LOCUS       NM_173552               4330 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens divergent protein kinase domain 2A (DIPK2A),
            transcript variant 1, mRNA.
ACCESSION   NM_173552
VERSION     NM_173552.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4330)
  AUTHORS   Tian,X., Zheng,P., Zhou,C., Wang,X., Ma,H., Ma,W., Zhou,X., Teng,J.
            and Chen,J.
  TITLE     DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome
            fusion by binding to VAMP7B
  JOURNAL   Autophagy 16 (5), 797-810 (2020)
   PUBMED   31251111
  REMARK    GeneRIF: DIPK2A promotes STX17- and VAMP7-mediated
            autophagosome-lysosome fusion by binding to VAMP7B.
REFERENCE   2  (bases 1 to 4330)
  AUTHORS   Hareza,A., Bakun,M., Swiderska,B., Dudkiewicz,M., Koscielny,A.,
            Bajur,A., Jaworski,J., Dadlez,M. and Pawlowski,K.
  TITLE     Phosphoproteomic insights into processes influenced by the
            kinase-like protein DIA1/C3orf58
  JOURNAL   PeerJ 6, e4599 (2018)
   PUBMED   29666759
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4330)
  AUTHORS   Bareja,A., Hodgkinson,C.P., Payne,A.J., Pratt,R.E. and Dzau,V.J.
  TITLE     HASF (C3orf58) is a novel ligand of the insulin-like growth factor
            1 receptor
  JOURNAL   Biochem J 474 (5), 771-780 (2017)
   PUBMED   28096202
  REMARK    GeneRIF: HASF (C3orf58) is a novel ligand of IGF1R.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4330)
  AUTHORS   Huang,J., Guo,J., Beigi,F., Hodgkinson,C.P., Facundo,H.T.,
            Zhang,Z., Espinoza-Derout,J., Zhou,X., Pratt,R.E., Mirotsou,M. and
            Dzau,V.J.
  TITLE     HASF is a stem cell paracrine factor that activates PKC epsilon
            mediated cytoprotection
  JOURNAL   J Mol Cell Cardiol 66, 157-164 (2014)
   PUBMED   24269490
REFERENCE   5  (bases 1 to 4330)
  AUTHORS   Beigi,F., Schmeckpeper,J., Pow-Anpongkul,P., Payne,J.A., Zhang,L.,
            Zhang,Z., Huang,J., Mirotsou,M. and Dzau,V.J.
  TITLE     C3orf58, a novel paracrine protein, stimulates cardiomyocyte
            cell-cycle progression through the PI3K-AKT-CDK7 pathway
  JOURNAL   Circ Res 113 (4), 372-380 (2013)
   PUBMED   23784961
REFERENCE   6  (bases 1 to 4330)
  AUTHORS   Aziz,A., Harrop,S.P. and Bishop,N.E.
  TITLE     Characterization of the deleted in autism 1 protein family:
            implications for studying cognitive disorders
  JOURNAL   PLoS One 6 (1), e14547 (2011)
   PUBMED   21283809
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4330)
  AUTHORS   Aziz,A., Harrop,S.P. and Bishop,N.E.
  TITLE     DIA1R is an X-linked gene related to Deleted In Autism-1
  JOURNAL   PLoS One 6 (1), e14534 (2011)
   PUBMED   21264219
  REMARK    GeneRIF: results support a model where the DIA1 and DIA1R regulate
            molecular traffic through the cellular secretory pathway or affect
            the function of secreted factors, and functional deficits cause
            disorders with ASD-like symptoms and/or mental retardation
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4330)
  AUTHORS   Takatalo,M., Jarvinen,E., Laitinen,S., Thesleff,I. and Ronnholm,R.
  TITLE     Expression of the novel Golgi protein GoPro49 is developmentally
            regulated during mesenchymal differentiation
  JOURNAL   Dev Dyn 237 (8), 2243-2255 (2008)
   PUBMED   18651652
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB067725.1, DA760601.1, BC037293.2, AK095400.1 and BM968874.1.
            
            On Aug 29, 2019 this sequence version replaced NM_173552.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037293.2, AL832839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000315691.8/ ENSP00000320081.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                DB067725.1         26-41
            17-248              DA760601.1         41-272
            249-2406            BC037293.2         1-2158
            2407-3189           AK095400.1         1339-2121
            3190-4321           BC037293.2         2942-4073
            4322-4330           BM968874.1         16-24               c
FEATURES             Location/Qualifiers
     source          1..4330
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q24"
     gene            1..4330
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /note="divergent protein kinase domain 2A"
                     /db_xref="GeneID:205428"
                     /db_xref="HGNC:HGNC:28490"
                     /db_xref="MIM:612200"
     exon            1..1167
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /inference="alignment:Splign:2.1.0"
     CDS             511..1803
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; Golgi protein GoPro49; UPF0672 protein C3orf58;
                     deleted in autism 1; deleted in autism protein 1; Golgi
                     Protein of 49 kDa; hypoxia and AKT-induced stem cell
                     factor; hypoxia and Akt induced stem cell factor"
                     /codon_start=1
                     /product="divergent protein kinase domain 2A isoform a
                     precursor"
                     /protein_id="NP_775823.1"
                     /db_xref="CCDS:CCDS3130.1"
                     /db_xref="GeneID:205428"
                     /db_xref="HGNC:HGNC:28490"
                     /db_xref="MIM:612200"
                     /translation="MWRLVPPKLGRLSRSLKLAALGSLLVLMVLHSPSLLASWQRNEL
                     TDRRFLQLNKCPACFGTSWCRRFLNGQVVFEAWGRLRLLDFLNVKNVYFAQYGEPREG
                     GRRRVVLKRLGSQRELAQLDQSICKRATGRPRCDLLQAMPRTEFARLNGDVRLLTPEA
                     VEGWSDLVHCPSQRLLDRLVRRYAETKDSGSFLLRNLKDSERMQLLLTLAFNPEPLVL
                     QSFPSDEGWPFAKYLGACGRMVAVNYVGEELWSYFNAPWEKRVDLAWQLMEIAEQLTN
                     NDFEFALYLLDVSFDNFAVGPRDGKVIIVDAENVLVADKRLIRQNKPENWDVWYESKF
                     DDCDKEACLSFSKEILCARATVDHNYYAVCQNLLSRHATWRGTSGGLLHDPPSEIAKD
                     GRLEALLDECANPKKRYGRFQAAKELREYLAQLSNNVR"
     exon            1168..1471
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..4330
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4306..4311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /note="hexamer: AATAAA"
     polyA_site      4330
                     /gene="DIPK2A"
                     /gene_synonym="C3orf58; DIA1; GoPro49; HASF"
                     /note="major polyA site"
ORIGIN      
        1 acaagcaagg gtgtgcggct ctgagacgtg cgttgctgct tgtgggtgtg agacatccta
       61 gctcctcttc cccttccgtg agtccctcct ttcctcgcag accccacttg tcgtggctgg
      121 ctgccgccgc agctcttgtg cgaagccagc agtgcgcgtg cgcgcgggca cgggcgcgcg
      181 accgtcgggt ccccgcgctc cctccccctc ccgctcctct ataacttggc tggcgtggag
      241 gaggcgccgc cggagtcgga gggcggggag ctaggaggag ggagctcgag agttgtggag
      301 actagtgact gggagaagtc gcagcccgct caggcccgcg ccttcccgct ccccgtcttc
      361 ctctctcaca cacctactcc gccctccgcc ccagcccgcg cgctagctcc ttctctcgcc
      421 cggggttcct gccggtagct ctccgggtct tggcgcggcg ggggcgcccc gggggtgccc
      481 tcgccctccc gttgcgggcg ggcgggcggt atgtggcgcc tggtgccccc gaagctgggc
      541 cgcctgtccc gctcgctgaa gctggcggcg ctgggcagcc tgttggtgct gatggtgctg
      601 cactcgccgt cgctgctcgc ctcttggcag cgcaacgaac tgaccgaccg gcgcttcctg
      661 cagctcaata agtgcccggc gtgcttcggc acgagctggt gccgccgctt cctcaacggg
      721 caggtggtat tcgaggcgtg gggccgcttg cgcctgctgg acttcctcaa cgtgaagaac
      781 gtgtacttcg cgcagtacgg cgagccccgc gagggcggcc gccgccgagt ggtgctcaag
      841 cgcctcggct cgcagcgcga gctggcgcag ctcgaccaga gcatctgcaa gcgggccacc
      901 ggccggcccc gctgcgacct gctgcaggcc atgccccgga ccgagttcgc gcgcctcaac
      961 ggcgacgtgc gtctgctcac gcccgaggcg gtggagggct ggtcggacct ggtgcactgc
     1021 ccctcgcagc gccttctcga ccgcctggtg cgccgctacg cggagaccaa ggactcgggc
     1081 agcttcctgc ttcgcaacct caaggactcg gagcgcatgc agctgctgct gaccctggcc
     1141 ttcaaccccg agccgctggt gctacagagt tttccgtctg atgaaggttg gccatttgca
     1201 aagtatcttg gagcttgtgg aagaatggtg gctgtaaatt atgttggaga agaactgtgg
     1261 agttacttta atgcgccatg ggaaaaacga gttgacctcg cttggcaatt aatggaaata
     1321 gcagaacagc ttacaaacaa tgactttgaa tttgcactct acctcctgga cgtcagcttt
     1381 gacaattttg cagttggtcc tagagatggg aaggtaatca ttgtggatgc tgaaaatgtt
     1441 ttggttgctg acaaaagatt aattagacaa aataaacctg aaaattggga tgtatggtat
     1501 gaaagcaagt ttgatgactg tgataaggag gcttgcttat cattttcaaa agaaattctt
     1561 tgtgctcgtg ccactgtgga ccacaattac tatgctgttt gtcagaacct cttatccaga
     1621 catgccacct ggcgtggcac ttctggagga ctccttcatg atccaccaag tgaaattgcc
     1681 aaagatggcc ggctcgaggc cttgctggat gagtgtgcca acccaaagaa gcgctatggc
     1741 agattccagg ctgcaaaaga actgcgtgaa tacctagcac aattaagtaa caacgtgagg
     1801 tagtctatgg tgaacttttc tttttttctc catttaaaca gcactggcta aaactaaacc
     1861 accaaaaaac gatctgaaaa aatgaaattt ggaagtgtta cattcagagg atgataaact
     1921 tgcactgata gatcttaatg ttaacatcca tcaaaataag acattacttc aaaaatcaca
     1981 tgatgcttct gcaaataagt atgttcttat actttggagg cttgagctgt catcagctgc
     2041 tccccactac cccggaatgc ttgagtggat taatgaatat tgttaagcta ttggaaatga
     2101 gtctgatagt acattggctt gtgtatcaaa gggtacttgg tacttagttt gcatttacta
     2161 tcatgatttt gtgaatctct tgcatttact ttgaatgtca agtcagattg gtctgtttta
     2221 taggccgctt tttccttctg atgtgtaggg ttttttcccc cttttttttt ttaattaaat
     2281 tttgaaaatt caggttactg taggtgttca tttaaatttt taatagttgt cattcagtgc
     2341 tatttggtac atatttactg ttagggcagg attcccaggt ttactgtgtt tttttttttt
     2401 ttttttaaag aaagctaaat attacattat gtaaatactt cttttcacca acttctgtag
     2461 tttcaccatt gcatggtgtc atttcaggtt atttaacagt tatatccctc tatgccaata
     2521 attagaagtg tacactaaac atgaagtttg gcatatgttg caaaatgtca ttttatcttt
     2581 tctaaaggct ttaagaagaa tatactagaa tctatatatt gatgttaatt ttgattcaga
     2641 aaaaaaatac aacccagtat ctaaaaagtg ttaactagtc caagatagta atgcatatgc
     2701 caaagaaata ttacacctaa tctcatgttt agaatttaaa atagaattgg tcagctactt
     2761 attcttacca ccctacttcc agtattttag ctctgtcatt attaaattca gatcttcctg
     2821 attatttttt ctgttgaaag ttaaactact gctttcaagt aatttaaagt tatcctacct
     2881 tttattcatg ggtagttttg caaaattaac atggtagcca ttgtttgaat ttaatcgggc
     2941 atcataactt ttcatttatt gaggaactaa tcattattac tataaagcat acaaattagc
     3001 cagtcagcac actttggtct tctttaccta agggttaaac atcagaacat caaatttaat
     3061 tatttgcata gaaatgtgtg ggctctttat ataagttgac tatcactaac aggtaatatt
     3121 tttctgtttg aagttgttac ttttgtttac agcaaagttt gatgtagtgt gcagtagtga
     3181 gctctagact gatctttttc taaatcagaa agtgattaaa gtatgcacaa ccaaaggcag
     3241 gtttttcttt ttcatttatt cagcaactat ttattaagca tcaactctgt gccaggcacg
     3301 ttactagctg ctacatactg tctgaacatg acatacggtt aagtaacttt acaattatta
     3361 tcaaatactt caatgtagat atttcttaag ttgaaatagc attaactagg ataatgcttt
     3421 catgttattt tattgtcttg tgatagaaat tcaacttgta ccatctaaaa ctaggttgct
     3481 ataaaaatag gaggatgaag tcaataaagt ttatgccagt ttaaaaactg gaaggaaaag
     3541 gtaagagctc tccattataa aatagttgca ttcggttaat ttttacacat tagtgcattg
     3601 cgtatatcaa ctggccctca atgaagcatt taagtgcttg gaattttact aaactgactt
     3661 ttttgcaact ttgggagatt tttgagggga gtgttgaaaa ttgccaaaca ctcacctctt
     3721 actcaaaact tcaaataaaa tacacatttt caagagggag caccttttat atttgataag
     3781 ttttcattat aaaccttata ataccagtca caaagaggtt gtctgtctat ggtttagcaa
     3841 acatttgctt ttctttttgg aagtgtgatt gcaattgcag aacagaaagt gagaaaacac
     3901 tgccagcggt gattgctact tgaggtagtt ttttacaact accatttccc ctccatgaaa
     3961 ttatgtgaaa tttattttat ctttgggaaa agttgagaag atagtaaaag aattaggaat
     4021 ttaaaattac agggaaaaat atgtaagtga aaagcaataa atattttgtt cactttgcta
     4081 tcaagatgtt cactatcaga tatttattat atggcagcaa tttatatttt taatcattgc
     4141 ccattaatag acgcagtaaa atatttttga atcagacatt tggggtttgt atgtgcatta
     4201 aaattgtctt ttgtactgta agttactgtt aatttgaata ttttattgaa ctgtctccct
     4261 gtgcctttat aatataaagt tgtttctaca acttttaatg atcttaataa agaatacttt
     4321 aagaatcaca
//
