LOCUS       NM_001044369            3035 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens divergent protein kinase domain 1C (DIPK1C), mRNA.
ACCESSION   NM_001044369 XM_058931 XM_941186
VERSION     NM_001044369.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3035)
  AUTHORS   Wu,Z., Mei,F., Gan,Y., Liu,A., Hu,J., Jin,Y. and Yin,Y.
  TITLE     FAM69C functions as a kinase for eIF2alpha and promotes stress
            granule assembly
  JOURNAL   EMBO Rep 24 (5), e55641 (2023)
   PUBMED   36929224
REFERENCE   2  (bases 1 to 3035)
  AUTHORS   Mei,F., Hu,J., Wu,Z., Zhang,G., Liu,A., Li,X., Zhu,M., Gan,Y.,
            Liang,L., Zhao,X., Yuan,Y., Meng,X., Li,Y., Jin,Y., Jia,J. and
            Yin,Y.
  TITLE     FAM69C, a kinase critical for synaptic function and memory, is
            defective in neurodegenerative dementia
  JOURNAL   Cell Rep 40 (3), 111101 (2022)
   PUBMED   35858575
REFERENCE   3  (bases 1 to 3035)
  AUTHORS   Dudkiewicz,M., Lenart,A. and Pawlowski,K.
  TITLE     A novel predicted calcium-regulated kinase family implicated in
            neurological disorders
  JOURNAL   PLoS One 8 (6), e66427 (2013)
   PUBMED   23840464
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3035)
  AUTHORS   Tennant-Eyles,A.J., Moffitt,H., Whitehouse,C.A. and Roberts,R.G.
  TITLE     Characterisation of the FAM69 family of cysteine-rich endoplasmic
            reticulum proteins
  JOURNAL   Biochem Biophys Res Commun 406 (3), 471-477 (2011)
   PUBMED   21334309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009704.8.
            
            On Jun 17, 2020 this sequence version replaced NM_001044369.2.
            
            Summary: This gene encodes a member of the FAM69 family of
            cysteine-rich type II transmembrane proteins. These proteins
            localize to the endoplasmic reticulum but their specific functions
            are unknown. [provided by RefSeq, Nov 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: MG029087.1, SRR1660803.79682.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145893
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343998.8/ ENSP00000344331.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-247               AC009704.8         70969-71215         c
            248-925             AC009704.8         60513-61190         c
            926-1090            AC009704.8         55859-56023         c
            1091-3035           AC009704.8         48682-50626         c
FEATURES             Location/Qualifiers
     source          1..3035
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..3035
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /note="divergent protein kinase domain 1C"
                     /db_xref="GeneID:125704"
                     /db_xref="HGNC:HGNC:31729"
                     /db_xref="MIM:614544"
     exon            1..247
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1309
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /note="protein FAM69C; family with sequence similarity 69
                     member C; familial non-conventional Alzheimer's dementia"
                     /codon_start=1
                     /product="divergent protein kinase domain 1C"
                     /protein_id="NP_001037834.2"
                     /db_xref="CCDS:CCDS42445.2"
                     /db_xref="GeneID:125704"
                     /db_xref="HGNC:HGNC:31729"
                     /db_xref="MIM:614544"
                     /translation="MARAAGARGPAGWCRRRGRCGRGTLLAFAAWTAGWVLAAALLLR
                     AHPGVLSERCTDEKSRRILAALCQDYQGGTLAGDLCEDLCVAGELLFQRCLHYNRGKK
                     VLQADWRGRPVVLKSKEEAFSSFPPLSLLEEEAGEGGQDMPEAELLLMVAGEVKSALG
                     LELSNSSLGPWWPGRRGPRWRGQLASLWALLQQEEYVYFSLLQDLSPHVLPVLGSCGH
                     FYAVEFLAAGSPHHRALFPLDRAPGAPGGGQAKAISDIALSFLDMVNHFDSDFSHRLH
                     LCDIKPENFAIRSDFTVVAIDVDMAFFEPKMREILEQNCTGDEDCNFFDCFSRCDLRV
                     NKCGAQRVNNNLQVICDKIFRHWFSAPLKSSAVSFQLQLQLQEAVQECADPGVPSGNT
                     RRAASSVFWKLRQLLQATLRELQEAEK"
     exon            248..925
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1090
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..3035
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2061..2066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /note="hexamer: AATAAA"
     regulatory      2072..2077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /note="hexamer: AATAAG"
     polyA_site      2082
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /note="major polyA site"
     polyA_site      2098
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
     regulatory      3012..3017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
                     /note="hexamer: ATTAAA"
     polyA_site      3035
                     /gene="DIPK1C"
                     /gene_synonym="C18orf51; FAM69C; FNCAD"
ORIGIN      
        1 aactcggggc gcgggcggcg gtggggcccg ggcgcgggca gggctggcca tggcgcgggc
       61 ggcgggcgcg cggggccctg ccgggtggtg caggaggcgc gggcgctgcg ggcggggcac
      121 gctcctcgcc ttcgccgcgt ggaccgcggg ctgggtgctg gcggccgcgc tgctgctccg
      181 cgcgcacccg ggtgtcctct ccgagcgctg caccgacgag aagagccggc gcatcctggc
      241 cgcgctgtgc caggactacc agggcggcac gctggccggg gacctctgcg aggacctgtg
      301 tgtggcggga gagctgctgt tccaacgctg cctgcactac aacagaggca agaaggtgct
      361 gcaggccgac tggcgcggcc ggcccgtggt cctcaagtcc aaggaggagg ccttctccag
      421 cttcccgccc ctcagcctgt tggaagagga ggcaggggag ggtggccagg acatgcccga
      481 ggccgaactc ctcctgatgg tggctgggga ggtcaagagc gctctgggcc tggagttgtc
      541 caacagcagc ctggggccgt ggtggccggg caggcggggc ccacgctggc ggggacagct
      601 ggccagcctg tgggccctgc tgcagcagga ggagtacgtc tacttcagcc tgctgcagga
      661 cctgagccca cacgtgctgc ccgtgctggg ttcctgcggc cacttctacg cggtggagtt
      721 cctggccgcg ggcagccccc accacagggc actcttcccc ctggaccggg ccccaggtgc
      781 ccctgggggt ggccaggcca aggccatcag tgacatcgca ctcagcttct tggacatggt
      841 gaaccatttt gacagtgact tttcccaccg cctccacctc tgcgacatca agccggaaaa
      901 ctttgccatc cggagcgact tcacagtggt ggctattgat gtggacatgg ccttttttga
      961 acctaaaatg agggaaatcc ttgagcaaaa ctgcacagga gatgaagact gcaatttctt
     1021 tgactgtttt tcaagatgtg atttacgagt caacaaatgc ggagcgcagc gcgtaaacaa
     1081 caacctgcag gtcatctgtg acaaaatatt tcgccattgg ttttccgcgc ctctcaagag
     1141 ctctgcggtc tctttccagc ttcagctgca gttacaggag gcggtgcagg aatgtgcaga
     1201 ccctggggtc cccagtggga acacccggag agcagcctcc agcgtgttct ggaagcttcg
     1261 ccaactcctc caagccacac tgagggagct gcaggaggca gagaagtagc cactctctgg
     1321 ccttaaacat gctcacacag gaaaagtgac cttggctgga tttcttctgc cattgtttta
     1381 aagatgagcc atttcccctg tgctctctgg ggtgccgttc tggtctccac attgtggagt
     1441 ggcaagtgct gctgccagag acagtgctcc ctcgctctcg tcccaccctg gcctctgacc
     1501 tgtcgccttg tgtaaaatga gatgagggag gaggtacaga cctcccttca ggagggctct
     1561 cggtcagaag acaccaacct gtgtgcactt attctctgca gagagcactt gtacctggtt
     1621 atcccagcac gagttccagc tgttctttcc tgtaaatcgt taccacgtta aaaagtgtgc
     1681 gtgtgtgcat acaaatgatg tgtatgcctg tgtctgggtg caaatgagca tgtgagcatg
     1741 tgtgagtgtg cccatgagtg tctgcatgtg tgtgagtgtg cacaggtgag tgtgcacagg
     1801 tgagtgtggt gtgctcatga ggagtatgag tatgcctgag tgtgaatatg tatgagtgtg
     1861 aatgagtgtg tgcacatgag tgcacgggtg tcagcatgtg tatataagtg tgggcatgtg
     1921 tatgtgattg tgtgagtgtg ggcaggtgag tgtgttgggg atgtgggtta gggtggggag
     1981 tggtgctttc tctagtgtgt cctccggaac atcttgccta cctagcaaag aagtgtgacc
     2041 attctttcgg aattaaatac aataaaaaga aaataagctg catctttagg gaagggaatt
     2101 tgcattggag agcgtgtgta acggcagctt atagtatttt tcattttgtg gaatccacca
     2161 aggttatgga tgggttttag ggcgcctcgt attgcaatac accttcccct gggcagggac
     2221 ttgtaggttg gcttgatgca gcattgtctt caccttcaga gaaaatttaa agtagagcaa
     2281 atgctgaggt ctgcattgac tccaggcagg accagagacc agcacctttc ttttgatgga
     2341 ttgaagacca agtgataggc atcaaatcct atggtggcat gatacgctca tcagtggtga
     2401 tcccaaggag gcttttccag caaaatacag gcagggggac aggccaggtg aagccagtga
     2461 gctttcactt aaagggacct ggtttctacc cataactgtg acccacgagt gctcaacaaa
     2521 ccaacgggtc accccttttc agaaatccca tgaaaaggga aatcgagaaa gatgagagaa
     2581 tcaggaagtc atgttggcag tttacacatt aaagaagaca aattaatcgg acgttgtgaa
     2641 agtcacaaac tgacacattc caaatggtct cttatcttgg cctgcagccc ctttctaaac
     2701 cagagaaacg ggaatgcctt cttccagact ttggggtcac atttactgac tctgcccttc
     2761 agggcacgct gagaaatggt gtgtgaggga ctagcatgat cagaggcccc cagctctaaa
     2821 ttctgccttc cccaaagacc tgttggaagg cccactgcca gctgttattc ttacccatca
     2881 ccactgggga tcttccaaat gacacagagt tccatagagg gcctcctcat catggacatg
     2941 aagactcgct ttgcaattgt attctagcaa gaaggaaaaa acccatgtca gtcaccctgt
     3001 ggcacgagca aattaaaacc aaagttcaac ggcca
//
