LOCUS       NM_001398537            2372 bp    mRNA    linear   PRI 07-AUG-2024
DEFINITION  Homo sapiens DLG associated protein 1 (DLGAP1), transcript variant
            21, mRNA.
ACCESSION   NM_001398537
VERSION     NM_001398537.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2372)
  AUTHORS   Santanasto,A.J., Acharya,S., Wojczynski,M.K., Cvejkus,R.K., Lin,S.,
            Brent,M.R., Anema,J.A., Wang,L., Thyagarajan,B., Christensen,K.,
            Daw,E.W. and Zmuda,J.M.
  TITLE     Whole Genome Linkage and Association Analyses Identify DLG
            Associated Protein-1 as a Novel Positional and Biological Candidate
            Gene for Muscle Strength: The Long Life Family Study
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (8) (2024)
   PUBMED   38808484
  REMARK    GeneRIF: Whole Genome Linkage and Association Analyses Identify DLG
            Associated Protein-1 as a Novel Positional and Biological Candidate
            Gene for Muscle Strength: The Long Life Family Study.
REFERENCE   2  (bases 1 to 2372)
  AUTHORS   Switlik,W., Wyzewski,Z., Gregorczyk-Zboroch,K., Gietler,M.,
            Pudlarz,A., Szewinska,J., Orzechowski,S., Jakiela,S. and Szemraj,J.
  TITLE     Deciphering the Role of miR-30a-5p and DLGAP1 Gene in Non-small
            Cell Lung Cancer
  JOURNAL   Anticancer Res 44 (6), 2445-2451 (2024)
   PUBMED   38821626
  REMARK    GeneRIF: Deciphering the Role of miR-30a-5p and DLGAP1 Gene in
            Non-small Cell Lung Cancer.
REFERENCE   3  (bases 1 to 2372)
  AUTHORS   Liang,X., Zhao,Y., Fang,Z., Shao,N., Zhai,D., Zhang,M., Yu,L. and
            Shi,Y.
  TITLE     DLGAP1-AS2 promotes estrogen receptor signalling and confers
            tamoxifen resistance in breast cancer
  JOURNAL   Mol Biol Rep 49 (5), 3939-3947 (2022)
   PUBMED   35449318
  REMARK    GeneRIF: DLGAP1-AS2 promotes estrogen receptor signalling and
            confers tamoxifen resistance in breast cancer.
REFERENCE   4  (bases 1 to 2372)
  AUTHORS   Huang,T., Cao,L., Feng,N., Xu,B., Dong,Y. and Wang,M.
  TITLE     N6-methyladenosine (m6A)-mediated lncRNA DLGAP1-AS1enhances breast
            canceradriamycin resistance through miR-299-3p/WTAP feedback loop
  JOURNAL   Bioengineered 12 (2), 10935-10944 (2021)
   PUBMED   34866525
  REMARK    GeneRIF: N(6)-methyladenosine (m(6)A)-mediated lncRNA
            DLGAP1-AS1enhances breast canceradriamycin resistance through
            miR-299-3p/WTAP feedback loop.
REFERENCE   5  (bases 1 to 2372)
  AUTHORS   Takahashi,Y., Yamazaki,K., Kamatani,Y., Kubo,M., Matsuda,K. and
            Asai,S.
  TITLE     A genome-wide association study identifies a novel candidate locus
            at the DLGAP1 gene with susceptibility to resistant hypertension in
            the Japanese population
  JOURNAL   Sci Rep 11 (1), 19497 (2021)
   PUBMED   34593835
  REMARK    GeneRIF: A genome-wide association study identifies a novel
            candidate locus at the DLGAP1 gene with susceptibility to resistant
            hypertension in the Japanese population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2372)
  AUTHORS   Hirao,K., Hata,Y., Ide,N., Takeuchi,M., Irie,M., Yao,I.,
            Deguchi,M., Toyoda,A., Sudhof,T.C. and Takai,Y.
  TITLE     A novel multiple PDZ domain-containing molecule interacting with
            N-methyl-D-aspartate receptors and neuronal cell adhesion proteins
  JOURNAL   J Biol Chem 273 (33), 21105-21110 (1998)
   PUBMED   9694864
REFERENCE   7  (bases 1 to 2372)
  AUTHORS   Naisbitt,S., Kim,E., Weinberg,R.J., Rao,A., Yang,F.C., Craig,A.M.
            and Sheng,M.
  TITLE     Characterization of guanylate kinase-associated protein, a
            postsynaptic density protein at excitatory synapses that interacts
            directly with postsynaptic density-95/synapse-associated protein 90
  JOURNAL   J Neurosci 17 (15), 5687-5696 (1997)
   PUBMED   9221768
REFERENCE   8  (bases 1 to 2372)
  AUTHORS   Satoh,K., Yanai,H., Senda,T., Kohu,K., Nakamura,T., Okumura,N.,
            Matsumine,A., Kobayashi,S., Toyoshima,K. and Akiyama,T.
  TITLE     DAP-1, a novel protein that interacts with the guanylate
            kinase-like domains of hDLG and PSD-95
  JOURNAL   Genes Cells 2 (6), 415-424 (1997)
   PUBMED   9286858
REFERENCE   9  (bases 1 to 2372)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   10 (bases 1 to 2372)
  AUTHORS   Kim,E., Naisbitt,S., Hsueh,Y.P., Rao,A., Rothschild,A., Craig,A.M.
            and Sheng,M.
  TITLE     GKAP, a novel synaptic protein that interacts with the guanylate
            kinase-like domain of the PSD-95/SAP90 family of channel clustering
            molecules
  JOURNAL   J Cell Biol 136 (3), 669-678 (1997)
   PUBMED   9024696
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005204.2, AP002478.3 and AP002472.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.51259.1,
                                           SRR1660805.18623.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AP005204.2         130910-131058       c
            150-263             AP005204.2         78648-78761         c
            264-478             AP005204.2         70815-71029         c
            479-656             AP002478.3         155489-155666       c
            657-897             AP002478.3         142289-142529       c
            898-1271            AP002472.2         102201-102574       c
            1272-1363           AP002472.2         87816-87907         c
            1364-1785           AP002472.2         54520-54941         c
            1786-1877           AP002472.2         28896-28987         c
            1878-2372           AP002472.2         22477-22971         c
FEATURES             Location/Qualifiers
     source          1..2372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.31"
     gene            1..2372
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="DLG associated protein 1"
                     /db_xref="GeneID:9229"
                     /db_xref="HGNC:HGNC:2905"
                     /db_xref="MIM:605445"
     exon            1..149
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..2096
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="isoform 19 is encoded by transcript variant 21;
                     disks large-associated protein 1; SAP90/PSD-95-associated
                     protein 1; PSD-95/SAP90 binding protein 1; guanylate
                     kinase-associated protein; discs large homolog associated
                     protein 1"
                     /codon_start=1
                     /product="disks large-associated protein 1 isoform 19"
                     /protein_id="NP_001385466.1"
                     /db_xref="GeneID:9229"
                     /db_xref="HGNC:HGNC:2905"
                     /db_xref="MIM:605445"
                     /translation="MIDLFKAEWVSSVCVQVSRNGRTDQSKLKRLKGHLSQVAFVKVK
                     AVWSRKAVLPAAKKMQRNRVPQDEWTGYTPRGKDDEIPCRRMRSGSYIKAMGDEDSGD
                     SDTSPKPSPKVAARRESYLKATQPSLTELTTLKISNEHSPKLQIRSHSYLRAVSEVSI
                     NRSLDSLDPAGLLTSPKFRSRNESYMRAMSTISQVSEMEVNGQFESVCESVFSELESQ
                     AVEALDLPMPGCFRMRSHSYVRAIEKGCSQDDECVSLRSSSPPRTTTTVRTIQSSTVS
                     SCITTYKKTPPPVPPRTTTKPFISITAQSSTESAQDAYMDGQGQRGDIISQSGLSNST
                     ESLDSMKALTAAIEAANAQIHGPASQHMGNNTATVTTTTTIATVTTEDRKKDHFKKNR
                     CLSIGIQVDDAEEPDKTGENKAPSKFQSVGVQVEEEKCFRRFTRSNSVTTAVQADLDF
                     HDNLENSLESIEDNSCPGPMARQFSRDASTSTVSIQGSGNHYHACAADDDFDTDFDPS
                     ILPPPDPWIDSITEDPLEAVQRSVCHRDGHWFLKLLQAERDRMEGWCQQMEREERENN
                     LPEDILGKIRTAVGSAQLLMAQKFYQFRELCEENLNPNAHPRPTSQDLAGFWDMLQLS
                     IENISMKFDELHQLKANNWKQMDPLDKKVEQCRFCMVHLKTCTNTGQSK"
     exon            150..263
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            264..478
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..656
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            657..897
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1271
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1363
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1785
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1877
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2372
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="hexamer: ATTAAA"
     polyA_site      2315
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="major polyA site"
     regulatory      2347..2352
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
                     /note="hexamer: AATAAA"
     polyA_site      2372
                     /gene="DLGAP1"
                     /gene_synonym="DAP-1; DAP-1-ALPHA; DAP-1-BETA; DAP1;
                     DLGAP1A; DLGAP1B; GKAP; SAPAP1"
ORIGIN      
        1 agagggagcg agagagagag caagacagac cgagaaggaa agcactccca gagatgaaat
       61 tttaggaaag caaaatgatc gaccttttta aggctgagtg ggtttcttca gtttgtgtgc
      121 aagtttcaag aaatggaagg actgaccaga gcaagctaaa aaggctaaag ggacatttaa
      181 gccaagtcgc atttgtcaag gtgaaagctg tgtggagcag aaaagcagtt ctcccagctg
      241 caaagaagat gcaaagaaat cgagttccac aagatgaatg gacagggtac accccacgag
      301 gtaaagatga tgaaattcca tgccgaagaa tgcggagtgg cagttatatc aaggccatgg
      361 gggatgaaga cagtggagac tcagacacga gtcctaagcc ttctccaaaa gttgctgcgc
      421 ggagagaaag ctatctcaag gctactcagc catcccttac agaactcacc acactcaaaa
      481 tctccaatga acactcaccc aaactccaga tccggagtca tagttacctg agggcagtga
      541 gtgaagtctc catcaaccgg agcctggaca gcctggaccc tgcaggcttg ctcacatcac
      601 caaagttccg ctccaggaat gagagctaca tgcgagccat gagcaccatc agccaggtga
      661 gcgagatgga agtgaacggg cagttcgagt ccgtgtgcga gtccgtgttc agcgagctgg
      721 agtcgcaggc cgtggaagcg ctggacctgc ccatgcccgg ctgcttccgc atgcggagcc
      781 acagctatgt gcgggccatt gagaaaggct gctcccagga cgacgagtgc gtgtccctga
      841 ggtcgtcctc gccgccgcgc accaccacca ccgttaggac catccagagc agcacggtgt
      901 catcttgcat tacaacatat aagaagacac cacctccagt cccacccaga actaccacga
      961 aacctttcat ttctatcaca gcccagagta gcacagagtc agcccaggat gcctacatgg
     1021 acggacaggg ccagcgagga gatattatca gccagtctgg actcagcaac tccaccgaga
     1081 gcctggacag tatgaaggct ctgacagccg ccatcgaagc tgcaaacgcc cagatccatg
     1141 gccctgccag tcaacacatg ggcaataaca ctgccaccgt caccaccacg actaccatag
     1201 ccaccgtcac cacggaggac aggaagaagg accactttaa gaaaaatcga tgcctgtcta
     1261 tcgggataca ggtggatgat gctgaagaac ctgacaaaac aggggagaat aaagcaccca
     1321 gtaagttcca gtccgtggga gtgcaagtag aagaagagaa gtgcttccgc aggttcactc
     1381 gatccaacag tgtgacgaca gcagtacagg ccgacctgga cttccatgat aatctggaaa
     1441 attctctgga atctatagag gacaattcgt gtcctggccc catggccaga cagttctccc
     1501 gcgatgccag cacctccaca gtcagcattc agggctcagg aaaccattac catgcctgtg
     1561 ccgccgatga tgactttgac acggattttg acccctctat tctgcctcct ccggacccct
     1621 ggattgactc tatcactgaa gaccctctgg aggccgtgca aaggtcagtg tgccaccggg
     1681 atggccactg gttcctgaag cttctccagg cagagcgaga ccgcatggag gggtggtgtc
     1741 aacagatgga gcgggaagaa cgggaaaaca acctgcccga agacattcta ggaaaaatcc
     1801 gaaccgcagt gggcagtgcc caacttctca tggcccagaa attctaccag ttcagagaac
     1861 tgtgtgaaga aaacctgaat cctaatgctc atccaagacc cacctcccag gatttggcgg
     1921 ggttttggga catgctgcag ttgtccatag aaaatattag tatgaaattt gatgaacttc
     1981 atcagttaaa ggccaataat tggaaacaga tggatcctct tgacaagaag gtagaacaat
     2041 gtagattttg tatggttcat ttaaaaacct gcacaaacac tggacagtct aaataggctt
     2101 ctgcattcag tcctgctgtt tacaatgtga aatggagctg atatcatatt aatttcattg
     2161 taatgacaat gtttacatag taatcatttg ggatattatc tgtaatatgt ttcaggcata
     2221 tttttaaaga aaaacctgtc tttgtgaatt ggaaaatggg aatgtggctt tttttgttaa
     2281 ttaaacttta agttaaacca ttttagtcac tggaaggaac tgcctccatt ttgcttttta
     2341 aactaaaata aatgacatct tcagtgcatg aa
//
