LOCUS       NM_014419                939 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens dickkopf like acrosomal protein 1 (DKKL1), transcript
            variant 1, mRNA.
ACCESSION   NM_014419
VERSION     NM_014419.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 939)
  AUTHORS   Hu,Y., Liu,M., Xu,S., Li,S., Yang,M., Su,T., Yuan,Z. and Peng,H.
  TITLE     The Clinical Significance of Dickkopf Wnt Signaling Pathway
            Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma
  JOURNAL   Med Sci Monit 26, e927368 (2020)
   PUBMED   33281184
  REMARK    GeneRIF: The Clinical Significance of Dickkopf Wnt Signaling
            Pathway Inhibitor Gene Family in Head and Neck Squamous Cell
            Carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 939)
  AUTHORS   Martin,G., Selcuklu,S.D., Schouest,K., Nembaware,V., McKeown,P.C.,
            Seoighe,C. and Spillane,C.
  TITLE     Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in
            HeLa cells
  JOURNAL   Gene 598, 107-112 (2017)
   PUBMED   27826023
  REMARK    GeneRIF: previously unreported alternative splicing patterns in the
            genes ZNF419 and DKKL1
REFERENCE   3  (bases 1 to 939)
  AUTHORS   Tarnowski,M., Czerewaty,M., Deskur,A., Safranow,K., Marlicz,W.,
            Urasinska,E., Ratajczak,M.Z. and Starzynska,T.
  TITLE     Expression of Cancer Testis Antigens in Colorectal Cancer: New
            Prognostic and Therapeutic Implications
  JOURNAL   Dis Markers 2016, 1987505 (2016)
   PUBMED   27635108
  REMARK    GeneRIF: DKKL was overexpressed in colorectal cancer tissue
            compared with healthy colon.  DKKL expression positively correlated
            with colorectal cancer progression.
REFERENCE   4  (bases 1 to 939)
  AUTHORS   Alfonso,R.J., Gorrono-Etxebarria,I., Rabano,M., Vivanco,Md. and
            Kypta,R.
  TITLE     Dickkopf-3 alters the morphological response to retinoic acid
            during neuronal differentiation of human embryonal carcinoma cells
  JOURNAL   Dev Neurobiol 74 (12), 1243-1254 (2014)
   PUBMED   24909558
  REMARK    GeneRIF: Findings suggest that Dkk-3 plays a role in the regulation
            of cell interactions during retinoic acid-induced neuronal
            differentiation; effect on apoptosis was also observed upon
            expression of the related protein Dkkl-1
REFERENCE   5  (bases 1 to 939)
  AUTHORS   Hsieh,J.C., Estess,R.C., Kaneko,I., Whitfield,G.K., Jurutka,P.W.
            and Haussler,M.R.
  TITLE     Vitamin D receptor-mediated control of Soggy, Wise, and Hairless
            gene expression in keratinocytes
  JOURNAL   J Endocrinol 220 (2), 165-178 (2014)
   PUBMED   24190897
  REMARK    GeneRIF: Unliganded VDR upregulates the expression of hairless, the
            gene product of which acts as a downstream comodulator to
            feedback-repress DKKL1 and SOSTDC1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 939)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   7  (bases 1 to 939)
  AUTHORS   Sawcer,S., Hellenthal,G., Pirinen,M., Spencer,C.C.,
            Patsopoulos,N.A., Moutsianas,L., Dilthey,A., Su,Z., Freeman,C.,
            Hunt,S.E., Edkins,S., Gray,E., Booth,D.R., Potter,S.C., Goris,A.,
            Band,G., Oturai,A.B., Strange,A., Saarela,J., Bellenguez,C.,
            Fontaine,B., Gillman,M., Hemmer,B., Gwilliam,R., Zipp,F.,
            Jayakumar,A., Martin,R., Leslie,S., Hawkins,S., Giannoulatou,E.,
            D'alfonso,S., Blackburn,H., Martinelli Boneschi,F., Liddle,J.,
            Harbo,H.F., Perez,M.L., Spurkland,A., Waller,M.J., Mycko,M.P.,
            Ricketts,M., Comabella,M., Hammond,N., Kockum,I., McCann,O.T.,
            Ban,M., Whittaker,P., Kemppinen,A., Weston,P., Hawkins,C.,
            Widaa,S., Zajicek,J., Dronov,S., Robertson,N., Bumpstead,S.J.,
            Barcellos,L.F., Ravindrarajah,R., Abraham,R., Alfredsson,L.,
            Ardlie,K., Aubin,C., Baker,A., Baker,K., Baranzini,S.E.,
            Bergamaschi,L., Bergamaschi,R., Bernstein,A., Berthele,A.,
            Boggild,M., Bradfield,J.P., Brassat,D., Broadley,S.A., Buck,D.,
            Butzkueven,H., Capra,R., Carroll,W.M., Cavalla,P., Celius,E.G.,
            Cepok,S., Chiavacci,R., Clerget-Darpoux,F., Clysters,K., Comi,G.,
            Cossburn,M., Cournu-Rebeix,I., Cox,M.B., Cozen,W., Cree,B.A.,
            Cross,A.H., Cusi,D., Daly,M.J., Davis,E., de Bakker,P.I.,
            Debouverie,M., D'hooghe,M.B., Dixon,K., Dobosi,R., Dubois,B.,
            Ellinghaus,D., Elovaara,I., Esposito,F., Fontenille,C., Foote,S.,
            Franke,A., Galimberti,D., Ghezzi,A., Glessner,J., Gomez,R.,
            Gout,O., Graham,C., Grant,S.F., Guerini,F.R., Hakonarson,H.,
            Hall,P., Hamsten,A., Hartung,H.P., Heard,R.N., Heath,S., Hobart,J.,
            Hoshi,M., Infante-Duarte,C., Ingram,G., Ingram,W., Islam,T.,
            Jagodic,M., Kabesch,M., Kermode,A.G., Kilpatrick,T.J., Kim,C.,
            Klopp,N., Koivisto,K., Larsson,M., Lathrop,M., Lechner-Scott,J.S.,
            Leone,M.A., Leppa,V., Liljedahl,U., Bomfim,I.L., Lincoln,R.R.,
            Link,J., Liu,J., Lorentzen,A.R., Lupoli,S., Macciardi,F., Mack,T.,
            Marriott,M., Martinelli,V., Mason,D., McCauley,J.L., Mentch,F.,
            Mero,I.L., Mihalova,T., Montalban,X., Mottershead,J., Myhr,K.M.,
            Naldi,P., Ollier,W., Page,A., Palotie,A., Pelletier,J., Piccio,L.,
            Pickersgill,T., Piehl,F., Pobywajlo,S., Quach,H.L., Ramsay,P.P.,
            Reunanen,M., Reynolds,R., Rioux,J.D., Rodegher,M., Roesner,S.,
            Rubio,J.P., Ruckert,I.M., Salvetti,M., Salvi,E., Santaniello,A.,
            Schaefer,C.A., Schreiber,S., Schulze,C., Scott,R.J., Sellebjerg,F.,
            Selmaj,K.W., Sexton,D., Shen,L., Simms-Acuna,B., Skidmore,S.,
            Sleiman,P.M., Smestad,C., Sorensen,P.S., Sondergaard,H.B.,
            Stankovich,J., Strange,R.C., Sulonen,A.M., Sundqvist,E.,
            Syvanen,A.C., Taddeo,F., Taylor,B., Blackwell,J.M., Tienari,P.,
            Bramon,E., Tourbah,A., Brown,M.A., Tronczynska,E., Casas,J.P.,
            Tubridy,N., Corvin,A., Vickery,J., Jankowski,J., Villoslada,P.,
            Markus,H.S., Wang,K., Mathew,C.G., Wason,J., Palmer,C.N.,
            Wichmann,H.E., Plomin,R., Willoughby,E., Rautanen,A.,
            Winkelmann,J., Wittig,M., Trembath,R.C., Yaouanq,J.,
            Viswanathan,A.C., Zhang,H., Wood,N.W., Zuvich,R., Deloukas,P.,
            Langford,C., Duncanson,A., Oksenberg,J.R., Pericak-Vance,M.A.,
            Haines,J.L., Olsson,T., Hillert,J., Ivinson,A.J., De Jager,P.L.,
            Peltonen,L., Stewart,G.J., Hafler,D.A., Hauser,S.L., McVean,G.,
            Donnelly,P. and Compston,A.
  CONSRTM   International Multiple Sclerosis Genetics Consortium; Wellcome
            Trust Case Control Consortium 2
  TITLE     Genetic risk and a primary role for cell-mediated immune mechanisms
            in multiple sclerosis
  JOURNAL   Nature 476 (7359), 214-219 (2011)
   PUBMED   21833088
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 939)
  AUTHORS   Wu,C., Ma,M.H., Brown,K.R., Geisler,M., Li,L., Tzeng,E., Jia,C.Y.,
            Jurisica,I. and Li,S.S.
  TITLE     Systematic identification of SH3 domain-mediated human
            protein-protein interactions by peptide array target screening
  JOURNAL   Proteomics 7 (11), 1775-1785 (2007)
   PUBMED   17474147
REFERENCE   9  (bases 1 to 939)
  AUTHORS   Kohn,M.J., Kaneko,K.J. and DePamphilis,M.L.
  TITLE     DkkL1 (Soggy), a Dickkopf family member, localizes to the acrosome
            during mammalian spermatogenesis
  JOURNAL   Mol Reprod Dev 71 (4), 516-522 (2005)
   PUBMED   15892050
REFERENCE   10 (bases 1 to 939)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY358922.1.
            
            On May 17, 2019 this sequence version replaced NM_014419.3.
            
            Summary: The dickkopf protein family interacts with the Wnt
            signaling pathway and its members are characterized by two
            conserved cysteine-rich domains. This gene encodes a secreted
            protein that has low sequence similarity to the dickkopf-3 protein.
            Multiple alternatively spliced transcript variants encoding
            distinct isoforms have been found for this gene. [provided by
            RefSeq, Oct 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005555.1, AY358922.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221498.7/ ENSP00000221498.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-939               AY358922.1         93-1031
FEATURES             Location/Qualifiers
     source          1..939
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..939
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /note="dickkopf like acrosomal protein 1"
                     /db_xref="GeneID:27120"
                     /db_xref="HGNC:HGNC:16528"
                     /db_xref="MIM:605418"
     exon            1..132
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..851
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; soggy; cancer/testis antigen 34; soggy-1;
                     dickkopf-like protein 1; protein soggy-1; testicular
                     secretory protein Li 15; dickkopf-like 1"
                     /codon_start=1
                     /product="dickkopf-like protein 1 isoform 1 precursor"
                     /protein_id="NP_055234.1"
                     /db_xref="CCDS:CCDS12762.1"
                     /db_xref="GeneID:27120"
                     /db_xref="HGNC:HGNC:16528"
                     /db_xref="MIM:605418"
                     /translation="MGEASPPAPARRHLLVLLLLLSTLVIPSAAAPIHDADAQESSLG
                     LTGLQSLLQGFSRLFLKGNLLRGIDSLFSAPMDFRGLPGNYHKEENQEHQLGNNTLSS
                     HLQIDKMTDNKTGEVLISENVVASIQPAEGSFEGDLKVPRMEEKEALVPIQKATDSFH
                     TELHPRVAFWIIKLPRRRSHQDALEGGHWLSEKRHRLQAIRDGLRKGTHKDVLEEGTE
                     SSSHSRLSPRKTHLLYILRPSRQL"
     exon            133..305
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /inference="alignment:Splign:2.1.0"
     exon            306..446
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..539
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..939
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /note="hexamer: AATAAA"
     polyA_site      939
                     /gene="DKKL1"
                     /gene_synonym="CT34; SGY; SGY-1; SGY1"
                     /note="major polyA site"
ORIGIN      
        1 agacctgggc tcgagaccat aactgtttgg ctttaacagt acgtgggcgg ccggaatccg
       61 ggagtccggt gacccgggct gtggtctagc ataaaggcgg agcccagaag aaggggcggg
      121 gtatgggaga agcctcccca cctgcccccg caaggcggca tctgctggtc ctgctgctgc
      181 tcctctctac cctggtgatc ccctccgctg cagctcctat ccatgatgct gacgcccaag
      241 agagctcctt gggtctcaca ggcctccaga gcctactcca aggcttcagc cgacttttcc
      301 tgaaaggtaa cctgcttcgg ggcatagaca gcttattctc tgcccccatg gacttccggg
      361 gcctccctgg gaactaccac aaagaggaga accaggagca ccagctgggg aacaacaccc
      421 tctccagcca cctccagatc gacaagatga ccgacaacaa gacaggagag gtgctgatct
      481 ccgagaatgt ggtggcatcc attcaaccag cggaggggag cttcgagggt gatttgaagg
      541 tacccaggat ggaggagaag gaggccctgg tacccatcca gaaggccacg gacagcttcc
      601 acacagaact ccatccccgg gtggccttct ggatcattaa gctgccacgg cggaggtccc
      661 accaggatgc cctggagggc ggccactggc tcagcgagaa gcgacaccgc ctgcaggcca
      721 tccgggatgg actccgcaag gggacccaca aggacgtcct agaagagggg accgagagct
      781 cctcccactc caggctgtcc ccccgaaaga cccacttact gtacatcctc aggccctctc
      841 ggcagctgta ggggtgggga ccggggagca cctgcctgta gcccccatca gaccctgccc
      901 caagcaccat atggaaataa agttctttct tacatctaa
//
