LOCUS       NM_004746               6655 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens DLG associated protein 1 (DLGAP1), transcript variant
            1, mRNA.
ACCESSION   NM_004746
VERSION     NM_004746.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6655)
  AUTHORS   Santanasto,A.J., Acharya,S., Wojczynski,M.K., Cvejkus,R.K., Lin,S.,
            Brent,M.R., Anema,J.A., Wang,L., Thyagarajan,B., Christensen,K.,
            Daw,E.W. and Zmuda,J.M.
  TITLE     Whole Genome Linkage and Association Analyses Identify DLG
            Associated Protein-1 as a Novel Positional and Biological Candidate
            Gene for Muscle Strength: The Long Life Family Study
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (8) (2024)
   PUBMED   38808484
  REMARK    GeneRIF: Whole Genome Linkage and Association Analyses Identify DLG
            Associated Protein-1 as a Novel Positional and Biological Candidate
            Gene for Muscle Strength: The Long Life Family Study.
REFERENCE   2  (bases 1 to 6655)
  AUTHORS   Switlik,W., Wyzewski,Z., Gregorczyk-Zboroch,K., Gietler,M.,
            Pudlarz,A., Szewinska,J., Orzechowski,S., Jakiela,S. and Szemraj,J.
  TITLE     Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small
            Cell Lung Cancer
  JOURNAL   Anticancer Res 44 (6), 2445-2451 (2024)
   PUBMED   38821626
  REMARK    GeneRIF: Deciphering the Role of miR-30a-5p and DLGAP1 Gene in
            Non-small Cell Lung Cancer.
REFERENCE   3  (bases 1 to 6655)
  AUTHORS   Liang,X., Zhao,Y., Fang,Z., Shao,N., Zhai,D., Zhang,M., Yu,L. and
            Shi,Y.
  TITLE     DLGAP1-AS2 promotes estrogen receptor signalling and confers
            tamoxifen resistance in breast cancer
  JOURNAL   Mol Biol Rep 49 (5), 3939-3947 (2022)
   PUBMED   35449318
  REMARK    GeneRIF: DLGAP1-AS2 promotes estrogen receptor signalling and
            confers tamoxifen resistance in breast cancer.
REFERENCE   4  (bases 1 to 6655)
  AUTHORS   Huang,T., Cao,L., Feng,N., Xu,B., Dong,Y. and Wang,M.
  TITLE     N6-methyladenosine (m6A)-mediated lncRNA DLGAP1-AS1enhances breast
            canceradriamycin resistance through miR-299-3p/WTAP feedback loop
  JOURNAL   Bioengineered 12 (2), 10935-10944 (2021)
   PUBMED   34866525
  REMARK    GeneRIF: N(6)-methyladenosine (m(6)A)-mediated lncRNA
            DLGAP1-AS1enhances breast canceradriamycin resistance through
            miR-299-3p/WTAP feedback loop.
REFERENCE   5  (bases 1 to 6655)
  AUTHORS   Takahashi,Y., Yamazaki,K., Kamatani,Y., Kubo,M., Matsuda,K. and
            Asai,S.
  TITLE     A genome-wide association study identifies a novel candidate locus
            at the DLGAP1 gene with susceptibility to resistant hypertension in
            the Japanese population
  JOURNAL   Sci Rep 11 (1), 19497 (2021)
   PUBMED   34593835
  REMARK    GeneRIF: A genome-wide association study identifies a novel
            candidate locus at the DLGAP1 gene with susceptibility to resistant
            hypertension in the Japanese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6655)
  AUTHORS   Hirao,K., Hata,Y., Ide,N., Takeuchi,M., Irie,M., Yao,I.,
            Deguchi,M., Toyoda,A., Sudhof,T.C. and Takai,Y.
  TITLE     A novel multiple PDZ domain-containing molecule interacting with
            N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
  JOURNAL   J Biol Chem 273 (33), 21105-21110 (1998)
   PUBMED   9694864
REFERENCE   7  (bases 1 to 6655)
  AUTHORS   Naisbitt,S., Kim,E., Weinberg,R.J., Rao,A., Yang,F.C., Craig,A.M.
            and Sheng,M.
  TITLE     Characterization of guanylate kinase-associated protein, a
            postsynaptic density protein at excitatory synapses that interacts
            directly with postsynaptic density-95/synapse-associated protein 90
  JOURNAL   J Neurosci 17 (15), 5687-5696 (1997)
   PUBMED   9221768
REFERENCE   8  (bases 1 to 6655)
  AUTHORS   Satoh,K., Yanai,H., Senda,T., Kohu,K., Nakamura,T., Okumura,N.,
            Matsumine,A., Kobayashi,S., Toyoshima,K. and Akiyama,T.
  TITLE     DAP-1, a novel protein that interacts with the guanylate
            kinase-like domains of hDLG and PSD-95
  JOURNAL   Genes Cells 2 (6), 415-424 (1997)
   PUBMED   9286858
REFERENCE   9  (bases 1 to 6655)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   10 (bases 1 to 6655)
  AUTHORS   Kim,E., Naisbitt,S., Hsueh,Y.P., Rao,A., Rothschild,A., Craig,A.M.
            and Sheng,M.
  TITLE     GKAP, a novel synaptic protein that interacts with the guanylate
            kinase-like domain of the PSD-95/SAP90 family of channel clustering
            molecules
  JOURNAL   J Cell Biol 136 (3), 669-678 (1997)
   PUBMED   9024696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005403.3, AK316099.1, AP005241.4, BC136453.1, AP002472.2,
            AK095761.1 and CR743383.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004746.3.
            
            Transcript Variant: This variant (1) represents the longest variant
            and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB000277.1, BC136453.1 [ECO:0000331]
            RNAseq introns       :: mixed sample support SAMEA1965299,
                                    SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315677.8/ ENSP00000316377.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AP005403.3         45837-45877         c
            42-489              AK316099.1         1-448
            490-490             AP005241.4         131896-131896       c
            491-3139            AK316099.1         450-3098
            3140-3706           BC136453.1         2631-3197
            3707-3835           AP002472.2         19178-19306         c
            3836-4618           AK095761.1         1-783
            4619-4994           AP002472.2         18019-18394         c
            4995-6650           AK095761.1         1160-2815
            6651-6655           CR743383.1         15-19               c
FEATURES             Location/Qualifiers
     source          1..6655
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..6655
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="DLG associated protein 1"
                     /db_xref="GeneID:9229"
                     /db_xref="HGNC:HGNC:2905"
                     /db_xref="MIM:605445"
     exon            1..302
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            303..410
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..496
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..1525
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             569..3502
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="isoform 1 is encoded by transcript variant 1; disks
                     large-associated protein 1; SAP90/PSD-95-associated
                     protein 1; PSD-95/SAP90 binding protein 1; guanylate
                     kinase-associated protein; discs large homolog associated
                     protein 1"
                     /codon_start=1
                     /product="disks large-associated protein 1 isoform 1"
                     /protein_id="NP_004737.2"
                     /db_xref="CCDS:CCDS11836.1"
                     /db_xref="GeneID:9229"
                     /db_xref="HGNC:HGNC:2905"
                     /db_xref="MIM:605445"
                     /translation="MKGLSGSRSHHHGVTCDSACDSLSHHSDRKPYLLSPVEHHPADH
                     PYYTQRNSFQAECVGPFSDPLASSTFPRRHYTSQQELKDECALVPRTLATKANRIPAN
                     LLDQFERQLPLSRDGYHTLQYKRTAVEHRSDSPGRIRHLVHSVQKLFTKSHSLEGPSK
                     GSVNGGKASPDEAQAARYGKRSKSKERRAEPKARPSTSPGWWSSDDNLDGDMCIYHAP
                     SGVMTMGRCPDRSASQYFLEAYNTISEQAVKASRSNNDVKCSTCANLPVSLDTPLLKK
                     SAWSSTLTVSRAREVYQKASVNMDQAMVKSESCQQERSCQYLQVPQDEWTGYTPRGKD
                     DEIPCRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKI
                     SNEHSPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQ
                     VSEMEVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDEC
                     VSLRSSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESA
                     QDAYMDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNTAT
                     VTTTTTIATVTTEDRKKDHFKKNRCLSIGIQVDDAEEPDKTGENKAPSKFQSVGVQVE
                     EEKCFRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDASTSTVS
                     IQGSGNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLK
                     LLQAERDRMEGWCQQMEREERENNLPEDILGKIRTAVGSAQLLMAQKFYQFRELCEEN
                     LNPNAHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKERRAPP
                     PVPKKPAKGPAPLIRERSLESSQRQEARKRLMAAKRAASVRQNSATESAESIEIYIPE
                     AQTRL"
     exon            1526..1740
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1918
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2159
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2160..2533
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2625
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            2626..3047
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3139
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3292
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..6655
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6594..6599
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="hexamer: AATAGA"
     polyA_site      6623
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="major polyA site"
     regulatory      6633..6638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="hexamer: AATAAA"
     polyA_site      6655
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="major polyA site"
ORIGIN      
        1 agcccagcct tgcagcccca gcccgccgcg tcccggcgct cagcctccgc tccagaggcg
       61 agcgctgcgc ttcgggcgcc gcaatctcca ggacacggcc tcgcggacac cttccgcctc
      121 ggggaatcgg cagcataggc ggcgcgaacg gccgccgccg cctcggctcc tctctcgagt
      181 ccttcccgtc acctcgctga gagccggtcc tggtcgcggg gacatctctc tccttcctcc
      241 gaggctcgtg ggaccaacgg acggacgcag ccagcgaggg ccggactgcg ggacgcggcc
      301 agagcagttg aacatcagat acccagagtg acatcaggtt aaaaaaaagc ctgcaatttg
      361 gatcttttcc tgactcggaa gcaaggaaaa tggacaattg ataatcaaag gctaaatctc
      421 ttctgggatc cactgaatgc cactagaggg tctgctcgag agaattcctg attgaatgac
      481 aacggcgcta agaacaatcc ctgcccaaga cgggtctgga gcctgacttc cgggtgtcca
      541 tgaccctggc ggctgcttcc ggtccgccat gaaagggcta tcaggcagcc gcagccatca
      601 ccacggggtc acctgcgact cggcctgtga ctcgctgtcg caccactccg accgcaagcc
      661 ctacctgctg agcccagtgg agcaccaccc cgcagaccac ccatactaca cccagcggaa
      721 ctccttccag gctgagtgcg tgggcccctt cagcgacccg ctggccagca gcaccttccc
      781 ccgcaggcac tacacctcgc agcaagagct gaaggacgag tgtgccctgg tgccccgcac
      841 cctggccacc aaggcgaacc gcatccccgc caacctgctg gaccagttcg agcggcagct
      901 gccactcagc cgcgatggct atcacaccct gcagtacaag cgcacggccg tggagcaccg
      961 cagcgacagc cccggccgca tccgccacct ggtgcactcg gtccagaagc tcttcaccaa
     1021 gtcgcactcc ctggaggggc cgtccaaggg cagcgtcaac gggggcaagg ccagccctga
     1081 cgaggcgcag gcggcgcgct atggcaaacg cagcaagagc aaggagcggc gcgcggagcc
     1141 caaggcccgg cccagcacct ccccgggctg gtggagctcg gacgacaacc tggatggtga
     1201 catgtgcatc taccacgccc cctcgggcgt gatgaccatg ggcaggtgcc ccgaccgctc
     1261 ggcctcacag tacttcctgg aggcctacaa caccatcagc gagcaggcgg tgaaggcctc
     1321 ccggagcaac aacgacgtca agtgctccac ctgcgccaac ctgccggtca gcctggacac
     1381 cccgctgctg aagaagagcg cctggtcctc cacgctcacc gtgagccggg cccgggaggt
     1441 ttaccagaag gcctcggtga acatggacca ggccatggtg aagtccgagt cgtgtcagca
     1501 agaacgctcc tgccagtacc tgcaggttcc acaagatgaa tggacagggt acaccccacg
     1561 aggtaaagat gatgaaattc catgccgaag aatgcggagt ggcagttata tcaaggccat
     1621 gggggatgaa gacagtggag actcagacac gagtcctaag ccttctccaa aagttgctgc
     1681 gcggagagaa agctatctca aggctactca gccatccctt acagaactca ccacactcaa
     1741 aatctccaat gaacactcac ccaaactcca gatccggagt catagttacc tgagggcagt
     1801 gagtgaagtc tccatcaacc ggagcctgga cagcctggac cctgcaggct tgctcacatc
     1861 accaaagttc cgctccagga atgagagcta catgcgagcc atgagcacca tcagccaggt
     1921 gagcgagatg gaagtgaacg ggcagttcga gtccgtgtgc gagtccgtgt tcagcgagct
     1981 ggagtcgcag gccgtggaag cgctggacct gcccatgccc ggctgcttcc gcatgcggag
     2041 ccacagctat gtgcgggcca ttgagaaagg ctgctcccag gacgacgagt gcgtgtccct
     2101 gaggtcgtcc tcgccgccgc gcaccaccac caccgttagg accatccaga gcagcacggt
     2161 gtcatcttgc attacaacat ataagaagac accacctcca gtcccaccca gaactaccac
     2221 gaaacctttc atttctatca cagcccagag tagcacagag tcagcccagg atgcctacat
     2281 ggacggacag ggccagcgag gagatattat cagccagtct ggactcagca actccaccga
     2341 gagcctggac agtatgaagg ctctgacagc cgccatcgaa gctgcaaacg cccagatcca
     2401 tggccctgcc agtcaacaca tgggcaataa cactgccacc gtcaccacca cgactaccat
     2461 agccaccgtc accacggagg acaggaagaa ggaccacttt aagaaaaatc gatgcctgtc
     2521 tatcgggata caggtggatg atgctgaaga acctgacaaa acaggggaga ataaagcacc
     2581 cagtaagttc cagtccgtgg gagtgcaagt agaagaagag aagtgcttcc gcaggttcac
     2641 tcgatccaac agtgtgacga cagcagtaca ggccgacctg gacttccatg ataatctgga
     2701 aaattctctg gaatctatag aggacaattc gtgtcctggc cccatggcca gacagttctc
     2761 ccgcgatgcc agcacctcca cagtcagcat tcagggctca ggaaaccatt accatgcctg
     2821 tgccgccgat gatgactttg acacggattt tgacccctct attctgcctc ctccggaccc
     2881 ctggattgac tctatcactg aagaccctct ggaggccgtg caaaggtcag tgtgccaccg
     2941 ggatggccac tggttcctga agcttctcca ggcagagcga gaccgcatgg aggggtggtg
     3001 tcaacagatg gagcgggaag aacgggaaaa caacctgccc gaagacattc taggaaaaat
     3061 ccgaaccgca gtgggcagtg cccaacttct catggcccag aaattctacc agttcagaga
     3121 actgtgtgaa gaaaacctga atcctaatgc tcatccaaga cccacctccc aggatttggc
     3181 ggggttttgg gacatgctgc agttgtccat agaaaatatt agtatgaaat ttgatgaact
     3241 tcatcagtta aaggccaata attggaaaca gatggatcct cttgacaaga aggagagaag
     3301 ggcccctcct ccagtgccaa agaagccggc gaagggcccc gcgccgctga tccgggagcg
     3361 ctcgctggag agctcgcagc gccaggaggc ccgcaagcgc ctgatggccg ccaagcgcgc
     3421 cgcgtccgtc cgccagaact cggccaccga gagcgccgag agcatcgaga tctacatccc
     3481 cgaggcgcag acccggctct gagcgccccg cagcccggcc gccgccgcca agcatctgtc
     3541 ccctcctccc ccggccgctc ctctgccggc tgcctctccc cctccgagcc cgtccgctcc
     3601 cgagctcggt gacttccact gtcgcggtgt agttgtccac ctcgcaggag ccgccccccg
     3661 ggcccccctc agccccccac ttcccgtacc cgtttgccca tctccttctt caccgagctt
     3721 cgccccctgt cctgatgccg tcgccctgcc tcatactgag atccaaccct ttattttctg
     3781 ggcaaagcca aacccacctg tgtagaagtg atgcctttag gtcacccgcc gtcctcagtt
     3841 ctctcgagct agtctgttca gcaatataaa accatagggt atttcagaaa tccagtatca
     3901 cagggtgatc ctttgggact taccgtcttc cacgtgaaag aaactaggcc tccgattccc
     3961 tttatttccc ctaaatggtt attcttttaa aaaagcagat ggagcacttt attcccaacc
     4021 tcagaaatca caccatctca ctggaatcca tgagggacac agagagaggg gaccaagcct
     4081 ggcctggggg tgggggacct ggatgtgtag caaggatggg agaagcgaaa tctgcaggtg
     4141 ctgggggcac ctgcacactc acagctgcac aaactgcctc actgttactt catcaatcac
     4201 agcttcaaat gtctcaatca gcagaagatt gtaaattcga tctttcaggg aaattaatct
     4261 attctgaaag gcaataacat gaagcaaggc aaaggaggca ctgatggttt agtatactac
     4321 ataagggatt tttttgttct attattaaga aaatctagac ctgaaatgtt ttctcaactc
     4381 ttattgtact gtgtatattt atattgttgt cgtggcggct gtttttaaag ggaaagtgtt
     4441 ggttctatta atttgttaag tgtccatcca ggtgggccta cctgattcca catatataag
     4501 tacatatctg cttataaagc gctgtaaatg gcagcaaggc tgtttttgga gaagagtttg
     4561 ggttttccta ccatcccttt gaatgctaca catccgtcta ttttaaccca agtagttcgt
     4621 atttcagata tattttctcc tttcatctcc tctcactact gcagagtcca gtaataccta
     4681 gcataggatt ctgtcctgtg tcaaatggct aaaataaatt tttgccccaa tagacatgct
     4741 gcctcattca aaagagctgc cgctgtcatc ttgaggttcc aggtagtgag agaagaaact
     4801 cgacctgcca gggtcaacag ccatgaagag gtggggggag tcatgattca taaacactga
     4861 aagaagtcaa ggcttttggc agagagtgtt gatttagatt tttagtcttg attgatgggc
     4921 agtatgcatc ggtgtctagc tgaagttgtc tttaaatgcc cttactcgtc acagtttaaa
     4981 cacttaggat gtggcaatct taagtatcaa tggcatttta tgtccagcta acatcctaaa
     5041 gcattagaaa ttaaaaacga aagactttta aaaacataca tcaaacatgc ttgcaccaga
     5101 gaagcttttt aaaataatac actctcatag ccaggtgcta atttaatttt acttatgaaa
     5161 ttaagagagg tgatgggttc tagcaacaga tattttcacg gacatattct aaaaccacta
     5221 gagaattcgc tacctctcag agccatcgat gctttgagct acctttataa acagggcaca
     5281 aatgtttact gctgtggttt acaagaaaag ggctactcac ttattttgaa accaacgaac
     5341 caacttttaa ctagggtgaa caaagcactc aaagtgcttt gtgaaattgg agcatacaga
     5401 gattttgagc ttcaagtatt tgctagtttt aaaaagaata caccttttct ttaccttgta
     5461 gcagcaatta aaagtcacac aaagcttgca tcgagtaggg ccaactgcca cttgggtagc
     5521 ctatggtcac attcaatact gagaatgact tggaactcac agattaatat gaaagaagca
     5581 gcgttcatcc caagacccat gctcacaatt acagctccgt gccctgaggt agagttgaga
     5641 tttggattaa gaaatagatt tctaatacga ctcaagatca tcctacaata ttttctttgg
     5701 aaactaattt agcccatgat attttaaaga gagacaagag aaggcctatt tatcttgtct
     5761 aagtgaacgg catttgtata ttcataagct atttttggta agaattttaa atcttttagc
     5821 tcaaggccta cagggcatca tgatctttgc cttccttgaa aatacaattt aaattgtaca
     5881 aacactttat aaaaagctaa ttattggtgt tagaacatga ccccacacaa tgctgcttga
     5941 cccctgaaac tgacattcat gagcataacc tttgttacat tgttcttttt gatgtaattt
     6001 gtagaaatgt tttttagttc gtaatggaaa atgtatgtac cctgaaaaat tacttatttt
     6061 gtttaacttt ggtataaagg tgttgggcat tttcttgggg agggggggat tacaaaagaa
     6121 gtttgtctcc cacatcaaaa aacgttcaaa gaaattaagt atttattata ttttttgcag
     6181 atgtttccat acaattcaca taaccttttt gtaaagagag atgaagaaat ggattaaaga
     6241 tttttaatat ttgaaatggt aaatagaact aatttattgt aatatatttc tgttatttat
     6301 agatgtttcc ttaatgtttt actgtgcatt accactttca tttaagcctt atccttgtga
     6361 atttaccatt tcttttttaa aacatgtcta gatgcatatt ttaaataact ggaatgtaaa
     6421 tcactagcat atctgaattc ccaaatgtaa tttttaaaaa ttattttggt ttggaaaaaa
     6481 aagattcatt tgaaagcctt cagatggagg ggtgggaaca tttttatggc tttatgaatt
     6541 ggaatttcat aggcttattt acctagattg tgtgtgaaca aaaaaatatt gtaaatagat
     6601 gaatgtttcc cataatgtaa aaagaagaaa ttaataaaat aattaatgca ctgct
//
