LOCUS       NM_001366207            4853 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens discs large MAGUK scaffold protein 1 (DLG1),
            transcript variant 12, mRNA.
ACCESSION   NM_001366207 XM_017005808
VERSION     NM_001366207.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4853)
  AUTHORS   Yang,Z.Y., Zhao,C., Liu,S.L., Pan,L.J., Zhu,Y.D., Zhao,J.W.,
            Wang,H.K., Ye,Y.Y., Qiang,J., Shi,L.Q., Mei,J.W., Xie,Y., Gong,W.,
            Shu,Y.J., Dong,P. and Xiang,S.S.
  TITLE     NONO promotes gallbladder cancer cell proliferation by enhancing
            oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14
  JOURNAL   Cancer Lett 587, 216703 (2024)
   PUBMED   38341127
  REMARK    GeneRIF: NONO promotes gallbladder cancer cell proliferation by
            enhancing oncogenic RNA splicing of DLG1 through interaction with
            IGF2BP3/RBM14.
REFERENCE   2  (bases 1 to 4853)
  AUTHORS   Xu,X., Luo,S., Wang,X., Wen,X., Yin,J., Luo,X., He,B., Liang,C.,
            Xiong,S., Zhu,D., Lv,D., Dai,Z., Lin,J., Li,Y., Lin,Z., Chen,W.,
            Luo,Z., Wang,Y. and Ma,G.
  TITLE     Genetic contribution of synapse-associated protein 97 to cerebellar
            functional connectivity changes in first-episode schizophrenia
  JOURNAL   BMC Psychiatry 23 (1), 630 (2023)
   PUBMED   37644438
  REMARK    GeneRIF: Genetic contribution of synapse-associated protein 97 to
            cerebellar functional connectivity changes in first-episode
            schizophrenia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4853)
  AUTHORS   Scott,H., Dong,L., Stevenson,A., MacDonald,A.I., Srinivasan,S.,
            Massimi,P., Banks,L., Martin,P.E., Johnstone,S.R. and Graham,S.V.
  TITLE     The human discs large protein 1 interacts with and maintains
            connexin 43 at the plasma membrane in keratinocytes
  JOURNAL   J Cell Sci 136 (11) (2023)
   PUBMED   37288673
  REMARK    GeneRIF: The human discs large protein 1 interacts with and
            maintains connexin 43 at the plasma membrane in keratinocytes.
REFERENCE   4  (bases 1 to 4853)
  AUTHORS   Veljacic Viskovic,D., Lozic,M., Vukoja,M., Soljic,V., Vukojevic,K.,
            Glavina Durdov,M., Filipovic,N. and Lozic,B.
  TITLE     Spatio-Temporal Expression Pattern of CAKUT Candidate Genes DLG1
            and KIF12 during Human Kidney Development
  JOURNAL   Biomolecules 13 (2), 340 (2023)
   PUBMED   36830709
  REMARK    GeneRIF: Spatio-Temporal Expression Pattern of CAKUT Candidate
            Genes DLG1 and KIF12 during Human Kidney Development.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4853)
  AUTHORS   Cavatorta,A.L., Facciuto,F., Valdano,M.B., Marziali,F., Giri,A.A.,
            Banks,L. and Gardiol,D.
  TITLE     Regulation of translational efficiency by different splice variants
            of the Disc large 1 oncosuppressor 5'-UTR
  JOURNAL   FEBS J 278 (14), 2596-2608 (2011)
   PUBMED   21595829
  REMARK    GeneRIF: Studies represent first analyses of 5'-UTR of DLG1
            transcripts; data suggest that differential expression of
            alternatively spliced 5'-UTRs with different translational
            properties result in changes in DLG1 expression.
REFERENCE   6  (bases 1 to 4853)
  AUTHORS   McLaughlin,M., Hale,R., Ellston,D., Gaudet,S., Lue,R.A. and Viel,A.
  TITLE     The distribution and function of alternatively spliced insertions
            in hDlg
  JOURNAL   J Biol Chem 277 (8), 6406-6412 (2002)
   PUBMED   11723125
  REMARK    GeneRIF: We identify the functions of the two alternatively spliced
            regions. The N-terminal alternatively spliced region is capable of
            binding several SH3 domains and also moderates the level of protein
            oligomerization.
REFERENCE   7  (bases 1 to 4853)
  AUTHORS   Mori,K., Iwao,K., Miyoshi,Y., Nakagawara,A., Kofu,K., Akiyama,T.,
            Arita,N., Hayakawa,T. and Nakamura,Y.
  TITLE     Identification of brain-specific splicing variants of the hDLG1
            gene and altered splicing in neuroblastoma cell lines
  JOURNAL   J Hum Genet 43 (2), 123-127 (1998)
   PUBMED   9621517
REFERENCE   8  (bases 1 to 4853)
  AUTHORS   Kim,E., Niethammer,M., Rothschild,A., Jan,Y.N. and Sheng,M.
  TITLE     Clustering of Shaker-type K+ channels by interaction with a family
            of membrane-associated guanylate kinases
  JOURNAL   Nature 378 (6552), 85-88 (1995)
   PUBMED   7477295
REFERENCE   9  (bases 1 to 4853)
  AUTHORS   Lue,R.A., Marfatia,S.M., Branton,D. and Chishti,A.H.
  TITLE     Cloning and characterization of hdlg: the human homologue of the
            Drosophila discs large tumor suppressor binds to protein 4.1
  JOURNAL   Proc Natl Acad Sci U S A 91 (21), 9818-9822 (1994)
   PUBMED   7937897
REFERENCE   10 (bases 1 to 4853)
  AUTHORS   Mukherjee,A., Varma,S.K. and Natarajan,K.
  TITLE     Ankle joint instability in poliomyelitis
  JOURNAL   Indian J Pediatr 39 (289), 37-38 (1972)
   PUBMED   5024025
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092937.8 and AC068302.18.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 26, 2018 this sequence version replaced XM_017005808.1.
            
            Summary: This gene encodes a multi-domain scaffolding protein that
            is required for normal development. This protein may have a role in
            septate junction formation, signal transduction, cell
            proliferation, synaptogenesis and lymphocyte activation. A
            multitude of transcript variants deriving from alternative splicing
            and the use of multiple alternate promoter have been observed,
            including some splice variants that may be specific to brain and
            other tissues. An upstream uORF may regulate translation at some
            splice variants of this gene. [provided by RefSeq, Sep 2018].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.2604120.1,
                                           SRR11853561.21817.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000667157.1/ ENSP00000499414.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AC092937.8         170355-170431       c
            78-127              AC092937.8         169005-169054       c
            128-259             AC092937.8         168165-168296       c
            260-426             AC092937.8         154498-154664       c
            427-591             AC092937.8         66244-66408         c
            592-645             AC092937.8         21562-21615         c
            646-696             AC092937.8         14537-14587         c
            697-821             AC092937.8         11959-12083         c
            822-991             AC092937.8         10041-10210         c
            992-1128            AC092937.8         8361-8497           c
            1129-1273           AC092937.8         2346-2490           c
            1274-1394           AC068302.18        130818-130938       c
            1395-1551           AC068302.18        127335-127491       c
            1552-1654           AC068302.18        116311-116413       c
            1655-1769           AC068302.18        102320-102434       c
            1770-1946           AC068302.18        96988-97164         c
            1947-2013           AC068302.18        92459-92525         c
            2014-2113           AC068302.18        87994-88093         c
            2114-2155           AC068302.18        80627-80668         c
            2156-2206           AC068302.18        78112-78162         c
            2207-2308           AC068302.18        77116-77217         c
            2309-2481           AC068302.18        76684-76856         c
            2482-2591           AC068302.18        71297-71406         c
            2592-2683           AC068302.18        62985-63076         c
            2684-4853           AC068302.18        53968-56137         c
FEATURES             Location/Qualifiers
     source          1..4853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..4853
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /note="discs large MAGUK scaffold protein 1"
                     /db_xref="GeneID:1739"
                     /db_xref="HGNC:HGNC:2900"
                     /db_xref="MIM:601014"
     exon            1..77
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            78..127
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..2790
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /note="isoform 6 is encoded by transcript variant 12;
                     presynaptic protein SAP97; synapse-associated protein 97;
                     discs large homolog 1, scribble cell polarity complex
                     component; dJ1061C18.1.1"
                     /codon_start=1
                     /product="disks large homolog 1 isoform 6"
                     /protein_id="NP_001353136.1"
                     /db_xref="CCDS:CCDS87192.1"
                     /db_xref="GeneID:1739"
                     /db_xref="HGNC:HGNC:2900"
                     /db_xref="MIM:601014"
                     /translation="MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSN
                     LFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLS
                     PSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPI
                     KANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDS
                     SIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR
                     RKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQI
                     GDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQ
                     PVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGG
                     EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTI
                     VAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSG
                     LPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKT
                     VKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASDSESSY
                     RGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKR
                     DYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILD
                     VSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEH
                     FTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL"
     exon            128..259
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            260..426
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            427..591
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            592..645
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            646..696
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            697..821
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            822..991
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1128
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1273
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1394
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1395..1551
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1654
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1769
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1946
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2013
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2113
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2114..2155
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2206
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2207..2308
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2481
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2591
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2683
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..4853
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4464..4469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /note="hexamer: AATAAA"
     polyA_site      4486
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /note="major polyA site"
     regulatory      4824..4829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
                     /note="hexamer: ATTAAA"
     polyA_site      4853
                     /gene="DLG1"
                     /gene_synonym="DLGH1; hdlg; SAP-97; SAP97"
ORIGIN      
        1 acccccgggg tcgccaggcg ctgtctctgc cgcggagttg gaaacggcac tgctgagtga
       61 ggttgagggg tgtctcggtg tgtgccctct tcctgattct ggagaaaaat gccggtccgg
      121 aagcaagata cccagagagc attgcacctt ttggaggaat atcgttcaaa actaagccaa
      181 actgaagaca gacagctcag aagttccata gaacgggtta ttaacatatt tcagagcaac
      241 ctctttcagg ctttaataga tattcaagaa ttttatgaag tgaccttact ggataatcca
      301 aaatgtatag atcgttcaaa gccgtctgaa ccaattcaac ctgtgaatac ttgggagatt
      361 tccagccttc caagctctac tgtgacttca gagacactgc caagcagcct tagccctagt
      421 gtagagaaat acaggtatca ggatgaagat acacctcctc aagagcatat ttccccacaa
      481 atcacaaatg aagtgatagg tccagaattg gttcatgtct cagagaagaa cttatcagag
      541 attgagaatg tccatggatt tgtttctcat tctcatattt caccaataaa ggcaaatcct
      601 cccccagtac tggtcaacac agatagcttg gaaacaccaa cttacgttaa tggcacagat
      661 gcagattatg aatatgaaga aatcacactt gaaaggggaa attcagggct tggtttcagc
      721 attgcaggag gtacggacaa cccacacatt ggagatgact caagtatttt cattaccaaa
      781 attatcacag ggggagcagc cgcccaagat ggaagattgc gggtcaatga ctgtatatta
      841 cgagtaaatg aagtagatgt tcgtgatgta acacatagca aagcagttga agcgttgaaa
      901 gaagcagggt ctattgtacg cttgtatgta aaaagaagga aaccagtgtc agaaaaaata
      961 atggaaataa agctcattaa aggtcctaaa ggtcttgggt ttagcattgc tggaggtgtt
     1021 ggaaatcagc atattcctgg ggataatagc atctatgtaa ccaaaataat tgaaggaggt
     1081 gcagcacata aggatggcaa acttcagatt ggagataaac ttttagcagt gaataacgta
     1141 tgtttagaag aagttactca tgaagaagca gtaactgcct taaagaacac atctgatttt
     1201 gtttatttga aagtggcaaa acccacaagt atgtatatga atgatggcta tgcaccacct
     1261 gatatcacca actcttcttc tcagcctgtt gataaccatg ttagcccatc ttccttcttg
     1321 ggccagacac cagcatctcc agccagatac tccccagttt ctaaagcagt acttggagat
     1381 gatgaaatta caagggaacc tagaaaagtt gttcttcatc gtggctcaac gggccttggt
     1441 ttcaacattg taggaggaga agatggagaa ggaatattta tttcctttat cttagccgga
     1501 ggacctgctg atctaagtgg agagctcaga aaaggagatc gtattatatc ggtaaacagt
     1561 gttgacctca gagctgctag tcatgagcag gcagcagctg cattgaaaaa tgctggccag
     1621 gctgtcacaa ttgttgcaca atatcgacct gaagaataca gtcgttttga agctaaaata
     1681 catgatttac gggagcagat gatgaatagt agtattagtt cagggtcagg ttctcttcga
     1741 actagccaga agcgatccct ctatgtcaga gccctttttg attatgacaa gactaaagac
     1801 agtgggcttc ccagtcaggg actgaacttc aaatttggag atatcctcca tgttattaat
     1861 gcttctgatg atgaatggtg gcaagccagg caggttacac cagatggtga gagcgatgag
     1921 gtcggagtga ttcccagtaa acgcagagtt gagaagaaag aacgagcccg attaaaaaca
     1981 gtgaaattca attctaaaac gagagataaa gggcagtcat tcaatgacaa gcgtaaaaag
     2041 aacctctttt cccgaaaatt ccccttctac aagaacaagg accagagtga gcaggaaaca
     2101 agtgatgctg accagcatgt aacttctaat gccagcgata gtgaaagtag ttaccgtggt
     2161 caagaagaat acgtcttatc ttatgaacca gtgaatcaac aagaagttaa ttatactcga
     2221 ccagtgatca tattgggacc tatgaaagac aggataaatg atgacttgat ctcagaattt
     2281 cctgacaaat ttggatcctg tgttcctcat acaactagac caaaacgaga ttatgaggta
     2341 gatggaagag attatcattt tgtgacttca agagagcaga tggaaaaaga tatccaggaa
     2401 cataaattca ttgaagctgg ccagtataac aatcatctat atggaacaag tgttcagtct
     2461 gtacgagaag tagcagaaaa gggcaaacac tgtatccttg atgtgtctgg aaatgccata
     2521 aagagattac agattgcaca gctttaccct atctccattt ttattaaacc caaatccatg
     2581 gaaaatatca tggaaatgaa taagcgtcta acagaagaac aagccagaaa aacatttgag
     2641 agagccatga aactggaaca ggagtttact gaacatttca cagctattgt acagggggat
     2701 acgctggaag acatttacaa ccaagtgaaa cagatcatag aagaacaatc tggttcttac
     2761 atctgggttc cggcaaaaga aaagctatga aaactcatgt ttctctgttt ctcttttcca
     2821 caattccatt ttctttggca tctctttgcc ctttcctctg gagtctttct tgagtactga
     2881 tttcatgttg aattgtatcc cacacatcat ggtctgcagc ttctttttca catgtagtgt
     2941 ctccttcaag ttacatcgtg tgtattattt aatgtcacta ttggttagtg gccatttttc
     3001 agaactgaag atggaatggc ctgaccagct attaagaacg tggggagacg cagaaattgt
     3061 ggtaaaattc cttaatgttt aagggaaagt aactttaaga gatttttgga aaagctttat
     3121 atacattctt ttcaaatttc agtacaaatg aaaaagtggt tttaatcagt gatttagtag
     3181 actttgagca actgtgcacg cttcagttta atagcatggt ttggccagtg tattactctc
     3241 aagtcctttt ctcaatcaac ttctatcatc aaagcaattg tttcattata gataaataag
     3301 gacatttttt aatttaaaaa ttcatgtctg agttgacttt cataagggat ttcatttttt
     3361 cctcaacatt cttaaagcct tttagtattt gacggttctt ttttcccagg acatttgcta
     3421 ggaataacaa cgtttcaatg tttttaatct acttgagcaa cactatcgtg tcttacaaaa
     3481 gttgttcata tgtaaatgat catcacattt cgtgaattga ggccatgttc aggtgctaag
     3541 gaagttcgcc ttttacacag aagattgaga aaatttccta gatataaata cagataaatc
     3601 agacgttaca gtggtgacgt agtaaccatc atggcaatgg aaaggagtcc aattcatagc
     3661 ctaaaacttc aaatgtattc ttaggagtca gattttactg aatattttac ccacaatagc
     3721 tgcctatttt gttataataa aatatatata aatatatata taaaactttc tttaaactgt
     3781 aactatggga attattttct ttacatagtt gcgcacacac acaaacatat atatatattt
     3841 aaaatatatt ttgtttcttt tgccacctac tcctaacttt ttgtttggtt tttaaattaa
     3901 atattaattg aatagactta tcttccttaa tcatgtgaac tgaaaatggg ggcatggtgg
     3961 tcatgaggag gaaacattta gggaaattag attataagta aaagtgtggg catattctcc
     4021 tcttttctac aaaggttttc aaatggttcc tgaggttttt tgttgttgtc cgtgttgtta
     4081 ctgttgttct tgtcatcagg tttgattttg gtccttgccc tttccttcta gttctccttt
     4141 tattaatagg aaggcaggca aaagccccat ttatgtgtgt gttttcccct cagacagctt
     4201 tcatccactg ctctgcacta gaattgcaca aatcttcatg gtgagcaatt ttaagaaatg
     4261 ttagtgaaag gtagaaatta tttcacaaat cagtttctct ggtccttcat attaataata
     4321 atatttggct tcccattgct ctttggagtt gtttattaaa tatgtgtttt tgacaacctc
     4381 ctcattagtt tcttaaatga gtactggttt gtaaagaatt atcaacatta tccattccat
     4441 ttatgaagaa gaggagaaca gctaataaac tgtattgtaa aatccatatg ttaagtgtgt
     4501 cttgaatttt gaaagaaaaa atatattttg caagctaaca ttttcttgaa acaatttgag
     4561 gcatcatgta acttataacc gaatccaaga gccgttaggc agcagagtgt gttaccacat
     4621 tgaaatacac agtgctgctg ttagactaaa tgtcgtaggt tgttaaccac atagaaacac
     4681 actagtatga agaaaactgt tgtaaaatct caagagcttc agaaactgcc ttacaagacc
     4741 gcagcataag ctattttgaa gtatttacca aatagtcaca tgttgtaaaa tatcaagtgg
     4801 ttataaaagg atgccattta tatattaaaa tttacataac attgttttct gga
//
