LOCUS       NM_014974               7885 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens disco interacting protein 2 homolog C (DIP2C), mRNA.
ACCESSION   NM_014974 XM_034536
VERSION     NM_014974.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7885)
  AUTHORS   Ha,T., Morgan,A., Bartos,M.N., Beatty,K., Cogne,B., Braun,D.,
            Gerber,C.B., Gaspar,H., Kopps,A.M., Rieubland,C., Hurst,A.C.E.,
            Amor,D.J., Nizon,M., Pasquier,L., Pfundt,R., Reis,A., Siu,V.M.,
            Tessarech,M., Thompson,M.L., Vincent,M., de Vries,B.B.A.,
            Walsh,M.B., Wechsler,S.B., Zweier,C., Schnur,R.E., Guillen
            Sacoto,M.J., Margot,H., Masotto,B., Palafoll,M.I.V., Nawaz,U.,
            Voineagu,I. and Slavotinek,A.
  TITLE     De novo variants predicting haploinsufficiency for DIP2C are
            associated with expressive speech delay
  JOURNAL   Am J Med Genet A 194 (7), e63559 (2024)
   PUBMED   38421105
  REMARK    GeneRIF: De novo variants predicting haploinsufficiency for DIP2C
            are associated with expressive speech delay.
REFERENCE   2  (bases 1 to 7885)
  AUTHORS   Li,Y., Sun,C., Guo,Y., Qiu,S., Li,Y., Liu,Y., Zhong,W., Wang,H.,
            Cheng,Y. and Liu,Y.
  TITLE     DIP2C polymorphisms are implicated in susceptibility and clinical
            phenotypes of autism spectrum disorder
  JOURNAL   Psychiatry Res 316, 114792 (2022)
   PUBMED   35987071
  REMARK    GeneRIF: DIP2C polymorphisms are implicated in susceptibility and
            clinical phenotypes of autism spectrum disorder.
REFERENCE   3  (bases 1 to 7885)
  AUTHORS   Li,J., Ping,J.L., Ma,B., Chen,Y.R. and Li,L.Q.
  TITLE     DIP2C expression in breast cancer and its clinical significance
  JOURNAL   Pathol Res Pract 213 (11), 1394-1399 (2017)
   PUBMED   28964575
  REMARK    GeneRIF: The data revealed DIP2C expression level decreased in
            breast cancer, especially in basal-like and HER-2 subtypes, and
            could be a valuable target for diagnosis on specific subtype of
            breast cancer
REFERENCE   4  (bases 1 to 7885)
  AUTHORS   Larsson,C., Ali,M.A., Pandzic,T., Lindroth,A.M., He,L. and
            Sjoblom,T.
  TITLE     Loss of DIP2C in RKO cells stimulates changes in DNA methylation
            and epithelial-mesenchymal transition
  JOURNAL   BMC Cancer 17 (1), 487 (2017)
   PUBMED   28716088
  REMARK    GeneRIF: Loss of DIP2C triggers substantial DNA methylation and
            gene expression changes, cellular senescence and
            epithelial-mesenchymal transition in cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7885)
  AUTHORS   Shin,S.Y., Fauman,E.B., Petersen,A.K., Krumsiek,J., Santos,R.,
            Huang,J., Arnold,M., Erte,I., Forgetta,V., Yang,T.P., Walter,K.,
            Menni,C., Chen,L., Vasquez,L., Valdes,A.M., Hyde,C.L., Wang,V.,
            Ziemek,D., Roberts,P., Xi,L., Grundberg,E., Waldenberger,M.,
            Richards,J.B., Mohney,R.P., Milburn,M.V., John,S.L., Trimmer,J.,
            Theis,F.J., Overington,J.P., Suhre,K., Brosnan,M.J., Gieger,C.,
            Kastenmuller,G., Spector,T.D. and Soranzo,N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   6  (bases 1 to 7885)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Association of genetic variants with hemorrhagic stroke in Japanese
            individuals
  JOURNAL   Int J Mol Med 25 (4), 649-656 (2010)
   PUBMED   20198315
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 7885)
  AUTHORS   Oguri,M., Kato,K., Yokoi,K., Yoshida,T., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nozawa,Y. and Yamada,Y.
  TITLE     Assessment of a polymorphism of SDK1 with hypertension in Japanese
            Individuals
  JOURNAL   Am J Hypertens 23 (1), 70-77 (2010)
   PUBMED   19851296
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7885)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 7885)
  AUTHORS   Winnepenninckx,B., Debacker,K., Ramsay,J., Smeets,D., Smits,A.,
            FitzPatrick,D.R. and Kooy,R.F.
  TITLE     CGG-repeat expansion in the DIP2B gene is associated with the
            fragile site FRA12A on chromosome 12q13.1
  JOURNAL   Am J Hum Genet 80 (2), 221-231 (2007)
   PUBMED   17236128
REFERENCE   10 (bases 1 to 7885)
  AUTHORS   Mukhopadhyay,M., Pelka,P., DeSousa,D., Kablar,B., Schindler,A.,
            Rudnicki,M.A. and Campos,A.R.
  TITLE     Cloning, genomic organization and expression pattern of a novel
            Drosophila gene, the disco-interacting protein 2 (dip2), and its
            murine homolog
  JOURNAL   Gene 293 (1-2), 59-65 (2002)
   PUBMED   12137943
  REMARK    GeneRIF: This publication discusses the expression pattern and
            potential function of similar genes in Drosophila and mouse.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC063313.1, AL603831.23,
            BC048327.1, AK311679.1, BX537672.1, AB023151.2, BC035216.1 and
            N27959.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014974.2.
            
            Summary: This gene encodes a member of the disco-interacting
            protein homolog 2 family. The protein shares strong similarity with
            a Drosophila protein which interacts with the transcription factor
            disco and is expressed in the nervous system. [provided by RefSeq,
            Oct 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063313.1, AB023151.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280886.12/ ENSP00000280886.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1337              BC063313.1         1-1337
            1338-1338           AL603831.23        148089-148089       c
            1339-5019           BC063313.1         1339-5019
            5020-5147           BC048327.1         1708-1835
            5148-5574           AK311679.1         668-1094
            5575-5581           BX537672.1         2933-2939
            5582-6594           AB023151.2         5582-6594
            6595-7628           BC035216.1         695-1728
            7629-7885           N27959.1           11-267              c
FEATURES             Location/Qualifiers
     source          1..7885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..7885
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /note="disco interacting protein 2 homolog C"
                     /db_xref="GeneID:22982"
                     /db_xref="HGNC:HGNC:29150"
                     /db_xref="MIM:611380"
     exon            1..175
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..4761
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /note="DIP2 homolog C; DIP2 disco-interacting protein 2
                     homolog C"
                     /codon_start=1
                     /product="disco-interacting protein 2 homolog C"
                     /protein_id="NP_055789.1"
                     /db_xref="CCDS:CCDS7054.1"
                     /db_xref="GeneID:22982"
                     /db_xref="HGNC:HGNC:29150"
                     /db_xref="MIM:611380"
                     /translation="MADRSLEGMALPLEVRARLAELELELSEGDITQKGYEKKRSKLI
                     GAYLPQPPRVDQALPQERRAPVTPSSASRYHRRRSSGSRDERYRSDVHTEAVQAALAK
                     HKERKMAVPMPSKRRSLVVQTSMDAYTPPDTSSGSEDEGSVQGDSQGTPTSSQGSINM
                     EHWISQAIHGSTTSTTSSSSTQSGGSGAAHRLADVMAQTHIENHSAPPDVTTYTSEHS
                     IQVERPQGSTGSRTAPKYGNAELMETGDGVPVSSRVSAKIQQLVNTLKRPKRPPLREF
                     FVDDFEELLEVQQPDPNQPKPEGAQMLAMRGEQLGVVTNWPPSLEAALQRWGTISPKA
                     PCLTTMDTNGKPLYILTYGKLWTRSMKVAYSILHKLGTKQEPMVRPGDRVALVFPNND
                     PAAFMAAFYGCLLAEVVPVPIEVPLTRKDAGSQQIGFLLGSCGVTVALTSDACHKGLP
                     KSPTGEIPQFKGWPKLLWFVTESKHLSKPPRDWFPHIKDANNDTAYIEYKTCKDGSVL
                     GVTVTRTALLTHCQALTQACGYTEAETIVNVLDFKKDVGLWHGILTSVMNMMHVISIP
                     YSLMKVNPLSWIQKVCQYKAKVACVKSRDMHWALVAHRDQRDINLSSLRMLIVADGAN
                     PWSISSCDAFLNVFQSKGLRQEVICPCASSPEALTVAIRRPTDDSNQPPGRGVLSMHG
                     LTYGVIRVDSEEKLSVLTVQDVGLVMPGAIMCSVKPDGVPQLCRTDEIGELCVCAVAT
                     GTSYYGLSGMTKNTFEVFPMTSSGAPISEYPFIRTGLLGFVGPGGLVFVVGKMDGLMV
                     VSGRRHNADDIVATALAVEPMKFVYRGRIAVFSVTVLHDERIVIVAEQRPDSTEEDSF
                     QWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHLSETKQLFLEGSLHPCNVLM
                     CPHTCVTNLPKPRQKQPEIGPASVMVGNLVSGKRIAQASGRDLGQIEDNDQARKFLFL
                     SEVLQWRAQTTPDHILYTLLNCRGAIANSLTCVQLHKRAEKIAVMLMERGHLQDGDHV
                     ALVYPPGIDLIAAFYGCLYAGCVPITVRPPHPQNIATTLPTVKMIVEVSRSACLMTTQ
                     LICKLLRSREAAAAVDVRTWPLILDTDDLPKKRPAQICKPCNPDTLAYLDFSVSTTGM
                     LAGVKMSHAATSAFCRSIKLQCELYPSREVAICLDPYCGLGFVLWCLCSVYSGHQSIL
                     IPPSELETNPALWLLAVSQYKVRDTFCSYSVMELCTKGLGSQTESLKARGLDLSRVRT
                     CVVVAEERPRIALTQSFSKLFKDLGLHPRAVSTSFGCRVNLAICLQGTSGPDPTTVYV
                     DMRALRHDRVRLVERGSPHSLPLMESGKILPGVRIIIANPETKGPLGDSHLGEIWVHS
                     AHNASGYFTIYGDESLQSDHFNSRLSFGDTQTIWARTGYLGFLRRTELTDANGERHDA
                     LYVVGALDEAMELRGMRYHPIDIETSVIRAHKSVTECAVFTWTNLLVVVVELDGSEQE
                     ALDLVPLVTNVVLEEHYLIVGVVVVVDIGVIPINSRGEKQRMHLRDGFLADQLDPIYV
                     AYNM"
     exon            176..247
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            248..358
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            359..484
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            485..694
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            695..829
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            830..949
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1147
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1239
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1350
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1474
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1584
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1687
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..1752
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1846
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1966
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2081
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2221
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2222..2358
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2359..2567
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2568..2682
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..2884
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2885..2994
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            2995..3075
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3076..3199
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3200..3321
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..3433
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3434..3543
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3544..3674
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3675..3843
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            3844..4014
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            4015..4076
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            4077..4134
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            4135..4209
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            4210..4384
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            4385..4508
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     exon            4509..7885
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7597..7602
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /note="hexamer: AATAAA"
     polyA_site      7628
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /note="major polyA site"
     regulatory      7860..7865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
                     /note="hexamer: AATATA"
     polyA_site      7885
                     /gene="DIP2C"
                     /gene_synonym="KIAA0934"
ORIGIN      
        1 ctcggtgcgg ttccgccggg cgcgaggagc cgccgagacc tccgcctgcg aacaaagagg
       61 aggccgtgcg gggcgcggcg cccgcggagc atggcggacc gcagcctgga gggcatggcg
      121 ctgcccctgg aggtgcgggc gcgcctggcc gagctggagc tggagctgtc ggaaggtgac
      181 atcacacaaa aaggatatga aaagaagagg tcaaagttaa ttggagccta ccttccgcag
      241 cctccgaggg tggaccaagc tttgccgcaa gaacgccggg ctcctgtcac tccttcctcc
      301 gcctctcgct accaccgccg acggtcttca gggtcacgag atgagcgcta tcggtcagac
      361 gtccacacgg aagctgtcca ggcggctctg gccaaacaca aagagcggaa gatggcagtg
      421 cctatgcctt ccaaacgcag gtccctggtc gtgcagacct cgatggacgc ctacacccct
      481 ccagatacct cttctggctc agaagatgaa ggctcagtgc agggggactc ccagggcacc
      541 cccacctcca gccagggcag catcaatatg gagcactgga tcagccaggc catccacggc
      601 tccaccacgt ccaccacctc ctcgtcctct acgcagagcg ggggcagcgg ggctgcccac
      661 aggctggcgg acgtcatggc tcagacccac atagaaaatc attctgcacc tcctgacgta
      721 accacgtaca cctcagagca ctcgatacag gtggagagac cgcagggttc cacggggtcc
      781 cggacagcgc ccaagtacgg caacgccgag ctcatggaga ccggggatgg agtaccagta
      841 agtagccggg tgtcagcaaa aatccagcag cttgtcaata ccctcaaacg accgaaacga
      901 ccacctttac gagaattctt tgtcgatgac tttgaagaat tattagaagt tcaacaaccg
      961 gatccgaacc aaccaaagcc ggagggggcc cagatgctgg ccatgcgcgg agagcagctg
     1021 ggcgtggtca cgaactggcc gccgtcgctg gaggccgcac tgcagaggtg gggcaccatc
     1081 tcgcccaagg cgccctgcct gaccaccatg gacaccaacg ggaagcccct ctacatcctc
     1141 acttacggca agctgtggac aagaagtatg aaggtcgctt acagcattct acacaaatta
     1201 ggcacaaagc aggaacccat ggtccggcct ggagataggg tggcactggt gttccccaac
     1261 aatgatccgg ctgccttcat ggcggctttc tacggctgcc tgctggccga ggtggtcccc
     1321 gtgcccatcg aggtgccgct caccaggaag gacgcaggga gccagcagat aggtttcttg
     1381 cttggaagct gtggagttac tgtagccttg actagtgacg cctgccataa aggacttcca
     1441 aaaagcccaa cgggagagat cccacagttt aaaggttggc caaagctgct gtggtttgtc
     1501 acagagtcta aacatctctc caaaccgccc cgagactggt tcccacacat taaagatgcc
     1561 aataacgaca ctgcgtatat tgagtacaag acgtgtaagg atggcagtgt gctgggtgtg
     1621 acggtgacga ggactgcgct gctgacacac tgccaggccc tgacgcaggc gtgtggctac
     1681 acggaagctg aaaccattgt gaatgtgctg gatttcaaga aggacgtcgg gctctggcat
     1741 ggcatcctga caagcgtcat gaacatgatg catgtgatca gcatcccgta ctcgctgatg
     1801 aaggtgaacc ctctctcctg gatccagaag gtctgccagt acaaagcaaa agtggcgtgt
     1861 gtgaaatcga gggatatgca ttgggcatta gtagcacaca gagatcagag agacatcaac
     1921 ctctcctctc tgcgaatgct gatagtggcg gacggcgcga acccctggtc tatttcttct
     1981 tgcgatgcat ttctcaatgt cttccaaagt aaaggccttc gacaggaggt catctgtcct
     2041 tgtgccagct cgccagaggc cctcactgtg gccatccgga ggcccacgga tgacagtaac
     2101 cagcccccgg gccggggtgt cctctccatg catggactga cctatggggt cattcgtgtg
     2161 gactcggaag agaagctgtc cgtgctcacc gtgcaggatg tcggcctcgt gatgcctgga
     2221 gccatcatgt gttcagtgaa gccagacggg gttcctcagc tgtgcagaac ggatgagatc
     2281 ggggagctgt gtgtgtgtgc agttgcgacg ggcacgtcct actatggcct ctctggcatg
     2341 accaagaaca cctttgaggt gtttcccatg acaagctccg gggctccgat cagtgaatac
     2401 ccattcataa ggacaggctt gctggggttc gtgggtcccg gaggcctcgt cttcgtggtg
     2461 ggcaagatgg atggcctcat ggtggtcagc gggcgcaggc acaacgccga cgacatcgtg
     2521 gccactgcgc tggccgtaga acccatgaag tttgtctacc ggggaaggat agccgtgttc
     2581 tcggtgaccg tgctgcacga cgagaggatc gtgatcgtgg ctgagcagag gcctgactcc
     2641 acggaagagg acagtttcca gtggatgagc cgtgtgctgc aggcgattga cagtatacat
     2701 caagttggag tttattgcct ggccttggtg ccagcaaaca ccctccccaa aaccccgctt
     2761 ggtgggatcc atttatcaga aacaaaacag ctttttctgg agggctctct gcacccctgc
     2821 aatgtcctaa tgtgccccca cacctgcgtc acaaacttgc ctaagcctcg acagaagcag
     2881 ccagaaatcg gccctgcctc tgtgatggtg gggaacctgg tctctgggaa gagaatcgcc
     2941 caggccagtg gcagagacct gggtcagatc gaagataacg accaggcacg caagttcctg
     3001 ttcctctcag aggtcttgca gtggagagca cagaccaccc cggaccacat cctctacacg
     3061 ctgctcaact gtcggggtgc gatagcgaac tcgctgacct gcgtgcagct gcacaagaga
     3121 gctgagaaga tcgccgtgat gctgatggag aggggccacc ttcaggacgg cgaccacgtg
     3181 gccttggtct accccccagg aatagacctg atagcagcgt tttatggttg cctgtacgca
     3241 ggctgtgtgc caataaccgt ccgtcccccg cacccacaga acatcgcgac gacgttgcct
     3301 accgtcaaga tgattgtgga ggtgagtcgc tctgcctgtc tgatgacgac acagctgatc
     3361 tgtaagttgc tgcggtccag ggaggcggcg gcggctgtgg acgtcaggac gtggcccctc
     3421 atcctggaca cagatgattt gccaaagaag cggcctgccc agatctgcaa accttgcaac
     3481 ccagacactc ttgcatatct cgacttcagc gtgtccacaa ctgggatgct agctggcgta
     3541 aagatgtctc acgcagccac cagtgccttc tgccgttcca ttaagctgca gtgtgaactt
     3601 tacccctcta gagaagtggc catctgcctg gacccttact gtggactggg atttgtcctc
     3661 tggtgcctct gcagtgtgta ttctgggcac cagtccatcc tgatcccgcc ctctgagctg
     3721 gaaaccaacc ccgccttgtg gcttcttgcc gtgagtcagt acaaagtccg agacacgttt
     3781 tgctcctact ccgtgatgga gctgtgcacc aaggggctgg gctcgcaaac agagtccctc
     3841 aaggcgcgag ggctggactt gtcccgagtg aggacctgcg tggttgtggc ggaagagagg
     3901 cctcggatcg cactcacaca gtcgttctca aagctgttta aggacctggg ccttcacccg
     3961 cgggccgtca gcacctcgtt cggttgcagg gtgaacctgg cgatttgctt gcagggaacc
     4021 tcaggacctg acccaaccac tgtctacgtg gacatgagag ccctgagaca cgacagagtc
     4081 cgcttagtgg aaagaggatc ccctcatagt ctgcccctga tggaatcggg aaagatactt
     4141 ccaggggttc ggattataat tgccaaccca gaaacaaaag gaccgctggg ggactcacac
     4201 cttggagaga tttgggttca cagtgcccac aatgccagcg gttatttcac tatttacgga
     4261 gacgaatccc tccagtcaga tcacttcaac tcaagactaa gttttggaga cacccagacc
     4321 atctgggcac gcacaggcta cttggggttc ctgcggagaa ctgagctcac agatgcaaat
     4381 ggagagcgcc atgatgccct ctacgtggta ggggcactgg acgaagccat ggagctgcgg
     4441 ggcatgcggt accacccaat cgacattgag acctcggtca tcagagccca taaaagcgtt
     4501 acggaatgtg ctgtgtttac ctggacaaat ttgttggtgg ttgtggttga gctggatggg
     4561 tcggaacaag aagccttgga cctggttccc ttggtgacca acgtggtcct ggaggagcac
     4621 tacctgatcg tcggagtggt ggtcgtggtg gacatcggcg tcatccccat caactcccgt
     4681 ggggagaagc agcgcatgca cctgcgagac gggtttttgg cagaccagct agaccccatc
     4741 tatgtggcct acaacatgta gtctcgtctc ttggcttcca tggacttttc tagagatgta
     4801 gacattgttc tccgtgtcca ctgaagcgtg cagacacagg gcaacactca ccagaataca
     4861 gccatttgtg gtgagagtgg aggaggaaga ggaggaggaa gaggacttct cacagcagcc
     4921 acgattggca tgggggtgaa atgtgaattt accactgaat ttcgctcaga aggactttgg
     4981 attactgcct tcagtttgtt ggaaaagccc atttcaaaac tttcttttct tttctttctt
     5041 ttttaattat tggataataa gtgctttctt cgtaaatgtg gtattttgtt aagccgaaat
     5101 agcaattaaa aaaatatcct gccctccaga tgggttcttt taaacaattt atgtagtgtg
     5161 acaaagaatt gttttctctg ttttaatgtg tcatgaaatc ttaatgacat ggatctgtta
     5221 ctaatttaag ccattgctag atctcatcct tttaggaaag tttgaggtac gagaaaacct
     5281 tccaaatagc accttccaat tagataatag cagctttctt tgtcagaaat gtgctgaaga
     5341 aacaaaggct ggtatacggc cttcgaagtt agtatagaat gagaagaaat tataaataag
     5401 gtgtatttcg gcaattatct tgcaaatatc tttgtactaa actaaaaaga taaaataagt
     5461 taacttcctc aatatgtaat tatgtacaaa acgtttaatt tattttgatc tctttagaac
     5521 tataaaagag aaaaacattc aagaatatta aagtcttgta atgtttgcta atataaaaaa
     5581 gtgttgtatt atcttgcgtg gatagtatca caacaaatat atatatatga aatataaatt
     5641 cactaatgaa caaaggagat tttaaagttt aagatgcaga acttgtcact tgcatggtgt
     5701 gccccccgta ctcacataca ctctgctgtt gccagcagtc gcagaccgca ggagccctgt
     5761 ctaaaagttt cttctagaac cagagaccag caagtgaaat tattgccatc tcaaggatgg
     5821 caaaagaatt caaagctcaa tgtgcactat ttttttcttt gctgtgggac aacagtgaat
     5881 gtgtttatgc cagcgtgtgc tgatgatact gaggggcttt aggttggcaa atagcactgt
     5941 tttcttagct gcaagaattc attgcacaat gtttttcatc atttttgtta atgtcatctt
     6001 tttttggtcc ttgctacgaa aaggaatgcg attctgtggt cattcgcact gggttgcatt
     6061 gattccccct ctgatggcca atgtggagtg gacaaagtgt ccggaactca catcggtgat
     6121 cgtcccctcg tcttaagacc cagcccgctc tgtgtgagcc tctggggctc cctcgctcag
     6181 tgagcacagt tccccggggg ttcatgccag agctccggct gaagcaagaa gtcctccagc
     6241 tgcgtcgttt gccgcctgtg gacgagtgcg ccccagtttc tgccctggca gctcctggcc
     6301 acaccttctc agagctcacc tgtgcacttc taaattgaat tggcccacgg tgtccaacca
     6361 agaaggagca tctgcactcc gagaaagatg tgttctgtaa ctgccccagt gtgaccccgc
     6421 agtggctctc ggtgctagat atgcatgact aagattgatg ctgggcaaaa tgtagatgat
     6481 ctttcattat gttgtgggca gcgtctttct ctgcctttgc tatatgcagt cagcagtaag
     6541 ccttttgcta aaagagtttt gtttgacttc tgagatccaa ggctgattgt tgttaaaaaa
     6601 aaaaaaaaaa aaaaagtggc acatttaaaa aaatgtgtct gcatatgtgg tgcatccttc
     6661 catctccaca aaccatttga ttcttgaaat attgtttgac ctcattgctg tgtgtgaata
     6721 tttctccaca tgcttcagat gcacattcct agtctctgct tcctaagggg ggaaccacca
     6781 cacattgggg ggaaaaaaga cattttccta cacccaccca ccttgttgaa agggaggtag
     6841 gtttggggct tcaggccagg cactgactat gaaacattag ctgcagtgtg caggacagct
     6901 ttgaggtcca gctgaagtca ggaagcaaaa caaatgtaga tgtcacttca aacataattt
     6961 caactgtcac cagatcaact ctacattcaa ggagtgtgga cgctgcagtg cagttgtgag
     7021 ggcagttagc agccgcctct tctgcatcct gtcaactctg attagttaga gtttaggctc
     7081 aaaagagttg gtggactgag attgaaattt ggttgtgcaa gagaaaggaa aggagacact
     7141 tagtaccacc agtttcagca ataaagaagg gtcattctgt attcaaaatt gtactgtaga
     7201 taaatcattc atgagattgt aaaaaatgtt tgtcttgtga ccttgtgctt ttgaagtcag
     7261 acaaaaccgt gtaatcaact tgcacaaaaa gagggtacac agtgaacata taaacacaga
     7321 cctaatcaaa caggagcaga ttcctcatgg tgcttgttta ttatatatat ttaatcctgc
     7381 ttgacacttt acccaaggga gatggtccct tttatcagtt gaatgttagc agcgttattt
     7441 cagagtgtgg tgactggtta gagaaactca tgtactcaac cagccacagt ttcaaacaaa
     7501 atttttatgt gcaaaggaca gcaaccttct tgtatgttaa accaccagta cgctttgtac
     7561 atctgtgata acgcctgttt tatattcaaa tgaacaaata aaagctttta tttttgttgc
     7621 tctgaaaata gcagtttctt aattggtccc ctggaaagat gtctgggaca gctttaatcc
     7681 cgggaaggaa gtgactccta cagggaaatg tatctgactc tgtttacata atttgttgca
     7741 ttacttagta cagataatca tactttgaaa aatgtttaaa ttttgatgtg ggcatttatt
     7801 gctaaaaata attcctatgg caacaaatgt tttgtgaaat gtttttttta attcttttaa
     7861 atatatctaa atatatttgt tcaca
//
