LOCUS       NM_021120               6042 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens discs large MAGUK scaffold protein 3 (DLG3),
            transcript variant 1, mRNA.
ACCESSION   NM_021120
VERSION     NM_021120.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6042)
  AUTHORS   Huyghebaert,J., Mateiu,L., Elinck,E., Van Rossem,K.E.,
            Christiaenssen,B., D'Incal,C.P., McCormack,M.K., Lazzarini,A.,
            Vandeweyer,G. and Kooy,R.F.
  TITLE     Identification of a DLG3 stop mutation in the MRX20 family
  JOURNAL   Eur J Hum Genet 32 (3), 317-323 (2024)
   PUBMED   38273165
  REMARK    GeneRIF: Identification of a DLG3 stop mutation in the MRX20
            family.
REFERENCE   2  (bases 1 to 6042)
  AUTHORS   Li,D., Hu,X., Yu,S., Deng,S., Yan,M., Sun,F., Song,J. and Tang,L.
  TITLE     Silence of lncRNA MIAT-mediated inhibition of DLG3 promoter
            methylation suppresses breast cancer progression via the Hippo
            signaling pathway
  JOURNAL   Cell Signal 73, 109697 (2020)
   PUBMED   32593652
  REMARK    GeneRIF: Silence of lncRNA MIAT-mediated inhibition of DLG3
            promoter methylation suppresses breast cancer progression via the
            Hippo signaling pathway.
REFERENCE   3  (bases 1 to 6042)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 6042)
  AUTHORS   Liu,J., Li,P., Wang,R., Li,J., Zhang,M., Song,Z. and Liu,P.
  TITLE     High expression of DLG3 is associated with decreased survival from
            breast cancer
  JOURNAL   Clin Exp Pharmacol Physiol 46 (10), 937-943 (2019)
   PUBMED   31271664
  REMARK    GeneRIF: High expression of DLG3 is associated with decreased
            survival from breast cancer.
REFERENCE   5  (bases 1 to 6042)
  AUTHORS   Stathakis,D.G., Lee,D. and Bryant,P.J.
  TITLE     DLG3, the gene encoding human neuroendocrine Dlg (NE-Dlg), is
            located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1
  JOURNAL   Genomics 49 (2), 310-313 (1998)
   PUBMED   9598320
REFERENCE   6  (bases 1 to 6042)
  AUTHORS   Irie,M., Hata,Y., Takeuchi,M., Ichtchenko,K., Toyoda,A., Hirao,K.,
            Takai,Y., Rosahl,T.W. and Sudhof,T.C.
  TITLE     Binding of neuroligins to PSD-95
  JOURNAL   Science 277 (5331), 1511-1515 (1997)
   PUBMED   9278515
REFERENCE   7  (bases 1 to 6042)
  AUTHORS   Makino,K., Kuwahara,H., Masuko,N., Nishiyama,Y., Morisaki,T.,
            Sasaki,J., Nakao,M., Kuwano,A., Nakata,M., Ushio,Y. and Saya,H.
  TITLE     Cloning and characterization of NE-dlg: a novel human homolog of
            the Drosophila discs large (dlg) tumor suppressor protein interacts
            with the APC protein
  JOURNAL   Oncogene 14 (20), 2425-2433 (1997)
   PUBMED   9188857
REFERENCE   8  (bases 1 to 6042)
  AUTHORS   Takeuchi,M., Hata,Y., Hirao,K., Toyoda,A., Irie,M. and Takai,Y.
  TITLE     SAPAPs. A family of PSD-95/SAP90-associated proteins localized at
            postsynaptic density
  JOURNAL   J Biol Chem 272 (18), 11943-11951 (1997)
   PUBMED   9115257
REFERENCE   9  (bases 1 to 6042)
  AUTHORS   Lau,L.F., Mammen,A., Ehlers,M.D., Kindler,S., Chung,W.J.,
            Garner,C.C. and Huganir,R.L.
  TITLE     Interaction of the N-methyl-D-aspartate receptor complex with a
            novel synapse-associated protein, SAP102
  JOURNAL   J Biol Chem 271 (35), 21622-21628 (1996)
   PUBMED   8702950
REFERENCE   10 (bases 1 to 6042)
  AUTHORS   Muller,B.M., Kistner,U., Kindler,S., Chung,W.J., Kuhlendahl,S.,
            Fenster,S.D., Lau,L.F., Veh,R.W., Huganir,R.L., Gundelfinger,E.D.
            and Garner,C.C.
  TITLE     SAP102, a novel postsynaptic protein that interacts with NMDA
            receptor complexes in vivo
  JOURNAL   Neuron 17 (2), 255-265 (1996)
   PUBMED   8780649
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL139398.20, AB209328.1,
            BC093866.1, AB033058.1 and CK300381.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021120.3.
            
            Summary: This gene encodes a member of the membrane-associated
            guanylate kinase protein family. The encoded protein may play a
            role in clustering of NMDA receptors at excitatory synapses. It may
            also negatively regulate cell proliferation through interaction
            with the C-terminal region of the adenomatosis polyposis coli tumor
            suppressor protein. Mutations in this gene have been associated
            with X-linked cognitive disability. Alternatively spliced
            transcript variants have been described. [provided by RefSeq, Oct
            2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.216999.1, U49089.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374360.8/ ENSP00000363480.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL139398.20        67247-67266
            21-319              AB209328.1         1-299
            320-2898            BC093866.1         1-2579
            2899-5432           AB033058.1         1932-4465
            5433-6042           CK300381.1         14-623              c
FEATURES             Location/Qualifiers
     source          1..6042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..6042
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /note="discs large MAGUK scaffold protein 3"
                     /db_xref="GeneID:1741"
                     /db_xref="HGNC:HGNC:2902"
                     /db_xref="MIM:300189"
     exon            1..724
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..2821
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /note="isoform a is encoded by transcript variant 1; disks
                     large homolog 3; neuroendocrine-DLG; protein phosphatase
                     1, regulatory subunit 82; synapse-associated protein 102;
                     discs, large homolog 3"
                     /codon_start=1
                     /product="disks large homolog 3 isoform a"
                     /protein_id="NP_066943.2"
                     /db_xref="CCDS:CCDS14403.1"
                     /db_xref="GeneID:1741"
                     /db_xref="HGNC:HGNC:2902"
                     /db_xref="MIM:300189"
                     /translation="MHKHQHCCKCPECYEVTRLAALRRLEPPGYGDWQVPDPYGPGGG
                     NGASAGYGGYSSQTLPSQAGATPTPRTKAKLIPTGRDVGPVPPKPVPGKSTPKLNGSG
                     PSWWPECTCTNRDWYEQVNGSDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGI
                     FITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVRRRQ
                     PPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGD
                     RLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALA
                     DNHISHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKG
                     STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAA
                     ALKRAGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRA
                     LFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKR
                     VEKKERARLKTVKFHARTGMIESNRDFPGLSDDYYGAKNLKGQEDAILSYEPVTRQEI
                     HYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQM
                     EKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIA
                     IFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIK
                     QIIEDQSGHYIWVPSPEKL"
     exon            725..775
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            776..900
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1070
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1207
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1352
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1512
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1669
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1772
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..1887
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2064
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2140
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2186
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2237
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2339
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2512
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2622
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2714
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..6042
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4898..4903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /note="hexamer: AATAAA"
     polyA_site      4919
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /note="major polyA site"
     regulatory      6018..6023
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
                     /note="hexamer: AATAAA"
     polyA_site      6042
                     /gene="DLG3"
                     /gene_synonym="MRX; MRX90; NEDLG; PPP1R82; SAP102; XLID90;
                     XLMR"
ORIGIN      
        1 actccactca gatccatcct ggggaccaga gcagaagcgg tcctcacagc acccattctc
       61 tgcttgagct cccgcttctt ctttgccgct gggcctcggc ccagaagcca cgacgggcga
      121 cacggagccg ccagtgctgg agggggagcc gtgggtgcgg ggcagcgtgg gggccgaggc
      181 cccgggacgc ccgcccggcc ccaggccccg ctcagcccgg gcgcccccac gggtgccccc
      241 cccttcttgg tccgagcagt gtgagtgtgc cagggagccc ggcggcggcg gcggcggtgg
      301 tggcggcggt ggcggcggcg tggaatccgg cgtgggctgg ggggtccgag ccgcgggggg
      361 cagtgccatg cacaagcacc agcactgctg taagtgccct gagtgctatg aggtgacccg
      421 cctggccgcc ctgcggcgcc tcgagcctcc gggctacggc gactggcaag tccccgaccc
      481 ttacgggcca ggtgggggca acggcgccag cgcgggttat gggggctaca gctcgcagac
      541 cttgccctcg caggcggggg ccacccccac ccctcgcacc aaggccaagc tcatccccac
      601 cggccgggat gtggggccgg tgcctcctaa gccagtcccg ggcaagagca cccccaaact
      661 caacggcagc ggccccagct ggtggccaga gtgcacctgt accaaccggg actggtatga
      721 gcaggtgaat ggcagtgatg gcatgttcaa atatgaggaa atcgtacttg agaggggcaa
      781 ctctggcctg ggcttcagta tcgcaggtgg catcgacaat ccccatgtcc ctgatgaccc
      841 tggcatcttt attaccaaga ttatccctgg tggagcagct gccatggatg ggaggctggg
      901 ggtgaatgac tgtgtgctgc gggtgaatga ggtggacgtg tcggaggtgg tacacagccg
      961 ggcggtggag gcgctgaagg aggcaggccc tgtggtgcga ttggtggtgc ggaggcgaca
     1021 gcctccaccc gagaccatca tggaggtcaa cctgctcaaa gggcccaaag gcctgggttt
     1081 cagcattgct gggggtattg gcaaccagca catcccagga gacaacagca tctacatcac
     1141 caagatcatt gaggggggtg ctgctcagaa ggatggacgc ctacagattg gggaccggct
     1201 gctggcggtg aacaacacca atctgcagga tgtgaggcac gaggaagctg tggcctcact
     1261 gaagaacaca tctgatatgg tgtatttgaa ggtggccaag ccaggcagcc tccacctcaa
     1321 cgacatgtac gctccccctg actacgccag cacttttact gccttggctg acaaccacat
     1381 aagccataat tccagcctgg gttatctcgg ggctgtggag agcaaggtca gctaccctgc
     1441 tcctcctcag gttcccccca cccgctactc tcctattccc aggcacatgc tggctgagga
     1501 ggacttcacc agagagcctc gcaagatcat cctgcacaaa ggctccacag gcctgggctt
     1561 caacatcgta ggaggagagg atggagaagg catttttgtc tccttcatcc tggcaggagg
     1621 cccagctgac ctgagtgggg agctgcgcag gggagaccgg atcttatcgg tgaatggagt
     1681 gaatctgagg aatgcaactc atgagcaggc tgcagctgct ctgaaacggg ccggccagtc
     1741 agtcaccatt gtggcccagt acagacctga agaatacagt cgctttgaat cgaagataca
     1801 tgacttacga gaacaaatga tgaacagcag catgagctct gggtctgggt ccctccgaac
     1861 aagtgaaaag aggtccttgt atgtcagggc cctgtttgat tatgatcgga ctcgggacag
     1921 ctgcctgcca agccaggggc tcagcttctc ttatggtgac attctgcatg tcattaatgc
     1981 ctctgatgat gagtggtggc aggcaaggct ggtgacccca cacggagaaa gtgagcagat
     2041 cggtgtgatc cccagtaaga agagggtgga aaagaaagaa agagctcgat tgaaaactgt
     2101 gaagttccat gccaggacgg ggatgattga gtctaacagg gacttcccgg ggttaagtga
     2161 cgattattat ggagcaaaga acctgaaagg acaagaggat gctattttgt catatgagcc
     2221 agtgacacgg caagaaattc actatgcaag gcctgtgatc atcctgggcc caatgaagga
     2281 ccgagtcaat gatgacctga tctccgaatt tccacataaa tttggatcct gtgtgccaca
     2341 tactacccgg cctcgacgtg ataatgaggt ggatggacaa gactaccact ttgtggtgtc
     2401 ccgagaacaa atggagaaag atattcagga caacaagttc atcgaggcgg gccaatttaa
     2461 tgataacctc tatgggacca gcatccagtc agtgcgggca gttgcagaga ggggcaagca
     2521 ctgcatctta gatgtttccg gcaatgctat caagagactg cagcaagcac aactttaccc
     2581 cattgccatt ttcatcaagc ccaagtccat tgaagccctt atggaaatga accgaaggca
     2641 gacatatgaa caagcaaata agatctatga caaagccatg aaactggagc aggaatttgg
     2701 agagtacttt acagccattg tacagggtga ctcactggaa gagatttata acaaaatcaa
     2761 acaaatcatt gaggaccagt ctgggcacta catttgggtc ccatcccctg aaaaactctg
     2821 aagaatcccc tccaaccatt ctcttgtgaa cagaagaaat caagtccctc ttccctcctc
     2881 cctcttcatt cctgtcccca tggggagaac aaatgctact gttcttgtcc ccttttttag
     2941 atatgtcaaa aaaaattaag ttttctagtc ctgttctttt ttttttttta agtttttgtt
     3001 tgtttcagtt tattttttgg gatgatgcca tctcattcat catgtgactg tgcccattcc
     3061 tgcatggacc tttcccaagc gctagcacag gtgcaaaatc catcagagcc attgttttca
     3121 taaaaaccaa gcagaagtga agagaaaaga ggaggactga tggaaagaca gactctggac
     3181 agctgcacgg cttgtgaagt gagctaaatg caccacatga tgagatgctc ctgggcattt
     3241 ctccctatct gtactgctgt cttgcagctc tgaacggtgc aacgtaatgg cgacagaaag
     3301 tatcttattt atatatagat atatatatgt aatttatata aaatatatag aaattattat
     3361 atatatatat tatacactct catataatat atatatattc acacacattt gggttagaaa
     3421 atctatggag acttcatcaa tggtactatg ttattagaga aatgctttaa ttttcatatt
     3481 ccaatcagat ggcatcttct atcccagctg gttgggaagg gattgaagat ggtagcaagt
     3541 gctgcactaa gggcactcgc atttggtcat tctcttgaga gctaggaggg gtcagcctga
     3601 ggccggagag gaagggcttt tgcctggggt gagagggtga gagacttgac ctgaaagcag
     3661 ctgctgcccc tgaggtgcag ccagagtcct gtgtgcggac agagagaatg gctaatgatg
     3721 ctccgcgtgg aattgcctat tgttttatgc cacctgatgt gtctgcatga gaggtttcct
     3781 ttttgttcct ttttaagctg ctgttaaacc aaaaccatgt tgtgctactg tgtcagcctt
     3841 ttcattattg caaattttac ttttactatt taagtgaatg catagaatcc aatttgccaa
     3901 ggttctaaag gcttatgagg tcctgaagga gccaggcctt gtgatggagt aggtgacaca
     3961 ggcctggttg tcctgtcagc agaagggaaa gcaggggctg ggctgagagg aggacacgga
     4021 gggctctgct gaggttcctt cctgggttcc accaacaggg acagggagtc acttgccttc
     4081 cagttctgtg ctgggatggc gggacagcac ttggcttgct tggccagctg cgtcatgagt
     4141 ttgatttggt tttttttttt ttgcagctgc ttcatatgct ctgctccagc ccctccccaa
     4201 cagctggtag cttatggttt cttcaagagg aaagtagact ttatgctgta catttgagct
     4261 gtagagctaa gattcgctta ctggtgagct gtgaaacctt gttgcttttt cccagagtct
     4321 gatggcagtg actgtgatca agggaatctt caccgccaca agtgcaggca gcaggtgtgg
     4381 ttcaggtccc cccccacccc actgtgctcc tttgaagcca acgtgcctcc ctcgcctcca
     4441 tactggaggg acgacgcagg ggagaacaga gaagtgcttg gccctaggat tgaggcactt
     4501 gtttcctagc ccgctgggtt agggctggtg caagcgaggc aatgttgagg atgctttaag
     4561 cactaccagc cgaatccggg aactctgtta acagttgtcc aaccagcaga atgaggctaa
     4621 ctgtataaag catgggaccc aggatgagga taaggaaagg acagcggctt tccctgggca
     4681 gtacaatggc ttgaaggcaa aaagggataa agtgacagcc gactgtgact ctggtgagga
     4741 ggggtgagca gggaggttga ttctctgatg ttaactaagt ggcaaagtct caaccgtgct
     4801 cagccctccc cctcccaggg aagagaaaca aagattcaaa gtaagcatga tactagtggg
     4861 tttaccagtg tttcttccaa ggagacatat attttttaat aaacgatagt tgcaatgaac
     4921 tgtggctcag agaccttctt aaagtagttg agaagggagg gcgtgggcaa agcagtggga
     4981 agaacatccc aaacttttgg gggccagagg gctctctcct tagtgatgat cagctagccg
     5041 agctgggccg tcctggggat cggtacagct ccctggggtg gtgacaggcc ctttgtgaaa
     5101 gttgtgtgct tggtcttcca ccccagcccc agacactgct tcaaatagca ccaaccagat
     5161 gggagtccac atctgtggtg gcaaaatgct gacattttcc caagaggtac acaaggtggg
     5221 agaggcctgc tgtagcagag gtgtgtgtta gagaaagcag gggcctgatt tagtagcaga
     5281 gaactgggtg agaaaaatgg ccagagaaag tgacctgcca gctaccagtg tttccgaaaa
     5341 tgagggtggg atgggcccat ttgcagagca ggacagcagt catccccata gccctctgag
     5401 gaggggaggg atgcttagag caggcagttc tggcagttct gacgtggcag gtgccattgc
     5461 aacttgtgcg gaggagtctt aggaagtgct gtcataattc ataaggtcaa gagcaacatc
     5521 tggatgaatg agccacctga aatgtgtgtg ggctgagcca caggaagggt gagtcctctt
     5581 gcttgtggtg ctttatggtg tgcaggttgc ttgctttccc acattctctc atttgcttga
     5641 aggcagccta acaaaaggga gtccccaaag agctccatga gagcttaaga aaattcatct
     5701 cctgaggaca aagagaacaa agatctgtcc tgtggtcaca ctgttgaggc tctgtcttca
     5761 cagctgatgt tctcctagtg gaggtacagc tgaagaacat tcagccccag cacgagaaga
     5821 tacagagcaa cttggaaacc ccaaagggag acacaccctt aacactgccg tgctgtgctg
     5881 tgccgtgtcc tgaaggagga gagagcccta tctcctcctg gttttgttgc tgacattgca
     5941 gctgatcatg ccttgactcc ttcatctcta acagaggaag aactgtatta tcaaacctta
     6001 tggtctaccc atgaataaat aaaatatttg ttcaagcaca aa
//
