LOCUS       NM_152421               2358 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens divergent protein kinase domain 1B (DIPK1B), mRNA.
ACCESSION   NM_152421 XM_942503 XM_946065
VERSION     NM_152421.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2358)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2358)
  AUTHORS   Dudkiewicz,M., Lenart,A. and Pawlowski,K.
  TITLE     A novel predicted calcium-regulated kinase family implicated in
            neurological disorders
  JOURNAL   PLoS One 8 (6), e66427 (2013)
   PUBMED   23840464
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2358)
  AUTHORS   Tennant-Eyles,A.J., Moffitt,H., Whitehouse,C.A. and Roberts,R.G.
  TITLE     Characterisation of the FAM69 family of cysteine-rich endoplasmic
            reticulum proteins
  JOURNAL   Biochem Biophys Res Commun 406 (3), 471-477 (2011)
   PUBMED   21334309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG700129.1, BC032097.2, AJ420457.1 and AL355987.31.
            
            On Nov 22, 2018 this sequence version replaced NM_152421.3.
            
            Summary: This gene encodes a member of the FAM69 family of
            cysteine-rich type II transmembrane proteins. These proteins
            localize to the endoplasmic reticulum but their specific functions
            are unknown. [provided by RefSeq, Nov 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.43734.1, BC032097.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371692.9/ ENSP00000360757.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BG700129.1         6-11
            7-563               BC032097.2         1-557
            564-570             AJ420457.1         404-410
            571-1653            BC032097.2         565-1647
            1654-2358           AL355987.31        2523-3227
FEATURES             Location/Qualifiers
     source          1..2358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..2358
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /note="divergent protein kinase domain 1B"
                     /db_xref="GeneID:138311"
                     /db_xref="HGNC:HGNC:28290"
                     /db_xref="MIM:614543"
     exon            1..157
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1390
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /note="protein FAM69B; family with sequence similarity 69
                     member B"
                     /codon_start=1
                     /product="divergent protein kinase domain 1B"
                     /protein_id="NP_689634.2"
                     /db_xref="CCDS:CCDS7004.1"
                     /db_xref="GeneID:138311"
                     /db_xref="HGNC:HGNC:28290"
                     /db_xref="MIM:614543"
                     /translation="MRRLRRLAHLVLFCPFSKRLQGRLPGLRVRCIFLAWLGVFAGSW
                     LVYVHYSSYSERCRGHVCQVVICDQYRKGIISGSVCQDLCELHMVEWRTCLSVAPGQQ
                     VYSGLWRDKDVTIKCGIEETLDSKARSDAAPRRELVLFDKPTRGTSIKEFREMTLSFL
                     KANLGDLPSLPALVGQVLLMADFNKDNRVSLAEAKSVWALLQRNEFLLLLSLQEKEHA
                     SRLLGYCGDLYLTEGVPHGAWHAAALPPLLRPLLPPALQGALQQWLGPAWPWRAKIAI
                     GLLEFVEELFHGSYGTFYMCETTLANVGYTATYDFKMADLQQVAPEATVRRFLQGRRC
                     EHSTDCTYGRDCRAPCDRLMRQCKGDLIQPNLAKVCALLRGYLLPGAPADLREELGTQ
                     LRTCTTLSGLASQVEAHHSLVLSHLKTLLWKKISNTKYS"
     exon            158..292
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /inference="alignment:Splign:2.1.0"
     exon            293..400
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /inference="alignment:Splign:2.1.0"
     exon            401..577
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /inference="alignment:Splign:2.1.0"
     exon            578..2358
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1634..1639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /note="hexamer: AATAAA"
     polyA_site      1653
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /note="major polyA site"
     polyA_site      2271
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
     regulatory      2314..2319
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
                     /note="hexamer: AATAAA"
     polyA_site      2358
                     /gene="DIPK1B"
                     /gene_synonym="C9orf136; FAM69B; pp6977"
ORIGIN      
        1 atggcgaggg agcggcggcc gctgcgggcc gggccgggcc ggggctgagg ccgagcgagc
       61 cgcggggccc gcgcagcccc ggccggagcc caccatgcgg cggctgcggc gcctggcgca
      121 cctggtgctc ttctgcccct tctccaagcg cctgcagggc cggctcccag gcctcagggt
      181 ccgctgcatc ttcctggcct ggctgggcgt ctttgcaggc agctggctgg tgtacgtgca
      241 ctactcgtcc tactcggagc gctgtcgcgg ccatgtctgc caggtggtca tttgtgacca
      301 gtaccgcaag gggatcatct cgggctccgt ctgccaggac ctgtgtgagc tgcatatggt
      361 ggagtggagg acctgcctct cggtggcccc gggccagcag gtgtacagcg ggctctggcg
      421 ggacaaggat gtaaccatca agtgtggcat tgaggagacc ctcgactcca aggcccggtc
      481 ggatgcggcc ccccggcggg agctggtact gtttgacaag cccacccggg gcacctccat
      541 caaggaattc cgggagatga ccctcagctt cctcaaggcg aacctgggag acctgccttc
      601 cctgccggcg ctggttggcc aggtcctgct catggctgac ttcaacaagg acaaccgggt
      661 gtccctggcg gaagccaagt ccgtgtgggc cctgctgcag cgtaacgagt tcctgctgct
      721 gctgtccctg caggagaagg agcacgcctc cagactgctg ggctactgtg gggacctcta
      781 cctcaccgag ggcgtgccgc atggcgcctg gcacgcggcc gcccttccac ccctgttgcg
      841 cccactgctg ccgcctgccc tgcagggtgc tctccagcag tggctggggc ctgcgtggcc
      901 ttggcgggcc aagatcgcca tcggcctgct ggagttcgtg gaggagctct tccacggctc
      961 ttacgggact ttctacatgt gtgagaccac actggccaac gtgggctaca cagccaccta
     1021 cgacttcaag atggccgacc tgcagcaggt ggcacccgag gccaccgtgc gccgcttcct
     1081 gcagggccgc cgctgcgagc acagcaccga ctgcacctac gggcgcgact gcagggcccc
     1141 gtgtgacagg ctcatgaggc agtgcaaggg cgacctcatc cagcccaacc tggccaaggt
     1201 gtgcgcactg ctacggggct acctgctgcc tggcgcgccc gccgacctcc gcgaggagct
     1261 gggcacacag ctgcgcacct gtaccacgct gagcgggctg gccagccagg tggaggccca
     1321 tcactcgctg gtgctcagcc acctcaagac tctgctctgg aagaagatct ccaacaccaa
     1381 gtactcttga tggggcagtg aggggcctgg ccacccttcc tggagctggc caggtgccag
     1441 ggtccaaccc tccctcaagg aatcctgtca gaagatgtga aatgcaactg tgttgcaaaa
     1501 tcactcccct accgtcaggg ctctggattc cagcaccaca gacatgagac cccagctcgg
     1561 agcaaaggcg gacatggaca tcccggcagg agagtcctcc aagggggttt gttactctga
     1621 agaacgtaat gtcaataaac agcttttatg taatgcccag ggctgagcac cctgagcccc
     1681 catcgatgct gtgtgtggga cccttcgccc cgctgtggat ccacccagcc caggcactca
     1741 ggctggggtt gagcccctga atccttcctg gcgaggcagc cctcaggtgt tagtccaagg
     1801 tgaggtctat tgcagagctg cctgcccttc aacccacaca cacctctgaa gccgccaggg
     1861 cagttcccca aacacagcgg cttctgaaac agtcaatgac cagtaccccc caaacctggg
     1921 ctgtgcacaa cagaccaaga aaaaggtgtt ccagtaagaa aacagatata tgcggtattt
     1981 taaaaactga ttttacaaaa tccagccatg agatgtacaa ctcattccct aggaaacagc
     2041 ccaggaatgg ccatcttctc cagccccgta cgctctcccc agtagcccag ggcacccagc
     2101 aaccatcccc taggagaaca ggcaaggacc ctcgtgggaa gatcccacca cagcaacacc
     2161 tttcttcagg gcgggctctg ctccgcaatg tgtgagtcaa gacaatccat tccattcaag
     2221 accaatttac tctcaaattt tgccaacaca gaaatattat ccttaaagaa atgtgcattt
     2281 aaatctttta attcacttca tcctgtattt taaaataaat gttttccata tagattttcc
     2341 ccttgggggg gaaaagaa
//
