LOCUS       NM_001398545            2258 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens DLG associated protein 1 (DLGAP1), transcript variant
            28, mRNA.
ACCESSION   NM_001398545 XM_017026085
VERSION     NM_001398545.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2258)
  AUTHORS   Santanasto,A.J., Acharya,S., Wojczynski,M.K., Cvejkus,R.K., Lin,S.,
            Brent,M.R., Anema,J.A., Wang,L., Thyagarajan,B., Christensen,K.,
            Daw,E.W. and Zmuda,J.M.
  TITLE     Whole Genome Linkage and Association Analyses Identify DLG
            Associated Protein-1 as a Novel Positional and Biological Candidate
            Gene for Muscle Strength: The Long Life Family Study
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (8) (2024)
   PUBMED   38808484
  REMARK    GeneRIF: Whole Genome Linkage and Association Analyses Identify DLG
            Associated Protein-1 as a Novel Positional and Biological Candidate
            Gene for Muscle Strength: The Long Life Family Study.
REFERENCE   2  (bases 1 to 2258)
  AUTHORS   Switlik,W., Wyzewski,Z., Gregorczyk-Zboroch,K., Gietler,M.,
            Pudlarz,A., Szewinska,J., Orzechowski,S., Jakiela,S. and Szemraj,J.
  TITLE     Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small
            Cell Lung Cancer
  JOURNAL   Anticancer Res 44 (6), 2445-2451 (2024)
   PUBMED   38821626
  REMARK    GeneRIF: Deciphering the Role of miR-30a-5p and DLGAP1 Gene in
            Non-small Cell Lung Cancer.
REFERENCE   3  (bases 1 to 2258)
  AUTHORS   Liang,X., Zhao,Y., Fang,Z., Shao,N., Zhai,D., Zhang,M., Yu,L. and
            Shi,Y.
  TITLE     DLGAP1-AS2 promotes estrogen receptor signalling and confers
            tamoxifen resistance in breast cancer
  JOURNAL   Mol Biol Rep 49 (5), 3939-3947 (2022)
   PUBMED   35449318
  REMARK    GeneRIF: DLGAP1-AS2 promotes estrogen receptor signalling and
            confers tamoxifen resistance in breast cancer.
REFERENCE   4  (bases 1 to 2258)
  AUTHORS   Huang,T., Cao,L., Feng,N., Xu,B., Dong,Y. and Wang,M.
  TITLE     N6-methyladenosine (m6A)-mediated lncRNA DLGAP1-AS1enhances breast
            canceradriamycin resistance through miR-299-3p/WTAP feedback loop
  JOURNAL   Bioengineered 12 (2), 10935-10944 (2021)
   PUBMED   34866525
  REMARK    GeneRIF: N(6)-methyladenosine (m(6)A)-mediated lncRNA
            DLGAP1-AS1enhances breast canceradriamycin resistance through
            miR-299-3p/WTAP feedback loop.
REFERENCE   5  (bases 1 to 2258)
  AUTHORS   Takahashi,Y., Yamazaki,K., Kamatani,Y., Kubo,M., Matsuda,K. and
            Asai,S.
  TITLE     A genome-wide association study identifies a novel candidate locus
            at the DLGAP1 gene with susceptibility to resistant hypertension in
            the Japanese population
  JOURNAL   Sci Rep 11 (1), 19497 (2021)
   PUBMED   34593835
  REMARK    GeneRIF: A genome-wide association study identifies a novel
            candidate locus at the DLGAP1 gene with susceptibility to resistant
            hypertension in the Japanese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2258)
  AUTHORS   Hirao,K., Hata,Y., Ide,N., Takeuchi,M., Irie,M., Yao,I.,
            Deguchi,M., Toyoda,A., Sudhof,T.C. and Takai,Y.
  TITLE     A novel multiple PDZ domain-containing molecule interacting with
            N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
  JOURNAL   J Biol Chem 273 (33), 21105-21110 (1998)
   PUBMED   9694864
REFERENCE   7  (bases 1 to 2258)
  AUTHORS   Naisbitt,S., Kim,E., Weinberg,R.J., Rao,A., Yang,F.C., Craig,A.M.
            and Sheng,M.
  TITLE     Characterization of guanylate kinase-associated protein, a
            postsynaptic density protein at excitatory synapses that interacts
            directly with postsynaptic density-95/synapse-associated protein 90
  JOURNAL   J Neurosci 17 (15), 5687-5696 (1997)
   PUBMED   9221768
REFERENCE   8  (bases 1 to 2258)
  AUTHORS   Satoh,K., Yanai,H., Senda,T., Kohu,K., Nakamura,T., Okumura,N.,
            Matsumine,A., Kobayashi,S., Toyoshima,K. and Akiyama,T.
  TITLE     DAP-1, a novel protein that interacts with the guanylate
            kinase-like domains of hDLG and PSD-95
  JOURNAL   Genes Cells 2 (6), 415-424 (1997)
   PUBMED   9286858
REFERENCE   9  (bases 1 to 2258)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   10 (bases 1 to 2258)
  AUTHORS   Kim,E., Naisbitt,S., Hsueh,Y.P., Rao,A., Rothschild,A., Craig,A.M.
            and Sheng,M.
  TITLE     GKAP, a novel synaptic protein that interacts with the guanylate
            kinase-like domain of the PSD-95/SAP90 family of channel clustering
            molecules
  JOURNAL   J Cell Biol 136 (3), 669-678 (1997)
   PUBMED   9024696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005204.2, AP002478.3 and AP002472.2.
            
            On Dec 20, 2021 this sequence version replaced XM_017026085.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.78426.1,
                                           SRR1803617.1580.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AP005204.2         130910-131058       c
            150-364             AP005204.2         70815-71029         c
            365-542             AP002478.3         155489-155666       c
            543-783             AP002478.3         142289-142529       c
            784-1157            AP002472.2         102201-102574       c
            1158-1249           AP002472.2         87816-87907         c
            1250-1671           AP002472.2         54520-54941         c
            1672-1763           AP002472.2         28896-28987         c
            1764-2258           AP002472.2         22477-22971         c
FEATURES             Location/Qualifiers
     source          1..2258
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..2258
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="DLG associated protein 1"
                     /db_xref="GeneID:9229"
                     /db_xref="HGNC:HGNC:2905"
                     /db_xref="MIM:605445"
     exon            1..149
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1982
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="isoform 26 is encoded by transcript variant 28;
                     disks large-associated protein 1; SAP90/PSD-95-associated
                     protein 1; PSD-95/SAP90 binding protein 1; guanylate
                     kinase-associated protein; discs large homolog associated
                     protein 1"
                     /codon_start=1
                     /product="disks large-associated protein 1 isoform 26"
                     /protein_id="NP_001385474.1"
                     /db_xref="GeneID:9229"
                     /db_xref="HGNC:HGNC:2905"
                     /db_xref="MIM:605445"
                     /translation="MIDLFKAEWVSSVCVQVSRNGRTDQVPQDEWTGYTPRGKDDEIP
                     CRRMRSGSYIKAMGDEDSGDSDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEH
                     SPKLQIRSHSYLRAVSEVSINRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEM
                     EVNGQFESVCESVFSELESQAVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLR
                     SSSPPRTTTTVRTIQSSTVSSCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAY
                     MDGQGQRGDIISQSGLSNSTESLDSMKALTAAIEAANAQIHGPASQHMGNNTATVTTT
                     TTIATVTTEDRKKDHFKKNRCLSIGIQVDDAEEPDKTGENKAPSKFQSVGVQVEEEKC
                     FRRFTRSNSVTTAVQADLDFHDNLENSLESIEDNSCPGPMARQFSRDASTSTVSIQGS
                     GNHYHACAADDDFDTDFDPSILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQA
                     ERDRMEGWCQQMEREERENNLPEDILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPN
                     AHPRPTSQDLAGFWDMLQLSIENISMKFDELHQLKANNWKQMDPLDKKVEQCRFCMVH
                     LKTCTNTGQSK"
     exon            150..364
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            365..542
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            543..783
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            784..1157
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1249
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1671
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1672..1763
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..2258
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2201
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="major polyA site"
     regulatory      2233..2238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2258
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
ORIGIN      
        1 agagggagcg agagagagag caagacagac cgagaaggaa agcactccca gagatgaaat
       61 tttaggaaag caaaatgatc gaccttttta aggctgagtg ggtttcttca gtttgtgtgc
      121 aagtttcaag aaatggaagg actgaccagg ttccacaaga tgaatggaca gggtacaccc
      181 cacgaggtaa agatgatgaa attccatgcc gaagaatgcg gagtggcagt tatatcaagg
      241 ccatggggga tgaagacagt ggagactcag acacgagtcc taagccttct ccaaaagttg
      301 ctgcgcggag agaaagctat ctcaaggcta ctcagccatc ccttacagaa ctcaccacac
      361 tcaaaatctc caatgaacac tcacccaaac tccagatccg gagtcatagt tacctgaggg
      421 cagtgagtga agtctccatc aaccggagcc tggacagcct ggaccctgca ggcttgctca
      481 catcaccaaa gttccgctcc aggaatgaga gctacatgcg agccatgagc accatcagcc
      541 aggtgagcga gatggaagtg aacgggcagt tcgagtccgt gtgcgagtcc gtgttcagcg
      601 agctggagtc gcaggccgtg gaagcgctgg acctgcccat gcccggctgc ttccgcatgc
      661 ggagccacag ctatgtgcgg gccattgaga aaggctgctc ccaggacgac gagtgcgtgt
      721 ccctgaggtc gtcctcgccg ccgcgcacca ccaccaccgt taggaccatc cagagcagca
      781 cggtgtcatc ttgcattaca acatataaga agacaccacc tccagtccca cccagaacta
      841 ccacgaaacc tttcatttct atcacagccc agagtagcac agagtcagcc caggatgcct
      901 acatggacgg acagggccag cgaggagata ttatcagcca gtctggactc agcaactcca
      961 ccgagagcct ggacagtatg aaggctctga cagccgccat cgaagctgca aacgcccaga
     1021 tccatggccc tgccagtcaa cacatgggca ataacactgc caccgtcacc accacgacta
     1081 ccatagccac cgtcaccacg gaggacagga agaaggacca ctttaagaaa aatcgatgcc
     1141 tgtctatcgg gatacaggtg gatgatgctg aagaacctga caaaacaggg gagaataaag
     1201 cacccagtaa gttccagtcc gtgggagtgc aagtagaaga agagaagtgc ttccgcaggt
     1261 tcactcgatc caacagtgtg acgacagcag tacaggccga cctggacttc catgataatc
     1321 tggaaaattc tctggaatct atagaggaca attcgtgtcc tggccccatg gccagacagt
     1381 tctcccgcga tgccagcacc tccacagtca gcattcaggg ctcaggaaac cattaccatg
     1441 cctgtgccgc cgatgatgac tttgacacgg attttgaccc ctctattctg cctcctccgg
     1501 acccctggat tgactctatc actgaagacc ctctggaggc cgtgcaaagg tcagtgtgcc
     1561 accgggatgg ccactggttc ctgaagcttc tccaggcaga gcgagaccgc atggaggggt
     1621 ggtgtcaaca gatggagcgg gaagaacggg aaaacaacct gcccgaagac attctaggaa
     1681 aaatccgaac cgcagtgggc agtgcccaac ttctcatggc ccagaaattc taccagttca
     1741 gagaactgtg tgaagaaaac ctgaatccta atgctcatcc aagacccacc tcccaggatt
     1801 tggcggggtt ttgggacatg ctgcagttgt ccatagaaaa tattagtatg aaatttgatg
     1861 aacttcatca gttaaaggcc aataattgga aacagatgga tcctcttgac aagaaggtag
     1921 aacaatgtag attttgtatg gttcatttaa aaacctgcac aaacactgga cagtctaaat
     1981 aggcttctgc attcagtcct gctgtttaca atgtgaaatg gagctgatat catattaatt
     2041 tcattgtaat gacaatgttt acatagtaat catttgggat attatctgta atatgtttca
     2101 ggcatatttt taaagaaaaa cctgtctttg tgaattggaa aatgggaatg tggctttttt
     2161 tgttaattaa actttaagtt aaaccatttt agtcactgga aggaactgcc tccattttgc
     2221 tttttaaact aaaataaatg acatcttcag tgcatgaa
//
