327-76524
            199-253             AC026950.16        82013-82067         c
            254-286             AC110288.10        56471-56503
            287-352             AC005010.2         111960-112025
            353-1410            AC005010.2         159220-160277
            1411-1622           AC005010.2         176277-176488
            1623-1770           AC126333.7         82546-82693         c
            1771-1990           AC126333.7         76387-76606         c
            1991-2340           AC126333.7         40755-41104         c
            2341-2382           AC126333.7         39649-39690         c
            2383-2468           AC126333.7         32815-32900         c
            2469-2884           AC126333.7         30804-31219         c
            2885-2976           AC126333.7         17807-17898         c
            2977-3129           AC126333.7         12134-12286         c
            3130-10401          AC126333.7         974-8245            c
            10402-10418         AW195368.1         7-23                c
FEATURES             Location/Qualifiers
     source          1..10418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p23.3"
     gene            1..10418
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="DLG associated protein 2"
                     /db_xref="GeneID:9228"
                     /db_xref="HGNC:HGNC:2906"
                     /db_xref="MIM:605438"
     exon            1..198
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..3348
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     PSD-95/SAP90-binding protein 2; SAP90/PSD-95-associated
                     protein 2; putative DAP-2 like protein; ERICH1 antisense
                     gene protein 1; discs large-associated protein 2; discs
                     large homolog associated protein 2; ERICH1 antisense RNA 1
                     (non-protein coding)"
                     /codon_start=1
                     /product="disks large-associated protein 2 isoform 3"
                     /protein_id="NP_001333739.1"
                     /db_xref="CCDS:CCDS87572.1"
                     /db_xref="GeneID:9228"
                     /db_xref="HGNC:HGNC:2906"
                     /db_xref="MIM:605438"
                     /translation="MSALRKVLPGILQKHCCILPDRNTESQCTLCGEPEEEEAGDLVQ
                     PGISFPGPAEEDLDPQYSWSPTQHFNEERYSPAPRSMKGLSGSRTQPPLCSGHTCGLA
                     PPEDCEHLHHGPDARPPYLLSPADSCPGGRHRCSPRSSVHSECVMMPVVLGDHVSSST
                     FPRMHYSSHYDTRDDCAVAHAGAKINRIPANLLDQFEKQLPLHRDGFHTLQYQRTSAA
                     AEQRSESPGRIRHLVHSVQKLFTKSHSLEGSSKSNANGTKADGRADDHHHAHHAKHSK
                     RSKSKERKPEGKPRPGMSSWWSSDDNLDSDSTYRTPSVLNRHHLGPVAHCYPDALQSP
                     FGDLSLKTSKSNNDVKCSACEGLALTPDAKYLKRSSWSTLTVSQAKEAYRKSSLNLDK
                     PLLHQDAKPALRPCHYLQVPQDEWGGYPTGGKDEEIPCRRMRSGSYIKAMGDEESGES
                     DSSPKTSPKSAILPEPLLKSIGQRPLGEHQTQTYLQAASDVPVGHSLDPAANYNSPKF
                     RSRNQSYMRAVSTLSQASCVSQVSEAEINGQFESVCESVFSEVESQAMDALDLPGCFR
                     TRSHSYLRAIQAGYSQDDECIPMMTPSDITSTIRSTAAVSYTNYKKTPPPVPPRTTSK
                     PLISVTAQSSTESTQDAYQDSRAQRMSPWPQDSRGLYNSTDSLDSNKAMNLALETAAA
                     QRHLPESQSSSVRTSDKAILVSKAEELLKSRCSSIGIQDSEFPEHQPYPRSDVETATD
                     SDTESRGLREYHSVGVQVEDEKRHGRFKRSNSVTAAVQADLELEGFPGHITTEDKGLQ
                     FGSSFQRHSEPSTPTQYSAVRTVRTQGLFSYREDYRTQVDTSTLPPPDPWLEPAIDTV
                     ETGRMSPCRRDGSWFLKLLHAETKRMEGWCKEMEREAEENDLSEEILGKIRSAVGSAQ
                     LLMSQKFQQFYWLCQQNMDPSAMPRPTSQDLAGYWDMLQLSIEDVSMKFDELQRLRLN
                     DWKMMESPERKEERKVPPPIPKKPPKGKFPITREKSLDLPDRQRQEARRRLMAAKRAA
                     SFRQNSASERADSIEIYIPEAQTRL"
     exon            199..253
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            254..286
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            287..352
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            353..1410
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1622
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1770
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1990
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2340
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2382
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2468
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2884
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2976
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2977..3129
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3130..10418
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6032..6037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="hexamer: AATAAA"
     polyA_site      6050
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="major polyA site"
     regulatory      10148..10153
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="hexamer: ATTAAA"
     polyA_site      10170
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="major polyA site"
     regulatory      10394..10399
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
                     /note="hexamer: AATAAA"
     polyA_site      10418
                     /gene="DLGAP2"
                     /gene_synonym="C8orf68; DAP2; ERICH1-AS1; SAPAP2"
ORIGIN      
        1 agaccgaccg tgcgccgggc tcgagcgcgg tctgagcgcg cggcgcctgc ggcggcgaac
       61 ggacggacgg accgcggacg gacgtactga ccccaacccg cgagccccgg gagccgtcgg
      121 tctgaggagg ggccgcttcg ccatgtcgcc ccgcacctgc tgagcccgga gcgtccgagg
      181 atgtccgcgc tgaggaaggt tttgcctggc attctgcaga agcattgctg tatcttacca
      241 gacaggaata cagagtcgca gtgcacgctc tgcggggagc cggaagagga agaagctgga
      301 gacttggtcc agccgggcat cagctttccg gggccggcag aggaggatct agacccgcag
      361 tactcatggt cgcccacgca gcacttcaat gaggagcgct actcgcccgc gcccaggagc
      421 atgaagggcc tttccggaag tcggacccag ccgccgctgt gttccgggca cacgtgtggt
      481 ctggcgcccc cggaggactg cgagcacctg caccacgggc ccgacgcgcg gccgccctac
      541 ctgctgagcc ccgccgacag ctgccccggg gggcgccacc gctgctcgcc gcgcagctcg
      601 gtgcactcgg agtgcgtgat gatgccggtg gtgctgggcg accacgtgtc cagcagcacc
      661 ttcccgcgga tgcactacag ctcgcactac gacacgcgcg acgactgcgc tgtggcccac
      721 gcgggcgcca agatcaaccg catcccggcc aacctgctgg accagttcga gaagcagctg
      781 ccgctgcacc gggacggctt ccacacgctg cagtaccaga ggacgtccgc ggccgccgag
      841 cagcgcagcg agagccccgg gcggatccgc cacctggtac actccgtgca gaagctcttc
      901 accaagtcgc actcgctgga gggctcctcc aaaagcaacg ccaacggcac caaggcggac
      961 ggccgggcgg acgaccacca ccacgcccac cacgccaagc acagcaagag gagcaagagc
     1021 aaggagcgca agccggaggg caagccccgg cccggcatga gcagctggtg gagctcggac
     1081 gacaacctgg acagcgacag cacctatcgg acgcccagcg tgctcaaccg gcaccacctg
     1141 ggccccgtgg cccactgcta ccccgacgcg ctgcagagcc ccttcgggga cctgtccctc
     1201 aagacctcca agagcaacaa cgacgtcaag tgctcggcct gtgaggggtt ggcgctgacg
     1261 cccgacgcca agtacctgaa gcgcagctcc tggtctacgc tgacggtcag ccaggccaag
     1321 gaggcctacc gcaagagctc gctgaacctg gacaagccgc tgctgcacca ggacgccaag
     1381 cccgccctga ggccgtgcca ctacctccag gtacctcagg atgagtgggg agggtacccc
     1441 accggtggca aagatgagga gattccctgc aggagaatga gaagtgggag ttacattaaa
     1501 gccatggggg acgaggagag cggagagtca gactccagcc ccaagacatc accaaagtcg
     1561 gcaatcctac cagagccgct gctgaagtcc atcggacaga gaccgcttgg agagcaccag
     1621 acccagacct acctgcaagc tgcaagcgat gtgcctgtgg gacacagcct ggaccccgct
     1681 gcgaactaca actccccgaa attccgctcc cggaaccaga gctacatgag ggccgtcagc
     1741 accctgagcc aggccagctg cgtgagccag gtgagcgagg cggagatcaa tgggcaattc
     1801 gagtccgtgt gcgagtccgt cttcagtgaa gttgaatctc aggccatgga tgccctcgac
     1861 ctcccgggat gtttccgaac aaggagtcac agctaccttc gagccattca agccggctac
     1921 tcccaagatg acgaatgtat tcccatgatg acaccctctg acatcacctc caccatcagg
     1981 tcaacagcag ctgtctcata tacaaattac aagaaaacgc ccccaccggt gccccctcgg
     2041 accacctcca agcctctgat ctcggtgacg gcgcagagca gcaccgaatc cacccaggac
     2101 gcctaccagg acagccgcgc acagaggatg tccccgtggc cccaggacag ccgcggcctc
     2161 tacaactcca cggacagcct ggacagcaac aaggccatga acctcgcgct ggaaacggcc
     2221 gctgcccagc gccacctgcc agagagccag agcagctctg tgcggaccag cgacaaggcc
     2281 atcctggtgt ccaaggcgga ggagctcctc aagagccgct gctcctccat cgggattcag
     2341 gattctgaat tcccagagca tcagccatac ccaaggtcag atgtggaaac ggccacagat
     2401 tctgacacgg agagccgcgg tctgcgggaa taccactctg tcggggtgca agtggaagat
     2461 gagaagcgac acggacgttt taaacgttct aacagcgtca cggccgccgt ccaagctgac
     2521 ctggagctgg aggggttccc aggccacatc accacggagg acaaaggcct tcagttcggc
     2581 tcatccttcc agcggcactc cgagcccagc acccccaccc agtacagcgc ggtgagaact
     2641 gtacggaccc aggggctctt cagctataga gaagactatc ggacccaagt ggacacctcc
     2701 accctgcccc ctccagaccc ctggctggag cccgccatcg acacggtaga gactgggagg
     2761 atgtctccgt gccgcaggga tggctcgtgg tttttgaagc tgctgcacgc agagacaaag
     2821 aggatggaag gctggtgcaa agagatggag agagaggcgg aggagaacga cctctcggag
     2881 gaaattctcg gtaaaatcag gagtgctgtt gggagtgccc agcttctcat gtcccagaaa
     2941 ttccagcagt tttattggct ttgccaacag aatatggacc ccagcgccat gccgaggccg
     3001 acgtcgcagg acctggccgg ctactgggac atgctgcagc tctccattga ggacgtcagc
     3061 atgaagttcg acgagctgca gcggctgcgg ctcaacgact ggaagatgat ggagtccccg
     3121 gaaagaaagg aagaaagaaa ggtcccgcct ccaataccaa agaagcctcc caaggggaag
     3181 tttcccatca caagagaaaa atccctggac ctgcccgaca gacaacgcca ggaagcccgg
     3241 aggcgcctca tggccgccaa gcgagcggcg tccttccggc agaattccgc ctccgagcgc
     3301 gcggacagca tcgagatcta catccccgag gcccagaccc ggctctgagg gcggaggccg
     3361 gcgccttccc ctcgtcgctt ccgctttccc ggacgcttgt gcagcgcggc gccgccctgg
     3421 tggtttctgt ctcctcctcc cgctgaacac gtcctcgctc ccgcgctccc cgcgccccgg
     3481 acacagcggg acgcggccgg cggcctcaga gtccacggag ctcgcggcga ggacgacttc
     3541 tgcttttgtt gttgttgttg ttgttcacgg gtggcctggc tcacacttgg ctctgaggga
     3601 caggtgtggc gagacctgat ttctcctgcg tgttctcaga ggacggcgag aaatgcctct
     3661 ggagctggaa cccagcttac attttgttat ttctattttt ataaattgtg tgataattag
     3721 aggtaagaat aacaagtaac tataaacggg tgcatcccac cactccctgg aggcattaga
     3781 cacccaagtg gaaggtgcta caacctgaag cgcaggaaag aaaggcccat tcccctcgca
     3841 cagccgagct tttactccct gagcacgggc cgctccgctc ccctgctcct gtctgtctcg
     3901 gacagaaaac acgaggctcc ttgtgtcaag cttcctgtga tggaaagcga cctctccaac
     3961 caccacactc cccgccgtac agttctccag aatcccaggc gatgacaagt ctgaacccac
     4021 gaaaataccc agcgcagcat ctacacattc aaaagataag ctgagtgttc ccaccaggaa
     4081 gtcacgcgca gagaggagag tcttacggag ggctgggagc ttaaaaggaa aacaatgtcc
     4141 ttacttgtaa acagttattg tattttttat ttctttctaa cttaaaatac gacacccagt
     4201 attttcttta agtttcacca tttacgctac atgtgatttt tttaatgtat gtatatatat
     4261 atattctcaa attgctctat cagctgactt ttcagggtat ccttaaaaaa aaacacacac
     4321 gaaaaacaaa agtttgcttg tttaaaatga cagttgtgat gtaaaaagtt taagaaatat
     4381 gaatgtgagt ggtaagtata tctcagttta aatggtaaag aagaaatgta gtttacattt
     4441 gtatttttcc agaattcttt tgtcctatgc agtattgcta aagtcgagaa tatattcctt
     4501 gcctgtgtta gacatgaagg gaaaaagagg tcacatattg tgatttccag ctgtagcatt
     4561 caaaaaaaaa attggtgttc atgactctgt ggtcggtgcc agaggaaaat aggaacgact
     4621 ctaattaata ggctttctgt gtatataatt aaatttagct gctgcaacca ttgttctgac
     4681 acgacttctg tttcacagtt cagaccggtc ttcaaaggaa aagcctgtcc gatttttcca
     4741 tgggttccag tttcagagtt ctcattatta ctcaaagtaa aagcggactg cgatttaaga
     4801 tgtttccacc ccaatacctg gtcttccttc ccggcttaag gagtaccatg tacttagcca
     4861 caggcagaat agctttcgat gaccccatag cactttgttt cttcgccttg atttgcactt
     4921 tacaatgtcc ccagcccctc tgcagcccgt ggctggcagg gcgttcgatg tgcggttggc
     4981 ccccagcgcg ccctccagag ctgcggtgtc tccctgcctc attccccaca tcccactgag
     5041 catgggacca ttgggagcag agctgatatt aaagcatgtt tagcttcgaa gttttacttt
     5101 tttaaagctg agtagttaag aattccctgt aaaaacaaaa ccctgtaaat tgagcctcat
     5161 gtctggtata tattttacca aacagcctta aaatatattt ggaagcaaaa atcagtacga
     5221 atgtatctcc ttgaaaaatg caaaaaaaaa aaaatccctg aaatattctt ctataaatga
     5281 atcctatttc cccagagtgt tcaaggcatt tttctaccta aatgaatacc taaatcttga
     5341 gtagtgtacg gtaatgacgc ttcttcctat atccactctt attatgttaa aacaaatgta
     5401 tttgcgagta ttggcatttt agactttaaa aatgctgtat gatttcagat gaactctgct
     5461 gtttagaagt aaccacagaa aagcaaagtc agtgtacact ctgagtgaaa ggaaatgtaa
     5521 tgtggataaa ggcccgccac ctcctcacat tggtctatct actggcagct gatacgttta
     5581 actcatttcc ttgagcttat acaaaacata gaaaagcaaa ctgttaaagt agtcaataat
     5641 tatttgtctc agatcccaga ttctatgatc cctgcttaaa agaaaatgtt cactgcatgt
     5701 aggttgattt cttatgtttt gtagactcat tgttattttt caatccccaa aagtcttggc
     5761 ctaaaccatc cctaggggag cagattaacc taccactaca ttgcacaggg ttggtgactc
     5821 gacgtggtga atgtgcacac gccctgcctg gtccgccatg ttccaaagaa gatgatttaa
     5881 tggtagaacg gatacctgct gctagacctg atggaatgtt acctgtccgt gttacataat
     5941 caagtgcaat atactcagtt ctcatgcagg tgacattcta ccatgaaacg cagaagataa
     6001 gccatgtttc tgtattgtac atgtaaagaa aaataaaact gtttatgata cttgtgttag
     6061 tcactcgagc tagcttattt cagccacttc tagcagatca tgccatggag ctcacgacgt
     6121 gtgaccattt cgtcatattt aaaatataac ttcaagaaaa gagtaaacat ccattggaga
     6181 acacggctga aaattattgt gctgttctag gaacatcatc ctagagagtg tgatgttcac
     6241 tataacccca tacctacatt ccctaatgat acagccaatg acaggtgaaa cccagacact
     6301 ctccttagag ccgacaggtt gatcctgctg tgttgaaggc tgtggttaat aaaacacaag
     6361 tatgataaac aggacctagc gtttagcccg ggaaaggaga atgctgcttg tcacctagag
     6421 tgctttcctt gtgatgcgtc tctcgcatct tcacgtgttg ttgtgtttga agtaaaacta
     6481 gttgttatcg atgacaattt ttaccatagt tttctcagca aatttatatc accatcttag
     6541 aatggtatat aaaaaaattg aactgtttat gataccaaaa aaattacagt tttgtttaaa
     6601 aggaaatgtt gatgttttca actccaaatc aattctaaaa acttcaagca cttaatggaa
     6661 aggtaaatgg tcagataaaa atataattac ctgtaaggtt atctggtttt aaaagaaaaa
     6721 aaaaaagcct acaaactcag tgacctacta cgcagaggga atttttccct gctgcttctt
     6781 atgaaagtgg ccaggtttat tattagaaga cacagtggca gagcacacat gtgcacaggt
     6841 tctgattatt tctcttggag catatgtcct tgtcttgatt tttgcctttt cgatgccata
     6901 ttaagcagcc accgtttcca cccctttcat tagaaggccc tgcatccgta aattcgcgca
     6961 tctctgtttt tgttagatcc ttgtaagcat cgctacccga gtccaggatg gaatttcaca
     7021 ggaaagtgaa gggatactgc aggcctgtgt ttgcagcgcc tgtggtaact gtggaatgag
     7081 ctctgttagg gacagttgtc tggtttgtgc caaaccttcg aggggcgagt agggagtggg
     7141 ggaggtgggt ccaagtctcc ctcaggaagg ccttttctat cggcagcaat tccatcaagc
     7201 caagcctcct gtggtcctga gcatgaaggg gccaggggac ctcctgggag atgcagcttt
     7261 tgtttccgct gcgtttcatc agtcagcctt gcttggaatt ctggcaggtt ccccggggtg
     7321 tttcagtgga caggaggccc ccgtgccgtg gctgagtcag cctgggtacc ccagtcacca
     7381 gcagggccac ccttgatgac agggcccccc acgaacctgg gaaaggcagc gggaaatgtg
     7441 tgagagggtg tgcgctggta cggacataaa agcattgtcc aaaacagcgc tggttcgggg
     7501 agggcccctg gatactgcct ttggcccaca ctgaaaactg aaattgcccc acctgtgagc
     7561 acagaaacac gcttctccaa cacgggccga aataactaaa ctccacatgg ttcctgcctg
     7621 ctcatttccc agccctcttc ttctcaagcc tgaacttcat tttttttttt agctgcaaat
     7681 ttaacaggct aatttaaaac tgcagttttc agacgacagc ccctgggaat gttccagggt
     7741 tctcttgttt tgatctgcat gtctgtttac acttctctgt aggcgtgggt tgaatacaag
     7801 tttccaaaac tttaaaatag aaaaccacga gcttaagagg tgaaaaagat gacccctttc
     7861 tgattaggat ctgtaactct gtgggctggg tcaatgcagt gtgcttcatt cagggccatg
     7921 tggcagccat gacacacacc acataaggtc agctcagagc ccatggcttc cctgcaggag
     7981 ccccatcttg tcgctattag ttgggagttg caatacattg ttggccataa acaaagtgct
     8041 aaaggaaagg gtttgcttct acacattcgg ctgaatgtcc cccagtgcag ggtggcagca
     8101 gaatgttctg gaaatgaagg agatattgct aggaatctct aggctgttag gcaacctggc
     8161 ttttattcat cctcagccgg caactcatct caagtttatg tctcagtttt tttcctctag
     8221 aaaggggatt acagttcctg tccctgtctt cctccaggac acactgtgag gattaatgac
     8281 atattggctc taaagtcctt tgagctcctg ggaacaggtg gtgaaagtgt gcgttactgc
     8341 taaggattag tccctggcct cttctagaat gccgccctcc cagctctgca gggcacgctg
     8401 ccagaatcca ggctggtcgt aaacatctca gagataatca gggaccacca gaggcagagg
     8461 ccatgagact gtctttggaa aggtttggaa atgcagaaat aactacaagg gccattctcc
     8521 ttagcttctg gctttcaact gtttctagat gcttccaaga acaagaaccc agcaccaacc
     8581 agaattaggc cacgttttca ccattactta agctcaatcg cctcttagat gaaatgagga
     8641 gataaactaa acattaaaat gatgaaggaa aaaaaattat ttggaagccg aaaaccgcat
     8701 gggtggggaa acatcaggaa cgaaatcaga cacactgact caaaccacgc aagggtttga
     8761 gaagcccacc cctctaattc caggcgtttg taatttttct acttcgcact tgagagaagg
     8821 cagaggtggt ccgtgggaaa gctccgggaa acagccgtct ttcatccttg ccacattgaa
     8881 aaatgtccac aattttatga attgctgtcc taaccctggc gtttttatcc agtgttaaaa
     8941 taaattattt caagtttcaa tgtaaacact taacagatga cttctttgca gaagaaatgt
     9001 tcgttaccta ctatcaaact actttttaac agattttgta tatacacaca caagttgaca
     9061 gaggtttacc tccctacttt cttagatttt atgtaactct tttcattggt gcttattcag
     9121 aacctgaaag ccttgggcat ccaagctttc acctactcaa tggaggagag gtgataatga
     9181 atgaaaagat tgacaccagg tttcttggac aaatttaagt tcaaatttat ctctttcaag
     9241 tagaccatgg tctccctaga gagtgtgttg gcttgtgtct gccagtacga caaaggacgc
     9301 tcccagcttg atcgtggtac cttatggaag ccactcacgc attctctgat ttacccccaa
     9361 aacactacca tgccccagcc ccactcattt aaataataca atcatatcac tttcaaaggg
     9421 ctcagcacga atgttcccct cactccactt tttaactcgt ttgctgaact cgacaaggct
     9481 tccccttacg agcagtgaga cctaggctac tttcgaacgc ttccttccga acggtaagcc
     9541 acttcgctct cgggcaggac aggtcctccc tgcagagaga gacaactcat cccccgacct
     9601 tccatactac agaccaaaat acccaggtgt ggcctaagga ctatattaaa tgcctcctat
     9661 agaaattcaa ggaatgttag aaccaggaaa ctagctgttt aaagttttaa agaagtatat
     9721 aaatatatat ataaatataa atatgaaatc atatcgagtg tgaggatgag cagagtgcca
     9781 aatattcagc atctgtacaa agtcattcac tggaattcaa ctattttatg tcattctctt
     9841 tctcacgctt ttatggttct tttgataaat tctatttagt agcatgcagg atacctaatc
     9901 tgaatgtgca atatgctatt catcaccacg acaatttctt acttcctctt aataacttac
     9961 cagaatgttg gtcattcctt taaggcagtt aaggattgct ttatttgtgt tcttttttcc
    10021 catgactttt tttcactctc agctgactgt aagaaactgt gcaccgtttc cgccataacc
    10081 gtcctgtgac gatgcctcca tttgacttct gtatcgctga tgttcacctc ctgtaaatag
    10141 tttggcaatt aaattttttg agaaaagtaa tgtttacttt tttattggag tgaattctcg
    10201 tgttatttta atctcagaaa aattatatag accaaagagt tttatccgaa aaaaaattac
    10261 actcttcctc cattatatat ttcattgttg aaatatcctc aatttctcta tattttaaga
    10321 agtaatggac atttattaag gttacagatt taatatgtat gcaaaatggt atagattaaa
    10381 tgagttttta attaataaat cctacagtat ttagttaa
//
