LOCUS       NM_012242               1805 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens dickkopf WNT signaling pathway inhibitor 1 (DKK1),
            mRNA.
ACCESSION   NM_012242
VERSION     NM_012242.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1805)
  AUTHORS   Ren,Y., Zheng,J., Cao,Y., Zhu,Y., Ling,Z., Zhang,Z. and Huang,M.
  TITLE     Diagnostic significance of LncRNA MIAT in periodontitis and the
            molecular mechanisms influencing periodontal ligament fibroblasts
            via the miR-204-5p/DKK1 axis
  JOURNAL   Arch Oral Biol 168, 106066 (2024)
   PUBMED   39190957
  REMARK    GeneRIF: Diagnostic significance of LncRNA MIAT in periodontitis
            and the molecular mechanisms influencing periodontal ligament
            fibroblasts via the miR-204-5p/DKK1 axis.
REFERENCE   2  (bases 1 to 1805)
  AUTHORS   Chen,L. and Kong,C.
  TITLE     SIRT2-dependent DKK1 deacetylation aggravates polycystic ovary
            syndrome by targeting the TGF-beta1/Smad3 signaling pathway
  JOURNAL   Gynecol Endocrinol 40 (1), 2353733 (2024)
   PUBMED   38818662
  REMARK    GeneRIF: SIRT2-dependent DKK1 deacetylation aggravates polycystic
            ovary syndrome by targeting the TGF-beta1/Smad3 signaling pathway.
REFERENCE   3  (bases 1 to 1805)
  AUTHORS   Sato,K., Takayama,K.I., Saito,Y. and Inoue,S.
  TITLE     ERRalpha and ERRgamma coordinate expression of genes associated
            with Alzheimer's disease, inhibiting DKK1 to suppress tau
            phosphorylation
  JOURNAL   Proc Natl Acad Sci U S A 121 (37), e2406854121 (2024)
   PUBMED   39231208
  REMARK    GeneRIF: ERRalpha and ERRgamma coordinate expression of genes
            associated with Alzheimer's disease, inhibiting DKK1 to suppress
            tau phosphorylation.
REFERENCE   4  (bases 1 to 1805)
  AUTHORS   Rinella,L., Fiorentino,G., Compagno,M., Grange,C., Cedrino,M.,
            Marano,F., Bosco,O., Vissio,E., Delsedime,L., D'Amelio,P.,
            Bussolati,B., Arvat,E. and Catalano,M.G.
  TITLE     Dickkopf-1 (DKK1) drives growth and metastases in
            castration-resistant prostate cancer
  JOURNAL   Cancer Gene Ther 31 (8), 1266-1279 (2024)
   PUBMED   38740881
  REMARK    GeneRIF: Dickkopf-1 (DKK1) drives growth and metastases in
            castration-resistant prostate cancer.
REFERENCE   5  (bases 1 to 1805)
  AUTHORS   Wang,H. and Zhang,Y.
  TITLE     Effect of miR-590-3p/DKK1 Axis on the Progression of Wilms' Tumour
  JOURNAL   Arch Esp Urol 77 (2), 135-141 (2024)
   PUBMED   38583005
  REMARK    GeneRIF: Effect of miR-590-3p/DKK1 Axis on the Progression of
            Wilms' Tumour.
REFERENCE   6  (bases 1 to 1805)
  AUTHORS   Kagey,M.H. and He,X.
  TITLE     Rationale for targeting the Wnt signalling modulator Dickkopf-1 for
            oncology
  JOURNAL   Br J Pharmacol 174 (24), 4637-4650 (2017)
   PUBMED   28574171
  REMARK    GeneRIF: The Dickkopf-1 (DKK1) is a secreted inhibitor of
            beta-catenin-dependent Wnt signalling and was originally
            characterized as a tumour suppressor based on the prevailing view
            that Wnt signalling promotes cancer pathogenesis.
            Review article
REFERENCE   7  (bases 1 to 1805)
  AUTHORS   Mao,B., Wu,W., Li,Y., Hoppe,D., Stannek,P., Glinka,A. and Niehrs,C.
  TITLE     LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
  JOURNAL   Nature 411 (6835), 321-325 (2001)
   PUBMED   11357136
REFERENCE   8  (bases 1 to 1805)
  AUTHORS   Roessler,E., Du,Y., Glinka,A., Dutra,A., Niehrs,C. and Muenke,M.
  TITLE     The genomic structure, chromosome location, and analysis of the
            human DKK1 head inducer gene as a candidate for holoprosencephaly
  JOURNAL   Cytogenet Cell Genet 89 (3-4), 220-224 (2000)
   PUBMED   10965128
REFERENCE   9  (bases 1 to 1805)
  AUTHORS   Krupnik,V.E., Sharp,J.D., Jiang,C., Robison,K., Chickering,T.W.,
            Amaravadi,L., Brown,D.E., Guyot,D., Mays,G., Leiby,K., Chang,B.,
            Duong,T., Goodearl,A.D., Gearing,D.P., Sokol,S.Y. and McCarthy,S.A.
  TITLE     Functional and structural diversity of the human Dickkopf gene
            family
  JOURNAL   Gene 238 (2), 301-313 (1999)
   PUBMED   10570958
REFERENCE   10 (bases 1 to 1805)
  AUTHORS   Fedi,P., Bafico,A., Nieto Soria,A., Burgess,W.H., Miki,T.,
            Bottaro,D.P., Kraus,M.H. and Aaronson,S.A.
  TITLE     Isolation and biochemical characterization of the human Dkk-1
            homologue, a novel inhibitor of mammalian Wnt signaling
  JOURNAL   J Biol Chem 274 (27), 19465-19472 (1999)
   PUBMED   10383463
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP265847.1, AF127563.1,
            AC009986.10 and BU752259.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012242.3.
            
            Summary: This gene encodes a member of the dickkopf family of
            proteins. Members of this family are secreted proteins
            characterized by two cysteine-rich domains that mediate
            protein-protein interactions. The encoded protein binds to the LRP6
            co-receptor and inhibits beta-catenin-dependent Wnt signaling. This
            gene plays a role in embryonic development and may be important in
            bone formation in adults. Elevated expression of this gene has been
            observed in numerous human cancers and this protein may promote
            proliferation, invasion and growth in cancer cell lines. [provided
            by RefSeq, Sep 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JN966744.1, SRR1803617.254553.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373970.4/ ENSP00000363081.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               BP265847.1         72-197
            127-470             AF127563.1         112-455
            471-473             AC009986.10        147331-147333       c
            474-1534            AF127563.1         459-1519
            1535-1805           BU752259.1         17-287              c
FEATURES             Location/Qualifiers
     source          1..1805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.1"
     gene            1..1805
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /note="dickkopf WNT signaling pathway inhibitor 1"
                     /db_xref="GeneID:22943"
                     /db_xref="HGNC:HGNC:2891"
                     /db_xref="MIM:605189"
     exon            1..397
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..955
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /note="dickkopf-1 like; dickkopf 1 homolog;
                     dickkopf-related protein 1; dickkopf-like protein 1"
                     /codon_start=1
                     /product="dickkopf-related protein 1 precursor"
                     /protein_id="NP_036374.1"
                     /db_xref="CCDS:CCDS7246.1"
                     /db_xref="GeneID:22943"
                     /db_xref="HGNC:HGNC:2891"
                     /db_xref="MIM:605189"
                     /translation="MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKN
                     LPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTR
                     GGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGN
                     DHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQ
                     VCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH"
     exon            398..560
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /inference="alignment:Splign:2.1.0"
     exon            561..701
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /inference="alignment:Splign:2.1.0"
     exon            702..1805
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1506..1511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /note="hexamer: AATAAA"
     polyA_site      1529
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /note="major polyA site"
     regulatory      1787..1792
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
                     /note="hexamer: AATAAA"
     polyA_site      1805
                     /gene="DKK1"
                     /gene_synonym="DKK-1; SK"
ORIGIN      
        1 gcagagctct gtgctccctg cagtcaggac tctgggaccg cagggggctc ccggaccctg
       61 actctgcagc cgaaccggca cggtttcgtg gggacccagg cttgcaaagt gacggtcatt
      121 ttctctttct ttctccctct tgagtccttc tgagatgatg gctctgggcg cagcgggagc
      181 tacccgggtc tttgtcgcga tggtagcggc ggctctcggc ggccaccctc tgctgggagt
      241 gagcgccacc ttgaactcgg ttctcaattc caacgctatc aagaacctgc ccccaccgct
      301 gggcggcgct gcggggcacc caggctctgc agtcagcgcc gcgccgggaa tcctgtaccc
      361 gggcgggaat aagtaccaga ccattgacaa ctaccagccg tacccgtgcg cagaggacga
      421 ggagtgcggc actgatgagt actgcgctag tcccacccgc ggaggggacg caggcgtgca
      481 aatctgtctc gcctgcagga agcgccgaaa acgctgcatg cgtcacgcta tgtgctgccc
      541 cgggaattac tgcaaaaatg gaatatgtgt gtcttctgat caaaatcatt tccgaggaga
      601 aattgaggaa accatcactg aaagctttgg taatgatcat agcaccttgg atgggtattc
      661 cagaagaacc accttgtctt caaaaatgta tcacaccaaa ggacaagaag gttctgtttg
      721 tctccggtca tcagactgtg cctcaggatt gtgttgtgct agacacttct ggtccaagat
      781 ctgtaaacct gtcctgaaag aaggtcaagt gtgtaccaag cataggagaa aaggctctca
      841 tggactagaa atattccagc gttgttactg tggagaaggt ctgtcttgcc ggatacagaa
      901 agatcaccat caagccagta attcttctag gcttcacact tgtcagagac actaaaccag
      961 ctatccaaat gcagtgaact ccttttatat aatagatgct atgaaaacct tttatgacct
     1021 tcatcaactc aatcctaagg atatacaagt tctgtggttt cagttaagca ttccaataac
     1081 accttccaaa aacctggagt gtaagagctt tgtttcttta tggaactccc ctgtgattgc
     1141 agtaaattac tgtattgtaa attctcagtg tggcacttac ctgtaaatgc aatgaaactt
     1201 ttaattattt ttctaaaggt gctgcactgc ctatttttcc tcttgttatg taaatttttg
     1261 tacacattga ttgttatctt gactgacaaa tattctatat tgaactgaag taaatcattt
     1321 cagcttatag ttcttaaaag cataaccctt taccccattt aattctagag tctagaacgc
     1381 aaggatctct tggaatgaca aatgataggt acctaaaatg taacatgaaa atactagctt
     1441 attttctgaa atgtactatc ttaatgctta aattatattt ccctttaggc tgtgatagtt
     1501 tttgaaataa aatttaacat ttaatatcat gaaatgttat aagtagacat acattttggg
     1561 attgtgatct tagaggtttg tgtgtgtgta cgtatgtgtg tgttctacaa gaacggaagt
     1621 gtgatatgtt taaagatgat cagagaaaag acagtgtcta aatataagac aatattgatc
     1681 agctctagaa taactttaaa gaaagacgtg ttctgcattg ataaactcaa atgatcatgg
     1741 cagaatgaga gtgaatctta cattactact ttcaaaaata gtttccaata aattaataat
     1801 accta
//
