LOCUS       NM_001006605            2536 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens divergent protein kinase domain 1A (DIPK1A),
            transcript variant 1, mRNA.
ACCESSION   NM_001006605 XM_371269
VERSION     NM_001006605.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2536)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2536)
  AUTHORS   Dudkiewicz,M., Lenart,A. and Pawlowski,K.
  TITLE     A novel predicted calcium-regulated kinase family implicated in
            neurological disorders
  JOURNAL   PLoS One 8 (6), e66427 (2013)
   PUBMED   23840464
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2536)
  AUTHORS   Tennant-Eyles,A.J., Moffitt,H., Whitehouse,C.A. and Roberts,R.G.
  TITLE     Characterisation of the FAM69 family of cysteine-rich endoplasmic
            reticulum proteins
  JOURNAL   Biochem Biophys Res Commun 406 (3), 471-477 (2011)
   PUBMED   21334309
REFERENCE   4  (bases 1 to 2536)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   5  (bases 1 to 2536)
  AUTHORS   Alcina,A., Fernandez,O., Gonzalez,J.R., Catala-Rabasa,A.,
            Fedetz,M., Ndagire,D., Leyva,L., Guerrero,M., Arnal,C., Delgado,C.,
            Lucas,M., Izquierdo,G. and Matesanz,F.
  TITLE     Tag-SNP analysis of the GFI1-EVI5-RPL5-FAM69 risk locus for
            multiple sclerosis
  JOURNAL   Eur J Hum Genet 18 (7), 827-831 (2010)
   PUBMED   20087403
  REMARK    GeneRIF: An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A
            locus, genotyping eight Tag-single nucleotide polymorphisms in 732
            multiple sclerosis patients and 974 controls from Spain, was
            performed.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 2536)
  AUTHORS   Hoppenbrouwers,I.A., Aulchenko,Y.S., Janssens,A.C.,
            Ramagopalan,S.V., Broer,L., Kayser,M., Ebers,G.C., Oostra,B.A., van
            Duijn,C.M. and Hintzen,R.Q.
  TITLE     Replication of CD58 and CLEC16A as genome-wide significant risk
            genes for multiple sclerosis
  JOURNAL   J Hum Genet 54 (11), 676-680 (2009)
   PUBMED   19834503
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 2536)
  CONSRTM   Australia and New Zealand Multiple Sclerosis Genetics Consortium
            (ANZgene)
  TITLE     Genome-wide association study identifies new multiple sclerosis
            susceptibility loci on chromosomes 12 and 20
  JOURNAL   Nat Genet 41 (7), 824-828 (2009)
   PUBMED   19525955
REFERENCE   8  (bases 1 to 2536)
  AUTHORS   D'Netto,M.J., Ward,H., Morrison,K.M., Ramagopalan,S.V.,
            Dyment,D.A., DeLuca,G.C., Handunnetthi,L., Sadovnick,A.D. and
            Ebers,G.C.
  TITLE     Risk alleles for multiple sclerosis in multiplex families
  JOURNAL   Neurology 72 (23), 1984-1988 (2009)
   PUBMED   19506219
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2536)
  AUTHORS   Hafler,D.A., Compston,A., Sawcer,S., Lander,E.S., Daly,M.J., De
            Jager,P.L., de Bakker,P.I., Gabriel,S.B., Mirel,D.B., Ivinson,A.J.,
            Pericak-Vance,M.A., Gregory,S.G., Rioux,J.D., McCauley,J.L.,
            Haines,J.L., Barcellos,L.F., Cree,B., Oksenberg,J.R. and
            Hauser,S.L.
  CONSRTM   International Multiple Sclerosis Genetics Consortium
  TITLE     Risk alleles for multiple sclerosis identified by a genomewide
            study
  JOURNAL   N Engl J Med 357 (9), 851-862 (2007)
   PUBMED   17660530
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL702320.1 and AL162740.13.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001006605.4.
            
            Summary: This gene encodes a member of the FAM69 family of
            cysteine-rich type II transmembrane proteins. These proteins
            localize to the endoplasmic reticulum but their specific functions
            are unknown. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.19228.1,
                                           SRR3476690.713774.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370310.5/ ENSP00000359333.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-532               AL702320.1         25-556
            533-2536            AL162740.13        10395-12398         c
FEATURES             Location/Qualifiers
     source          1..2536
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..2536
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /note="divergent protein kinase domain 1A"
                     /db_xref="GeneID:388650"
                     /db_xref="HGNC:HGNC:32213"
                     /db_xref="MIM:614542"
     exon            1..87
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1320
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM69A; family with sequence similarity 69 member
                     A"
                     /codon_start=1
                     /product="divergent protein kinase domain 1A isoform 1"
                     /protein_id="NP_001006606.2"
                     /db_xref="CCDS:CCDS44173.1"
                     /db_xref="GeneID:388650"
                     /db_xref="HGNC:HGNC:32213"
                     /db_xref="MIM:614542"
                     /translation="MARSLCPGAWLRKPYYLQARFSYVRMKYLFFSWLVVFVGSWIIY
                     VQYSTYTELCRGKDCKKIICDKYKTGVIDGPACNSLCVTETLYFGKCLSTKPNNQMYL
                     GIWDNLPGVVKCQMEQALHLDFGTELEPRKEIVLFDKPTRGTTVQKFKEMVYSLFKAK
                     LGDQGNLSELVNLILTVADGDKDGQVSLGEAKSAWALLQLNEFLLMVILQDKEHTPKL
                     MGFCGDLYVMESVEYTSLYGISLPWVIELFIPSGFRRSMDQLFTPSWPRKAKIAIGLL
                     EFVEDVFHGPYGNFLMCDTSAKNLGYNDKYDLKMVDMRKIVPETNLKELIKDRHCESD
                     LDCVYGTDCRTSCDQSTMKCTSEVIQPNLAKACQLLKDYLLRGAPSEIREELEKQLYS
                     CIALKVTANQMEMEHSLILNNLKTLLWKKISYTNDS"
     exon            88..222
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /inference="alignment:Splign:2.1.0"
     exon            223..330
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /inference="alignment:Splign:2.1.0"
     exon            331..507
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /inference="alignment:Splign:2.1.0"
     exon            508..2536
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2516..2521
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /note="hexamer: AATAAA"
     polyA_site      2536
                     /gene="DIPK1A"
                     /gene_synonym="FAM69A"
                     /note="major polyA site"
ORIGIN      
        1 gactgcagcg cggcggggcg atgtgtgatt accatggcga ggagtctctg tccgggggcc
       61 tggctaagga aaccctatta cctccaggct cgcttctcat atgtgcggat gaaatatctt
      121 ttcttttcct ggttagtggt ttttgttgga agctggatta tatatgtgca gtattctacc
      181 tatacagaat tatgcagagg aaaggactgt aagaaaataa tatgtgacaa gtacaagact
      241 ggagttattg atgggcctgc atgtaacagc ctttgtgtta cagaaactct ttactttgga
      301 aaatgtttat ccaccaagcc caacaatcag atgtatttag ggatttggga taatctacca
      361 ggtgttgtga aatgtcaaat ggaacaagcg cttcatcttg attttggaac tgaattggaa
      421 ccaagaaaag aaatagtgct atttgataag ccaactagag gaactactgt acaaaaattt
      481 aaagaaatgg tctatagtct ctttaaggca aaattgggtg accaaggaaa cctctctgaa
      541 ctggttaatc tcatcttgac ggtggctgat ggagacaaag atggccaggt ttccttggga
      601 gaagcaaagt cggcatgggc acttcttcaa ctgaatgaat ttcttctcat ggtgatactt
      661 caagataaag aacatacccc caaattaatg ggattctgtg gtgacctcta tgtgatggaa
      721 agtgttgaat atacctctct ttatggaata agccttcctt gggtcattga actttttatt
      781 ccatctgggt tcagaagaag catggatcag ctgttcacac catcatggcc aagaaaggcc
      841 aaaatagcca taggacttct agaatttgtg gaagatgttt tccatggccc ctacggaaat
      901 ttcctcatgt gcgatactag tgccaaaaac ctaggatata atgataagta tgatttgaaa
      961 atggtggata tgagaaaaat tgtgccagag acaaacctga aagaacttat taaggatcgt
     1021 cactgtgagt ctgatttgga ctgtgtctat ggcacagatt gtagaactag ctgtgatcag
     1081 agtacaatga agtgtacttc agaagtgata caaccaaact tggcaaaagc ttgtcagtta
     1141 ctcaaagact acctactgcg tggtgctcca agtgaaattc gtgaagaatt agaaaagcag
     1201 ctttattctt gtattgctct caaagtcaca gcaaatcaaa tggaaatgga acattctttg
     1261 atactaaata acctaaaaac attattgtgg aagaaaattt cctacactaa tgactcttag
     1321 ttcatttgga cataattacc attttaagaa acctgccact tttaaagaac aattttgagc
     1381 attaaaaaaa aatggcttca aattccggcc agttacacaa aactccttcc ccccaggcct
     1441 gagaagccat cagtatgtga tcactgaagt aatggcaggt gtaggatcaa caggtcccca
     1501 agatgtcatt cctgcccttt tagaagccct gttacatctc cgaagtacat tcattgtgta
     1561 actattttga ctgactttaa aaaccaatgc tgtgaaaagc ttcattccat aaacatcaac
     1621 agtgagtgat ttgtagattt accttagcca aaataccaat gctggaagca ttgtgtttgc
     1681 attgaagctg ctgttcaaca agaaaattta taaatttact aatgtcttag catggtaaag
     1741 tttgcacatt aacagaaatt aagactgcaa agcaggttaa acttgcttct ttataaaaca
     1801 gatgttgggt taatagcatg gtttactgta ttaaagactt atacacccat ttttaacctc
     1861 attcagacat caagttatgt gtagcttcac aatggttcaa gtggcttact tcaagaaatc
     1921 ttatacttga cagtacacca attttattga ctaaaaatgg atgaactttc ctaaagattc
     1981 aaagggccca tcttagtatc acgcagctga ctgagccctt caaaactgac atcttaaggc
     2041 ccaatcaaga tccacatatc ctgattttga actatgtgaa agtgggactg taagtgcaag
     2101 actaaaataa attatagcag actttttagt aataactttc cattttcaaa cagtatatcc
     2161 tgtgggccaa agggctattt cttaaagagg catgtaaatg tatttattta tctaatgttt
     2221 ttttccccat gtaaacttga tatacaaggt ttagtatttg ctcctctttc atattatttt
     2281 cacacgtata ctcagatttg gcatgtacct ttcaacatct ccataaaatt aaacaccttt
     2341 tggagaaaag aaccactatt ttctgctcaa aggtttcgcc tacctaaagt ggaacatgtt
     2401 aaaaatctat gtgaccatca ctggacagct ttctctcaaa actttccttc aacgccatgg
     2461 attagcacca gttttgttta ctttaaggta cttttcccat tcatcatctg gttataataa
     2521 atggatggaa gaaata
//
