LOCUS       NM_176819               4631 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens divergent protein kinase domain 2B (DIPK2B),
            transcript variant 1, mRNA.
ACCESSION   NM_176819
VERSION     NM_176819.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4631)
  AUTHORS   Dudkiewicz,M., Lenart,A. and Pawlowski,K.
  TITLE     A novel predicted calcium-regulated kinase family implicated in
            neurological disorders
  JOURNAL   PLoS One 8 (6), e66427 (2013)
   PUBMED   23840464
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4631)
  AUTHORS   Aziz,A., Harrop,S.P. and Bishop,N.E.
  TITLE     Characterization of the deleted in autism 1 protein family:
            implications for studying cognitive disorders
  JOURNAL   PLoS One 6 (1), e14547 (2011)
   PUBMED   21283809
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4631)
  AUTHORS   Aziz,A., Harrop,S.P. and Bishop,N.E.
  TITLE     DIA1R is an X-linked gene related to Deleted In Autism-1
  JOURNAL   PLoS One 6 (1), e14534 (2011)
   PUBMED   21264219
  REMARK    GeneRIF: results support a model where the DIA1 and DIA1R regulate
            molecular traffic through the cellular secretory pathway or affect
            the function of secreted factors, and functional deficits cause
            disorders with ASD-like symptoms and/or mental retardation
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4631)
  AUTHORS   Tarpey,P.S., Smith,R., Pleasance,E., Whibley,A., Edkins,S.,
            Hardy,C., O'Meara,S., Latimer,C., Dicks,E., Menzies,A.,
            Stephens,P., Blow,M., Greenman,C., Xue,Y., Tyler-Smith,C.,
            Thompson,D., Gray,K., Andrews,J., Barthorpe,S., Buck,G., Cole,J.,
            Dunmore,R., Jones,D., Maddison,M., Mironenko,T., Turner,R.,
            Turrell,K., Varian,J., West,S., Widaa,S., Wray,P., Teague,J.,
            Butler,A., Jenkinson,A., Jia,M., Richardson,D., Shepherd,R.,
            Wooster,R., Tejada,M.I., Martinez,F., Carvill,G., Goliath,R., de
            Brouwer,A.P., van Bokhoven,H., Van Esch,H., Chelly,J., Raynaud,M.,
            Ropers,H.H., Abidi,F.E., Srivastava,A.K., Cox,J., Luo,Y.,
            Mallya,U., Moon,J., Parnau,J., Mohammed,S., Tolmie,J.L.,
            Shoubridge,C., Corbett,M., Gardner,A., Haan,E., Rujirabanjerd,S.,
            Shaw,M., Vandeleur,L., Fullston,T., Easton,D.F., Boyle,J.,
            Partington,M., Hackett,A., Field,M., Skinner,C., Stevenson,R.E.,
            Bobrow,M., Turner,G., Schwartz,C.E., Gecz,J., Raymond,F.L.,
            Futreal,P.A. and Stratton,M.R.
  TITLE     A systematic, large-scale resequencing screen of X-chromosome
            coding exons in mental retardation
  JOURNAL   Nat Genet 41 (5), 535-543 (2009)
   PUBMED   19377476
REFERENCE   5  (bases 1 to 4631)
  AUTHORS   Thiselton,D.L., McDowall,J., Brandau,O., Ramser,J., d'Esposito,F.,
            Bhattacharya,S.S., Ross,M.T., Hardcastle,A.J. and Meindl,A.
  TITLE     An integrated, functionally annotated gene map of the DXS8026-ELK1
            interval on human Xp11.3-Xp11.23: potential hotspot for
            neurogenetic disorders
  JOURNAL   Genomics 79 (4), 560-572 (2002)
   PUBMED   11944989
  REMARK    Erratum:[Genomics 2002 Jun;79(6):891]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK024165.1, BP231945.1, DC332862.1, DA378381.1, AC136488.3 and
            AF289581.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_176819.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and it encodes the longer protein (isoform 1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.181391.1,
                                           SRR1803612.119416.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2146982,
                                           SAMEA2147920 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398000.7/ ENSP00000381086.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-432               AK024165.1         26-457
            433-548             BP231945.1         409-524
            549-946             DC332862.1         145-542
            947-1512            DA378381.1         66-631
            1513-4513           AC136488.3         152786-155786       c
            4514-4631           AF289581.1         1791-1908
FEATURES             Location/Qualifiers
     source          1..4631
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.3"
     gene            1..4631
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /note="divergent protein kinase domain 2B"
                     /db_xref="GeneID:79742"
                     /db_xref="HGNC:HGNC:25866"
                     /db_xref="MIM:300959"
     exon            1..283
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1352
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; hCG1981635; deleted in autism-1 related
                     protein; UPF0672 protein CXorf36; deleted in
                     autism-related protein 1"
                     /codon_start=1
                     /product="divergent protein kinase domain 2B isoform 1
                     precursor"
                     /protein_id="NP_789789.2"
                     /db_xref="CCDS:CCDS48096.1"
                     /db_xref="GeneID:79742"
                     /db_xref="HGNC:HGNC:25866"
                     /db_xref="MIM:300959"
                     /translation="MEPQLGPEAAALRPGWLALLLWVSALSCSFSLPASSLSSLVPQV
                     RTSYNFGRTFLGLDKCNACIGTSICKKFFKEEIRSDNWLASHLGLPPDSLLSYPANYS
                     DDSKIWRPVEIFRLVSKYQNEISDRRICASASAPKTCSIERVLRKTERFQKWLQAKRL
                     TPDLVQGLASPLLRCPSQRLLDRVVRRYAEVADAGSIFMDHFTDRDKLRLLYTLAVNS
                     HPILLQIFPGAEGWPLPKYLGSCGRFLVSTSTRPLQEFYDAPPDQAADLAYQLLGVLE
                     SLRSNDLNYFFYFTHIDAGMFGVFNNGHLFIRDASAVGVIDKQEGSQEANRAGENKDI
                     FSCLVSGCQAQLPSCESISEKQSLVLVCQKLLPRLLQGRFPSPVQDDIDSILVQCGDS
                     IRPDPEVLGAASQLKDILRPLRTCDSRFAYRYPDCKYNDKF"
     exon            284..548
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /inference="alignment:Splign:2.1.0"
     exon            549..722
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1011
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..4631
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4606..4611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /note="hexamer: AATAAA"
     polyA_site      4631
                     /gene="DIPK2B"
                     /gene_synonym="4930578C19Rik; bA435K1.1; CXorf36; DIA1R;
                     EPQL1862; PRO3743"
                     /note="major polyA site"
ORIGIN      
        1 acagcctcga gtggacagcc agaggctgca gctggagccc agagcccaag atggagcccc
       61 agctggggcc tgaggctgcc gccctccgcc ctggctggct ggccctgctg ctgtgggtct
      121 cagccctgag ctgttctttc tccttgccag cttcttccct ttcttctctg gtgccccaag
      181 tcagaaccag ctacaatttt ggaaggactt tcctcggtct tgataaatgc aatgcctgca
      241 tcgggacatc tatttgcaag aagttcttta aagaagaaat aagatctgac aactggctgg
      301 cttcccacct tggactgcct cccgattcct tgctttctta tcctgcaaat tactcagatg
      361 attccaaaat ctggcgccct gtggagatct ttagactggt cagcaaatat caaaacgaga
      421 tctcagacag gagaatctgt gcctctgcat cagccccaaa gacctgcagc attgagcgtg
      481 tcctgcggaa aacagagagg ttccagaaat ggctgcaggc caagcgcctc acgccggacc
      541 tggtgcaggg cctggccagc ccgctcctgc gctgcccttc gcagcgactc ctggatcgcg
      601 tggtcaggcg ctatgcagag gtggccgacg ccggcagcat cttcatggac cacttcaccg
      661 accgtgacaa gctgcgcctg ctctacacgc tggctgtcaa ctcgcacccc atcctcctac
      721 agatcttccc tggggctgag ggatggccgc tgcccaagta cctgggctcc tgtggcagat
      781 tcctcgtcag caccagcacc agaccgctgc aggaattcta tgatgcaccc ccagatcagg
      841 cagccgacct tgcctaccag ctcctgggtg tcctggagtc tttgaggagc aacgatttga
      901 actatttctt ctacttcacc cacattgatg caggcatgtt cggcgtcttt aacaacgggc
      961 atctgttcat ccgggatgcc agtgcagtgg gcgtcatcga caagcaggaa ggcagccaag
     1021 aagccaacag ggcaggagag aataaagaca tttttagctg cctggtttcc ggctgccagg
     1081 cccagctgcc ctcctgcgaa agcatctctg agaagcagag cctggtgctg gtgtgtcaga
     1141 agttgctgcc tcgacttctc caggggaggt tcccctcccc agtgcaagac gacatagact
     1201 ccatccttgt tcagtgtggg gacagcatcc gcccagaccc agaagtcctt ggggccgcca
     1261 gccagctgaa agacatcttg aggcccctga gaacgtgtga ctccagattt gcctatcgtt
     1321 acccagattg caaatataac gataagttct gaagggctgg tgtctagctg gccttgggga
     1381 caacacgctt ggctctccat tctcccagtc gggttgctgc aaggtagaaa gaagcagctc
     1441 ttttttaaag atgagaagaa aggcacactc atttcttagg gactgagagg ggagttgtga
     1501 gataccacgt ggctgtctct gctggctggg acgtcctggc aaagcccgcg gtgggcatca
     1561 gaagacctgg gtgtggacgc tcactcaatg tctttgagcc tcagtttcct ctgttctcca
     1621 ccagactctc ctgagggtga aagaagacac agatggagcc accactgagc atatatccca
     1681 agcatgggtc ttgggacaca tgctcaccac ctccatccca ggtggttaca aagtgtgttc
     1741 tggaaaagca cagaggcggg gagcatgaga aagagctgct caggtcagga ggctggagtg
     1801 gagggaaggc aggggaagga caggctccct gccactacca ctttagactc ggacaagagg
     1861 ggcccccttc ctgctcccta tggccctgcg tcactcccca caccatcgcg ggatgaggag
     1921 actgcaggcc aaggggacat gcctgccacc acctagagcc tggtacctga ggctccatac
     1981 acctgcgcat ggggcttctc gtggtgtggg aagaagccag gggtaagaag ataaaggggg
     2041 gccggcgggg gaccaatgtg ttagcccaag tcttccaaga atatgtgtca agatagagtg
     2101 aatggaacaa agatttgtta ggggaaatga ttgtgtgtaa ggaaagaagg agggagccgg
     2161 agaagattgg gaggaccagt aagtcgagct gcaagctgag ccccggtgaa ggagagaatg
     2221 tctggcagga gcttgctaag ctcaaaatca aagaaaggtt cagcaaggct gtcagggtgt
     2281 cctcaagaca aaggcagcca tcagaagagc cccgtgtctc ccacaaatag accccgttag
     2341 catccctgct gcactcagtg gttggcggaa acagcaaaga tagatttcag agcacagcag
     2401 caggggtccc tggtcagccc cgctccctag agcaggagat cttgagtggg agaacattct
     2461 tgttgtagcc acagctgagg ccctggacca gctctctcca caccgcatgc tccgagttgg
     2521 gactctaagg agtctaggaa ttttcattca aacttggcct tacaggtcac tcatcagaaa
     2581 aatacttttt tcaaggtcaa ccaatagaac atactttatt caacagtttg ttagtttgct
     2641 ttttaaatat ttagccacat ggtatgtagg cttccatgta cactcttgcc ctggcccctg
     2701 aaacataagc agggggctct tctgtacatt tgcccagctt ccctgccagc ctttaacccc
     2761 aggaacctct cagtctacct cctcttttct gcctctgaat ccctaccttt aaagtcagaa
     2821 caggccaggc ccggtggctc acgcctgtaa tcccagcact ttgggaggct gaggtgggtg
     2881 gatcacttga catcagtagt tcaagaccag cctggccaac atggtgaaac cccatcctta
     2941 ctaaaaatac aaaaattagc caggtgtggt ggcgggcacc tgtaatccca gctactcagg
     3001 aggctgaggc aggagaatca cttgaaccca ggaggcagag tttgcagtca gccaagatca
     3061 cgccactgta ctccagcctg gatgacacag cgagactccg tctcaaaata aataaataaa
     3121 aataaagtca gaacacctgg cttaataggc ctcactgtgc agatgaggaa actgaggccc
     3181 agggaggaag agcgatctgt ggagatattt ctagaacccc tgcaagctga gccccagtga
     3241 aggagagaag gtccagtagg agcttgctaa gctcaaaatc gaagaaaggt tcagcaagac
     3301 tgtcagggtg acctcaaagc aatggcagcc atcagaggag ccccattgct attaggaggc
     3361 tcctattgcc ctccccttca gcctctgact ttcacctgtg ctacccaatt ctggttcctt
     3421 cactcccatt caaaaatgga ccccagaaaa gccttatttt gtggagtacc tagttccctt
     3481 ttgggtttgt ctcttgactg ctacgggcat tgccccaggg caaccatgac agtgaagatg
     3541 actggccaag cttgtggact ggccagcaag cttgggctgc ctgagacgct ttgaaatggc
     3601 tgccttctga gttggtcttg agggtgaaga ctgaccaccc ttctcacctg cacagtcaca
     3661 gtccctctcc tgctggcctg actgcagctg tcctcccagc tggccacctg accagagacc
     3721 aggagagagg ccacagcctc cagaccctcc agagtcccac ggaggaagaa ggcttaccag
     3781 agagaccctc tgatgcatga gccaggcccc agcccttctc cctgcatcca ggtgtgtttc
     3841 caccgcaaaa tgcctccaca caatgagcga ctttggccct gcgtgggtca gcatgtggtc
     3901 tgaggtaacc ctcaaatgcc tccaccacac atctgtccac ctgcacgggt tcaaggtaag
     3961 cacttgcccc cttctctcct ccagaccagt cgcctgaaat tctgagcaac attccttcaa
     4021 gactatcatg taacccttgg tgatgctgag tccagacagg aaatgcagac ttgggaccca
     4081 cctgtatcag cagaaagagg ccttgtgccc cgtttgtccg agtcccagaa cggagcaaat
     4141 gagaaaaccg gcgagctgtc ccccgaggag ctgtagggag attggttttt agtataaatt
     4201 acaataaaat tttgtgtatg tgtacagctg tgttcacatc cacagtgtaa gctgtgatat
     4261 ggtttggatg tttgtcccct ccaaatctca tgttgaaatg tgatccccag cattggaggt
     4321 ggggcctgat gggaggtgat tgggtgatgg gggaagttgc ctcatgaatg acttggtgcc
     4381 ctcctggaag tgatgagtga gttctcgctg agctcactca agatgtggtt gtttaaaaga
     4441 gtgtggcacg tccctccccc aactctccct ctcactcccg ctctcaccat gtgacacacc
     4501 tgctccccct tcgccttcca ccatgattgg aagcttcctg aagcccttac cagaagcaga
     4561 tgccagcccc acacttcctg taccacctgc agaaccataa accaaaataa agctcttttc
     4621 tttatcaatt a
//
