LOCUS       NM_001321075            6176 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens discs large MAGUK scaffold protein 4 (DLG4),
            transcript variant 4, mRNA.
ACCESSION   NM_001321075 XM_005256492
VERSION     NM_001321075.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6176)
  AUTHORS   Fadahunsi,N., Petersen,J., Metz,S., Jakobsen,A., Vad Mathiesen,C.,
            Silke Buch-Rasmussen,A., Kurgan,N., Kjaergaard Larsen,J.,
            Andersen,R.C., Topilko,T., Svendsen,C., Apuschkin,M., Skovbjerg,G.,
            Hendrik Schmidt,J., Houser,G., Elgaard Jager,S., Bach,A.,
            Deshmukh,A.S., Kilpelainen,T.O., Stromgaard,K., Madsen,K.L. and
            Clemmensen,C.
  TITLE     Targeting postsynaptic glutamate receptor scaffolding proteins
            PSD-95 and PICK1 for obesity treatment
  JOURNAL   Sci Adv 10 (9), eadg2636 (2024)
   PUBMED   38427737
  REMARK    GeneRIF: Targeting postsynaptic glutamate receptor scaffolding
            proteins PSD-95 and PICK1 for obesity treatment.
REFERENCE   2  (bases 1 to 6176)
  AUTHORS   Shen,Z., Sun,D., Savastano,A., Varga,S.J., Cima-Omori,M.S.,
            Becker,S., Honigmann,A. and Zweckstetter,M.
  TITLE     Multivalent Tau/PSD-95 interactions arrest in vitro condensates and
            clusters mimicking the postsynaptic density
  JOURNAL   Nat Commun 14 (1), 6839 (2023)
   PUBMED   37891164
  REMARK    GeneRIF: Multivalent Tau/PSD-95 interactions arrest in vitro
            condensates and clusters mimicking the postsynaptic density.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6176)
  AUTHORS   Shimizu,H. and Hohjoh,H.
  TITLE     FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile
            X syndrome, are involved in the ubiquitin-proteasome system
  JOURNAL   Sci Rep 13 (1), 1956 (2023)
   PUBMED   36732356
  REMARK    GeneRIF: FMRP, FXR1 protein and Dlg4 mRNA, which are associated
            with fragile X syndrome, are involved in the ubiquitin-proteasome
            system.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6176)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6176)
  AUTHORS   Kivisakk,P., Carlyle,B.C., Sweeney,T., Quinn,J.P., Ramirez,C.E.,
            Trombetta,B.A., Mendes,M., Brock,M., Rubel,C., Czerkowicz,J.,
            Graham,D. and Arnold,S.E.
  TITLE     Increased levels of the synaptic proteins PSD-95, SNAP-25, and
            neurogranin in the cerebrospinal fluid of patients with Alzheimer's
            disease
  JOURNAL   Alzheimers Res Ther 14 (1), 58 (2022)
   PUBMED   35461266
  REMARK    GeneRIF: Increased levels of the synaptic proteins PSD-95, SNAP-25,
            and neurogranin in the cerebrospinal fluid of patients with
            Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6176)
  AUTHORS   Niethammer,M., Kim,E. and Sheng,M.
  TITLE     Interaction between the C terminus of NMDA receptor subunits and
            multiple members of the PSD-95 family of membrane-associated
            guanylate kinases
  JOURNAL   J Neurosci 16 (7), 2157-2163 (1996)
   PUBMED   8601796
REFERENCE   7  (bases 1 to 6176)
  AUTHORS   Williams,C.L., Phelps,S.H. and Porter,R.A.
  TITLE     Expression of Ca2+/calmodulin-dependent protein kinase types II and
            IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent
            protein kinase inhibitor KN-62
            (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenyl
            piperazine) in small cell lung carcinoma
  JOURNAL   Biochem Pharmacol 51 (5), 707-715 (1996)
   PUBMED   8615909
REFERENCE   8  (bases 1 to 6176)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   9  (bases 1 to 6176)
  AUTHORS   Kornau,H.C., Schenker,L.T., Kennedy,M.B. and Seeburg,P.H.
  TITLE     Domain interaction between NMDA receptor subunits and the
            postsynaptic density protein PSD-95
  JOURNAL   Science 269 (5231), 1737-1740 (1995)
   PUBMED   7569905
REFERENCE   10 (bases 1 to 6176)
  AUTHORS   Tumer,Z., Dye,T.J., Prada,C., White-Brown,A.M., MacKenzie,A. and
            Levy,A.M.
  TITLE     DLG4-Related Synaptopathy
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   37347881
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC336011.1, AK293835.1,
            BC030203.1, BG059570.1 and AC120057.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 8, 2019 this sequence version replaced NM_001321075.2.
            
            Summary: This gene encodes a member of the membrane-associated
            guanylate kinase (MAGUK) family. It heteromultimerizes with another
            MAGUK protein, DLG2, and is recruited into NMDA receptor and
            potassium channel clusters. These two MAGUK proteins may interact
            at postsynaptic sites to form a multimeric scaffold for the
            clustering of receptors, ion channels, and associated signaling
            proteins. Multiple transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293835.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399506.9/ ENSP00000382425.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DC336011.1         6-6
            2-2708              AK293835.1         1-2707
            2709-3215           BC030203.1         1130-1636
            3216-3470           BG059570.1         1-255               c
            3471-6176           AC120057.9         141333-144038       c
FEATURES             Location/Qualifiers
     source          1..6176
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..6176
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /note="discs large MAGUK scaffold protein 4"
                     /db_xref="GeneID:1742"
                     /db_xref="HGNC:HGNC:2903"
                     /db_xref="MIM:602887"
     exon            1..510
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     CDS             481..2655
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /note="isoform 4 is encoded by transcript variant 4; disks
                     large homolog 4; Tax interaction protein 15; post-synaptic
                     density protein 95; synapse-associated protein 90; discs
                     large homolog 4"
                     /codon_start=1
                     /product="disks large homolog 4 isoform 4"
                     /protein_id="NP_001308004.1"
                     /db_xref="CCDS:CCDS82050.1"
                     /db_xref="GeneID:1742"
                     /db_xref="HGNC:HGNC:2903"
                     /db_xref="MIM:602887"
                     /translation="MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDT
                     LEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPG
                     GAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVME
                     IKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSV
                     GLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSS
                     YLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGE
                     GIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQY
                     KPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQ
                     ALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWG
                     SSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHT
                     TRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGK
                     HCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQ
                     EFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL"
     exon            511..576
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            577..630
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            631..690
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            691..815
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            816..985
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1122
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1267
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1563
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1666
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1781
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1958
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..1995
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2023
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2071
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..2173
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2346
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2456
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2548
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..6176
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3473
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /note="major polyA site"
     regulatory      6159..6164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
                     /note="hexamer: AATAAA"
     polyA_site      6176
                     /gene="DLG4"
                     /gene_synonym="MRD62; PSD95; SAP-90; SAP90"
ORIGIN      
        1 cctcctctct ccccttccct cttcggctcc acggctccct cggccgctgc cgtttccaac
       61 ccccccaccc cactcccccg ccacggcccc tagcccctgg ccgtttggca agaccccccc
      121 ctaccccggg gctccccgaa atccagttcc cctcccccac cccagctcat gccccagccc
      181 ccgaactccg gggctgccag cccccggtgc ccccgcccct cctgagaatc ggggtgtgct
      241 ccccaagccc cctcccctcc actggggagc cccttttagg gcccccttcc cctccctccc
      301 acgctcccct ccccttccct tctccaaccc cctccttccc ctctcacccc tccccccatc
      361 ctggcccccc ctgcaaaagt ggggtgcgga ggggggaggg gtgagaaccc acggagggga
      421 ggaacgaaac tccgatgaag tcagagcccc ttacccgccg ccgcggccag gccccccaac
      481 atggactgtc tctgtatagt gacaaccaag aaataccgct accaagatga agacacgccc
      541 cctctggagc acagcccggc ccacctcccc aaccaggcca attctccccc agtgattgtc
      601 aacacagata ccctagaagc cccaggatat gagttgcagg tgaacgggac cgagggggag
      661 atggaatacg aggaaatcac attggaaagg ggtaactcag gtctgggctt cagcatcgca
      721 ggtggcactg acaacccaca catcggtgac gacccatcca ttttcatcac caagatcatt
      781 cctggtgggg ctgcggccca ggatggccgc ctcagggtca acgacagcat cctgtttgta
      841 aatgaagtgg acgtgcgcga ggtgacccac tcagcggcgg tggaagccct caaagaggca
      901 ggctccatcg ttcgcctcta tgtcatgcgc cggaagcccc cggctgagaa ggtcatggag
      961 atcaagctca tcaaggggcc taaaggtctt ggcttcagca tcgcaggggg cgtagggaac
     1021 cagcacatcc caggagataa tagcatctat gtaacaaaga tcatcgaagg gggtgctgcc
     1081 cacaaggatg ggaggttgca gattggagac aagatcctgg cggtcaacag tgtggggcta
     1141 gaggacgtca tgcatgaaga tgctgtggca gccctgaaga acacgtatga tgttgtctac
     1201 ctaaaggtgg ccaagcccag caatgcctac ctgagtgaca gctatgctcc cccagacatc
     1261 acaacctctt attcccagca cctggacaat gagatcagtc acagcagcta cctgggcacc
     1321 gactacccca cagccatgac ccccacttcc cctcggcgct actctccagt ggccaaggac
     1381 ctgctcgggg aggaagacat tccccgagaa ccgaggcgaa ttgtgatcca ccggggctcc
     1441 acgggcctgg gcttcaacat cgtgggtggc gaggacggtg aaggcatctt catctccttt
     1501 atcctggccg ggggccctgc agacctcagt ggggagctgc ggaaggggga ccagatcctg
     1561 tcggtcaacg gtgtggacct ccgaaatgcc agccatgagc aggctgccat tgccctgaag
     1621 aatgcgggtc agacggtcac gatcatcgct cagtataaac cagaagagta cagccgattc
     1681 gaggccaaga tccacgacct tcgggaacag ctcatgaaca gcagcctggg ctcagggact
     1741 gcgtccctgc ggagcaaccc caaaaggggt ttctacatca gggccctgtt tgattacgac
     1801 aagaccaagg actgcggctt cctgagccag gccctgagct tccgctttgg ggatgtgctg
     1861 catgtcatcg atgctagtga tgaggagtgg tggcaggcac ggcgggtcca ctctgacagt
     1921 gagaccgacg acattgggtt catccccagc aaacggcggg ttgagcgacg agagtggtca
     1981 aggttaaagg ccaaggactg gggctccagc tctggatcgc agggtcgaga agactcggtt
     2041 ctgagctacg agacagtgac gcagatggaa gtgcactatg ctcgccccat catcatcctt
     2101 gggcccacca aggaccgcgc caacgatgat cttctctccg agttccccga caagtttgga
     2161 tcctgtgttc cccatacgac acggcccaag cgggagtatg agatagatgg ccgggattac
     2221 cactttgtgt cgtcccggga gaaaatggag aaggacattc aggcgcacaa gttcattgag
     2281 gccggccagt acaacagcca cctctatggg accagcgtcc agtccgtgcg agaggtggca
     2341 gagcagggga agcactgcat cctcgatgtc tcggccaatg ccgtgcggcg gctgcaggcg
     2401 gcccacctgc accccatcgc catcttcatc cgcccccgct ccctggagaa tgtgctagag
     2461 attaacaagc ggatcacaga ggagcaagcc cgcaaagcct tcgacagagc caccaagctg
     2521 gagcaggagt tcacagagtg cttctcagcc atcgtggagg gtgacagctt tgaggagatc
     2581 taccacaagg tgaagcgtgt catcgaggac ctctcaggcc cctacatctg ggttccagcc
     2641 cgagagagac tctgattcct gccctggctt ggcctggact cgccctgcct ccatcacctg
     2701 ggcccttggt ctggactgaa ttgcccaagc ccttggctcc ccccggcctc cctcccaccc
     2761 cttcttattt atttcctttc taactggatc cagcctgttg gaggggggac actcctctgc
     2821 atgtatcccc gcaccccaga actgggctcc tgaacgccag gaacctgggg tctggggggg
     2881 agctgggctc cttgttccga gcccttgctc cttaggatcc ccgcccccac ctgcccccaa
     2941 tgcacacaca gacccaccgg gggccacctg ccctccccca tcctctccca cacacattcc
     3001 agaagtcagg gccccctcga ggagcacccg ctgcagggat gcagggccac aggcctccgc
     3061 tctctcctaa ggcagggtct ggggtcaccc ctgccctcat cgtaattccc catgttcctt
     3121 gatttctcat ttattttttc cacttttttt cttctcaaag gtggtttttt ggggggagaa
     3181 gcaggggact ccgcagcggg cccctgcctt ccacatgccc ccaccatttt tctttgccgg
     3241 tttgcatgag tggaaggtct aaatgtggct tttttttttt tttttcctgg gaattttttt
     3301 ggggaaaagg gagggatggg tctagggagt gggaaatgcg ggagggaggg tggggggcag
     3361 gggtcggggg tcgggtgtcc gggagccagg gaagactgga aatgctgccg ccttctgcaa
     3421 tttatttatt tttttctttt gagagagtga aaggaagaga cagatacttg aaacttggtg
     3481 tgtggcctgg ttatttggga cctgggtgtg gagggagatg ggcgcagcag agtcagatcc
     3541 ttcttcactc caagccagag aggttagtgg cctggaaaat gggccaggga ggtaactggc
     3601 aaatcaagga acccgagttg gtgaagactg agcctgggaa ggtctggagc tctgtccaaa
     3661 gtcatgacag gccagaaagg ggaggctgga acttgtctgg ggccctgcag acttagtcca
     3721 gctctgatcc ctgccgggct gtctcagtcc tgttgggaag cacaacagtc cttaaaggaa
     3781 aatagagagg aaacttcgtt cattcatgtt catggagttg tggacagagc taggatctgg
     3841 aaatgatttt ttttgttttt ttgttttttt ttttgagaca gagtcttgct ctgtcgcaca
     3901 ggctggagtg cagtggctcg atctcggctc actgtgatct ctgccaccct ggttcaagtg
     3961 attctcctgc ctcagccccc tgagtagctg ggattacaga ttactgccac catgcctggc
     4021 taattttgta tttttagtag agatggggtt tcaccatgtt ggtcaggctg gtcttgaact
     4081 cctgaccttg ttatccaccc gcctcagcct cccaaagtgc tgggattaca ggcgtgagcc
     4141 accgcgcctg gcctggaaat gatctttaca gagttctgct gataagaact gctgtgtgaa
     4201 tatacgctag gtttctttat gcgccccccc cacccttttt tttttttttt tgagacagag
     4261 tttcgctctt tcgctcaggc tggagtgctg tggtgcgatc ttggctcact gcaacctctg
     4321 cctgctgggt tcacacggtt ctcctgcctc agcctctcga atagctggga ttacaggcgc
     4381 ctgccaccac tcctggctaa tttttgtatt tttagtagag atggggtttt gctttgttgg
     4441 ccaggctggt ctcgaactcc tgacctcagg tgatccgccc agcttggcct cccacagtgt
     4501 taagattaca ggcatgagcc actacgccca gcctttatgt cctatctcta tgggaaagat
     4561 ctgaggcagc tttgtaaata atgagggtag gaaaataaga atctaaatgc caaagatgaa
     4621 aactggagaa atgtatatga actgtgaggg taaatgtgat ctctgagctt cctgatagcc
     4681 atggcaaaaa aggaaattgt caattaccta cttctttatt ataagggaga aataatttta
     4741 gttcttttag ggagtcatat tttcctggcc ctaagtccta actgaagctc ctgagatcct
     4801 gctatgtaga atggtgactc tcagccttct gccttcttca tgtgtttggc acagatgaac
     4861 ctttgggggc acctgctggg gtactattcc tttctctgat tctcaggtgc tccagtgggt
     4921 aaggctgagg cagagggccc taagagttat ggtggttaaa tcccaaacag tgcaaaaggg
     4981 cattttttgt agccactcct gactaaagtt gagagtttca tgcaaaagac caacccaggg
     5041 gtagtgattc tgtggatggc atggccgtcc aagcctaaag tagtccaaga atagaggcag
     5101 agattgctga aggggtgtca cttcaaccag tagccacgta ttgccctgca ggattttcta
     5161 tgcaggaccg agtccatcag gatcctgggg atagggacca ggggtctgca tttctggaaa
     5221 gctcccgggt gattttgatg tctcactggg tggagaagca ctgcttcaga ggattttttt
     5281 tttttttttt ttgaggtcga gtttcacttt tgttgcccaa gctggagtgc aatggcgcga
     5341 tctcggctca ctgcaacctc caactccagg gttcaagtga ttctcctgcc tcagcttccc
     5401 aagtagctgg gattacagat gcgtgccata acacacagct attttttaat atttttagta
     5461 gaaacggggt ttcaccatgt tagccaagct ggtctcaaac tcttgacctc aggtgatctg
     5521 cccgccttgg cctcccaaag tgctgggatt acaggcgtga gccactgcac ctggccctga
     5581 tgtttttcaa ataatccttc tcttagcttg gttctgtgta atagcagatg gcttgaggct
     5641 gtgataacgt tctctatcgt gagctgaagg gagaaatcta ggagctgagg aaggtgtgtg
     5701 caggtaatgc gtctgcgtgt taaactagaa ggggcagaat cacatatttg acctggatgg
     5761 ggtagaatca cataattttg catgtattat tattattatt attattatta ttattggaga
     5821 cagagtttcg ctcttgttgc ccaggctgga gtgcagtggt gcgatctctg ctcactgcaa
     5881 cctctgcctt ccggattcaa gctattctcc tgcctcagcc tcccgagtag ctgggattac
     5941 aggtgcatgc caccacgccc agctaatttt ttgtatttag tagagatggg gatttcacca
     6001 tattgatcag gctggtctcg aactcctgac ctcgggtgat ccaccccccc ccccctcggc
     6061 ctcccaaagt gctaggatta caggcatgag ccaccgcgcc tggcctgcat gcattatttt
     6121 gtaaattata atcagtacac gtacctgaca acaattcaaa taaatataga aataca
//
