LOCUS       NM_001037954            5826 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens DIX domain containing 1 (DIXDC1), transcript variant
            1, mRNA.
ACCESSION   NM_001037954
VERSION     NM_001037954.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5826)
  AUTHORS   Huang,C.Q., Yang,P., Liu,J., Wang,Y.P., Hao,D.D. and Yang,X.
  TITLE     Circular RNA circ_0000423 promotes gastric cancer cell
            proliferation, migration and invasion via the
            microR-582-3p/Disheveled-Axin domain containing 1 axis
  JOURNAL   Bioengineered 12 (2), 12755-12766 (2021)
   PUBMED   34898351
  REMARK    GeneRIF: Circular RNA circ_0000423 promotes gastric cancer cell
            proliferation, migration and invasion via the
            microR-582-3p/Disheveled-Axin domain containing 1 axis.
REFERENCE   2  (bases 1 to 5826)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5826)
  AUTHORS   Chen,Z.F., Wang,Y., Sun,L.L., Ding,S.Y. and Jinag,H.
  TITLE     LncRNA SNHG20 enhances the progression of oral squamous cell
            carcinoma by regulating the miR-29a/DIXDC1/Wnt regulatory axis
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (10), 5436-5445 (2020)
   PUBMED   32495922
  REMARK    GeneRIF: LncRNA SNHG20 enhances the progression of oral squamous
            cell carcinoma by regulating the miR-29a/DIXDC1/Wnt regulatory
            axis.
REFERENCE   4  (bases 1 to 5826)
  AUTHORS   Sugis,E., Dauvillier,J., Leontjeva,A., Adler,P., Hindie,V.,
            Moncion,T., Collura,V., Daudin,R., Loe-Mie,Y., Herault,Y.,
            Lambert,J.C., Hermjakob,H., Pupko,T., Rain,J.C., Xenarios,I.,
            Vilo,J., Simonneau,M. and Peterson,H.
  TITLE     HENA, heterogeneous network-based data set for Alzheimer's disease
  JOURNAL   Sci Data 6 (1), 151 (2019)
   PUBMED   31413325
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5826)
  AUTHORS   Wu,Y., Jing,X., Ma,X., Wu,Y., Ding,X., Fan,W. and Fan,M.
  TITLE     DIXDC1 co-localizes and interacts with gamma-tubulin in HEK293
            cells
  JOURNAL   Cell Biol Int 33 (6), 697-701 (2009)
   PUBMED   19375513
  REMARK    GeneRIF: The GFP-tag fused DIXDC1 exogenously expressed co-localize
            with gamma-tubulin both at interphase and mitotic phase in the
            centrosomes.
REFERENCE   6  (bases 1 to 5826)
  AUTHORS   Jing,X.T., Wu,H.T., Wu,Y., Ma,X., Liu,S.H., Wu,Y.R., Ding,X.F.,
            Peng,X.Z., Qiang,B.Q., Yuan,J.G., Fan,W.H. and Fan,M.
  TITLE     DIXDC1 promotes retinoic acid-induced neuronal differentiation and
            inhibits gliogenesis in P19 cells
  JOURNAL   Cell Mol Neurobiol 29 (1), 55-67 (2009)
   PUBMED   18629627
  REMARK    GeneRIF: DIXDC1 might play an important role during neurogenesis,
            overexpression of DIXDC1 in embryonic carcinoma P19 cells promoted
            neuronal differentiation, and inhibited gliogenesis induced by
            retinoic acid.
REFERENCE   7  (bases 1 to 5826)
  AUTHORS   Camargo,L.M., Collura,V., Rain,J.C., Mizuguchi,K., Hermjakob,H.,
            Kerrien,S., Bonnert,T.P., Whiting,P.J. and Brandon,N.J.
  TITLE     Disrupted in Schizophrenia 1 Interactome: evidence for the close
            connectivity of risk genes and a potential synaptic basis for
            schizophrenia
  JOURNAL   Mol Psychiatry 12 (1), 74-86 (2007)
   PUBMED   17043677
REFERENCE   8  (bases 1 to 5826)
  AUTHORS   Wang,X., Zheng,L., Zeng,Z., Zhou,G., Chien,J., Qian,C.,
            Vasmatzis,G., Shridhar,V., Chen,L. and Liu,W.
  TITLE     DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding
            protein
  JOURNAL   Biochem Biophys Res Commun 347 (1), 22-30 (2006)
   PUBMED   16814745
  REMARK    GeneRIF: Thus, our data provide the first evidence that l-DIXDC1
            may act as a novel branching component in the Wnt signaling pathway
            targeting both beta-catenin-TCF complex for gene expression and
            cytoskeleton for regulating dynamics of actin filaments.
REFERENCE   9  (bases 1 to 5826)
  AUTHORS   Wong,C.K., Luo,W., Deng,Y., Zou,H., Ye,Z. and Lin,S.C.
  TITLE     The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal
            kinase activation by Axin and dishevelled through distinct
            mechanisms
  JOURNAL   J Biol Chem 279 (38), 39366-39373 (2004)
   PUBMED   15262978
  REMARK    GeneRIF: Ccd1 inhibits Axin-mediated JNK activation by
            simultaneously adopting two distinct mechanisms, one through
            conformational changes that disallow MEKK1 binding and the other
            via direct sequestration of MEKK4.
REFERENCE   10 (bases 1 to 5826)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein
            with myosine-tail homologous domain and C-terminal DIX domain
  JOURNAL   Int J Oncol 23 (1), 145-150 (2003)
   PUBMED   12792787
  REMARK    GeneRIF: KIAA1735 maps to human chromosome 11q23.1 and encodes a
            novel protein with a myosine-tail homologous domain and C-terminal
            DIX domain
            GeneRIF: MTHDIX (KIAA1735) protein consists of Myosine-tail
            homologous (MTH) domain and C-terminal DIX domain.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DQ642016.1, BC064479.1,
            AB051522.1, AB074187.1, DB358954.1 and AP000907.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001037954.3.
            
            Summary: The protein encoded by this gene is a positive regulator
            of the Wnt signaling pathway. The encoded protein is found
            associated with gamma tubulin at the centrosome. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a, also known as
            l-DIXDC1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.209402.1,
                                           SRR1660803.98652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000440460.7/ ENSP00000394352.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DQ642016.1         141-184
            45-1036             BC064479.1         1-992
            1037-2019           DQ642016.1         1177-2159
            2020-5152           AB051522.1         1600-4732
            5153-5757           AB074187.1         1108-1712
            5758-5823           DB358954.1         1-66                c
            5824-5826           AP000907.6         124268-124270
FEATURES             Location/Qualifiers
     source          1..5826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..5826
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /note="DIX domain containing 1"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
     exon            1..217
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2209
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /note="isoform a is encoded by transcript variant 1;
                     dixin; coiled-coil protein DIX1"
                     /codon_start=1
                     /product="dixin isoform a"
                     /protein_id="NP_001033043.1"
                     /db_xref="CCDS:CCDS73381.1"
                     /db_xref="GeneID:85458"
                     /db_xref="HGNC:HGNC:23695"
                     /db_xref="MIM:610493"
                     /translation="MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPAVKPVQ
                     DLRQDLRDGVILAYLIEIVAGEKLSGVQLSPGNQQEMKNNVEKVLQFVASKKIRMHQT
                     SAKDIVDGNLKSIMRLVLALAAHFKPGSSRTVNQGRDSRAPLQSHRPHCATAVAQGAA
                     AALADVCHDMSRSGRDVFRYRQRNSSMDEEIENPYWSVRALVQQYEGQQRSPSESSCS
                     SLTSPSPIHSAKSESIITQSEEKADFVIIPAEGIENRTEGTDSPLSRDWRPGSPGTYL
                     ETSWEEQLLEQQEYLEKEMEEAKKMISGLQALLLNGSLPEDEQERPLALCEPGVNPEE
                     QLIIIQSRLDQSMEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQEL
                     LRANMDKDELHNQNVDLQRKLDERNRLLGEYKKELGQKDRLLQQHQAKLEEALRKLSD
                     VSYHQVDLERELEHKDVLLAHCMKREADEATNYNSHNSQSNGFLLPTAGKGATSVSNR
                     GTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVMETQKKQERKVRV
                     KSPRTQVGSEYRESWPPNSKLPHSQSSPTVSSTCTKVLYFTDRSLTPFMVNIPKRLEE
                     VTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEIFHDDDAIPGWEGKIVAWVEEDHGE
                     N"
     exon            218..347
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..473
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            474..705
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            706..813
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            814..926
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1075
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1165
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1219
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1270
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1375
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1429
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1522
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1594
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1684
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1846
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1913
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2019
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2128
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..5826
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5733..5738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /note="hexamer: AATAAA"
     polyA_site      5757
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /note="major polyA site"
     regulatory      5801..5806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
                     /note="hexamer: AATAAA"
     polyA_site      5826
                     /gene="DIXDC1"
                     /gene_synonym="CCD1"
ORIGIN      
        1 agtttggctc cagtctaggt ttccagtaag tggcatgcgg gactccggag ggatcccaat
       61 gagctgagcc gagagccttt gtgtgcagag ggaggaggag gaggcggcgg cggccgccgg
      121 gctggagacc ccgcccgggg agcccccagc aggaacaatg ctagcctgcc tgacccgagg
      181 gaacttactg gacgtcctgc aggagggctt caatgagcaa cagctgcagg cctatgtggc
      241 ctgggtgaat gcacagctga agaagaggcc agcagtgaag cctgtgcagg acctgcgaca
      301 agatctccgg gatggggtga tcctggcata tctcatcgag attgttgcag gagaaaagct
      361 gagtggggta cagctgagtc ccggtaacca acaggagatg aagaataatg tggagaaagt
      421 gctacagttt gtggcctcta aaaagattcg tatgcaccag acttcggcta aagatattgt
      481 ggatggaaac ctgaagtcta tcatgaggct ggtccttgcc ttggcagctc atttcaaacc
      541 tggctccagc aggacggtga accaaggacg ggactccaga gcccctctgc aaagtcaccg
      601 accacactgt gccactgctg ttgcccaggg agcagctgct gctctggccg atgtgtgtca
      661 tgacatgtcc cgatcaggac gggatgtctt tcgatataga cagaggaaca gcagcatgga
      721 tgaggaaatt gagaatccat actggagtgt gcgggcccta gtgcagcagt acgaagggca
      781 acaaaggtcc ccgtctgaat ccagctgctc cagcctgact tcacccagtc caatccacag
      841 tgcaaagagc gagtccatta taacccagtc agaagagaag gcagattttg tgattattcc
      901 cgctgaagga atagagaaca gaacagaagg gacagattct ccattatctc gagactggcg
      961 gccagggagc cctggaacct atctggagac ctcatgggaa gaacagctgt tggaacaaca
     1021 agaatattta gaaaaagaaa tggaggaagc aaagaaaatg atatcaggac tacaggcctt
     1081 actgctcaat ggatccttac ctgaagatga acaggagagg cccttggccc tctgtgaacc
     1141 aggtgtcaat cccgaggaac aactgattat aatccaaagt cgtctggatc agagtatgga
     1201 ggagaatcag gacttaaaga aggaactgct gaaatgtaaa caagaagcca gaaacttaca
     1261 ggggataaag gatgccttgc agcagagatt gactcagcag gacacatctg ttcttcagct
     1321 caaacaagag ctactgaggg caaatatgga caaagatgag ctgcacaacc agaatgtgga
     1381 tctgcagagg aagctagatg agaggaaccg gctcttggga gaatataaaa aagagctggg
     1441 gcagaaggat cgccttcttc agcagcacca ggccaagtta gaagaagcac tccggaaact
     1501 ctctgatgtc agttaccacc aggtggatct agagcgagag ctagaacaca aagatgtcct
     1561 cttggctcac tgtatgaaaa gagaggcaga tgaggcgacc aactacaaca gtcacaactc
     1621 tcaaagcaat ggttttctcc ttccaacggc aggaaaagga gctacttcag tcagcaacag
     1681 agggaccagc gacctgcagc ttgttcgaga tgctctccgc agcctgcgca acagcttcag
     1741 tggccacgat cctcagcacc acactattga cagcttggag cagggcattt ctagcctcat
     1801 ggagcgcctg catgttatgg agacgcagaa gaaacaagaa agaaaggttc gggtcaagtc
     1861 acccagaact caagtaggta gtgaataccg ggagtcctgg ccccctaact caaagttgcc
     1921 tcactcacag agctctccaa ctgtcagcag cacctgtact aaagtgctct atttcactga
     1981 ccggtcactt acgcccttca tggtcaatat accaaagagg ttggaggagg tgacgttaaa
     2041 ggattttaaa gcagctattg atcgggaagg aaatcaccgg tatcacttca aagcactgga
     2101 tcctgagttt ggcactgtca aagaggagat tttccatgat gatgatgcca tccctggatg
     2161 ggaagggaaa attgtagctt gggtggaaga agaccatgga gagaattaat gccaagtatc
     2221 agattgaggg cttatggaac ctggtcactc cctggctgct tcactcagga aagggaacta
     2281 aaaccagaat acactaagaa gtttctagtt tgtgtgccaa aacagaagct tctccaagca
     2341 tgatggccac aggtcagtcc tctttctgtg cctggcatat ctggtactta aaattctgtc
     2401 caaatgtaga ccatgggttc atctggagtt ccttgtccgt gggaacacag tgttctattc
     2461 tactctgagg acaacaaacc gaaggcctta aacgatgggg atggatgatc ccgcctctgt
     2521 aggggcatgg ctgctattat ctggaaatta ggaattggat gcatcattcc tgtgtgttac
     2581 agtattattt taattggcct caatggttgc agcaatcaga gtcccagcgt ttgtactcac
     2641 agacaaggca aaggtaccag cttttctgtt tctttgaacc tactgcaaac caagaataac
     2701 tcatgaggtg gtaccaaaga tgaaagccca gacttcagta atcttttgaa ccagacgtgg
     2761 atggtgctga attgttgctt ggatggaaaa agggctgccc atgttgtgct acactatgct
     2821 aaaactgtaa tttagtaaga ccttgggctg cctcttctgt cttaactggt tctgcagctt
     2881 gtccttttgc ccacataggg cctatttcat gtactgttag ttttctctgg ggactcttta
     2941 actttagagc catttctttt tcttcaaact gatgaacttt tgtttgaaag gcataaggag
     3001 tgaaaagctc cttgaaaatc caggcgggta tggaaaggtg ctgctaccca tatctttttg
     3061 actttctttg tttcatgact ttaactcatg gcatctcctt tgtagtaaaa ggagacagac
     3121 cattaatttc agcatttctt tgtgatttat aagtactgag catgaagtac ttgtctgccc
     3181 ctcatttcaa ggccagagtt attttctatt tatgtattag tctaggctga tcttttaggg
     3241 cacaatagaa accatggggc gtggagcatg agttgtgaat ggcagggatc attctgggta
     3301 aaaaaaacct agaatcattt ctgatgtgca acattgtcaa gtgaagaagc taacagttca
     3361 actaccgaga ttatttgata acctgggttt tctcattcat ccatcaagca ccatcaacca
     3421 gtcagccatt attatttata tatgtattac caaaagcagt ctatctgcct gtgacctcca
     3481 atgtacactg ccaaacacaa gagtaggaca catctgttct gggttcttga cctatctgtc
     3541 tccaattcat ctcccctttt cagccatttc aacaaactac tctttggagc tctgagatga
     3601 catcttgttg ttttatatag atgtatcttt taaaaatagt tcacgtttgg agaattcttt
     3661 tgtactcatt tgctttttgt ctgagaacca tgtctatttt tataactgga gtgtgagttc
     3721 tgtatcttct cacattctgt atactgtatc cattttctag agaacccagt agcttttata
     3781 cagtctcttc ttaccacccc ttgtggtttc agaacaagct ttattttatt acgagtatat
     3841 taatgacaac taattcctgt tccaattcta cctgttttag ttgtgaaggt agttttgtgt
     3901 aatccagttg attgctcctc tggcagagag aaggagctca aaagatactt gatgtctttc
     3961 atgtaagttt acctggtctt ttcctattga agaatttttc atcagaaacg actgggaaag
     4021 tttgggaaag tcagcaaaag aaagaatgca tttcgaaagc aaacagaaga aaaaagtata
     4081 ttctcacagt ttttccccag gaagtctgga gaaaaagtcc tcatgtcacc aatttctctg
     4141 ttgcatgaat tttagtgttt tgctataaga cagcatgagg gctatcaggc caaaattcat
     4201 tattgtattt ccaatacagt ttgtcttgaa tgtctgtctc ttaaaccagt ttttacttgt
     4261 cagttttctc tcagcaaaca gtcttactat tatgtggaat ttaacttttc agagaaaatt
     4321 tccaaagtcc tctaccttat ttggctttta tctgtgtctt ttggaaaagg agctgcatgg
     4381 cctcagtgcc tccataaaaa gcttaagttg agttcatggg agaacattaa gatcgttttt
     4441 tttccctttt agctcggtaa tctcatgtac cacaggtaat gaccaagcat ctctgctaga
     4501 ggatgtaact ctcataactc ctgtgtaaaa tgaggatcct gttggtgatc ctcattccag
     4561 tttccaaagc gagaggagcc ttctgagcag aagtatgcaa gactgattct gtttggaaca
     4621 gtttcctatt tggctgcatt ctaggaggcc tcctgactta ttcatagtat tgtcgcctgg
     4681 tggcattggt gtggggtagc ttgtcctgct acttgctaaa gttctctttc tttgagaaaa
     4741 ctgaggaacc agaatgctta gagttcataa aataatctct aaaccatgtt aggttaaaac
     4801 aaaatgacca tctcacaaaa acgagtttag ttgaatgctc aattccttac aaaatcttca
     4861 tttaaggctg agtgtggtgg ctcatgcctg taattccagc actttgggag gccgaggcag
     4921 gaagactgct tgagcccagg agttcaagac cagcctgggc aacgtaggaa gactccgtct
     4981 ctacatagaa attttattat aaaagtagct ggggatggtg gcacacacct gtagtcccag
     5041 ctactcagga ggttgaggtg ggaagattgc ttgagcccag gagtttgagg ttgcagtgag
     5101 ctgatcatgc cactgcactc tagcctaggc tacagagcag gaccccatct ccaaaaaaaa
     5161 aaaaaaaaaa gtcatttaaa aactgaagaa tgttctcttc ttgctcagtt ccctaaatta
     5221 gctgggggga ttgggatact ttacaatttt tacattttta aatttgaaga atttgtttta
     5281 aacttacttg gtaatggcac ttctacttac tgaccaactt ttcagctctt tttgaccagg
     5341 atggttgcaa attagggaaa atatctttat actatacatc caattcaaga ggactttaat
     5401 tacttaaaag catttaggtc ataattaaaa ttattttcac tgtttccata aaataagcat
     5461 tatgattgca cactccttct actgtctgaa tttatgtaag aggtatagct tgcttaaaat
     5521 acatatatat gtaaagttat attttcttag aaacatggat gtttacagcc attgctttca
     5581 aagagattat tactgtgtat tctccctgtt ttacaatatg ttttcatgaa gactatgtta
     5641 caccagaggc ttctgattat caaagtgata accagtttta actgccggta tgtaccagat
     5701 ttgtgaacta atttaaaaaa ccacaaacta tgaataaaat ggggtttgca aactaaatat
     5761 cattaatgat tttcacttgc gtttactgat gagattaatc aataaagcca tttacattta
     5821 gtgaaa
//
