LOCUS       NM_004747               7644 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens discs large MAGUK scaffold protein 5 (DLG5), mRNA.
ACCESSION   NM_004747
VERSION     NM_004747.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7644)
  AUTHORS   Song,X.Q., Li,Q. and Zhang,J.
  TITLE     A double-edged sword: DLG5 in diseases
  JOURNAL   Biomed Pharmacother 162, 114611 (2023)
   PUBMED   37001186
  REMARK    GeneRIF: A double-edged sword: DLG5 in diseases.
            Review article
REFERENCE   2  (bases 1 to 7644)
  AUTHORS   Kundu,S., Nandhu,M.S., Longo,S.L., Longo,J.A., Rai,S., Chin,L.S.,
            Richardson,T.E. and Viapiano,M.S.
  TITLE     The scaffolding protein DLG5 promotes glioblastoma growth by
            controlling Sonic Hedgehog signaling in tumor stem cells
  JOURNAL   Neuro Oncol 24 (8), 1230-1242 (2022)
   PUBMED   34984467
  REMARK    GeneRIF: The scaffolding protein DLG5 promotes glioblastoma growth
            by controlling Sonic Hedgehog signaling in tumor stem cells.
REFERENCE   3  (bases 1 to 7644)
  AUTHORS   Andolfi,C., Tiribelli,C. and Pascut,D.
  TITLE     Recent Hints on the Dual Role of Discs Large MAGUK Scaffold Protein
            5 in Cancers and in Hepatocellular Carcinoma
  JOURNAL   Front Biosci (Landmark Ed) 27 (5), 164 (2022)
   PUBMED   35638431
  REMARK    GeneRIF: Recent Hints on the Dual Role of Discs Large MAGUK
            Scaffold Protein 5 in Cancers and in Hepatocellular Carcinoma.
            Review article
REFERENCE   4  (bases 1 to 7644)
  AUTHORS   Marquez,J., Mann,N., Arana,K., Deniz,E., Ji,W., Konstantino,M.,
            Mis,E.K., Deshpande,C., Jeffries,L., McGlynn,J., Hugo,H.,
            Widmeier,E., Konrad,M., Tasic,V., Morotti,R., Baptista,J.,
            Ellard,S., Lakhani,S.A., Hildebrandt,F. and Khokha,M.K.
  TITLE     DLG5 variants are associated with multiple congenital anomalies
            including ciliopathy phenotypes
  JOURNAL   J Med Genet 58 (7), 453-464 (2021)
   PUBMED   32631816
  REMARK    GeneRIF: DLG5 variants are associated with multiple congenital
            anomalies including ciliopathy phenotypes.
REFERENCE   5  (bases 1 to 7644)
  AUTHORS   Liu,J., Li,J., Li,P., Jiang,Y., Chen,H., Wang,R., Cao,F. and Liu,P.
  TITLE     DLG5 suppresses breast cancer stem cell-like characteristics to
            restore tamoxifen sensitivity by inhibiting TAZ expression
  JOURNAL   J Cell Mol Med 23 (1), 512-521 (2019)
   PUBMED   30450766
  REMARK    GeneRIF: Down-regulated DLG5 expression increases the stemness of
            breast cancer cells by enhancing TAZ expression, contributing to
            TAM resistance in breast cancer.
REFERENCE   6  (bases 1 to 7644)
  AUTHORS   Wakabayashi,M., Ito,T., Mitsushima,M., Aizawa,S., Ueda,K.,
            Amachi,T. and Kioka,N.
  TITLE     Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate
            kinase family protein, with vinexin and beta-catenin at sites of
            cell-cell contact
  JOURNAL   J Biol Chem 278 (24), 21709-21714 (2003)
   PUBMED   12657639
  REMARK    GeneRIF: findings suggest that lp-dlg/KIAA0583 is a novel
            scaffolding protein that can link the vinexin-vinculin complex and
            beta-catenin at sites of cell-cell contact
REFERENCE   7  (bases 1 to 7644)
  AUTHORS   Purmonen,S., Ahola,T.M., Pennanen,P., Aksenov,N., Zhuang,Y.H.,
            Tuohimaa,P. and Ylikomi,T.
  TITLE     HDLG5/KIAA0583, encoding a MAGUK-family protein, is a primary
            progesterone target gene in breast cancer cells
  JOURNAL   Int J Cancer 102 (1), 1-6 (2002)
   PUBMED   12353226
REFERENCE   8  (bases 1 to 7644)
  AUTHORS   Shah,G., Brugada,R., Gonzalez,O., Czernuszewicz,G., Gibbs,R.A.,
            Bachinski,L. and Roberts,R.
  TITLE     The cloning, genomic organization and tissue expression profile of
            the human DLG5 gene
  JOURNAL   BMC Genomics 3, 6 (2002)
   PUBMED   11876824
  REMARK    Erratum:[BMC Genomics. 2002 Jun 11;3:14. doi:
            10.1186/1471-2164-3-14.. PMID: 12060488]
REFERENCE   9  (bases 1 to 7644)
  AUTHORS   Bowles,K.R., Abraham,S.E., Brugada,R., Zintz,C., Comeaux,J.,
            Sorajja,D., Tsubata,S., Li,H., Brandon,L., Gibbs,R.A.,
            Scherer,S.E., Bowles,N.E. and Towbin,J.A.
  TITLE     Construction of a high-resolution physical map of the chromosome
            10q22-q23 dilated cardiomyopathy locus and analysis of candidate
            genes
  JOURNAL   Genomics 67 (2), 109-127 (2000)
   PUBMED   10903836
REFERENCE   10 (bases 1 to 7644)
  AUTHORS   Nakamura,H., Sudo,T., Tsuiki,H., Miyake,H., Morisaki,T., Sasaki,J.,
            Masuko,N., Kochi,M., Ushio,Y. and Saya,H.
  TITLE     Identification of a novel human homolog of the Drosophila dlg,
            P-dlg, specifically expressed in the gland tissues and interacting
            with p55
  JOURNAL   FEBS Lett 433 (1-2), 63-67 (1998)
   PUBMED   9738934
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391421.27, AB011155.2,
            AK122931.1 and BC030250.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004747.3.
            
            Summary: This gene encodes a member of the family of discs large
            (DLG) homologs, a subset of the membrane-associated guanylate
            kinase (MAGUK) superfamily. The MAGUK proteins are composed of a
            catalytically inactive guanylate kinase domain, in addition to PDZ
            and SH3 domains, and are thought to function as scaffolding
            molecules at sites of cell-cell contact. The protein encoded by
            this gene localizes to the plasma membrane and cytoplasm, and
            interacts with components of adherens junctions and the
            cytoskeleton. It is proposed to function in the transmission of
            extracellular signals to the cytoskeleton and in the maintenance of
            epithelial cell structure. Alternative splice variants have been
            described but their biological nature has not been determined.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146794.1, AB011155.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372391.7/ ENSP00000361467.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AL391421.27        120746-120910       c
            166-653             AB011155.2         31-518
            654-654             AL391421.27        51002-51002         c
            655-2580            AB011155.2         520-2445
            2581-5086           AK122931.1         2348-4853
            5087-5739           AB011155.2         4952-5604
            5740-7644           BC030250.1         2398-4302
FEATURES             Location/Qualifiers
     source          1..7644
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..7644
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /note="discs large MAGUK scaffold protein 5"
                     /db_xref="GeneID:9231"
                     /db_xref="HGNC:HGNC:2904"
                     /db_xref="MIM:604090"
     exon            1..539
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     CDS             236..5995
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /note="discs large protein LP-DLG; large type of P-DLG;
                     placenta and prostate DLG; discs large protein P-dlg;
                     discs, large homolog 5"
                     /codon_start=1
                     /product="disks large homolog 5"
                     /protein_id="NP_004738.3"
                     /db_xref="CCDS:CCDS7353.2"
                     /db_xref="GeneID:9231"
                     /db_xref="HGNC:HGNC:2904"
                     /db_xref="MIM:604090"
                     /translation="MEPQRRELLAQCQQSLAQAMTEVEAVLGLLEAAGALSPGERRQL
                     DEEAGGAKAELLLKLLLAKERDHFQDLRAALEKTQPHLLPILYLNGVVGPPQPAEGAG
                     STYSVLSTMPSDSESSSSLSSVGTTGKAPSPPPLLTDQQVNEKVENLSIQLRLMTRER
                     NELRKRLAFATHGTAFDKRPYHRLNPDYERLKIQCVRAMSDLQSLQNQHTNALKRCEE
                     VAKETDFYHTLHSRLLSDQTRLKDDVDMLRRENGQLLRERNLLQQSWEDMKRLHEEDQ
                     KEIGDLRAQQQQVLKHNGSSEILNKLYDTAMDKLEVVKKDYDALRKRYSEKVAIHNAD
                     LSRLEQLGEENQRLLKQTEMLTQQRDTAIQLQHQCALSLRRFEAIHHELNKATAQNKD
                     LQWEMELLQSELTELRTTQVKTAKESEKYREERDAVYSEYKLIMSERDQVISELDKLQ
                     TEVELAESKLKSSTSEKKAANEEMEALRQIKDTVTMDAGRANKEVEILRKQCKALCQE
                     LKEALQEADVAKCRRDWAFQERDKIVAERDSIRTLCDNLRRERDRAVSELAEALRSLD
                     DTRKQKNDVSRELKELKEQMESQLEKEARFRQLMAHSSHDSAIDTDSMEWETEVVEFE
                     RETEDIDLKALGFDMAEGVNEPCFPGDCGIFVTKVDKGSIADGRLRVNDWLLRINDVD
                     LINKDKKQAIKALLNGEGAINMVVRRRKSLGGKVVTPLHINLSGQKDSGISLENGVYA
                     AAVLPGSPAAKEGSLAVGDRIVAINGIALDNKSLNECESLLRSCQDSLTLSLLKVFPQ
                     SSSWSGQNIFENIKDSDKMLSFRAHGPEVQAHNKRNLIQHNNSTQTDIFYTDRLEDRK
                     EPGPPGGSSSFLHKPFPGGPLQVCPQACPSASERSLSSFRSDASGDRGFGLVDVRGRR
                     PLLPFETEVGPCGVGEASLDKADSEGSNSGGTWPKAMLSSTAVPEKLSVYKKPKQRKS
                     IFDPNTFKRPQTPPKIDYLLPGPGPAHSPQPSKRAGPLTPPKPPRRSDSIKFQHRLET
                     SSESEATLVGSSPSTSPPSALPPDVDPGEPMHASPPRKARVRIASSYYPEGDGDSSHL
                     PAKKSCDEDLTSQKVDELGQKRRRPKSAPSFRPKLAPVVIPAQFLEEQKCVPASGELS
                     PELQEWAPYSPGHSSRHSNPPLYPSRPSVGTVPRSLTPSTTVSSILRNPIYTVRSHRV
                     GPCSSPPAARDAGPQGLHPSVQHQGRLSLDLSHRTCSDYSEMRATHGSNSLPSSARLG
                     SSSNLQFKAERIKIPSTPRYPRSVVGSERGSVSHSECSTPPQSPLNIDTLSSCSQSQT
                     SASTLPRIAVNPASLGERRKDRPYVEEPRHVKVQKGSEPLGISIVSGEKGGIYVSKVT
                     VGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPHVHQLSS
                     HSRSSSHLDPAGTHSTLQGSGTTTPEHPSVIDPLMEQDEGPSTPPAKQSSSRIAGDAN
                     KKTLEPRVVFIKKSQLELGVHLCGGNLHGVFVAEVEDDSPAKGPDGLVPGDLILEYGS
                     LDVRNKTVEEVYVEMLKPRDGVRLKVQYRPEEFTKAKGLPGDSFYIRALYDRLADVEQ
                     ELSFKKDDILYVDDTLPQGTFGSWMAWQLDENAQKIQRGQIPSKYVMDQEFSRRLSMS
                     EVKDDNSATKTLSAAARRSFFRRKHKHKRSGSKDGKDLLALDAFSSDSIPLFEDSVSL
                     AYQRVQKVDCTALRPVLILGPLLDVVKEMLVNEAPGKFCRCPLEVMKASQQAIERGVK
                     DCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDIAPHAIERLHHMHIYPIVIFIHY
                     KSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEYSRYFTGVIQGGALSSICTQI
                     LAMVNQEQNKVLWIPACPL"
     exon            540..608
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            609..771
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            772..915
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1099
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1359
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1672
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1857
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1858..1983
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            1984..2116
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2117..2244
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2420
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2524
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2525..2617
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..3637
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            3638..3761
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            3762..3906
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4019
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4020..4109
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4260
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4261..4423
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4424..4557
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4558..4698
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4699..4882
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            4883..5031
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5202
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5203..5399
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5543
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5544..5671
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5672..5781
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5782..5891
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     exon            5892..7644
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7624..7629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /note="hexamer: AATAAA"
     polyA_site      7644
                     /gene="DLG5"
                     /gene_synonym="LP-DLG; P-DLG5; PDLG; YUVOB"
                     /note="major polyA site"
ORIGIN      
        1 cagtcccgcc gccgcggcag ccaacatggc tgcgctccgg agcccgggag gcggccgctg
       61 ctgagcgccg cccgccgccc cgggccccca gcccgcccag gccccggccc atggctcccg
      121 ccgcctcacg gctcccggcg ccctagggct gctgccgagg tgctcgcctg cccgcccgcc
      181 ggcctcgggg ggcccgggag gcgtccggcg gggcggggcg gcgcggcccg ccaccatgga
      241 gccccagcgc cgggagctgc tcgcccagtg tcagcagagc ctggcccagg ccatgacgga
      301 ggtggaagcc gtgctcgggc tgctcgaggc cgcgggagcg ctcagtcccg gcgagcggcg
      361 gcagctggac gaggaggcgg gaggcgccaa ggcggagctg ctgctcaagc tgctcttggc
      421 caaggagcgg gaccacttcc aggacctgcg ggcggcgctg gagaagacgc agcctcacct
      481 gctgcccatt ctctacctga acggcgtcgt cgggccgccg cagcccgccg aaggcgcggg
      541 ttctacctac agcgtcctgt ccaccatgcc ctcagactca gaaagcagca gctccctcag
      601 cagtgtgggc actaccggga aggcgccgtc cccaccaccc ctcctcactg accagcaagt
      661 gaatgagaag gtggagaacc tctccattca gctgcggctg atgacccggg agagaaacga
      721 gctccgcaag cgcctggcct ttgctacgca tggcacggcc tttgacaaga ggccctacca
      781 caggctgaat cctgactatg agaggctgaa gatccagtgc gtgcgagcca tgtcggacct
      841 gcagagcctg cagaaccagc acaccaacgc cttgaagagg tgtgaggagg tggccaagga
      901 gactgacttc taccacacac tccacagccg gctcctgagt gaccagactc ggctgaagga
      961 tgacgtggac atgctgaggc gggagaatgg gcagctgctg cgggagcgaa acctgctgca
     1021 gcagtcatgg gaggacatga agcggctcca cgaggaggac cagaaggaga tcggtgacct
     1081 ccgtgcccag cagcagcagg tgttgaagca caacgggtca tccgagattc tcaacaaact
     1141 gtatgacacg gccatggaca agttggaggt ggtcaagaag gactatgacg cccttcggaa
     1201 gaggtacagt gagaaagtcg ccatccacaa tgcagacctg agccgcctgg agcagctggg
     1261 ggaggagaac cagcggttgc tgaagcagac agagatgctg acccagcaga gggacacggc
     1321 catccagctg cagcaccagt gcgccctctc cctgaggagg tttgaggcga tccaccatga
     1381 gctgaacaag gccacggcgc agaacaagga cctgcagtgg gagatggagc tgctgcagtc
     1441 agagctgacc gagctgagaa ccacgcaggt gaagacagca aaggagtcgg agaaatacag
     1501 ggaggagcgg gacgctgtgt acagcgagta caagctcatc atgagtgagc gtgaccaggt
     1561 catctctgag ctggacaagc tgcagaccga agtggagctg gccgagtcca agctcaagag
     1621 cagcacatct gagaagaagg cggccaatga ggagatggag gcgctgcggc agatcaaaga
     1681 cacggtgaca atggatgctg ggagagccaa caaggaggtt gaaatccttc gaaagcagtg
     1741 caaggctctg tgccaggagc tgaaggaagc cctccaggag gcggatgtgg ccaagtgccg
     1801 gcgggactgg gccttccagg agcgagacaa gattgtagca gagcgtgaca gcatccggac
     1861 actgtgtgac aacctgaggc gggagcggga ccgtgcggtg agcgagctgg ctgaggccct
     1921 gcgcagcctg gatgacaccc gcaagcagaa gaatgatgtc agccgcgagc tgaaggagct
     1981 caaggaacag atggaatccc agttggaaaa ggaggcccgg ttccgacagc tgatggccca
     2041 cagctcccac gactcggcca ttgacacgga ttccatggag tgggaaacgg aagttgtaga
     2101 gttcgagagg gagacggagg atattgactt gaaggcactg gggtttgata tggcagaagg
     2161 tgtgaatgag ccttgtttcc cgggggactg tggcatattt gtcactaaag tggacaaagg
     2221 aagcattgct gatggccgct taagggtcaa tgactggctg ctgagaatca acgatgtgga
     2281 cctcatcaac aaggacaaga agcaggccat caaggcgctc ctcaatgggg agggggccat
     2341 caacatggtc gtgcggcgga ggaagtccct gggtgggaag gtggtcacgc cgctgcacat
     2401 caacctcagt ggacagaaag acagtggcat cagtctggag aatggagtgt atgctgccgc
     2461 tgtgctgcct ggaagccctg ccgctaaaga agggtccctt gctgtgggag acaggatcgt
     2521 tgcgatcaat ggcattgcac tggacaacaa gtctctgaat gaatgtgaat ctctgctgcg
     2581 cagctgccag gactccctga ccctgtccct cctgaaggta ttccctcaga gctcctcgtg
     2641 gagtggccag aacatttttg aaaatatcaa agactctgat aagatgctga gttttcgagc
     2701 ccatggcccg gaggtccagg ctcataacaa acggaacttg atacagcaca ataactccac
     2761 gcagacagac atcttctaca cggacaggct ggaagacagg aaggagccag gccccccagg
     2821 aggcagcagc tcctttctgc ataagccatt ccctggggga cccttgcagg tctgccccca
     2881 ggcctgtccc agtgcctctg agcgtagcct gagctccttc cgctcagatg cctctgggga
     2941 ccgtggcttt gggctggtgg acgtgcgtgg ccggcggcca ctgctgccct ttgagaccga
     3001 ggtgggcccc tgtggggttg gggaggcctc cctggacaag gcagactctg aaggctccaa
     3061 cagcggcggg acctggccca aggccatgct cagctccacg gcagtgcctg agaagctctc
     3121 tgtttataaa aagccaaagc aaagaaagtc catctttgac cctaacactt tcaaacgccc
     3181 ccagacaccc cccaaaatag actacctgct tccaggtcct gggcctgctc actctcccca
     3241 gccctccaag agggcggggc ctctgacacc cccaaaacct cccagaagga gcgactccat
     3301 taagttccag cacaggctgg agactagctc cgagtcagaa gccactctgg tgggcagctc
     3361 cccatccact agtcccccga gcgccctgcc ccctgacgtg gaccccgggg agcccatgca
     3421 cgcatcaccc cctcgcaagg ccagggtccg cattgcttcc agctactacc ctgaaggaga
     3481 tggggactcc tcccacctgc cggccaagaa atcctgtgat gaggacctca cctcccagaa
     3541 ggtggatgag ctggggcaga agcgtcgccg gccaaaatct gctcccagtt ttcggccgaa
     3601 gcttgctcca gtagtgattc ctgctcagtt cctggaggaa cagaagtgtg tcccggccag
     3661 tggagaactc tccccggagc tccaggagtg ggcaccttac tcgcctgggc attccagccg
     3721 gcacagcaac cccccgctat accctagcag gccgtctgtg ggcactgttc cccggagttt
     3781 gacccccagc accactgtga gctccatcct gcggaacccc atctacactg tgcgcagtca
     3841 cagggtcggc ccctgcagct ctccacctgc ggcccgagat gctggccccc agggtttgca
     3901 tcccagtgtc cagcaccagg gacgcctgag cctggacctg agccacagga cctgcagcga
     3961 ctactccgag atgagagcca cccatgggtc caactcactg ccctccagcg cccgcctggg
     4021 ttcttcgagt aacttgcagt tcaaggcgga acgcattaaa atcccatcaa caccaagata
     4081 tccgcggagt gtcgtgggct ccgagagagg ttcagtgtca cattctgaat gcagcactcc
     4141 tccacagtca cccctgaaca tcgacaccct gtcctcttgt agccagtccc agacctcagc
     4201 ctccacattg cccagaatcg ctgtcaaccc cgcgtccctc ggggagcgga gaaaggacag
     4261 gccttatgtg gaggagccac gccacgtgaa ggtgcagaag ggctcagagc cgctgggcat
     4321 ctccatcgtg agtggagaga agggcggcat ctacgtctcc aaggtgaccg tggggagcat
     4381 cgctcaccag gctggcctcg agtatgggga tcagttactg gagttcaacg gcataaacct
     4441 gcggagcgcc acggagcagc aggcgcggct catcatcggg cagcagtgtg ataccatcac
     4501 catcctggcc cagtacaacc cccacgtgca ccagctcagc agccactccc ggtccagctc
     4561 acacctggac cctgccggta cccactccac tctccagggc agtggcacca ccaccccgga
     4621 gcatccatct gtcatcgacc cactgatgga gcaggacgag gggcctagca cccccccagc
     4681 caagcagagc agctccagga ttgcgggaga tgccaacaag aagaccctgg agccacgcgt
     4741 tgtcttcatc aaaaagtccc agctggagct tggggtgcac ttgtgtggtg ggaacctgca
     4801 tggggtgttt gtggccgagg tggaggatga cagtcctgcc aagggtcctg acggcctcgt
     4861 gccaggggac ctcatcctgg agtatggcag cctggacgtg cggaacaaga cagtggagga
     4921 agtctatgtg gagatgctga agcccaggga tggcgtccgc ctgaaggtgc agtaccgccc
     4981 tgaggagttc acgaaggcca agggcctgcc tggtgacagc ttctacatca gggccctgta
     5041 cgaccggctg gcagatgtgg agcaagagtt gagctttaag aaggacgaca tcctctacgt
     5101 ggatgacacc ttaccccagg gcacgttcgg gtcctggatg gcttggcagc tggacgagaa
     5161 tgcccagaag atccagcgcg ggcagattcc cagcaaatat gtgatggacc aagaattctc
     5221 caggaggctc agcatgtctg aagtcaaaga tgacaatagc gccacaaaga cgctgtcagc
     5281 ggctgcacgc cggtcctttt ttcggaggaa acacaagcac aaacgcagcg ggtccaagga
     5341 cgggaaagac ctgctcgcct tggatgcctt ttccagtgac tccattccac tctttgaaga
     5401 ttcggtgagc ctggcctatc agcgggtcca gaaggtggac tgcaccgctc tgaggcctgt
     5461 cctgattctg gggcctttgc tggacgtggt gaaggagatg ctggtgaatg aggctcctgg
     5521 caagttctgc agatgtcccc ttgaggtgat gaaggcctcc cagcaggcca ttgagcgggg
     5581 tgtcaaagat tgcctgtttg tcgactataa gcggagaagc ggccatttcg atgtgaccac
     5641 tgtggcgtca ataaaggaga tcacagaaaa gaaccgacac tgcctcctgg acattgctcc
     5701 gcacgctatt gagcggctcc accacatgca catctacccc attgtcatct tcatccacta
     5761 caagagcgcc aagcacatca aggagcagag agaccccatc tacctgaggg acaaggtgac
     5821 tcagaggcat tccaaagagc agtttgaggc ggcgcagaag cttgagcagg agtacagcag
     5881 gtacttcaca ggggtcatcc agggaggagc cctgtcaagc atttgcactc agatcttggc
     5941 aatggtcaat caagaacaaa ataaagtcct gtggattcca gcctgcccgc tctaggagaa
     6001 tgctgtgctg tggatgactg cagctggccg cctgagggga caccagactc agctcttttc
     6061 tagcgactga aagtagaagt ctgtccgtct atgaacatgc gggggaagga tccggaacca
     6121 ggacccagaa gcacctcctt tgtagacaga gggccacggc tgcgtgcgat ccaggcccag
     6181 gcccacacac tctgcccgtg tcacacgtgt gctttaacac aaaacagata acactaaaga
     6241 cgggttcagc acccaccttt ctttagccag ctgatcagag atgctgcaaa gagaaccttt
     6301 cggatcactc gtttacaagc cttttctaag tatttggtgg tttatgttta cttgaacggc
     6361 tccatgttgc cggtgcccag cccctgtccc ctctgtcaac cccctgtcgc tttggtgttg
     6421 gtttcgttcc cgtcttcagc aaaacgacct tggaacctca atgggggctg ctttgctttg
     6481 ggaggttctt gttggtggga ccagagcttt gacaaacctc ctgctccttg gtggcacctc
     6541 tcctggaagg acgtcacaac tccaggtgct cagactgcct gtggcagcag aaccagtgcc
     6601 tttggcattt tcctcccaca atggggaagg tgactttggc attcttacaa actcgtctct
     6661 cggcctttct ctcctgcctt ccacagcctc tcgtttctcc tccatctgtg cttattactt
     6721 gaggactgtg tctgctccgt gagagctgcg tgggcagggc tgcagtgggg tccaggtggt
     6781 gttcagctgt gctgatgcct gccattgggt cctccttagg ctctgtaagt cgtgacagcc
     6841 ttcatcagtg caatgtttgc agggtaattc ttaaactttt tagagggtgg caggtacatc
     6901 agttcttttt gatatgaaaa cattcatgtt tcagacattg aattgagagc ttttagggga
     6961 agcataatgg ttattgtcac tatcaacagt ctaaaaagaa aaactgaggt ctttttaatc
     7021 ttgattacag cactcacggc atgcacccta ctcagtgtgg gtgtcttcgt ttgggggctt
     7081 tttttttttt tgcacttctg aggctagata tgtctggctg aagatttgat gtggttcctc
     7141 cttaagctat gcgtcctgtt aataataggt actgtactgg gctctgtgta agtgtcgttg
     7201 gggtaggacc tatattttaa tactgttcct aacatttcat tttactagcg agaaatcttt
     7261 gatttcattt tattctttgt aattctagac actagattgt agtttagcca taactgatgt
     7321 tttttaaaaa gggatatatt ttcttgcaca gttgttcaaa aaagagacaa gtttcagtcc
     7381 tcaatgctgt cctttgtttt acaggtacaa gttttctagc tcagacaaac tatgaaaaac
     7441 tgtagactat tctcaaggta ttaactcgca gaccctctgg gggtaggggc tgttttctaa
     7501 gttacaggca gagtgggact gagatggtac agtgtgcaca gacaggtact gagctgacag
     7561 actgggattt tctgtactaa aatgttactt tgtatcaaaa gttaaacagg ctttagtaca
     7621 acaaataaag gtcaatttct gtaa
//
