LOCUS       NM_020780               5265 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens dispatched RND transporter family member 3 (DISP3),
            mRNA.
ACCESSION   NM_020780 XM_052561 XM_938154
VERSION     NM_020780.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5265)
  AUTHORS   Konirova,J., Oltova,J., Corlett,A., Kopycinska,J., Kolar,M.,
            Bartunek,P. and Zikova,M.
  TITLE     Modulated DISP3/PTCHD2 expression influences neural stem cell fate
            decisions
  JOURNAL   Sci Rep 7, 41597 (2017)
   PUBMED   28134287
  REMARK    GeneRIF: our findings imply that DISP3 may help dictate the NSC
            cell fate to either undergo self-renewal or switch to the terminal
            differentiation cell program.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5265)
  AUTHORS   Zikova,M., Konirova,J., Ditrychova,K., Corlett,A., Kolar,M. and
            Bartunek,P.
  TITLE     DISP3 promotes proliferation and delays differentiation of neural
            progenitor cells
  JOURNAL   FEBS Lett 588 (21), 4071-4077 (2014)
   PUBMED   25281927
  REMARK    GeneRIF: impact of DISP3 on the proliferation and differentiation
            of neural precursors
REFERENCE   3  (bases 1 to 5265)
  AUTHORS   Cartmel,B., Dewan,A., Ferrucci,L.M., Gelernter,J., Stapleton,J.,
            Leffell,D.J., Mayne,S.T. and Bale,A.E.
  TITLE     Novel gene identified in an exome-wide association study of tanning
            dependence
  JOURNAL   Exp Dermatol 23 (10), 757-759 (2014)
   PUBMED   25041255
  REMARK    GeneRIF: patched domain containing 2 (PTCHD2), yielded a
            statistically significant P-value of 2.5 x 10(-6) (OR = 0.27) with
            fewer individuals classified as exhibiting symptoms of dependence
            to ultraviolet light, a known carcinogen, in the context of tanning
REFERENCE   4  (bases 1 to 5265)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5265)
  AUTHORS   Zikova,M., Corlett,A., Bendova,Z., Pajer,P. and Bartunek,P.
  TITLE     DISP3, a sterol-sensing domain-containing protein that links
            thyroid hormone action and cholesterol metabolism
  JOURNAL   Mol Endocrinol 23 (4), 520-528 (2009)
   PUBMED   19179482
REFERENCE   6  (bases 1 to 5265)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Hedgehog signaling pathway and gastric cancer
  JOURNAL   Cancer Biol Ther 4 (10), 1050-1054 (2005)
   PUBMED   16258256
  REMARK    Review article
REFERENCE   7  (bases 1 to 5265)
  AUTHORS   Peart,M.J., Smyth,G.K., van Laar,R.K., Bowtell,D.D., Richon,V.M.,
            Marks,P.A., Holloway,A.J. and Johnstone,R.W.
  TITLE     Identification and functional significance of genes regulated by
            structurally different histone deacetylase inhibitors
  JOURNAL   Proc Natl Acad Sci U S A 102 (10), 3697-3702 (2005)
   PUBMED   15738394
REFERENCE   8  (bases 1 to 5265)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Identification and characterization of DISP3 gene in silico
  JOURNAL   Int J Oncol 26 (2), 551-556 (2005)
   PUBMED   15645143
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590989.15, AB037758.1, AL117236.1 and BU733859.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020780.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593117.1, AB037758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294484.7/ ENSP00000294484.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AL590989.15        86756-86838
            84-764              AB037758.1         1-681
            765-1317            AL590989.15        109137-109689
            1318-2168           AB037758.1         1235-2085
            2169-3019           AL117236.1         1006-1856
            3020-5264           AB037758.1         2937-5181
            5265-5265           BU733859.1         50-50               c
FEATURES             Location/Qualifiers
     source          1..5265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..5265
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /note="dispatched RND transporter family member 3"
                     /db_xref="GeneID:57540"
                     /db_xref="HGNC:HGNC:29251"
                     /db_xref="MIM:611251"
     exon            1..218
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            219..1317
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..4400
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /note="dispatched 3; patched domain-containing protein 2;
                     patched domain containing 2; dispatched homolog 3"
                     /codon_start=1
                     /product="protein dispatched homolog 3"
                     /protein_id="NP_065831.1"
                     /db_xref="CCDS:CCDS41247.1"
                     /db_xref="GeneID:57540"
                     /db_xref="HGNC:HGNC:29251"
                     /db_xref="MIM:611251"
                     /translation="MDTEDDPLLQDVWLEEEQEEEEATGETFLGAQKPGPQPGAGGQC
                     CWRHWPLASRPPASGFWSTLGWAFTNPCCAGLVLFLGCSIPMALSAFMFLYYPPLDID
                     ISYNAFEIRNHEASQRFDALTLALKSQFGSWGRNRRDLADFTSETLQRLISEQLQQLH
                     LGNRSRQASRAPRVIPAASLGGPGPYRDTSAAQKPTANRSGRLRRETPPLEDLAANQS
                     EDPRNQRLSKNGRYQPSIPPHAAVAANQSRARRGASRWDYSRAYVSANTQTHAHWRIE
                     LIFLARGDAERNIFTSERLVTIHEIERKIMDHPGFREFCWKPHEVLKDLPLGSYSYCS
                     PPSSLMTYFFPTERGGKIYYDGMGQDLADIRGSLELAMTHPEFYWYVDEGLSADNLKS
                     SLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLAKQSTSKVQVLYGGTDL
                     FDYEVRRTFNNDMLLAFISSSCIAALVYILTSCSVFLSFFGIASIGLSCLVALFLYHV
                     VFGIQYLGILNGVAAFVIVGIGVDDVFVFINTYRQATHLEDPQLRMIHTVQTAGKATF
                     FTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVSCCWLAVLVTMPAALGLWSLYLAPLE
                     SSCQTSCHQNCSRKTSLHFPGDVFAAPEQVGGSPAQGPIPYLDDDIPLLEVEEEPVSL
                     ELGDVSLVSVSPEGLQPASNTGSRGHLIVQLQELLHHWVLWSAVKSRWVIVGLFVSIL
                     ILSLVFASRLRPASRAPLLFRPDTNIQVLLDLKYNLSAEGISCITCSGLFQEKPHSLQ
                     NNIRTSLEKKRRGSGVPWASRPEATLQDFPGTVYISKVKSQGHPAVYRLSLNASLPAP
                     WQAVSPGDGEVPSFQVYRAPFGNFTKKLTACMSTVGLLQAASPSRKWMLTTLACDAKR
                     GWKFDFSFYVATKEQQHTRKLYFAQSHKPPFHGRVCMAPPGCLLSSSPDGPTKGFFFV
                     PSEKVPKARLSATFGFNPCVNTGCGKPAVRPLVDTGAMVFVVFGIIGVNRTRQVDNHV
                     IGDPGSVVYDSSFDLFKEIGHLCHLCKAIAANSELVKPGGAQCLPSGYSISSFLQMLH
                     PECKELPEPNLLPGQLSHGAVGVREGRVQWISMAFESTTYKGKSSFQTYSDYLRWESF
                     LQQQLQALPEGSVLRRGFQTCEHWKQIFMEIVGVQSALCGLVLSLLICVAAVAVFTTH
                     ILLLLPVLLSILGIVCLVVTIMYWSGWEMGAVEAISLSILVGSSVDYCVHLVEGYLLA
                     GENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVPLFFCIIAPFAKFGK
                     IVALNTGVSILYTLTVSTALLGIMAPSSFTRTRTSFLKALGAVLLAGALGLGACLVLL
                     QSGYKIPLPAGASL"
     exon            1318..1537
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1674
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1809
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1970
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2110
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2259
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2421
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2422..2583
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2697
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2834
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3019
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3020..3150
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3323
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3324..3450
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3451..3596
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3597..3756
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3757..3870
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4037
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     exon            4038..5265
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5244..5249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /note="hexamer: ATTAAA"
     polyA_site      5265
                     /gene="DISP3"
                     /gene_synonym="PTCHD2"
                     /note="major polyA site"
ORIGIN      
        1 gggttgcgag ctgaggactg ggattcgcgc gcagcttccc gcggtctgct tgccctggag
       61 cggaggggga gccccagcct cctgcggctc cgagaagctt ccccctgcga cttccgcgag
      121 gagacgagtc tgcgcagcgt ggtggccgcc gccccccgac cctctgcgca ctctctcccg
      181 cgccggcggc tcagcctagc cccgttcggc cggccgagac tatggacacg gaggatgacc
      241 ccttgctgca ggatgtgtgg ctagaggagg agcaggagga ggaagaagca acgggtgaaa
      301 cctttttagg ggcccagaag ccagggcccc aacctggggc agggggacag tgttgctggc
      361 ggcactggcc cctggcttcc cgacccccag cttcgggctt ctggagtacc ctgggctggg
      421 ccttcaccaa tccgtgctgt gctgggctgg tgctcttcct gggctgcagc atccccatgg
      481 ccctgtcagc cttcatgttc ctttactacc caccgctgga cattgacatc tcctacaacg
      541 cctttgagat ccgcaaccac gaggcctcac agcgtttcga cgctctcact ctggcgctta
      601 agtcccagtt tggatcctgg gggcggaacc ggcgcgattt ggccgacttc acctccgaga
      661 cgcttcagcg ccttatctca gagcagctgc agcagctgca tctcggcaac cgctcgcggc
      721 aagcctcccg agccccccgc gtcatccccg cggcctcact cggtggccca ggcccttacc
      781 gggacacttc cgcggctcaa aagcccacag ccaatcggag cgggcgactt cggcgtgaga
      841 ccccgcccct ggaggatctg gcagccaacc agagtgaaga cccgcgaaac cagcggctga
      901 gcaagaatgg gcggtaccag cccagcatcc cgccccacgc ggcagtcgcg gccaatcaga
      961 gccgtgcccg ccgaggcgcc tcgcgctggg actactcgcg cgcctatgtg agtgccaaca
     1021 ctcagacgca cgcgcactgg cgcatcgagc tcatcttcct ggcgcgcggc gacgcggagc
     1081 gcaacatttt caccagtgag cgcctggtca cgatccatga gatcgagcgc aagatcatgg
     1141 accacccagg cttccgggag ttctgctgga agccccacga ggtgctcaag gatctgccgc
     1201 tgggctccta ctcctactgc tcgcccccca gctcgctcat gacctacttt tttcccaccg
     1261 agaggggcgg caagatctac tatgacggca tgggccagga cctggcggac atccggggct
     1321 ccctggagct ggccatgact caccctgagt tctactggta tgtggatgag ggcctctctg
     1381 cagacaatct gaagagctcc ctcctgcgca gtgagatcct gtttggagca cccctgccca
     1441 actactactc agtagatgac cgctgggagg aacaacgggc taagtttcag agcttcgtgg
     1501 tcacctacgt ggccatgctg gccaagcagt ctaccagcaa agtccaggtt ctctatgggg
     1561 ggacagacct gtttgactat gaagtgcgca ggacgttcaa caatgacatg ctcctggcct
     1621 tcatcagcag cagctgcatt gctgccctgg tctacatcct cacctcctgc tcagtgttcc
     1681 tgtccttctt tgggattgcc agcattggtc tcagctgcct ggtggccctc ttcctgtacc
     1741 acgtggtctt tggtatccag tacttgggca tcctgaatgg ggtggccgcc ttcgtgatcg
     1801 tgggcattgg tgtggacgat gtctttgtgt tcatcaacac ctaccgccag gccacccacc
     1861 tggaagaccc acagctgcgc atgatccaca ccgtccaaac tgcaggcaag gccaccttct
     1921 tcacctccct gaccacagcc gccgcctacg cagctaacgt cttctcccag atcccagccg
     1981 tccacgactt tggcctgttc atgtctctca tcgtgtcctg ttgctggctg gccgtgcttg
     2041 tcaccatgcc tgcagctctg ggcctctgga gcctctacct ggcaccactg gagagctcct
     2101 gccagaccag ctgccaccag aattgcagcc ggaagacctc cctgcacttc cccggagacg
     2161 tgtttgccgc tcccgagcag gttggaggca gccctgccca gggccccata ccctacctgg
     2221 atgatgacat ccccttgctg gaggtcgagg aagagccagt gtcactggag ctgggagacg
     2281 tgtccctggt gtctgtgtcc cccgagggtc tgcagccagc ctccaacacg ggcagccgcg
     2341 gccatctcat cgtgcagctg caggagctgc tgcaccactg ggtcctgtgg tcagccgtca
     2401 agagccgctg ggtgattgtg gggctgttcg tctccatcct catcttgtcc ctggtgttcg
     2461 ccagccggct ccgccccgcc agccgggccc cgctactctt ccggcctgat accaacatcc
     2521 aggtgctgct ggacctcaag tacaacctga gcgccgaggg catctcctgc atcacctgtt
     2581 caggtctgtt ccaggagaag ccccacagcc tgcagaacaa catccggacg tccctggaga
     2641 agaagaggcg aggctcaggg gtcccctggg ctagccggcc tgaggccacc ctgcaggatt
     2701 tcccaggcac cgtgtacatc tctaaagtga agagtcaagg ccaccccgct gtctacaggc
     2761 tctccctcaa tgccagcctg cctgctcctt ggcaggctgt gtcgcctggg gatggagagg
     2821 tgccctcctt ccaggtgtat agagcgcctt ttggtaactt caccaagaag ctgaccgctt
     2881 gtatgtctac agtagggctg ctccaggcgg cgagcccctc ccgcaagtgg atgctgacga
     2941 ccttggcctg tgatgccaag cggggctgga agtttgactt cagcttctac gtggccacca
     3001 aggagcagca gcacacccgg aagctgtact tcgcccagtc ccacaagccc cccttccacg
     3061 ggcgcgtatg catggcaccc cctggctgcc tgcttagctc cagccccgat gggcctacca
     3121 aaggcttctt cttcgtgcct agtgagaaag tgcccaaggc ccgtctctca gccaccttcg
     3181 gcttcaaccc ctgcgtgaac acgggctgcg ggaagccggc ggtgcggcca ctagtggata
     3241 ccggggccat ggtctttgtg gtcttcggca ttattggcgt caaccgcact cggcaggtgg
     3301 acaaccacgt cattggagac ccgggtagtg ttgtctacga cagcagcttt gacctcttca
     3361 aggaaattgg gcacctgtgt cacctctgca aggccatcgc agccaactcc gagctggtga
     3421 agccgggtgg ggcccagtgc ctgccttcag gctacagcat ctcctccttc ctgcagatgt
     3481 tgcaccctga gtgcaaggag ctgcccgagc ccaacctgct cccggggcag ctgtcccacg
     3541 gggcagtggg cgtcagggag ggccgcgtgc agtggatctc catggctttc gagtcgacca
     3601 cgtacaaggg caaatcctcc ttccagacct actcggacta cctgcgctgg gagagcttcc
     3661 tccagcagca gctgcaggcc ttgcccgagg gctcagtcct gcgccggggc ttccagacct
     3721 gcgagcactg gaagcagata ttcatggaaa tcgtaggggt gcagagcgcc ctgtgcggcc
     3781 tggtgctatc cctgctcatc tgcgtggccg cggtggccgt gttcaccacc cacatcctgc
     3841 tcctgctgcc cgtgctcctc agcatcttgg gcatcgtgtg cctggtggtg accatcatgt
     3901 actggagcgg ctgggagatg ggggctgtgg aagccatctc cctgtccatc ctcgttggct
     3961 cctccgtgga ttactgcgtc cacctggtcg agggctacct gctggctgga gagaacctgc
     4021 ccccccacca ggccgaggac gcccgaacgc agcgccagtg gcgtacgctg gaggccgtgc
     4081 ggcacgtggg cgtggccatc gtctccagtg ccctcaccac ggtcatcgcc acagtgcccc
     4141 tcttcttctg catcatcgcc ccatttgcca agttcggcaa gattgtggca ctcaacacgg
     4201 gcgtgtccat cctctacacg ctgaccgtca gcaccgccct gctgggcatc atggcgccca
     4261 gctctttcac tcggacccgg acttccttcc tcaaggccct gggtgccgtg ctgctggcag
     4321 gggccctggg gctgggtgcc tgcctcgtgc tcctgcagag cggctataag attcccctgc
     4381 ccgcaggggc ctccctatag cccgggacgg gctctggaca cttgcacctt tggtcccatg
     4441 ggtgggggac aggagctgct tcccagctcg acttcagcta gctgtgtccc caggcctggg
     4501 cccagggcgc cctgcgggcc agcgtggagg ctgacaccca cacagatggt gtggaccatg
     4561 ctgccttgtg gagctgggag ttggagacag ccgccacccc acaggccggg ctactggcag
     4621 ccacactcgg ctttttgccc agtggcagaa gagaccagcc ctcctcccat gcccggtcac
     4681 catgggggtc aggttatttt tgtagggggt ctccctctca cactgcctca gtgctcacaa
     4741 ccttccagtg tggatgttac agggtggccc ccattctacc gatgtgaaaa ctgaggcgcc
     4801 aggacacagt ggctgccctg tcgctggatc agtagcagag ccagagctgc ctccgagcgc
     4861 catgccgccc tcgggaatca tacaggaaga gcacagtgga tccagggtgg gggcctctca
     4921 ccccctaacc ccgccccccc gcaaccctcc ccttcagctt tacggcggcc agtgctgaat
     4981 ggccctgtgg ccctccctgg gccttttggt cttggccaga gaagacagaa ggacccggct
     5041 tgggcttctg catgtcctac ccctgacccc agcctcaagg ggcccctcaa aggccctctc
     5101 tgggggctct ggggctcagc acagctttcc tcatggatct aagcccctgt ctttcccacc
     5161 tgactctgag tggatgtttt gggggatggc ccctgtgggg aggagctgcc atgccggccg
     5221 cctgctcacg gcagaaggtt gctattaaaa tgacatagga ttgca
//
