LOCUS       NM_033510              12612 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens dispatched RND transporter family member 2 (DISP2),
            mRNA.
ACCESSION   NM_033510
VERSION     NM_033510.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12612)
  AUTHORS   Khamse,S., Alizadeh,S., Khorshid,H.R.K., Delbari,A., Tajeddin,N.
            and Ohadi,M.
  TITLE     A Hypermutable Region in the DISP2 Gene Links to Natural Selection
            and Late-Onset Neurocognitive Disorders in Humans
  JOURNAL   Mol Neurobiol 61 (11), 8777-8786 (2024)
   PUBMED   38565786
  REMARK    GeneRIF: A Hypermutable Region in the DISP2 Gene Links to Natural
            Selection and Late-Onset Neurocognitive Disorders in Humans.
REFERENCE   2  (bases 1 to 12612)
  AUTHORS   Hald,J., Galbo,T., Rescan,C., Radzikowski,L., Sprinkel,A.E.,
            Heimberg,H., Ahnfelt-Ronne,J., Jensen,J., Scharfmann,R.,
            Gradwohl,G., Kaestner,K.H., Stoeckert,C. Jr., Jensen,J.N. and
            Madsen,O.D.
  TITLE     Pancreatic islet and progenitor cell surface markers with cell
            sorting potential
  JOURNAL   Diabetologia 55 (1), 154-165 (2012)
   PUBMED   21947380
REFERENCE   3  (bases 1 to 12612)
  AUTHORS   Katoh,Y. and Katoh,M.
  TITLE     Hedgehog signaling pathway and gastric cancer
  JOURNAL   Cancer Biol Ther 4 (10), 1050-1054 (2005)
   PUBMED   16258256
  REMARK    Review article
REFERENCE   4  (bases 1 to 12612)
  AUTHORS   Ma,Y., Erkner,A., Gong,R., Yao,S., Taipale,J., Basler,K. and
            Beachy,P.A.
  TITLE     Hedgehog-mediated patterning of the mammalian embryo requires
            transporter-like function of dispatched
  JOURNAL   Cell 111 (1), 63-75 (2002)
   PUBMED   12372301
REFERENCE   5  (bases 1 to 12612)
  AUTHORS   Burke,R., Nellen,D., Bellotto,M., Hafen,E., Senti,K.A.,
            Dickson,B.J. and Basler,K.
  TITLE     Dispatched, a novel sterol-sensing domain protein dedicated to the
            release of cholesterol-modified hedgehog from signaling cells
  JOURNAL   Cell 99 (7), 803-815 (1999)
   PUBMED   10619433
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC013356.8, AB051529.2,
            HY171765.1 and CB305650.1.
            
            On Nov 23, 2018 this sequence version replaced NM_033510.2.
            
            Summary: This gene is one of two human homologs of a
            segment-polarity gene known as dispatched identified in Drosophila.
            The product of this gene may be required for normal Hedgehog (Hh)
            signaling during embryonic pattern formation. [provided by RefSeq,
            Jan 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051529.2, BC151833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000267889.5/ ENSP00000267889.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AC013356.8         43943-43958
            17-61               AB051529.2         3-47
            62-241              AB051529.2         51-230
            242-242             AC013356.8         49368-49368
            243-465             HY171765.1         226-448
            466-2355            AB051529.2         455-2344
            2356-2356           AC013356.8         54089-54089
            2357-5038           AB051529.2         2346-5027
            5039-5047           CB305650.1         18-26               c
            5048-12612          AC013356.8         56781-64345
FEATURES             Location/Qualifiers
     source          1..12612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q15.1"
     gene            1..12612
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /note="dispatched RND transporter family member 2"
                     /db_xref="GeneID:85455"
                     /db_xref="HGNC:HGNC:19712"
                     /db_xref="MIM:607503"
     exon            1..222
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..4309
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /note="dispatched B; long intergenic non-protein coding
                     RNA 594"
                     /codon_start=1
                     /product="protein dispatched homolog 2"
                     /protein_id="NP_277045.1"
                     /db_xref="CCDS:CCDS10056.1"
                     /db_xref="GeneID:85455"
                     /db_xref="HGNC:HGNC:19712"
                     /db_xref="MIM:607503"
                     /translation="MDGDSSSSSGGSGPAPGPGPEGEQRPEGEPLAPDGGSPDSTQTK
                     AVPPEASPERSCSLHSCPLEDPSSSSGPPPTTSTLQPVGPSSPLAPAHFTYPRALQEY
                     QGGSSLPGLGDRAALCSHGSSLSPSPAPSQRDGTWKPPAVQHHVVSVRQERAFQMPKS
                     YSQLIAEWPVAVLMLCLAVIFLCTLAGLLGARLPDFSKPLLGFEPRDTDIGSKLVVWR
                     ALQALTGPRKLLFLSPDLELNSSSSHNTLRPAPRGSAQESAVRPRRMVEPLEDRRQEN
                     FFCGPPEKSYAKLVFMSTSSGSLWNLHAIHSMCRMEQDQIRSHTSFGALCQRTAANQC
                     CPSWSLGNYLAVLSNRSSCLDTTQADAARTLALLRTCALYYHSGALVPSCLGPGQNKS
                     PRCAQVPTKCSQSSAIYQLLHFLLDRDFLSPQTTDYQVPSLKYSLLFLPTPKGASLMD
                     IYLDRLATPWGLADNYTSVTGMDLGLKQELLRHFLVQDTVYPLLALVAIFFGMALYLR
                     SLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVNLAALLLLSSVCANHTLIFFDLW
                     RLSKSQLPSGGLAQRVGRTMHHFGYLLLVSGLTTSAAFYASYLSRLPAVRCLALFMGT
                     AVLVHLALTLVWLPASAVLHERYLARGCARRARGRWEGSAPRRLLLALHRRLRGLRRA
                     AAGTSRLLFQRLLPCGVIKFRYIWICWFAALAAGGAYIAGVSPRLRLPTLPPPGGQVF
                     RPSHPFERFDAEYRQLFLFEQLPQGEGGHMPVVLVWGVLPVDTGDPLDPRSNSSLVRD
                     PAFSASGPEAQRWLLALCHRARNQSFFDTLQEGWPTLCFVETLQRWMESPSCARLGPD
                     LCCGHSDFPWAPQFFLHCLKMMALEQGPDGTQDLGLRFDAHGSLAALVLQFQTNFRNS
                     PDYNQTQLFYNEVSHWLAAELGMAPPGLRRGWFTSRLELYSLQHSLSTEPAVVLGLAL
                     ALAFATLLLGTWNVPLSLFSVAAVAGTVLLTVGLLVLLEWQLNTAEALFLSASVGLSV
                     DFTVNYCISYHLCPHPDRLSRVAFSLRQTSCATAVGAAALFAAGVLMLPATVLLYRKL
                     GIILMMVKCVSCGFASFFFQSLCCFFGPEKNCGQILWPCAHLPWDAGTGDPGGEKAGR
                     PRPGSVGGMPGSCSEQYELQPLARRRSPSFDTSTATSKLSHRPSVLSEDLQLHDGPCC
                     SRPPPAPASPRELLLDHQAVFSQCPALQTSSPYKQAGPSPKTRARQDSQGEEAEPLPA
                     SPEAPAHSPKAKAADPPDGFCSSASTLEGLSVSDETCLSTSEPSARVPDSVGVSPDDL
                     DDTGQPVLERGQLNGKRDTLWLALRETVYDPSLPASHHSSLSWKGRGGPGDGSPVVLP
                     NSQPDLPDVWLRRPSTHTSGYSS"
     exon            223..552
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     exon            553..582
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     exon            583..706
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     exon            707..822
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     exon            823..950
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1048
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..12612
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5016..5021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /note="hexamer: AATAAA"
     polyA_site      5047
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /note="major polyA site"
     regulatory      12020..12025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /note="hexamer: AACAAA"
     polyA_site      12053
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
     regulatory      12595..12600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
                     /note="hexamer: ATTATA"
     polyA_site      12612
                     /gene="DISP2"
                     /gene_synonym="C15orf36; DISPB; HsT16908; LINC00594"
ORIGIN      
        1 atgcgcacga gcaccccgcc gccgctgccg ccgccaccgc cgccgccgcc gccgccgccg
       61 cggcttcagc accagcgccc ggacagcggt gccgcccacg ggcatggacg gtgacagcag
      121 cagcagcagc ggcggcagcg gtccggctcc cggcccgggt ccggaagggg agcaacggcc
      181 cgagggggag cccttggccc cagacggcgg ctccccggac agcacccaga ccaaggctgt
      241 gccccctgag gcaagcccag agagaagctg ctccctccac agctgccccc tggaggaccc
      301 ttccagctct tcaggacccc caccaacaac ttccaccctc cagcctgtgg gtccatccag
      361 ccccttggcc cctgcccact tcacctatcc ccgggcactg caggaatacc aggggggcag
      421 ttccctgcca ggacttgggg atcgggcagc tctctgctcc cacggctcca gcctcagccc
      481 ttctccagcc ccctcacagc gcgatgggac ctggaagcca cccgctgtgc agcaccatgt
      541 ggtcagcgtc aggcaggaac gagccttcca gatgccaaag agctattccc agctgattgc
      601 tgagtggcca gtggccgtgc tgatgctgtg tctggctgtc atcttcctct gcaccctggc
      661 tggactgttg ggggcccggc tgcccgactt ctccaagcct ttgctgggct ttgagccacg
      721 ggacacagac attgggagca agttagtggt ctggagagca ctacaagccc tcacaggccc
      781 caggaagctg cttttccttt ccccagacct tgagctgaac agctcgagct cccacaacac
      841 tctgaggcct gcacccagag gcagtgccca ggagagcgct gtccggcctc ggagaatggt
      901 ggagcccctg gaggacagaa ggcaagagaa cttcttctgt ggcccccctg agaagagcta
      961 tgcaaagctg gtgttcatgt ccacctcctc gggcagccta tggaacctgc atgccatcca
     1021 ttccatgtgt cgcatggaac aggaccagat ccgctcccat accagcttcg gggctctgtg
     1081 ccagcggaca gcagccaacc agtgctgccc cagctggtcc ctgggcaact atctggctgt
     1141 gctctccaac cgctcctcct gcctggacac tacccaagct gacgcagccc gcacactggc
     1201 cctgcttcgg acctgtgccc tctactacca cagtggcgcc ttggtgccct cttgtctggg
     1261 acctgggcag aacaagtccc cacgctgtgc ccaggttccc accaagtgct cccagagtag
     1321 tgccatctac caactcctgc actttctgct tgacagggac tttctgagtc cccagaccac
     1381 tgactaccag gtgccttccc tcaagtacag cctgctcttc ctgcccaccc caaagggtgc
     1441 ttccctcatg gacatctacc tggaccggct ggccaccccc tgggggcttg ctgacaacta
     1501 cacctctgtc actggcatgg acctgggcct caagcaggag ctgctgaggc acttcctggt
     1561 ccaggacacg gtgtacccct tgctggctct ggttgccatc ttcttcggca tggccctgta
     1621 cctgcgctca ctcttcctca cgctcatggt gctgctgggg gtgctgggct cactgctggt
     1681 ggccttcttc ctttaccagg tggccttccg catggcctac ttccccttcg tcaatctggc
     1741 agccctcctc ctgctgagca gcgtctgcgc caaccacacg ctcatcttct tcgacctgtg
     1801 gcgccttagc aagagccagc tgccgtcggg ggggctggcg cagcgcgtgg gccgcaccat
     1861 gcaccacttc ggctacctgc tgctggtctc cggcctcacc acgagcgcgg ccttctatgc
     1921 cagctacctg agccgcctgc cggccgttcg ctgcctcgcc ctcttcatgg gcacggctgt
     1981 gctggtgcac ctggcgctca cgctggtctg gctgcccgcc tccgccgtgc tccacgagcg
     2041 ctacctggcg cgcggctgtg cgcgccgggc gcggggccgg tgggagggca gcgcgccccg
     2101 gcggctactg ctggcgctgc accggcggct ccgcggcctg cggagggcgg cggctggcac
     2161 ctcgcgtctg ctcttccagc gcctgctgcc ctgcggcgtc atcaagttcc gctacatctg
     2221 gatctgctgg ttcgcagcac tggcggcagg gggcgcctac atcgccggag tcagcccccg
     2281 cctgcggctg cccacgctgc cgccgcccgg cggccaggtc ttccggccca gccacccctt
     2341 cgagcgcttc gacgcggagt atcgccagct gttcctgttc gagcagctgc cgcagggcga
     2401 gggcggccac atgcccgtgg ttttggtgtg gggcgtcctg cctgtggaca ctggcgaccc
     2461 tctggaccct cgtagcaaca gcagcctggt gagggaccct gccttctcgg ccagcggccc
     2521 tgaggcccag cgctggctgc tggcactctg tcaccgggcc cggaatcaga gcttcttcga
     2581 caccctgcag gaaggctggc ccacgctgtg tttcgtggag accctccagc gctggatgga
     2641 gagccccagc tgcgcccgcc tggggcctga cctctgctgc ggccactcgg acttcccctg
     2701 ggccccccag tttttcctgc actgcctgaa aatgatggct ctggagcaag gccccgatgg
     2761 cacccaggac ctgggactcc gctttgatgc ccatggcagc ctggccgccc tggtcctaca
     2821 attccagacc aacttccgga acagtccgga ctacaaccag acccagctct tctacaatga
     2881 ggtcagccac tggctggcag cggagctggg catggcacct ccaggcctcc gccgtggttg
     2941 gttcactagc cgtctagagc tgtatagcct gcagcacagc ctgagcactg agcctgctgt
     3001 ggtgctgggc ctggctttgg cgctggcctt tgccacactg ctcctgggca cctggaatgt
     3061 tcccctcagc ctattctccg tggcagctgt ggcaggcacc gtgctgctca ctgtaggact
     3121 cctggttctc ctcgagtggc agctcaacac tgccgaggcc ctgtttctct ctgcctcagt
     3181 gggcctctca gtagacttca ctgtcaacta ctgcatctcc tatcacctgt gcccacaccc
     3241 tgaccgcctg agccgtgtgg ccttctctct gcgccagacc agctgcgcca cagccgtggg
     3301 ggctgcagcc ctgtttgcgg caggcgtgct catgctgcct gccacagtgc tgctctatcg
     3361 caagctgggc atcatcctca tgatggtcaa atgcgtcagt tgtggctttg ccagcttctt
     3421 cttccaatct ctctgctgtt tcttcgggcc agagaagaac tgtgggcaga tcctctggcc
     3481 ctgtgcccac ctgccatggg atgctggtac tggggaccct ggtggggaga aggcaggccg
     3541 cccacgacca gggtcagtgg gagggatgcc cgggtcctgc tcagagcaat atgagctaca
     3601 gcccctggca cggcgtcgga gccccagctt tgacaccagc acagccacca gcaagctgtc
     3661 ccaccggccc tcagtactct ctgaggatct gcagctccat gatggtccgt gctgttcccg
     3721 gcccccacca gcccctgcct ccccaaggga gctgctgctg gaccaccagg cagtcttcag
     3781 ccagtgccct gccctgcaga cctcctcccc ctataagcag gctggcccca gccccaaaac
     3841 ccgggccagg caggactccc aaggggagga ggctgagccc ctgccagcct caccagaagc
     3901 cccagcccac tctcctaagg ccaaggctgc agatcctcct gatggcttct gttcctcagc
     3961 cagcaccctg gaggggctca gcgtctctga tgagacctgc ctaagcacct ctgagcccag
     4021 tgcccgtgta ccagattccg tgggtgtgtc cccagatgac ctggatgaca ctgggcagcc
     4081 agtccttgag cgaggccagc tcaatgggaa gcgggacacc ctgtggctgg cgctgaggga
     4141 gacagtgtat gacccatcat tgcccgcttc ccatcacagc agcttgtcct ggaagggccg
     4201 aggggggcca ggggatggca gccctgtggt gctgcccaat agccagccag acctgccaga
     4261 tgtttggctg cgcaggccca gcactcacac gtcaggctat agcagctgag ggggacccgg
     4321 ggaggctgga cagggcgcgg aaccctgtca tggatgacaa ggcaagggca gcaataggct
     4381 ggagcccgaa ggtatttctc cagatccaca gggagaggtc tcaccctcca gctgtggatg
     4441 ttaaaccctg ccagatgtcc cagccttgat ctgtctgctc ctactcctca catctggagg
     4501 attccagcag gaggggtttt ggaggggacc tgcttgcgac ctgctgaggg cttgtctgct
     4561 cccacagcac catctaagac ccctcctcta gaagtgggga aggccagatg tgtagcttcg
     4621 ggtatcagag gaggctgacc tggcccccat cccaagttac aagaacttca gtgagactaa
     4681 gggaccccca tcctagggat cttgtcaggg ttccttactg accagaggag cccgcagcaa
     4741 tctccacagc ctcctgggtc tcaccccttt catgggctct tcatcaggac acttccctct
     4801 cttttgggag cttctctggg cagaattggg ctgggacctc tctccccaac tgccctgctc
     4861 tcctcatact caccggtttg accagaaatt ctccaaatcc agccatagat ggctgctggg
     4921 tgtgcagcag gagaaggagg atggtcagcc ttggagcatc tctcaattac gggacagtcc
     4981 ctctttggaa gcaggctcct gtgctttcct gtgttaataa acagtaataa tcctttccat
     5041 ctctgcacat tttagtctcc ttggaatcta tctcactact tcactacagg gtagcctgac
     5101 attggtcagg ttcttttgac acccaattta taggtaaaga cattgagact aagtaagatg
     5161 aactgacctc agggtcactt agccactaaa tggcagagcg gtttcattcc accactacaa
     5221 cctccagttt ccctttggct acctgccttc tttcaccgct agcaccctcc tccaatctgc
     5281 tttctctggt gtctctgact gaatccagcc accctctttg ggcctccact tcctgagaga
     5341 gctgtattcc aaaaaaaccc aggagttcct ctccatctcc cccgtgcctc cctctggaat
     5401 ctggctgaga tgtctgctgg ccctggggcg tcctagctga cctgattccc aggcttcagg
     5461 accgtgcctc ttctacagcc acagtgtata agaggcccca ccagaagagg tactgagggg
     5521 cagaagaggt gaagccaaat ccaatcaagg caggaactca gacctgccct ttgggaagtg
     5581 tatgagtctg aagctgcttc ccaggttagg gtccccagct ttttaaggac aagtctctct
     5641 gtggagcgtt aagcagacca aaggctggtt cctccttccc aaacttcctg gtagggaagt
     5701 tttatcccat gtgagagctc atgacaccag gtggcatcaa catgtttatt gaacacctac
     5761 tttgcatatg gtattacaag gggacagagg tgtggaagaa aaattgaaca ccaccctcaa
     5821 agagctcacc ttctagctgg ggagacagct tatgcacaca tgcaggcatc ggatggctca
     5881 cggacggcac catatgcctg ccatcatcat tattgttgga gctcaagtac ccaggactgg
     5941 gtaacaagaa aggctttctg gaggaggaaa aacttgagct gggcttcaga agaccaagcg
     6001 tctcagactg gaaggggcct tggcgatcgt ttattccagc agttttcaaa ttttgtagcc
     6061 tcaggactct ttcttcaaag aagctctgtg tggaaaaaca atatataaaa caggtaaaag
     6121 gcagctactc tggtgggcgc tgggtgttgg gggtggagtc agcttagcct gtctttccac
     6181 tgcagcctct ccgggtatct ggggaacccc tccggctcct ggcagcttca cagaatgtaa
     6241 tatgaaagct actgatccag gctattttac agaggagtat caggaaaggg aagggattgt
     6301 tctagggcca aatagtctgt ggcagagctg gaggcaaatc agatgatgtt tttgttttat
     6361 ttagtttttt attattgaga cctacttcct actccaagta gcccatgaga agtggagcag
     6421 aaaccgaaaa gagacatggg agttgtggaa gagacagaag gcaataggca ggtacggcag
     6481 gataccttgg ctcctttgca agataagtaa atcaagatga gtaactcctg acaccaggaa
     6541 ggggaagctg gaacctaatt tgaacctgtc cccagggggt ctgctgggac ctctctcttc
     6601 atgtccaggt agcattcggc ctctctgacc tagagctgct catcagccct ggtttctctg
     6661 ataatggtgt ccctctgtca tcatgcagcc aggctgagag agccctggta tcctcaggga
     6721 caatgagcca cagggaggtt aagggaactc ttcctcccaa gcatgagcag aagacacttt
     6781 gcctgaacat aaccactgaa atgttagaat gcagaggggt ggatgggtgg gcatgaggga
     6841 tctgagcaca cccgagggcc ctacctgggg atttccaggt catattcttg caggctgtgg
     6901 ccacacaaca cttcaggaag gtgaatgagc catagcagct gatgcattga ttagatttgt
     6961 tctttatgtt gccaggccca gaagaaccca gcagtaatct aaaacattac cttataccta
     7021 gaatggccca aaccaacagc aggcaatcca catcagcagg aaatccagcc tgcctctcta
     7081 gccctgactt tggaatgtgg aacttaaagc acttcctatt tcctttgagt tgcagcagat
     7141 cctttgcttt attattatta ggggcactta caatgagtgt atggccctgg agacatggct
     7201 tacaagcacg ctgtgaggcg tacaaaaatg agtcaaagca cttatgcttg ccctgcaaaa
     7261 ttcaagaaat gatttctccc cactcagaca ctctaataga actacattaa catttggaac
     7321 ttgaggtcat ttcccctatt tgtgccactg atccttgaac tcacattctg agtacgagta
     7381 tgtatcctgt atgctattaa aatataactt gaggccggac atgatggctc atgcctgtaa
     7441 tcccagcact ttgggaggct gaggcaggtg gatcactaga cgttaggagt ttgagaccag
     7501 cctggccaac atggtgaaac cccgcctcta ctaaaaatac aaaaattagt tgggcgtggt
     7561 gggggatgcc tgtagtccta gctacccagg aggctgaggc aggaaaatca tttgaacccg
     7621 ggatgcagag gttgaagtga gccgagatcg tgccactgca ctccagcctg gatgacagag
     7681 caagacaccg tctcaaaaaa taaataaata aataagtcgg gcacggtggc tcacgcctgt
     7741 aatcccagca ctttgggagg ccaaggcagg tggatcatga ggtcaggaga tcgaaaccat
     7801 cctggctaac atggtgaaac cccgtctcta ctaaaaatac aaaaattagc cgggtgtggt
     7861 ggcgggcgcc tgtagtccca gctactcggg aggctgaggc aggagaatga tgtgaaccca
     7921 ggaggcagag cttgcagtaa gccgagattg cgccactgca ctccagcctg ggcaacagag
     7981 cgagactcca tcttaaaaaa aaaaaatata tatatatata tatgtaaact tgatatagtc
     8041 tgttaccatg ggaaaaccat ccttccatgg ctgtggtgat ttggggactt ttagagtgac
     8101 agtgttagac agactgattt tattggctga atcttagatt ttactgatat atagcatatc
     8161 ccataccatg atatgcgggc aatattccag cttgagacaa tttttttttt ttttttttga
     8221 gacagagtct tgctctgtcg cccaggctgg agtgcagtgg cacaatttcg gctcactgca
     8281 ctaatttttt gtatttttag tagagacagt agagtatttt tagtgttagc caggatggtc
     8341 tcgatctcct gacctcatga tccgcctgcc tcggcctccc agagtgctgg gattacaggc
     8401 atgagccacc gcgcctggcc gagacaattt ttaaaaagac atttctcaag agagttataa
     8461 gccaaaattt ccctagcccc ctccaactca ttctgtcctt ctcccagtgc atgtcaggac
     8521 agggaagaag gctttaaatc agattttaag aaagaggata cattggttta caacctttgc
     8581 ctatcgtcca gagagtttct gatcttttct ttttttttga gacggagtct tgctctgtcg
     8641 cccaggctgg agtgtagtgg cacgatcttg gctcactgca agctctgcct cccaggttca
     8701 cgccattctc ctgccccagc ctcccgagca gttgggacta caggcacctg ccaccacgcc
     8761 tggcaaattt tttgtatttt tagtaaagac ggggtttcat tgtgttagcc aggatggttt
     8821 cgatctcctg accttgtgat ccgcccacct cggcctccca gagtgctggg attacaggtg
     8881 tgagccacta cacccggccc tgatcttttc tttgacggtg gcagtatctc attttttgat
     8941 aatacacatg ggtaatggca agctcttggg accccatgcc aagcatcaag atcccattta
     9001 cctggtgata ggaaagacag acattcctca ccctttctac ccacaccctt gttcacaggg
     9061 atgactgtaa ctaaggtctg caggtattta tgcttaggag aagaaatcgt agttcaattc
     9121 accaggaata tgagaaacaa aagaaagcca ctatgtgcta tgtaaatgtc tggccatcca
     9181 aagccacctt atgcagagga acactggaag ggccttgata aatttctcat aattattatc
     9241 gggcctcttt gtgattactc acatttttct caatataggg gaaagatcag cattttacca
     9301 aatccacaac catcaaacaa acaagagctt taatattgct aaagaaaatc acacagctga
     9361 gcagattgat gtagatttga attcatgacc acctatctta actggaccct cagctctgcc
     9421 tagctagtat tcattctagc tactagtttt gattatttgt attgactctt ttatattttc
     9481 tccaccttcc tcaaatatct caccttcccc cacccctcag tggacaaaaa aaaaaaaaaa
     9541 attcttcatg aagaaaactg aagccttcaa atagaaattt cctcaccttc aaggcaccaa
     9601 agccacaact tacctacccc cgctcctgcc tgctcctctc cccatccctt ctgctacaac
     9661 gaaggaagca gtaatggctc catcaatggc ttctcacact tggtgtcaga ggccttcaca
     9721 cgagggtttg cactccccta caaggacatg aagactttct agaaggtagg tggacacaga
     9781 tagttttaaa gtaatcagtt tccagagccg ccttctccat atgttcccct ccttatattg
     9841 gtgggcctaa gaagccacag gcctgacagc tgtccttccc aacttccact ttcccagttg
     9901 cctcccctcc ctcattctga atcctactct ggctccttgc tctgcgctgt aaaaaacaaa
     9961 taaaagggcc acttgagaat gctctgcttg aggaagtcct tgaaagagca aagcctggag
    10021 agcttctttg agaaagttca caggggcagc cctgtggctc agttctgtgc cttcttcatt
    10081 taagaattca aattcattga catgttatat tgtaaaatat ataaatatat attaaaaagg
    10141 aaaaaataat aaaaattttt aaaaataatt caacttcagg tgagacacag tggctcatgc
    10201 ctataatccc agtgttttga aaggctgaag tgggaggatg gcttgaggcc aggagtttga
    10261 gaccagcttg ggcaacatag caagatcccg tatctacaaa aaataatttt aaaaattagc
    10321 tgggcatggg ccgggcgcgg tggctcacgc ctgtaatccc agcactctgg gaggccgagg
    10381 caggtagatc atctgaggtc aggagttcaa caccagcctg gccaacatgg caaaaccctg
    10441 tctctactaa aaatacaaaa attagccggg cgtggtggag catgcctgta gtcccagcta
    10501 ctcaggaggc tgaggaagga caatcgcttg aaccctggag gcagaggttg cagtgagcca
    10561 agatcatgcc attgcactcc agcctgggtg acagagcgag actacatctc aaaataaata
    10621 aataaataat aaaataaaaa taaaaattag ctgggcatgg tgatatgcgc ctgtagaccc
    10681 agctactcca gaggctgaag caagaggatc acttgaactc tggagttcga ggttacagtg
    10741 agccataatc acattatggc actccagcct ggcaacagag cgagacctta actctaaaaa
    10801 aagaaataaa gaagaattta aactgaaagt gagatggttg acacaggata catattaacc
    10861 acattgattt gaatggaaaa ataaaatcag actttttctg ttagaaggtc agaattggct
    10921 cacaggtttg acagagagga tagtctttgc aagtaggatg tatggtggac attttcccta
    10981 aaatggaata actttaatct gcagctccac agtttgaaca aaaacagact gaaggctggg
    11041 cgtggtggct catgcctgta atcccaacac tttgggaggc ctaggcgggc agatcacgag
    11101 gtcaggagat cgagaccatc ctggctaaca tggtgaaacc tcatctctac taaaaataca
    11161 aaaaaatagc tgggcgtggt ggcgggcacc tgtagtccca gctactcagg aggctgaggc
    11221 aggcgaatgg cgtgaacccg ggaggcggag cttgcagtga gccgagattg cgccactgca
    11281 ctccatcctg ggcaacagag tctcaaaaaa aaaaaaaaaa atttttgact gaaagtacag
    11341 atacaacttc cctttccagc caagatggag gagcaggggc caagtttatc ctcctgcctg
    11401 aaacaaccaa ccaaacagta aatacatgaa ataatgagtt tcaagacact ggacatgagg
    11461 taacaaaaga cagtgatctc tcagaggcaa gaaacaaaca aggagaaccc ctcggttgcc
    11521 cagcttaccg cttgagagga tgtatttcac ggagggagaa cccaggcaaa gcaagtgact
    11581 ctgaggtgag gggatagctg ggagtgtgga gcagccaagc tggctagagt gctcaggaca
    11641 gggtactgga gaggagaaag gtggatatat agagaattct ggggatctgc aaagggcccc
    11701 ccttgagtgt tccacagagc atgattcatc atataagtgt aaggaaacca cttgagacaa
    11761 aggaaaggac cacccaaaac aatgggccgg aacagtagcc agaagtcaca cacagcctgg
    11821 accacgcctg tccccatcag ccagattgga aaacctcaaa tttatggagc attggtcaga
    11881 ggtctcagaa gggccttgcc tcgtagtggg gattcattag ccctagttta aacattgctg
    11941 gaacctacct aacaaatctc aaaagcaaga cctgaattca ggaatcaagc tgtttctaag
    12001 taactgaagt gtatcccaga acaaaaccca agaacattaa cagaaatcca aaattaacga
    12061 gcacccaaaa atgtaaaatt cacaatggct ggttttccaa taaaaaatta ccagtcatgc
    12121 aaactataac ccatcataag gagaaaaatc agttgaaacc actacagctg acacctatgt
    12181 gagaattaga caaggacact aaaagaatta ttataactgt attccatatg tactaagtag
    12241 agactaggaa gatattttta aatacccact ttgaatttta gagacgaaaa ctaaaatgtc
    12301 tgagatgatg gggtgggtgg ggtaggcaga aagaggagga tgggaagaag taccaagggg
    12361 aaggaggaat gatttgggga tgacggctgt gtttattatc ttaattgtgg tgatggtttc
    12421 acaggtatat gtaatttcta aacttatcaa attgtacact taaaatatgt ggtctatgga
    12481 atgttaatta tatctcaata aagctgttaa aattgtactg aaacaaaacc attgggggaa
    12541 actgggtaaa gagtccaaag gacctcccta tactatcatt gtaacttcct gtcaattata
    12601 acgattccaa aa
//
