LOCUS       NM_001142699            7959 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens discs large MAGUK scaffold protein 2 (DLG2),
            transcript variant 1, mRNA.
ACCESSION   NM_001142699
VERSION     NM_001142699.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7959)
  AUTHORS   Li,H., Zhu,J., Liu,X., Liu,L., Huang,S., Wu,A., Xu,Z., Zhang,X.,
            Li,Z., Ni,F., Liu,L. and Dong,J.
  TITLE     Glioma stem cell-derived exosomes induce the transformation of
            astrocytes via the miR-3065-5p/DLG2 signaling axis
  JOURNAL   Glia 72 (5), 857-871 (2024)
   PUBMED   38234042
  REMARK    GeneRIF: Glioma stem cell-derived exosomes induce the
            transformation of astrocytes via the miR-3065-5p/DLG2 signaling
            axis.
REFERENCE   2  (bases 1 to 7959)
  AUTHORS   Chen,Y., Karaca,E., Robin,N.H., Goodloe,D., Al-Beshri,A.,
            Dean,S.J., Hurst,A.C.E., Carroll,A.J. and Mikhail,F.M.
  TITLE     DLG2 intragenic exonic deletions reinforce the link to
            neurodevelopmental disorders and suggest a potential association
            with congenital anomalies and dysmorphism
  JOURNAL   Genet Med 26 (1), 101010 (2024)
   PUBMED   37860969
  REMARK    GeneRIF: DLG2 intragenic exonic deletions reinforce the link to
            neurodevelopmental disorders and suggest a potential association
            with congenital anomalies and dysmorphism.
REFERENCE   3  (bases 1 to 7959)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7959)
  AUTHORS   Bertini,V., Milone,R., Cristofani,P., Cambi,F., Bosetti,C.,
            Barbieri,F., Bertelloni,S., Cioni,G., Valetto,A. and Battini,R.
  TITLE     Enhancing DLG2 Implications in Neuropsychiatric Disorders: Analysis
            of a Cohort of Eight Patients with 11q14.1 Imbalances
  JOURNAL   Genes (Basel) 13 (5), 859 (2022)
   PUBMED   35627244
  REMARK    GeneRIF: Enhancing DLG2 Implications in Neuropsychiatric Disorders:
            Analysis of a Cohort of Eight Patients with 11q14.1 Imbalances.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7959)
  AUTHORS   Stathakis,D.G., Lee,D. and Bryant,P.J.
  TITLE     Fine-scale physical map of the 11q21 region surrounding the human
            DLG2 locus, the gene encoding Chapsyn-110
  JOURNAL   Genomics 54 (1), 186-188 (1998)
   PUBMED   9806853
REFERENCE   6  (bases 1 to 7959)
  AUTHORS   Irie,M., Hata,Y., Takeuchi,M., Ichtchenko,K., Toyoda,A., Hirao,K.,
            Takai,Y., Rosahl,T.W. and Sudhof,T.C.
  TITLE     Binding of neuroligins to PSD-95
  JOURNAL   Science 277 (5331), 1511-1515 (1997)
   PUBMED   9278515
REFERENCE   7  (bases 1 to 7959)
  AUTHORS   Hsueh,Y.P., Kim,E. and Sheng,M.
  TITLE     Disulfide-linked head-to-head multimerization in the mechanism of
            ion channel clustering by PSD-95
  JOURNAL   Neuron 18 (5), 803-814 (1997)
   PUBMED   9182804
REFERENCE   8  (bases 1 to 7959)
  AUTHORS   Kim,E., Cho,K.O., Rothschild,A. and Sheng,M.
  TITLE     Heteromultimerization and NMDA receptor-clustering activity of
            Chapsyn-110, a member of the PSD-95 family of proteins
  JOURNAL   Neuron 17 (1), 103-113 (1996)
   PUBMED   8755482
REFERENCE   9  (bases 1 to 7959)
  AUTHORS   Brenman,J.E., Chao,D.S., Gee,S.H., McGee,A.W., Craven,S.E.,
            Santillano,D.R., Wu,Z., Huang,F., Xia,H., Peters,M.F.,
            Froehner,S.C. and Bredt,D.S.
  TITLE     Interaction of nitric oxide synthase with the postsynaptic density
            protein PSD-95 and alpha1-syntrophin mediated by PDZ domains
  JOURNAL   Cell 84 (5), 757-767 (1996)
   PUBMED   8625413
REFERENCE   10 (bases 1 to 7959)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000642.5, AP002878.3,
            AP002803.3, AP003093.2, AP000639.4, AP001791.4, AP003305.2,
            AP002797.3, AC023118.4, AP002751.3, AP002370.5, AP000773.4 and
            AP003026.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001142699.2.
            
            Summary: This gene encodes a member of the membrane-associated
            guanylate kinase (MAGUK) family. The encoded protein forms a
            heterodimer with a related family member that may interact at
            postsynaptic sites to form a multimeric scaffold for the clustering
            of receptors, ion channels, and associated signaling proteins.
            Multiple transcript variants encoding different isoforms have been
            found for this gene. Additional transcript variants have been
            described, but their full-length nature is not known. [provided by
            RefSeq, Dec 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CR749820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376104.7/ ENSP00000365272.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               AP000642.5         5937-6063           c
            128-294             AP000642.5         5306-5472           c
            295-426             AP002878.3         82598-82729         c
            427-572             AP002803.3         58508-58653         c
            573-668             AP003093.2         30059-30154         c
            669-743             AP000639.4         88422-88496         c
            744-905             AP001791.4         137155-137316       c
            906-959             AP003305.2         46307-46360         c
            960-1010            AP002797.3         141857-141907       c
            1011-1135           AP002797.3         77319-77443         c
            1136-1305           AP002797.3         37711-37880         c
            1306-1442           AC023118.4         88882-89018         c
            1443-1587           AC023118.4         73700-73844         c
            1588-1726           AC023118.4         71261-71399         c
            1727-1882           AC023118.4         38704-38859         c
            1883-1951           AP002751.3         150141-150209       c
            1952-2108           AP002751.3         109335-109491       c
            2109-2211           AP002370.5         141381-141483       c
            2212-2326           AP000773.4         82721-82835         c
            2327-2503           AP003026.2         87446-87622         c
            2504-2579           AP003026.2         78472-78547         c
            2580-2679           AP003026.2         29893-29992         c
            2680-2730           AP003026.2         18491-18541         c
            2731-2832           AP003026.2         17390-17491         c
            2833-3005           AP003026.2         14965-15137         c
            3006-3115           AP003026.2         12472-12581         c
            3116-3207           AP003026.2         7766-7857           c
            3208-7959           AP003026.2         937-5688            c
FEATURES             Location/Qualifiers
     source          1..7959
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q14.1"
     gene            1..7959
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /note="discs large MAGUK scaffold protein 2"
                     /db_xref="GeneID:1740"
                     /db_xref="HGNC:HGNC:2901"
                     /db_xref="MIM:603583"
     exon            1..127
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            128..294
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            295..426
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..3314
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /note="isoform 1 is encoded by transcript variant 1;
                     channel-associated protein of synapses, 110kDa;
                     postsynaptic density protein PSD-93; channel-associated
                     protein of synapse-110; discs, large homolog 2,
                     chapsyn-110; protein phosphatase 1, regulatory subunit 58;
                     disks large homolog 2"
                     /codon_start=1
                     /product="disks large homolog 2 isoform 1"
                     /protein_id="NP_001136171.1"
                     /db_xref="CCDS:CCDS44690.1"
                     /db_xref="GeneID:1740"
                     /db_xref="HGNC:HGNC:2901"
                     /db_xref="MIM:603583"
                     /translation="MGIFKSSLFQALLDIQEFYEVTLLNSQKSCEQKIEEANQVLQKW
                     EKTSLLAPCHDRLQKSSELTDCSGSKENASCIEQNKENQSFENETDETTTQNQGRCPA
                     QNCSVEAPAWMPVHHCTKYRYQDEDAPHDHSLPRLTHEVRGPELVHVSEKNLSQIENV
                     HGYVLQSHISPLKASPAPIIVNTDTLDTIPYVNGTEIEYEFEEITLERGNSGLGFSIA
                     GGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALK
                     EAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIID
                     GGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTIYMTDP
                     YGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTRPPE
                     PVYSTVNKLCDKPASPRHYSPVECDKSFLLSAPYSHYHLGLLPDSEMTSHSQHSTATR
                     QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGEL
                     QRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIHDLREQM
                     MNHSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDE
                     WWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGSFNDKRKKS
                     FIFSRKFPFYKNKEQSEQETSDPERGQEDLILSYEPVTRQEINYTRPVIILGPMKDRI
                     NDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYN
                     DNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNK
                     RLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSK
                     EKL"
     exon            427..572
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            573..668
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            669..743
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            744..905
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            906..959
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1010
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1135
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1305
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1442
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1587
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1726
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1882
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..1951
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2108
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2211
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2326
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2503
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..2579
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2679
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2730
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2832
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..3005
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3006..3115
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3116..3207
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3208..7959
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7932..7937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /note="hexamer: AATAAA"
     polyA_site      7959
                     /gene="DLG2"
                     /gene_synonym="chapsyn-110; PPP1R58; PSD-93; PSD93"
                     /note="major polyA site"
ORIGIN      
        1 aatcctctcg gttaatacat gggaggatca gaatcagagg ggcattaagg atcaagcctg
       61 ggggcttgga gagcacagaa gaaaaaaatg aaagggacag caagctggat tctgagttac
      121 tgaggggaag actcagcctg gatttcaaaa ctgaacactg aagtggtttg caacagttac
      181 ctggctcttg gcctcaatcc agctggatca aactgagacc tgaaaagaga tattgactcc
      241 tgtggcagtg gaaagaccca agaatgccag tcaagaagac aggtgggcca taagatactg
      301 accgagcttt atcattactg gaagaatact gcaaaaaatt aaggaaacca gaggagcagc
      361 tgttgaaaaa tgcggttaaa aaggtgatgg gtatctttaa gagcagctta ttccaagctt
      421 tgctagatat ccaagaattt tatgaggtga cattgctaaa ttctcaaaaa agttgtgagc
      481 agaagataga agaagccaat caagttttac agaaatggga gaagacatcc cttcttgctc
      541 cgtgccatga cagacttcaa aaatcttcag agcttacaga ttgcagtgga tcaaaggaaa
      601 atgcttcatg tattgagcaa aataaagaaa atcagagttt tgaaaatgaa actgatgaga
      661 cgacaactca aaaccaaggc agatgcccag cccagaattg ttcagtggaa gcccctgctt
      721 ggatgcctgt ccaccactgt actaagtatc gatatcaaga tgaggacgct ccacatgatc
      781 attccttacc tcgactaacc cacgaagtaa gaggcccaga actcgtgcat gtatcagaaa
      841 agaacctctc tcaaatagaa aatgtccatg gatatgtctt gcagtctcat atttctcctc
      901 tgaaggccag tcctgctcct ataattgtca acacagatac tttggacaca attccttatg
      961 tcaatgggac agaaattgaa tatgaatttg aagaaattac actggagagg gggaattctg
     1021 gcctgggatt cagtattgct ggggggacag ataatcccca cattggagat gaccctggca
     1081 tatttattac gaagattata ccaggaggtg ctgcagcaga ggatggcaga ctcagggtca
     1141 atgattgtat cttgcgggtg aatgaggttg atgtgtcaga ggtttcccac agtaaagcgg
     1201 tggaagccct gaaggaagca gggtctatcg ttcggctgta tgtgcgtaga agacgaccta
     1261 ttttggagac cgttgtggaa atcaaactgt tcaaaggccc taaaggttta ggcttcagta
     1321 ttgcaggagg tgtggggaac caacacattc ctggagacaa cagcatttat gtaactaaaa
     1381 ttatagatgg aggagctgca caaaaagatg gaaggttgca agtaggagat agactactaa
     1441 tggtaaacaa ctacagttta gaagaagtaa cacacgaaga ggcagtagca atattaaaga
     1501 acacatcaga ggtagtttat ttaaaagttg gcaaacccac taccatttat atgactgatc
     1561 cttatggtcc acctgatatt actcactctt attctccacc aatggaaaac catctactct
     1621 ctggcaacaa tggcacttta gaatataaaa cctccctgcc acccatctct ccaggaaggt
     1681 actcaccaat tccaaagcac atgcttgttg acgacgacta caccaggcct ccggaacctg
     1741 tttacagcac tgtgaacaaa ctatgtgata agcctgcttc tcccaggcac tattcccctg
     1801 ttgagtgtga caaaagcttc ctcctctcag ctccctattc ccactaccac ctaggcctgc
     1861 tacctgactc tgagatgacc agtcattccc aacatagcac cgcaactcgt cagccttcaa
     1921 tgactctcca acgggccgtc tccctggaag gagagcctcg caaggtagtc ctgcacaaag
     1981 gctccactgg cctgggcttc aacattgtcg gtggggaaga tggagaaggt atttttgtgt
     2041 ccttcattct ggctggtgga ccagcagacc taagtgggga gctccagaga ggagaccaga
     2101 tcctatcggt gaatggcatt gacctccgtg gtgcatccca cgagcaggca gctgctgcac
     2161 taaagggggc tggacagaca gtgacgatta tagcacaata tcaacctgaa gattacgctc
     2221 gatttgaggc caaaatccat gacctacgag agcagatgat gaaccacagc atgagctccg
     2281 ggtccggatc cctgcgaacc aatcagaaac gctccctcta cgtcagagcc atgttcgact
     2341 acgacaagag caaggacagt gggctgccaa gtcaaggact tagttttaaa tatggagata
     2401 ttctccacgt tatcaatgcc tctgatgatg agtggtggca agccaggaga gtcatgctgg
     2461 agggagacag tgaggagatg ggggtcatcc ccagcaaaag gagggtggaa agaaaggaac
     2521 gtgcccgatt gaagacagtg aagtttaatg ccaaacctgg agtgattgat tcgaaagggt
     2581 cattcaatga caagcgtaaa aagagcttca tcttttcacg aaaattccca ttctacaaga
     2641 acaaggagca gagtgagcag gaaaccagtg atcctgaacg aggacaagaa gacctcattc
     2701 tttcctatga gcctgttaca aggcaggaaa taaactacac ccggccggtg attatcctgg
     2761 ggcccatgaa ggatcggatc aatgacgact tgatatctga attccctgat aaatttggct
     2821 cctgtgtgcc tcatactacg aggccaaagc gagactacga ggtggatggc agagactatc
     2881 actttgtcat ttccagagaa caaatggaga aagatatcca agagcacaag tttatagaag
     2941 ccggccagta caatgacaat ttatatggaa ccagtgtgca gtctgtgaga tttgtagcag
     3001 aaagaggcaa acactgtata cttgatgtat caggaaatgc tatcaagcgg ttacaagttg
     3061 cccagctcta tcccattgcc atcttcataa aacccaggtc tctggaacct cttatggaga
     3121 tgaataagcg tctaacagag gaacaagcca agaaaaccta tgatcgagca attaagctag
     3181 aacaagaatt tggagaatat tttacagcta ttgtccaagg agatacttta gaagatatat
     3241 ataaccaatg caagcttgtt attgaagagc aatctgggcc tttcatctgg attccctcaa
     3301 aggaaaagtt ataaattagc tactgcgcct ctgacaacga cagaagagca tttagaagaa
     3361 caaaatatat ataacatact acttggaggc ttttatgttt ttgttgcatt tatgtttttg
     3421 cagtcaatgt gaattcttac gaatgtacaa cacaaactgt atgaagccat gaaggaaaca
     3481 gaggggccaa agggtgggac agaaaagaca ttgcagtatg aaggaaggct ttggtttgct
     3541 caaagtgcca ggtgtaggga tgaacctctg acgggctttc tgcccaagag atgagatgag
     3601 agcctcctca ccccagcaga tgtccagagc tgatttagct gcagagctct ctgtgtcttt
     3661 tgctttaaag aaaaattgcc agcactcgaa cctcatcagc cttcccatta cccacatctg
     3721 taattggtac actttgaatt ttataactat gcacatcttt tgatttctta acaagcaaat
     3781 gaaagaaaga aggaaaaaag aaaggaatcc ctttggagat gacatactat cagggaagga
     3841 taagtgtgta gttttttgac tggcatctgc aaagacaaga atttcataaa atttgcaagt
     3901 gtatggagga ctaacctcac tgacaggagg ggattccacc tgggattagc tttatgattg
     3961 ttgattgcct attttgccat ttataaactg aaagaaggca ctaaagatga gaataattta
     4021 tacaataaaa atatattaaa tgtatagaaa caaatttcta taggttaaaa aagttttgtg
     4081 aaatattttg taaagactaa tattgaaaga ctaaatgtat gcaacatcag cagatgatca
     4141 aattcaagac ctgaaagttg cactctccct tttgttgcca atgatctgtt aagagcatct
     4201 gagttccttt taagtctgac aaagacttct tcctcactta cctcccttcc acattagtga
     4261 tacactctca tgcagcacat cccttaatga gttgccctca tggatatttt tggaagacat
     4321 ttggttaatg cattttttta tgctgatggc ttttcagaga caaacttatg caaatgatct
     4381 aaagggaagt ttttgctttc ctctagttaa ataacctgag cctgccatgc aaatagttga
     4441 ataactttgt tcctagttac tgacatacaa ttcttaaagg accatttagc attttggcca
     4501 acaatgagta attaggatta gtaccttttt gttttacaga gtaactgaga gttttgtaac
     4561 atccagagat ggtactagag ccaatgagag atctgttcct agatgcacta tttctttgag
     4621 gaagagagag aagagaagtg tctggttggg ggtgaggggg tgcagacttt tttgtttcta
     4681 tgtacagagc aaagagatag agtcacaagg aaagacaatt aatgactttg agctcaacca
     4741 actgaactgc ctttcttgga gctgcacctg gaccaagttt attttttaac aattataata
     4801 acgatgattt aaaaaaagaa acctcccaaa gcctataaac tgaactagaa gagttggttt
     4861 cccactttag agtggatggc gacatcagca ttgcttttgc ccatggtgtt tggggagaga
     4921 cttttcagtg ataataacca ctctactctg ggttctgtgc atgcccagac taagccccat
     4981 cgccttattt ctggggtaca tccagacctg gcagggattc tgccacactg tgcagcaaac
     5041 cagcatgtag gctgggtagg agagcaagag atagagccat cagagtgatg gggcttcttc
     5101 acagtaagaa catcggagct tagaatgaga gtctctttcc aaaaacaggc attgttcatc
     5161 ttacgctaaa catcattgtc tgcctggcta cagtcaccaa aacaaaacag aaatgcaaaa
     5221 ttatgcatct tcccatagtc ctgaggcttc ctttgccaat ggaagggcta gcaatgcatt
     5281 ctccctctca tgaaagttaa atttccagag acttccttag attgctcaaa atgttaaaga
     5341 tatgtccatg tctgcaattc gccagtttca ggtcaaggcc tactttcatc aatattgctc
     5401 ccagaagttt tctgacacca gaatgccatt cctgatccca gctctatttt taggccacca
     5461 cgataacttc tttggtttct caactgagca tgcaaccatt tatttaaaag actgtcatta
     5521 atgagtagat gttttcgcgg gtcgtgtgat gtgctttcca tttactagtg ttgctgtggc
     5581 taagtacaat caaattgaac caccaaccct tggttttgta gtaatataac tatttatttt
     5641 cctagtgtag atgctttcag attagaattg gcatttgcac tgattttttt atgtagattt
     5701 atataaatat atagatacat atatatttgc ttgaagaatc accaagcaaa ttggtgagag
     5761 ggtcttttcc aatagaattt acacctccat ttgttgtgtt gtcttgcact tcccaatgtt
     5821 gatgtctcta tggctccaat gaactggtgt attttgcagc aaatctgatg acttgtatgg
     5881 aaatggcatg aaagttaccc agattacatc tggtgcaaat gcactcggag cctggggcca
     5941 gactggtgct aacactgcaa actttgtcca gagctctctc caacctgaag gcttgctggg
     6001 ggtgcaatgt caccttcaca catgctgggc cctttcagaa aagtgccaga tcgtgtaact
     6061 ggtgctattt ttcatgctct ggtacaatgt gtagcaccac gggggtctca gctttaccaa
     6121 aatcaaaatt ccatttgtca gctaagtgca gaggcatttg ttttttgctc tcctcccaca
     6181 gaattgtcgg ccatttattt gcaggccttt tgcgggattt cttggctatt tatttgcagg
     6241 ccttttttcc cagccccaaa ttcttgggtt ggctctgtct gcttaaagag cctgtcttca
     6301 caaagctgca ctcgggtgcc tctgtgcgct gtcttagatc ctactgccgg cccttcagga
     6361 ctccgagcca ggaaagaact ctccaacctc tggctcgaga ctctactttt tttctcattc
     6421 ttttccttac tctcctcctc cttctacttc cgactaattc catctctttt tttttttgtt
     6481 cctctccttt tcctattcct ccttcccacc atctctgagt tgttgacttt ctcctataat
     6541 ccttctctat tccctttctc tttttgtcca cctctccttt agtctctgtt tctctgccct
     6601 tcttattcct cttctgtcct ttctcctctc ctcaaatctc tgatcatctt ctcccgtaca
     6661 tccctgtatt gatttttctg tcctctaaag ggctcatggc tgattcagac agcaagtcca
     6721 tgcactggac taatgacaca aatactttag gtcgccgttt cacctactca gcccagaaag
     6781 taaagctgag cgtgaggccc tgacctggag cctgctccag cccgcctccc ggagccagcc
     6841 tgcaccgttg ccctggcagc gatgatgcat gtgctgtggg ccctgccggc gcctgagtgc
     6901 ctctgcctga acactgctcc taagcgagcc cactcccagc actaccgcat ggctctgagg
     6961 acattttctt tcaataaagg cagactctgg ccccaattat tctgatagca aacctcttcc
     7021 tcctcattga agccatgcca tcaccttggt ttggagagag acattttttt cccattcata
     7081 agctttcttt ttcccatttt tatgtgaagc cccctctgct tttcagctgg tgattgctct
     7141 ggtgagactg aatggacttg ctggtgaaat gaaatctctt ctttcctgtc ttggtcctgc
     7201 ctaaattcct acaaatatat ttaagccaag gactcaggct aattcctaag ttgatcacat
     7261 taatttgtta ctcctagagg gaaaaagatc aattcccttg aagcatgtgg agtacctcct
     7321 gtgacagctg acttgccagg ggactcccta cagaattctg tgatatacat tttacttctg
     7381 tgtatgtatg gtatatatgg tatgtatacc atgtacacac gttacattga gtatgaatga
     7441 ctgtggttgg aaacacacac acacactcaa gtctgtaaat atccttcctc actgaaacct
     7501 gtgctttgga aatcatttct tgtacagctg tgcagtttct tgtaacagct gaggacaaag
     7561 ctaagacagg cggacaattt agacaaagat catctaaaga gtatagtatc tccctagcaa
     7621 ctcatgagga cagacaacca agtggcaagg ttgactccca atgggatggc agacttttct
     7681 tctctccttt ttgagtttgt gtttcctaag tgtttcttaa cttctgagtg caccaggctg
     7741 tacccgttag atcctttcaa tatgacagtt ttgtgcttct ctctgacagg atgtttctcc
     7801 accgagctgt agcacaggat gggagggagg tgggaatact ccttgcctag gctggagttt
     7861 acagagacac tgcacagctt acactcctgt taagtgtaaa tattcaacac ttccattcca
     7921 tttgtgtaaa aaataaagca cacacgatta taaaatcaa
//
