LOCUS       NM_001143688            3780 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens DIS3 like exosome 3'-5' exoribonuclease (DIS3L),
            transcript variant 1, mRNA.
ACCESSION   NM_001143688
VERSION     NM_001143688.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3780)
  AUTHORS   Huntzinger,E., Sinteff,J., Morlet,B. and Seraphin,B.
  TITLE     HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of
            the RNB family is expressed from a non-canonical initiation codon
  JOURNAL   Nucleic Acids Res 51 (17), 9279-9293 (2023)
   PUBMED   37602378
REFERENCE   2  (bases 1 to 3780)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3780)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3780)
  AUTHORS   Lee,J.Y., Moon,S., Kim,Y.K., Lee,S.H., Lee,B.S., Park,M.Y.,
            Park,J.E., Jang,Y. and Han,B.G.
  TITLE     Genome-based exome sequencing analysis identifies GYG1, DIS3L and
            DDRGK1 are associated with myocardial infarction in Koreans
  JOURNAL   J Genet 96 (6), 1041-1046 (2017)
   PUBMED   29321365
  REMARK    GeneRIF: we screened the susceptibility loci for Myocardial
            infarction (MI) using exome sequencing and validated candidate
            variants in replication sets. We identified that three genes (GYG1,
            DIS3L and DDRGK1) were associated with MI at the discovery and
            replication stages.
REFERENCE   5  (bases 1 to 3780)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   6  (bases 1 to 3780)
  AUTHORS   Li,L., Fridley,B.L., Kalari,K., Niu,N., Jenkins,G., Batzler,A.,
            Abo,R.P., Schaid,D. and Wang,L.
  TITLE     Discovery of genetic biomarkers contributing to variation in drug
            response of cytidine analogues using human lymphoblastoid cell
            lines
  JOURNAL   BMC Genomics 15, 93 (2014)
   PUBMED   24483146
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3780)
  AUTHORS   Lubas,M., Damgaard,C.K., Tomecki,R., Cysewski,D., Jensen,T.H. and
            Dziembowski,A.
  TITLE     Exonuclease hDIS3L2 specifies an exosome-independent 3'-5'
            degradation pathway of human cytoplasmic mRNA
  JOURNAL   EMBO J 32 (13), 1855-1868 (2013)
   PUBMED   23756462
REFERENCE   8  (bases 1 to 3780)
  AUTHORS   Staals,R.H., Bronkhorst,A.W., Schilders,G., Slomovic,S.,
            Schuster,G., Heck,A.J., Raijmakers,R. and Pruijn,G.J.
  TITLE     Dis3-like 1: a novel exoribonuclease associated with the human
            exosome
  JOURNAL   EMBO J 29 (14), 2358-2367 (2010)
   PUBMED   20531389
  REMARK    GeneRIF: Data indicate that hDis3L1 is a novel exosome-associated
            exoribonuclease in the cytoplasm of human cells.
REFERENCE   9  (bases 1 to 3780)
  AUTHORS   Tomecki,R., Kristiansen,M.S., Lykke-Andersen,S., Chlebowski,A.,
            Larsen,K.M., Szczesny,R.J., Drazkowska,K., Pastula,A.,
            Andersen,J.S., Stepien,P.P., Dziembowski,A. and Jensen,T.H.
  TITLE     The human core exosome interacts with differentially localized
            processive RNases: hDIS3 and hDIS3L
  JOURNAL   EMBO J 29 (14), 2342-2357 (2010)
   PUBMED   20531386
  REMARK    GeneRIF: Data show that hDIS3 and hDIS3L are active exonucleases,
            but only hDIS3 has retained endonucleolytic activity, and suggest
            that three different ribonucleases can serve as catalytic subunits
            for the exosome in human cells.
REFERENCE   10 (bases 1 to 3780)
  AUTHORS   Slomovic,S., Fremder,E., Staals,R.H., Pruijn,G.J. and Schuster,G.
  TITLE     Addition of poly(A) and poly(A)-rich tails during RNA degradation
            in the cytoplasm of human cells
  JOURNAL   Proc Natl Acad Sci U S A 107 (16), 7407-7412 (2010)
   PUBMED   20368444
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055855.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001143688.2.
            
            Summary: The cytoplasmic RNA exosome complex degrades unstable
            mRNAs and is involved in the regular turnover of other mRNAs. The
            protein encoded by this gene contains 3'-5' exoribonuclease
            activity and is a catalytic component of this complex. [provided by
            RefSeq, May 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.129073.1,
                                           SRR1660807.228454.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319212.9/ ENSP00000321711.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-168               AC055855.9         56962-57129
            169-322             AC055855.9         58382-58535
            323-451             AC055855.9         70218-70346
            452-587             AC055855.9         72103-72238
            588-764             AC055855.9         75118-75294
            765-843             AC055855.9         77433-77511
            844-1023            AC055855.9         78430-78609
            1024-1193           AC055855.9         81843-82012
            1194-1355           AC055855.9         83965-84126
            1356-1603           AC055855.9         86081-86328
            1604-1696           AC055855.9         86887-86979
            1697-2230           AC055855.9         89225-89758
            2231-2385           AC055855.9         92364-92518
            2386-2564           AC055855.9         92615-92793
            2565-2710           AC055855.9         95269-95414
            2711-2885           AC055855.9         96130-96304
            2886-3780           AC055855.9         96398-97292
FEATURES             Location/Qualifiers
     source          1..3780
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..3780
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /note="DIS3 like exosome 3'-5' exoribonuclease"
                     /db_xref="GeneID:115752"
                     /db_xref="HGNC:HGNC:28698"
                     /db_xref="MIM:614183"
     exon            1..168
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..3194
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /EC_number="3.1.13.1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DIS3-like exonuclease 1; DIS3 mitotic control
                     homolog-like"
                     /codon_start=1
                     /product="DIS3-like exonuclease 1 isoform 1"
                     /protein_id="NP_001137160.1"
                     /db_xref="CCDS:CCDS45286.1"
                     /db_xref="GeneID:115752"
                     /db_xref="HGNC:HGNC:28698"
                     /db_xref="MIM:614183"
                     /translation="MLQKREKVLLLRTFQGRTLRIVREHYLRPCVPCHSPLCPQPAAC
                     SHDGKLLSSDVTHYVIPDWKVVQDYLEILEFPELKGIIFMQTACQAVQHQRGRRQYNK
                     LRNLLKDARHDCILFANEFQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPI
                     VMVTEDEEAIQQYGSETEGVFVITFKNYLDNFWPDLKAAHELCDSILQSRRERENESQ
                     ESHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLQGASSKDSDLVSD
                     ILIHGMKARNRSIHGDVVVVELLPKNEWKGRTVALCENDCDDKASGESPSEPMPTGRV
                     VGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAETLQDFRV
                     VVRIDSWESTSVYPNGHFVRVLGRIGDLEGEIATILVENSISVIPFSEAQMCEMPVNT
                     PESPWKVSPEEEQKRKDLRKSHLVFSIDPKGCEDVDDTLSVRTLNNGNLELGVHIADV
                     THFVAPNSYIDIEARTRATTYYLADRRYDMLPSVLSADLCSLLGGVDRYAVSIMWELD
                     KASYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNLSVVDDIPEFKDLDEKSRQAKLEE
                     LVWAIGKLTDIARHVRAKRDGCGALELEGVEVCVQLDDKKNIHDLIPKQPLEVHETVA
                     ECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLA
                     DSLDNANDPHDPIVNRLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSP
                     IRRYSDIVVHRLLMAAISKDKKMEIKGNLFSNKDLEELCRHINNRNQAAQHSQKQSTE
                     LFQCMYFKDKDPATEERCISDGVIYSIRTNGVLLFIPRFGIKGAAYLKNKDGLVISCG
                     PDSCSEWKPGSLQRFQNKITSTTTDGESVTFHLFDHVTVRISIQASRCHSDTIRLEII
                     SNKPYKIPNTELIHQSSPLLKSELVKEVTKSVEEAQLAQEVKVNIIQEEYQEYRQTKG
                     RSLYTLLEEIRDLALLDVSNNYGI"
     exon            169..322
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            323..451
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            452..587
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            588..764
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..843
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..1023
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1193
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1355
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1603
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1696
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..2230
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2385
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2564
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2565..2710
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2885
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3780
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3758..3763
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /note="hexamer: AATAAA"
     polyA_site      3780
                     /gene="DIS3L"
                     /gene_synonym="DIS3L1"
                     /note="major polyA site"
ORIGIN      
        1 actccgcggc cgccgggaga cacgccgcca tgctgcagaa gcgggagaag gtgctgctgc
       61 tgaggacctt ccagggccgc acgctgcgga tcgtgcgcga gcactacctg cggccctgcg
      121 tgccctgcca cagcccgctc tgcccgcagc ccgccgcctg cagccacgat gggaaactct
      181 tgtctagtga tgtgactcat tacgtgatcc cagactggaa agttgttcaa gattatcttg
      241 agatccttga gtttcctgag ttgaagggaa ttattttcat gcagacagct tgtcaagctg
      301 tgcagcatca aagaggcagg agacagtata acaaactgcg aaacctgctg aaggatgcgc
      361 gtcatgattg cattctcttt gctaatgaat tccagcaatg ctgctatctg ccacgggaaa
      421 gaggagagtc catggagaag tggcagacca ggagcatata caacgcagct gtttggtact
      481 atcatcactg ccaggacagg atgccaattg ttatggtgac agaagatgaa gaggcaattc
      541 agcagtatgg aagtgaaaca gaaggagtat tcgtgattac tttcaagaat tacctggaca
      601 atttctggcc tgatttaaaa gctgcccacg agctttgtga ttctatcctt cagtctcgac
      661 gggagagaga gaatgagagt caggagagcc atgggaagga gtacccagaa catcttcccc
      721 tggaagtgtt agaagctggg attaaatctg gacgctatat ccagggaatt ctgaatgtca
      781 acaaacacag agcccaaata gaagcttttg ttcgacttca aggagccagc agtaaagatt
      841 cagatttagt cagtgacatc ctaatccacg ggatgaaggc tcgaaaccgc tcaattcatg
      901 gagatgtggt agttgtggag ctgcttccta aaaatgaatg gaaaggaaga accgtagccc
      961 tgtgtgagaa tgactgtgac gacaaggctt cgggcgagtc cccaagtgag cccatgccta
     1021 caggtcgagt ggtgggcata cttcagaaga actggcggga ttatgtggtg acatttccgt
     1081 ccaaagaaga ggtccaatct cagggcaaaa atgctcagaa aatcctggtt acaccttggg
     1141 attacagaat tcccaaaatt cgaattagca ctcagcaagc agaaaccctc caggacttca
     1201 gggtggtcgt gcgcatcgat tcctgggagt caacatctgt gtatccaaat ggacattttg
     1261 tgcgtgtttt aggaagaatc ggagatctgg aaggggaaat tgcaaccatc ctggtggaaa
     1321 acagtatttc agttattcct ttctcagaag ctcagatgtg tgagatgcca gtaaacacac
     1381 cagaaagtcc ctggaaggtg agtcctgaag aggaacaaaa acgtaaagac ttgaggaaaa
     1441 gccatctcgt attcagcatt gaccccaaag gttgtgaaga tgtggatgac acactctcag
     1501 tcagaacctt aaataatggc aacctggaac ttggggtcca catcgcagat gtaacacact
     1561 ttgtggcacc aaattcttac attgatattg aagctagaac aagggccacc acttattatc
     1621 tagcagatcg tcgctatgac atgctgcctt ccgtcctcag tgcagatttg tgttcccttc
     1681 tgggaggcgt tgataggtat gctgtaagca tcatgtggga actggataaa gcctcttatg
     1741 aaattaagaa agtgtggtat ggcagaacca ttattcgatc agcatacaaa ctgttctatg
     1801 aagcagccca agaactactg gatggaaact taagcgttgt tgatgatatt ccagaattca
     1861 aagacttgga tgagaagagc agacaagcca agctggagga gttggtgtgg gcaattggaa
     1921 agctgaccga catagctcgc catgtcagag ctaaacgaga cggatgtggt gccctggaac
     1981 tggaaggggt agaggtttgc gtacagctag atgacaaaaa gaacattcac gacctcatcc
     2041 ccaagcagcc cctggaagtc cacgagacag tggctgaatg catgatcctg gccaaccact
     2101 gggtcgccaa aaagatctgg gagagcttcc ctcatcaggc cttgctgcgc cagcaccctc
     2161 ctccacacca ggagttcttt tcagaactcc gggaatgtgc taaagccaaa ggcttcttca
     2221 tagatacacg gtccaataaa acactggctg attctctgga taatgcgaac gacccccacg
     2281 atcccattgt gaacaggcta ctgcgctcca tggccacgca ggccatgtcg aatgctctgt
     2341 acttctccac cggatcctgt gcggaggagg agttccatca ttacggtctt gcattagata
     2401 aatataccca ctttacttct ccaataagaa gatattcaga tattgtagta caccgcttgt
     2461 taatggcagc catttcaaaa gataagaaaa tggaaattaa gggaaatctg ttcagcaaca
     2521 aagatcttga ggaattatgc agacatatca acaacagaaa ccaagcagca cagcattctc
     2581 agaagcagtc tactgagctc ttccagtgca tgtacttcaa agacaaagac cctgccaccg
     2641 aggagcgttg catatctgac ggagttattt attcaattag aacaaatggt gtgcttctat
     2701 ttataccaag gtttgggatt aaaggtgctg cttatctaaa aaataaagat ggtttagtca
     2761 tctcatgtgg cccagatagc tgttctgaat ggaaaccagg atcccttcaa cgatttcaaa
     2821 acaaaattac ctctactaca acagatgggg aatctgttac gttccatttg tttgaccatg
     2881 taaccgtaag aatatccata caggcctcac gttgccattc tgatacaatc agacttgaaa
     2941 taattagtaa caaaccatac aagataccaa atacagaact tattcatcag agttccccct
     3001 tgctgaagag tgagttagtg aaagaagtaa ctaaatctgt ggaagaagct cagcttgccc
     3061 aagaagtcaa agtaaacatc attcaggagg aatatcaaga atatcgccaa acaaagggaa
     3121 ggagcctata cacacttcta gaggagatac gggacctagc tctcctggat gtttcaaaca
     3181 attatggaat atgagaggct cttacttcac taagagctgt catatgtgaa tgttttacag
     3241 tcttttcaaa cttaacattt aatgtgtgtc actcagtgct ctagtcgatc aggactgggt
     3301 agctatttcg catatatgta aaatgttctc agccgggcac ggtggctcac gcctgtaacc
     3361 ccagcacttt gggaggctga ggcgggcgga tcacgaggtc aggagattga gaccatcctg
     3421 gctaacacgg tgaaacccag tctctactaa aaatacaaaa attagcccgg cgtggtggca
     3481 tgcgcctgta gtcccagcta cttgggaggc tgaagcagga gaattgcctg aacccaggaa
     3541 gaggaggttg cagtgagccg agatcgcacc actgcattcc agcctgggca acagagcgag
     3601 actccatctc aaaaaaaaaa aaaaaaaaaa aaaaagttct ctcattcatt aaagttgcat
     3661 taaataaagt ataattaggt cactatggaa acagagtttt cagtaatgag tggacagtaa
     3721 gtggtggctc tgcagatggc ccctttctaa taagtttaat aaacccgaaa ttactggtta
//
