LOCUS       NM_018662               7084 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens DISC1 scaffold protein (DISC1), transcript variant L,
            mRNA.
ACCESSION   NM_018662
VERSION     NM_018662.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7084)
  AUTHORS   Pils,M., Rutsch,J., Eren,F., Engberg,G., Piehl,F., Cervenka,S.,
            Sellgren,C., Trossbach,S., Willbold,D., Erhardt,S., Bannach,O. and
            Korth,C.
  TITLE     Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal
            fluid are elevated in patients with first-episode psychosis
  JOURNAL   Psychiatry Clin Neurosci 77 (12), 665-671 (2023)
   PUBMED   37668563
  REMARK    GeneRIF: Disrupted-in-schizophrenia 1 protein aggregates in
            cerebrospinal fluid are elevated in patients with first-episode
            psychosis.
REFERENCE   2  (bases 1 to 7084)
  AUTHORS   Habibi,S., Yaghoubzad-Maleki,M., Heshmati,E. and Khalifeh,K.
  TITLE     Effects of representative point mutations on dynamic behavior of
            the DISC1-Ndel1 complex: a molecular dynamics study
  JOURNAL   J Biomol Struct Dyn 41 (22), 13228-13234 (2023)
   PUBMED   36858606
  REMARK    GeneRIF: Effects of representative point mutations on dynamic
            behavior of the DISC1-Ndel1 complex: a molecular dynamics study.
REFERENCE   3  (bases 1 to 7084)
  AUTHORS   Li,W., Jiang,H., Chen,X., Yang,K., Deng,X., Tang,Z., Hu,Z.,
            Zhang,X., Lin,S., Zou,Y. and Wu,H.
  TITLE     The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated
            with Graves' disease in the Chinese population
  JOURNAL   Medicine (Baltimore) 101 (45), e31501 (2022)
   PUBMED   36397361
  REMARK    GeneRIF: The variants in PTPRB, TRAF3IP3, and DISC1 genes were
            associated with Graves' disease in the Chinese population.
REFERENCE   4  (bases 1 to 7084)
  AUTHORS   Wang,A.L., Chao,O.Y., Nikolaus,S., Lamounier-Zepter,V.,
            Hollenberg,C.P., Lubec,G., Trossbach,S.V., Korth,C. and Huston,J.P.
  TITLE     Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive
            Flexibility and Social Behaviors in a Transgenic Rat Model
  JOURNAL   Neuroscience 493, 41-51 (2022)
   PUBMED   35461978
  REMARK    GeneRIF: Disrupted-in-schizophrenia 1 Protein Misassembly Impairs
            Cognitive Flexibility and Social Behaviors in a Transgenic Rat
            Model.
REFERENCE   5  (bases 1 to 7084)
  AUTHORS   Guardiola-Ripoll,M., Sotero-Moreno,A., Almodovar-Paya,C.,
            Hostalet,N., Guerrero-Pedraza,A., Ramiro,N., Ortiz-Gil,J.,
            Arias,B., Madre,M., Soler-Vidal,J., Salvador,R., McKenna,P.J.,
            Pomarol-Clotet,E. and Fatjo-Vilas,M.
  TITLE     Combining fMRI and DISC1 gene haplotypes to understand working
            memory-related brain activity in schizophrenia
  JOURNAL   Sci Rep 12 (1), 7351 (2022)
   PUBMED   35513527
  REMARK    GeneRIF: Combining fMRI and DISC1 gene haplotypes to understand
            working memory-related brain activity in schizophrenia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7084)
  AUTHORS   Ozeki,Y., Tomoda,T., Kleiderlein,J., Kamiya,A., Bord,L., Fujii,K.,
            Okawa,M., Yamada,N., Hatten,M.E., Snyder,S.H., Ross,C.A. and
            Sawa,A.
  TITLE     Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents
            binding to NudE-like (NUDEL) and inhibits neurite outgrowth
  JOURNAL   Proc Natl Acad Sci U S A 100 (1), 289-294 (2003)
   PUBMED   12506198
  REMARK    GeneRIF: Mutant truncation prevents binding to NudE-like (NUDEL)
            and inhibits neurite outgrowth
            Erratum:[Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969]
REFERENCE   7  (bases 1 to 7084)
  AUTHORS   Blackwood,D.H., Fordyce,A., Walker,M.T., St Clair,D.M.,
            Porteous,D.J. and Muir,W.J.
  TITLE     Schizophrenia and affective disorders--cosegregation with a
            translocation at chromosome 1q42 that directly disrupts
            brain-expressed genes: clinical and P300 findings in a family
  JOURNAL   Am J Hum Genet 69 (2), 428-433 (2001)
   PUBMED   11443544
REFERENCE   8  (bases 1 to 7084)
  AUTHORS   Ekelund,J., Hovatta,I., Parker,A., Paunio,T., Varilo,T., Martin,R.,
            Suhonen,J., Ellonen,P., Chan,G., Sinsheimer,J.S., Sobel,E.,
            Juvonen,H., Arajarvi,R., Partonen,T., Suvisaari,J., Lonnqvist,J.,
            Meyer,J. and Peltonen,L.
  TITLE     Chromosome 1 loci in Finnish schizophrenia families
  JOURNAL   Hum Mol Genet 10 (15), 1611-1617 (2001)
   PUBMED   11468279
REFERENCE   9  (bases 1 to 7084)
  AUTHORS   Millar,J.K., Christie,S., Semple,C.A. and Porteous,D.J.
  TITLE     Chromosomal location and genomic structure of the human
            translin-associated factor X gene (TRAX; TSNAX) revealed by
            intergenic splicing to DISC1, a gene disrupted by a translocation
            segregating with schizophrenia
  JOURNAL   Genomics 67 (1), 69-77 (2000)
   PUBMED   10945471
REFERENCE   10 (bases 1 to 7084)
  AUTHORS   Millar,J.K., Wilson-Annan,J.C., Anderson,S., Christie,S.,
            Taylor,M.S., Semple,C.A., Devon,R.S., St Clair,D.M., Muir,W.J.,
            Blackwood,D.H. and Porteous,D.J.
  TITLE     Disruption of two novel genes by a translocation co-segregating
            with schizophrenia
  JOURNAL   Hum Mol Genet 9 (9), 1415-1423 (2000)
   PUBMED   10814723
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL626763.11, AF222980.1,
            AJ506178.1, AB007926.1 and AI075754.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_018662.2.
            
            Summary: This gene encodes a protein with multiple coiled coil
            motifs which is located in the nucleus, cytoplasm and mitochondria.
            The protein is involved in neurite outgrowth and cortical
            development through its interaction with other proteins. This gene
            is disrupted in a t(1;11)(q42.1;q14.3) translocation which
            segregates with schizophrenia and related psychiatric disorders in
            a large Scottish family. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (L) encodes isoform L, also known
            as the 'Long' isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF222980.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000439617.8/ ENSP00000403888.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AL626763.11        65497-65521
            26-867              AF222980.1         1-842
            868-870             AJ506178.1         843-845
            871-2186            AF222980.1         846-2161
            2187-2189           AB007926.1         2148-2150
            2190-6939           AF222980.1         2165-6914
            6940-7084           AI075754.1         14-158              c
FEATURES             Location/Qualifiers
     source          1..7084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..7084
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /note="DISC1 scaffold protein"
                     /db_xref="GeneID:27185"
                     /db_xref="HGNC:HGNC:2888"
                     /db_xref="MIM:605210"
     exon            1..145
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2643
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /note="isoform L is encoded by transcript variant L;
                     disrupted in schizophrenia 1 protein"
                     /codon_start=1
                     /product="disrupted in schizophrenia 1 protein isoform L"
                     /protein_id="NP_061132.2"
                     /db_xref="CCDS:CCDS86059.1"
                     /db_xref="GeneID:27185"
                     /db_xref="HGNC:HGNC:2888"
                     /db_xref="MIM:605210"
                     /translation="MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPG
                     YMRSSTGPGIGFLSPAVGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKS
                     AAAPTVTSVRGTSAHFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASW
                     EAACSDGARRVRAAGSLPSAELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLG
                     SAGERGEAEGCPPSREAESHCQSPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSAD
                     LAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWE
                     PVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHF
                     QLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHV
                     SITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLV
                     GQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCM
                     SEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGL
                     LSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSC
                     KCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSED
                     KRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGEKCEDIGKKLLYLEDQLHT
                     AIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA"
     exon            146..1125
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1195
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1346
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1476
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1712
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1767
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1870
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..2059
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2120
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2385
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2503
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     exon            2504..7084
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6917..6922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /note="hexamer: AATAAA"
     polyA_site      6939
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /note="major polyA site"
     regulatory      7065..7070
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
                     /note="hexamer: AATAAA"
     polyA_site      7084
                     /gene="DISC1"
                     /gene_synonym="C1orf136; SCZD9"
ORIGIN      
        1 cccttccccc cgcctctggc ctcggggaag gagcaggagg cagcccaggc ggagcgggag
       61 gagctggcag cggggcgcat gccaggcggg ggtcctcagg gcgccccagc cgccgccggc
      121 ggcggcggcg tgagccaccg cgcaggcagc cgggattgct taccacctgc agcgtgcttt
      181 cggaggcggc ggctggcacg gaggccgggc tacatgagaa gctcgacagg gcctgggatc
      241 gggttccttt ccccagcagt gggcacactg ttccggttcc caggaggggt gtctggcgag
      301 gagtcccacc actcggagtc cagggccaga cagtgtggcc ttgactcgag aggcctcttg
      361 gtccggagcc ctgtttccaa gagtgcagca gcccctactg tgacctctgt gagaggaacc
      421 tcggcgcact ttgggattca gctcagaggt ggcaccagat tgcctgacag gcttagctgg
      481 ccgtgtggcc ctgggagtgc tgggtggcag caagagtttg cagccatgga tagttctgag
      541 accctggacg ccagctggga ggcagcctgc agcgatggag caaggcgtgt ccgggcagca
      601 ggctctctgc catcagcaga gttgagtagc aacagctgca gccctggctg tggccctgag
      661 gtccccccaa cccctcctgg ctctcacagt gcctttacct caagctttag ctttattcgg
      721 ctctcgcttg gctctgccgg ggaacgtgga gaagcagaag gctgcccacc atccagagag
      781 gctgagtccc attgccagag cccccaggag atgggagcca aagctgccag cttggacggg
      841 cctcacgagg acccgcgatg tctctctcgg cccttcagtc tcttggctac acgggtctct
      901 gcagacttgg cccaggccgc aaggaacagc tccaggccag agcgtgacat gcattcttta
      961 ccagacatgg accctggctc ctccagttct ctggatccct cactggctgg ctgtggtggt
     1021 gatgggagca gcggctcagg ggatgcccac tcttgggaca ccctgctcag gaaatgggag
     1081 ccagtgctgc gggactgcct gctgagaaac cggaggcaga tggaggtaat atccttaaga
     1141 ttaaaacttc agaaacttca ggaagatgca gttgagaatg atgattatga taaagctgag
     1201 acgttacaac aaagattaga agacctggaa caagagaaaa tcagcctgca ctttcaactt
     1261 ccttcaaggc agccagctct tagcagtttc ctgggtcacc tggcagcaca agtccaggct
     1321 gccttgcgcc gtggggccac tcagcaggcc agcggagatg acacccacac cccactgaga
     1381 atggagccga ggctgttgga acccactgct caggacagct tgcacgtgtc catcacgaga
     1441 cgagactggc ttcttcagga aaagcagcag ctacagaaag aaatcgaagc tctccaagca
     1501 aggatgtttg tgctggaagc caaagatcaa cagctgagaa gggaaataga ggagcaagag
     1561 cagcaactcc agtggcaggg ctgcgacctg accccactgg tgggccagct gtccctgggt
     1621 cagctgcagg aggtcagcaa ggccttgcag gacaccctgg cctcagccgg tcagattccc
     1681 ttccatgcag agccaccgga aaccataagg agcctccagg aaagaataaa atccctcaac
     1741 ttgtcactta aagaaatcac tactaaggtg tgtatgagtg agaaattctg cagcaccctg
     1801 aggaagaaag ttaacgatat tgaaacccaa ctaccagcct tgcttgaagc caaaatgcat
     1861 gccatatcag gaaaccattt ctggacggct aaagacctca ccgaggagat tagatcatta
     1921 acatcagaga gagaagggct ggagggactc ctcagcaagc tgttggtgtt gagttccagg
     1981 aatgtcaaaa agctgggaag tgttaaagaa gattacaaca gactgagaag agaagtggag
     2041 caccaggaga ctgcctatga aacaagtgtg aaggaaaata ctatgaagta catggaaaca
     2101 cttaagaata aactgtgcag ctgcaagtgt ccactgcttg ggaaagtgtg ggaagctgac
     2161 ttggaagctt gtcgattgct tatccagagc ctacagctcc aggaagccag gggaagcctg
     2221 tctgtagaag atgagaggca gatggatgac ttagagggag ctgctcctcc tattcccccc
     2281 aggctccact ccgaggataa aaggaagacc cctttgaagg tattggaaga atggaagact
     2341 cacctcatcc cctctctgca ctgtgctgga ggtgaacaga aagaggaatc ttacatcctt
     2401 tctgcagaac ttggagaaaa gtgtgaagac ataggcaaga agctattgta cttggaagat
     2461 caacttcaca cagcaatcca cagtcatgat gaagatctca ttcagtctct caggagggag
     2521 ctccagatgg tgaaggaaac tctgcaggcc atgatcctgc agctccagcc agcaaaggag
     2581 gcgggagaaa gagaagctgc agcttcctgc atgacagctg gtgtccacga agcacaagcc
     2641 tgaggagtga cgggatgggg gagggaggtg ggccaccatg tttggacccg gggggctgct
     2701 cttccctccc ccgccatagc taagatgcct gaatcaatta cggagataca gagccttgag
     2761 gtctttcagt ggaaaggtgg ttcatgttca ttctcatcag tgtgaaactg aggagtctgc
     2821 aatttggaat atggagagag agactgattt gctgaatttc cttctaaatg tcactcaaaa
     2881 atttcttttc catgtcattc ttgggaatgt cttccacagg atttgagaat agtttcatct
     2941 cagcccccat tagagagaag ttggggtgaa ttctggaaaa atgtctcttt ttcctgtgcc
     3001 atttgccttc tgctgcaacg aaaatatttc ctgattcaag attctataaa aaggaaacca
     3061 agcataagac tctgtcatca tacctgttac acgttcctac aggtgcacaa tctaagagag
     3121 ctaattaacc tcagagtctg gagttaacag cttttcacct tacttctcct gtgatctaat
     3181 attatcttag aaaaattaat atgcaatttc caaaagatat tttggtaaga caacaacctc
     3241 ccagtgatat gccacctttc aattttcctt ttgtggcaat gattgcatct gaagaaagga
     3301 tccctgagag tctctgtttc atcaggacat tctgaaattt acccacagtg aggctgtgga
     3361 tggatcaggg gacctgtata aaatgtttga gcctgttcca ttttcccgtg gaacctgttt
     3421 cactcaatgc caggcagtgc agcatttagg aaagcagtgc agtactcagt aaggcagtgc
     3481 agtactcagt aacacaatac agtactcagg cagtgcagta ctcagtaaga cagtgcagtg
     3541 ctcagtaagg cagtgcaata ctcagtaaca gtgtagtact cagtaacagt gaagtactca
     3601 gtaatacagt acagtattca gtaaggcagt gaagtactca gtaatacaat acagtactca
     3661 gttaggcagt gcagtactca ggaatgcagc acagtactca ggcagtgcaa tactcagtgc
     3721 ggtactcagt aacacagtgc agtactcagt aacagtgcag tactcagtaa cagtgcagta
     3781 ctcagtaagg cagtgcagta ctcagtaaca cagtgcagta ctcagtaata cagtacagta
     3841 ctcagtaagg cagtatggta ctcagtaaag caatgcaatg ctcagtaaca cagtgcagtg
     3901 ctcaataagg cagtgcagtg ctcagtaagg cagtgaattg cttagtaaca cagtgtagtg
     3961 ctcagtagga cagcatagta ctcagtaaca cagggcagct agtactcagt actataagta
     4021 ctgagtactt atataggcaa tgtagtactc agtaaatcag tgcagtactc agtaatgcaa
     4081 gggcatttca ggctcctgct gggctgcttc tttggcccag ctgggactcc tattgagaca
     4141 gctgcaaaac aggctgattt caattaggca gcacttccca aagtgcactg aggaaggtgg
     4201 ccccaagaga agctctctaa acaaaggagt accctctctg gtcaagtacc tttggtaaat
     4261 acaccatacc ataatatctg cttggagaac cacaatgcac attagcatat tagtctgaga
     4321 gagaacttat agtaaggaaa ctcacttgat tttatctaac ctcaaacttt ccaagtttaa
     4381 tggatcgtga atttttttca tgtaactcct attcatatcc catagatcta gtattgtaca
     4441 gcactgcatt ctctgaggaa gtcccagtcc aaactctgat ttacatcact ttagaaacca
     4501 cactcacact tttgcagagt gttgagctta ataactacct gccacagatt ggtaaattta
     4561 atccagtggt tgttctgttt gtgcttctgt tctcatttat gtgtttaggg atagtgaggt
     4621 tcctgccttc actaggatcc acggatatga gaccattttt gtcatttcct gaagtcacac
     4681 tggcgtttcc agaaggcatc tggtgctttg ctcagccttc catgctgtgc agcacttctg
     4741 tcctcagtca aggagatggc catgcttaag ccagcaattg gctggggtcc aggaaacaaa
     4801 gcaaaagcac aatatgtgaa tgtgctgatt gtgttcccta tggctttatc tcgagcaaaa
     4861 tacactctac atattttaat aataagtata attagcttgt tcctggactt cattttcaat
     4921 gatgaaccaa attcctgaat tatttataat tgtgtctaaa gaaaattatg aactggtcac
     4981 atggcacttg gaatccttga gttaattcca gtgaagcaaa acttgggaag agtcaggatt
     5041 ggccacattg ccaataacaa attcctactt cgacatatgt cttttcaaaa agcctcccag
     5101 acacaagaca tcttaaccgt cactagccca agtgttttgt attactcaga caccatcatg
     5161 aaataattct gtgaggtcat gatgtatttg aaaattctgc aagttaataa ctgccttgaa
     5221 ttgtttgaac ccgaaataag ggttctttgg tacctctagt agatagtgtg ttcatttccc
     5281 tgctgcaaat tttgaagtat ttgggcaggt gagtcatgtt ttaaccacaa gccataactc
     5341 atctgttgtc tttgcttggt cttagagtat cattcagaaa gtccgctaag ggccagcgtg
     5401 cttcttctgg ctacacaacc ttctcaggac aagcccactg tcttaagcca ctttgaccct
     5461 gggagacaca ggactgtgta tcctcaatca tactatacag cagtttttgt caggggaaca
     5521 taaaaatatc caagagaggt tagggcttag atttaaaagc atcaaaacaa caacaatgga
     5581 aatttatgtt ggcgatagcc aagaccacaa gcaaaagcac atactggaaa tgatgagtta
     5641 gaatctgatt tgactgggat gttttatgag aatgtaagtg tgatattata ctgtctgcct
     5701 tgctggaatg ctggctttca aatggtcacc catttttctt tcactggcct gagttaggac
     5761 atgctatcag taatagtccc agttccatcc aactttctga aatttcattt ttttttttga
     5821 gatggagtct ctctctgtca cccaagttgg agtgcagtgg ccccgcaatc tcggctcact
     5881 gcaacctcta cctcccaggt tcaagctatt ctactgcctc agcctcccaa gtagctgggg
     5941 ttacaggcat ttgccaccgg gccctgatga tttttgtatt tttagtagag acagggcttc
     6001 accatgttgg ctaggagggt ctcaaactcc tgacctcagg cgatccaccc ccacctcggc
     6061 ttcccaaagt gctgagatta caggtgtgag ccaccgcacc cggccaactt tctgaaattt
     6121 caaaactgaa ttgatccttc tccaaattag tatatactat tggaaacttg tctttccctg
     6181 cagtaaggct ggtttcccca ccccagaaac atgtaacggt tggtaccatg ctaagccctt
     6241 gccatgctaa gccctttaca gtcatatcct ataatcccca tatcaacctt ataaggaagg
     6301 tgtttgtaga tgatgcaact gagccttaag aggactaatt ccctttttct aaggcacaga
     6361 gctggtaaaa tgtgaagtaa tagtgaacct aacagtcaga gacaggcagc atgctcttaa
     6421 ctagtgctct tcctaaagtt cctttaatgt ccttttgaga ttttgagcca tggaacttac
     6481 ttgttcacct ggctaagaac tcatggccac tgtggaaatc ttggttaggg agtcaaagaa
     6541 actgagcctg gggcaaacga ggcttcccac actgccaggg gagcctcact gtgaagtcta
     6601 ggctcagaca ggcatcaaca aacctattca ccccaccatc atcctgatct aaccattccc
     6661 cagtcatccc aggaaaacca ctcacagcct gacactgggc tgactttctt gaagatcctc
     6721 atccaattgg tgtttttcag aagtgttcca atattatgaa ttctgtgttg tggagaaaag
     6781 caaccatgca tttactggtc aatgccttct tgtatatgta attcaatact tttactttta
     6841 atatcctcac cttatctaat ctttgaattt tgtcatgtaa tttattgctt cattaaggtt
     6901 actttttgtt atacaaaata aaagctgata tccaaggcat ggtgcatctt gatgattttt
     6961 tgtcctttga agtatggatg atagaaaaat gtatcaggtt tattcatctc atctttctgt
     7021 tacaggatga ttaattgtac agttacatca cacgaaacat ttataataaa gtcatgcttt
     7081 agaa
//
