LOCUS       NM_001018057            2525 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens dickkopf WNT signaling pathway inhibitor 3 (DKK3),
            transcript variant 3, mRNA.
ACCESSION   NM_001018057
VERSION     NM_001018057.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Song,J., Chen,Y., Chen,Y., Qiu,M., Xiang,W., Ke,B. and Fang,X.
  TITLE     DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner
  JOURNAL   Ren Fail 46 (1), 2343817 (2024)
   PUBMED   38682264
  REMARK    GeneRIF: DKK3 promotes renal fibrosis by increasing MFF-mediated
            mitochondrial dysfunction in Wnt/beta-catenin pathway-dependent
            manner.
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Caffo,M., Casili,G., Caruso,G., Barresi,V., Campolo,M.,
            Paterniti,I., Minutoli,L., Ius,T. and Esposito,E.
  TITLE     DKK3 Expression in Glioblastoma: Correlations with Biomolecular
            Markers
  JOURNAL   Int J Mol Sci 25 (7), 4091 (2024)
   PUBMED   38612910
  REMARK    GeneRIF: DKK3 Expression in Glioblastoma: Correlations with
            Biomolecular Markers.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Cao,Q., Wang,X., Liu,J., Dong,Y., Wu,X., Mi,Y., Liu,K., Zhang,M.,
            Shi,Y. and Fan,R.
  TITLE     ICBP90, an epigenetic regulator, induces DKK3 promoter methylation,
            promotes glioma progression, and reduces sensitivity to
            cis-platinum
  JOURNAL   Exp Cell Res 436 (2), 113976 (2024)
   PUBMED   38401687
  REMARK    GeneRIF: ICBP90, an epigenetic regulator, induces DKK3 promoter
            methylation, promotes glioma progression, and reduces sensitivity
            to cis-platinum.
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Zhong,D., Luo,C., Wang,N. and Lin,J.
  TITLE     MiR-98-3p alleviates lipopolysaccharide-induced pulmonary
            microvascular endothelial barrier dysfunction by targeting DKK3 in
            sepsis-induced acute lung injury
  JOURNAL   J Toxicol Sci 49 (7), 289-299 (2024)
   PUBMED   38945840
  REMARK    GeneRIF: MiR-98-3p alleviates lipopolysaccharide-induced pulmonary
            microvascular endothelial barrier dysfunction by targeting DKK3 in
            sepsis-induced acute lung injury.
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Mourtada,J., Thibaudeau,C., Wasylyk,B. and Jung,A.C.
  TITLE     The Multifaceted Role of Human Dickkopf-3 (DKK-3) in Development,
            Immune Modulation and Cancer
  JOURNAL   Cells 13 (1), 75 (2023)
   PUBMED   38201279
  REMARK    GeneRIF: The Multifaceted Role of Human Dickkopf-3 (DKK-3) in
            Development, Immune Modulation and Cancer.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Mao,B. and Niehrs,C.
  TITLE     Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
  JOURNAL   Gene 302 (1-2), 179-183 (2003)
   PUBMED   12527209
REFERENCE   7  (bases 1 to 2525)
  AUTHORS   Kobayashi,K., Ouchida,M., Tsuji,T., Hanafusa,H., Miyazaki,M.,
            Namba,M., Shimizu,N. and Shimizu,K.
  TITLE     Reduced expression of the REIC/Dkk-3 gene by
            promoter-hypermethylation in human tumor cells
  JOURNAL   Gene 282 (1-2), 151-158 (2002)
   PUBMED   11814687
  REMARK    GeneRIF: REIC gene expression was decreased in 14 of 24 fresh
            non-small cell lung cancer specimens (58%) compared to that in
            corresponding non-cancerous tissue.
REFERENCE   8  (bases 1 to 2525)
  AUTHORS   Tsuji,T., Miyazaki,M., Sakaguchi,M., Inoue,Y. and Namba,M.
  TITLE     A REIC gene shows down-regulation in human immortalized cells and
            human tumor-derived cell lines
  JOURNAL   Biochem Biophys Res Commun 268 (1), 20-24 (2000)
   PUBMED   10652205
REFERENCE   9  (bases 1 to 2525)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
REFERENCE   10 (bases 1 to 2525)
  AUTHORS   Ligon,A.H., Pershouse,M.A., Jasser,S.A., Yung,W.K. and Steck,P.A.
  TITLE     Identification of a novel gene product, RIG, that is down-regulated
            in human glioblastoma
  JOURNAL   Oncogene 14 (9), 1075-1081 (1997)
   PUBMED   9070656
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL535720.3, BC007660.2,
            BQ690088.1 and H18461.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001018057.1.
            
            Summary: This gene encodes a protein that is a member of the
            dickkopf family. The secreted protein contains two cysteine rich
            regions and is involved in embryonic development through its
            interactions with the Wnt signaling pathway. The expression of this
            gene is decreased in a variety of cancer cell lines and it may
            function as a tumor suppressor gene. Alternative splicing results
            in multiple transcript variants encoding the same protein.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF177396.1, SRR1803614.135202.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2159607
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683431.1/ ENSP00000506835.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL535720.3         14-31
            19-1046             BC007660.2         213-1240
            1047-1546           BQ690088.1         307-806
            1547-2455           BC007660.2         1741-2649
            2456-2525           H18461.1           50-119              c
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..2525
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /note="dickkopf WNT signaling pathway inhibitor 3"
                     /db_xref="GeneID:27122"
                     /db_xref="HGNC:HGNC:2893"
                     /db_xref="MIM:605416"
     exon            1..257
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1097
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; regulated in glioma; RIG-like 7-1; RIG-like
                     5-6; dickkopf-related protein 3; dkk-3; hDkk-3;
                     dickkopf-3; dickkopf homolog 3; dickkopf 3 homolog;
                     cardiomyocyte regeneration-related lncRNA"
                     /codon_start=1
                     /product="dickkopf-related protein 3 isoform 1 precursor"
                     /protein_id="NP_001018067.1"
                     /db_xref="CCDS:CCDS7808.1"
                     /db_xref="GeneID:27122"
                     /db_xref="HGNC:HGNC:2893"
                     /db_xref="MIM:605416"
                     /translation="MQRLGATLLCLLLAAAVPTAPAPAPTATSAPVKPGPALSYPQEE
                     ATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKASSEVNLANLPPSYHNETNTDT
                     KVGNNTIHVHREIHKITNNQTGQMVFSETVITSVGDEEGRRSHECIIDEDCGPSMYCQ
                     FASFQYTCQPCRGQRMLCTRDSECCGDQLCVWGHCTKMATRGSNGTICDNQRDCQPGL
                     CCAFQRGLLFPVCTPLPVEGELCHDPASRLLDLITWELEPDGALDRCPCASGLLCQPH
                     SHSLVYVCKPTFVGSRDQDGEILLPREVPDEYEVGSFMEEVRQELEDLERSLTEEMAL
                     REPAAAAAALLGGEEI"
     exon            258..395
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     exon            396..479
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     exon            480..572
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     exon            573..717
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     exon            718..874
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     exon            875..2525
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /note="hexamer: TATAAA"
     polyA_site      2455
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /note="major polyA site"
     regulatory      2495..2500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
                     /note="hexamer: AATAAA"
     polyA_site      2525
                     /gene="DKK3"
                     /gene_synonym="CRRL; REIC; RIG"
ORIGIN      
        1 gcgttccggg acacacaggc ggcggctgcg ggcgcagagc ggagatgcag cggcttgggg
       61 ccaccctgct gtgcctgctg ctggcggcgg cggtccccac ggcccccgcg cccgctccga
      121 cggcgacctc ggctccagtc aagcccggcc cggctctcag ctacccgcag gaggaggcca
      181 ccctcaatga gatgttccgc gaggttgagg aactgatgga ggacacgcag cacaaattgc
      241 gcagcgcggt ggaagagatg gaggcagaag aagctgctgc taaagcatca tcagaagtga
      301 acctggcaaa cttacctccc agctatcaca atgagaccaa cacagacacg aaggttggaa
      361 ataataccat ccatgtgcac cgagaaattc acaagataac caacaaccag actggacaaa
      421 tggtcttttc agagacagtt atcacatctg tgggagacga agaaggcaga aggagccacg
      481 agtgcatcat cgacgaggac tgtgggccca gcatgtactg ccagtttgcc agcttccagt
      541 acacctgcca gccatgccgg ggccagagga tgctctgcac ccgggacagt gagtgctgtg
      601 gagaccagct gtgtgtctgg ggtcactgca ccaaaatggc caccaggggc agcaatggga
      661 ccatctgtga caaccagagg gactgccagc cggggctgtg ctgtgccttc cagagaggcc
      721 tgctgttccc tgtgtgcaca cccctgcccg tggagggcga gctttgccat gaccccgcca
      781 gccggcttct ggacctcatc acctgggagc tagagcctga tggagccttg gaccgatgcc
      841 cttgtgccag tggcctcctc tgccagcccc acagccacag cctggtgtat gtgtgcaagc
      901 cgaccttcgt ggggagccgt gaccaagatg gggagatcct gctgcccaga gaggtccccg
      961 atgagtatga agttggcagc ttcatggagg aggtgcgcca ggagctggag gacctggaga
     1021 ggagcctgac tgaagagatg gcgctgaggg agcctgcggc tgccgccgct gcactgctgg
     1081 gaggggaaga gatttagatc tggaccaggc tgtgggtaga tgtgcaatag aaatagctaa
     1141 tttatttccc caggtgtgtg ctttaggcgt gggctgacca ggcttcttcc tacatcttct
     1201 tcccagtaag tttcccctct ggcttgacag catgaggtgt tgtgcatttg ttcagctccc
     1261 ccaggctgtt ctccaggctt cacagtctgg tgcttgggag agtcaggcag ggttaaactg
     1321 caggagcagt ttgccacccc tgtccagatt attggctgct ttgcctctac cagttggcag
     1381 acagccgttt gttctacatg gctttgataa ttgtttgagg ggaggagatg gaaacaatgt
     1441 ggagtctccc tctgattggt tttggggaaa tgtggagaag agtgccctgc tttgcaaaca
     1501 tcaacctggc aaaaatgcaa caaatgaatt ttccacgcag ttctttccat gggcataggt
     1561 aagctgtgcc ttcagctgtt gcagatgaaa tgttctgttc accctgcatt acatgtgttt
     1621 attcatccag cagtgttgct cagctcctac ctctgtgcca gggcagcatt ttcatatcca
     1681 agatcaattc cctctctcag cacagcctgg ggagggggtc attgttctcc tcgtccatca
     1741 gggatctcag aggctcagag actgcaagct gcttgcccaa gtcacacagc tagtgaagac
     1801 cagagcagtt tcatctggtt gtgactctaa gctcagtgct ctctccacta ccccacacca
     1861 gccttggtgc caccaaaagt gctccccaaa aggaaggaga atgggatttt tcttttgagg
     1921 catgcacatc tggaattaag gtcaaactaa ttctcacatc cctctaaaag taaactactg
     1981 ttaggaacag cagtgttctc acagtgtggg gcagccgtcc ttctaatgaa gacaatgata
     2041 ttgacactgt ccctctttgg cagttgcatt agtaactttg aaaggtatat gactgagcgt
     2101 agcatacagg ttaacctgca gaaacagtac ttaggtaatt gtagggcgag gattataaat
     2161 gaaatttgca aaatcactta gcagcaactg aagacaatta tcaaccacgt ggagaaaatc
     2221 aaaccgagca gggctgtgtg aaacatggtt gtaatatgcg actgcgaaca ctgaactcta
     2281 cgccactcca caaatgatgt tttcaggtgt catggactgt tgccaccatg tattcatcca
     2341 gagttcttaa agtttaaagt tgcacatgat tgtataagca tgctttcttt gagttttaaa
     2401 ttatgtataa acataagttg catttagaaa tcaagcataa atcacttcaa ctgctcttct
     2461 gtagttcttg gatttctttt cccttttgac tttgaataaa tgtaaaatcc tttcagccag
     2521 aaaaa
//
