LOCUS       NM_173602               8705 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens disco interacting protein 2 homolog B (DIP2B), mRNA.
ACCESSION   NM_173602 XM_498447
VERSION     NM_173602.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8705)
  AUTHORS   Yuan,Y., Bao,J., Chen,Z., Villanueva,A.D., Wen,W., Wang,F.,
            Zhao,D., Fu,X., Cai,Q., Long,J., Shu,X.O., Zheng,D., Moreno,V.,
            Zheng,W., Lin,W. and Guo,X.
  TITLE     Multi-omics analysis to identify susceptibility genes for
            colorectal cancer
  JOURNAL   Hum Mol Genet 30 (5), 321-330 (2021)
   PUBMED   33481017
  REMARK    GeneRIF: Multi-omics analysis to identify susceptibility genes for
            colorectal cancer.
REFERENCE   2  (bases 1 to 8705)
  AUTHORS   Whiffin,N., Hosking,F.J., Farrington,S.M., Palles,C., Dobbins,S.E.,
            Zgaga,L., Lloyd,A., Kinnersley,B., Gorman,M., Tenesa,A.,
            Broderick,P., Wang,Y., Barclay,E., Hayward,C., Martin,L.,
            Buchanan,D.D., Win,A.K., Hopper,J., Jenkins,M., Lindor,N.M.,
            Newcomb,P.A., Gallinger,S., Conti,D., Schumacher,F., Casey,G.,
            Liu,T., Campbell,H., Lindblom,A., Houlston,R.S., Tomlinson,I.P. and
            Dunlop,M.G.
  CONSRTM   Swedish Low-Risk Colorectal Cancer Study Group
  TITLE     Identification of susceptibility loci for colorectal cancer in a
            genome-wide meta-analysis
  JOURNAL   Hum Mol Genet 23 (17), 4729-4737 (2014)
   PUBMED   24737748
REFERENCE   3  (bases 1 to 8705)
  AUTHORS   Sabater-Lleal,M., Huang,J., Chasman,D., Naitza,S., Dehghan,A.,
            Johnson,A.D., Teumer,A., Reiner,A.P., Folkersen,L., Basu,S.,
            Rudnicka,A.R., Trompet,S., Malarstig,A., Baumert,J., Bis,J.C.,
            Guo,X., Hottenga,J.J., Shin,S.Y., Lopez,L.M., Lahti,J., Tanaka,T.,
            Yanek,L.R., Oudot-Mellakh,T., Wilson,J.F., Navarro,P.,
            Huffman,J.E., Zemunik,T., Redline,S., Mehra,R., Pulanic,D.,
            Rudan,I., Wright,A.F., Kolcic,I., Polasek,O., Wild,S.H.,
            Campbell,H., Curb,J.D., Wallace,R., Liu,S., Eaton,C.B.,
            Becker,D.M., Becker,L.C., Bandinelli,S., Raikkonen,K., Widen,E.,
            Palotie,A., Fornage,M., Green,D., Gross,M., Davies,G., Harris,S.E.,
            Liewald,D.C., Starr,J.M., Williams,F.M., Grant,P.J., Spector,T.D.,
            Strawbridge,R.J., Silveira,A., Sennblad,B., Rivadeneira,F.,
            Uitterlinden,A.G., Franco,O.H., Hofman,A., van Dongen,J.,
            Willemsen,G., Boomsma,D.I., Yao,J., Swords Jenny,N.,
            Haritunians,T., McKnight,B., Lumley,T., Taylor,K.D., Rotter,J.I.,
            Psaty,B.M., Peters,A., Gieger,C., Illig,T., Grotevendt,A.,
            Homuth,G., Volzke,H., Kocher,T., Goel,A., Franzosi,M.G.,
            Seedorf,U., Clarke,R., Steri,M., Tarasov,K.V., Sanna,S.,
            Schlessinger,D., Stott,D.J., Sattar,N., Buckley,B.M., Rumley,A.,
            Lowe,G.D., McArdle,W.L., Chen,M.H., Tofler,G.H., Song,J.,
            Boerwinkle,E., Folsom,A.R., Rose,L.M., Franco-Cereceda,A.,
            Teichert,M., Ikram,M.A., Mosley,T.H., Bevan,S., Dichgans,M.,
            Rothwell,P.M., Sudlow,C.L., Hopewell,J.C., Chambers,J.C.,
            Saleheen,D., Kooner,J.S., Danesh,J., Nelson,C.P., Erdmann,J.,
            Reilly,M.P., Kathiresan,S., Schunkert,H., Morange,P.E.,
            Ferrucci,L., Eriksson,J.G., Jacobs,D., Deary,I.J., Soranzo,N.,
            Witteman,J.C., de Geus,E.J., Tracy,R.P., Hayward,C., Koenig,W.,
            Cucca,F., Jukema,J.W., Eriksson,P., Seshadri,S., Markus,H.S.,
            Watkins,H., Samani,N.J., Wallaschofski,H., Smith,N.L., Tregouet,D.,
            Ridker,P.M., Tang,W., Strachan,D.P., Hamsten,A. and O'Donnell,C.J.
  CONSRTM   VTE Consortium; STROKE Consortium; Wellcome Trust Case Control
            Consortium 2 (WTCCC2); C4D Consortium; CARDIoGRAM Consortium
  TITLE     Multiethnic meta-analysis of genome-wide association studies in
            >100 000 subjects identifies 23 fibrinogen-associated Loci but no
            strong evidence of a causal association between circulating
            fibrinogen and cardiovascular disease
  JOURNAL   Circulation 128 (12), 1310-1324 (2013)
   PUBMED   23969696
REFERENCE   4  (bases 1 to 8705)
  AUTHORS   Houlston,R.S., Cheadle,J., Dobbins,S.E., Tenesa,A., Jones,A.M.,
            Howarth,K., Spain,S.L., Broderick,P., Domingo,E., Farrington,S.,
            Prendergast,J.G., Pittman,A.M., Theodoratou,E., Smith,C.G.,
            Olver,B., Walther,A., Barnetson,R.A., Churchman,M., Jaeger,E.E.,
            Penegar,S., Barclay,E., Martin,L., Gorman,M., Mager,R.,
            Johnstone,E., Midgley,R., Niittymaki,I., Tuupanen,S., Colley,J.,
            Idziaszczyk,S., Thomas,H.J., Lucassen,A.M., Evans,D.G., Maher,E.R.,
            Maughan,T., Dimas,A., Dermitzakis,E., Cazier,J.B., Aaltonen,L.A.,
            Pharoah,P., Kerr,D.J., Carvajal-Carmona,L.G., Campbell,H.,
            Dunlop,M.G. and Tomlinson,I.P.
  CONSRTM   COGENT Consortium; CORGI Consortium; COIN Collaborative Group;
            COINB Collaborative Group
  TITLE     Meta-analysis of three genome-wide association studies identifies
            susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13
            and 20q13.33
  JOURNAL   Nat Genet 42 (11), 973-977 (2010)
   PUBMED   20972440
REFERENCE   5  (bases 1 to 8705)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   6  (bases 1 to 8705)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 8705)
  AUTHORS   Winnepenninckx,B., Debacker,K., Ramsay,J., Smeets,D., Smits,A.,
            FitzPatrick,D.R. and Kooy,R.F.
  TITLE     CGG-repeat expansion in the DIP2B gene is associated with the
            fragile site FRA12A on chromosome 12q13.1
  JOURNAL   Am J Hum Genet 80 (2), 221-231 (2007)
   PUBMED   17236128
  REMARK    GeneRIF: Deficiency of DIP2B, a brain-expressed gene, may mediate
            the neurocognitive problems associated with FRA12A.
REFERENCE   8  (bases 1 to 8705)
  AUTHORS   Khorram,O., Garthwaite,M., Johnson,M.S., Denessiouk,K.A., Han,G.,
            Guo,T., McPhaul,L.W., Magee,T.R., Westerman,B. and Golos,T.G.
  TITLE     Identification and characterization of a novel luciferase-like
            protein in the human female reproductive tract
  JOURNAL   J Clin Endocrinol Metab 89 (11), 5837-5846 (2004)
   PUBMED   15531550
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK091597.1, BX537905.1,
            BU101773.1, BU102128.1, AB040896.2, BC030156.2, BU429622.1,
            AK097369.1 and AC078818.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_173602.2.
            
            Summary: This gene encodes a member of the disco-interacting
            protein homolog 2 protein family. The encoded protein contains a
            binding site for the transcriptional regulator DNA
            methyltransferase 1 associated protein 1 as well as AMP-binding
            sites. The presence of these sites suggests that the encoded
            protein may participate in DNA methylation. This gene is located
            near a folate-sensitive fragile site, and CGG-repeat expansion in
            the promoter of this gene which affects transcription has been
            detected in individuals containing this fragile site on chromosome
            12. [provided by RefSeq, Aug 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.250003.1,
                                           SRR1660803.112122.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301180.10/ ENSP00000301180.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-801               AK091597.1         1-801
            802-1229            BX537905.1         423-850
            1230-1268           BU101773.1         262-300             c
            1269-1453           BU102128.1         1-185               c
            1454-2747           AB040896.2         68-1361
            2748-4586           BC030156.2         672-2510
            4587-4595           BU429622.1         234-242
            4596-5159           AK097369.1         2152-2715
            5160-8705           AC078818.19        131301-134846
FEATURES             Location/Qualifiers
     source          1..8705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..8705
                     /gene="DIP2B"
                     /note="disco interacting protein 2 homolog B"
                     /db_xref="GeneID:57609"
                     /db_xref="HGNC:HGNC:29284"
                     /db_xref="MIM:611379"
     exon            1..256
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..4887
                     /gene="DIP2B"
                     /note="DIP2 disco-interacting protein 2 homolog B"
                     /codon_start=1
                     /product="disco-interacting protein 2 homolog B"
                     /protein_id="NP_775873.2"
                     /db_xref="CCDS:CCDS31799.1"
                     /db_xref="GeneID:57609"
                     /db_xref="HGNC:HGNC:29284"
                     /db_xref="MIM:611379"
                     /translation="MAERGLEPSPAAVAALPPEVRAQLAELELELSEGDITQKGYEKK
                     RSKLLSPYSPQTQETDSAVQKELRNQTPAPSAAQTSAPSKYHRTRSGGARDERYRSDI
                     HTEAVQAALAKHKEQKMALPMPTKRRSTFVQSPADACTPPDTSSASEDEGSLRRQAAL
                     SAALQQSLQNAESWINRSIQGSSTSSSASSTLSHGEVKGTSGSLADVFANTRIENFSA
                     PPDVTTTTSSSSSSSSIRPANIDLPPSGIVKGMHKGSNRSSLMDTADGVPVSSRVSTK
                     IQQLLNTLKRPKRPPLKEFFVDDSEEIVEVPQPDPNQPKPEGRQMTPVKGEPLGVICN
                     WPPALESALQRWGTTQAKCSCLTALDMTGKPVYTLTYGKLWSRSLKLAYTLLNKLGTK
                     NEPVLKPGDRVALVYPNNDPVMFMVAFYGCLLAEVIPVPIEVPLTRKDAGGQQIGFLL
                     GSCGIALALTSEVCLKGLPKTQNGEIVQFKGWPRLKWVVTDSKYLSKPPKDWQPHISP
                     AGTEPAYIEYKTSKEGSVMGVTVSRLAMLSHCQALSQACNYSEGETIVNVLDFKKDAG
                     LWHGMFANVMNKMHTISVPYSVMKTCPLSWVQRVHAHKAKVALVKCRDLHWAMMAHRD
                     QRDVSLSSLRMLIVTDGANPWSVSSCDAFLSLFQSHGLKPEAICPCATSAEAMTVAIR
                     RPGVPGAPLPGRAILSMNGLSYGVIRVNTEDKNSALTVQDVGHVMPGGMMCIVKPDGP
                     PQLCKTDEIGEICVSSRTGGMMYFGLAGVTKNTFEVIPVNSAGSPVGDVPFIRSGLLG
                     FVGPGSLVFVVGKMDGLLMVSGRRHNADDIVATGLAVESIKTVYRGRIAVFSVSVFYD
                     ERIVVVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKTPLGGIHI
                     SQTKQLFLEGSLHPCNILMCPHTCVTNLPKPRQKQPGVGPASVMVGNLVAGKRIAQAA
                     GRDLGQIEENDLVRKHQFLAEILQWRAQATPDHVLFMLLNAKGTTVCTASCLQLHKRA
                     ERIASVLGDKGHLNAGDNVVLLYPPGIELIAAFYGCLYAGCIPVTVRPPHAQNLTATL
                     PTVRMIVDVSKAACILTSQTLMRLLRSREAAAAVDVKTWPTIIDTDDLPRKRLPQLYK
                     PPTPEMLAYLDFSVSTTGMLTGVKMSHSAVNALCRAIKLQCELYSSRQIAICLDPYCG
                     LGFALWCLCSVYSGHQSVLIPPMELENNLFLWLSTVNQYKIRDTFCSYSVMELCTKGL
                     GNQVEVLKTRGINLSCVRTCVVVAEERPRVALQQSFSKLFKDIGLSPRAVSTTFGSRV
                     NVAICLQGTSGPDPTTVYVDLKSLRHDRVRLVERGAPQSLLLSESGKILPGVKVVIVN
                     PETKGPVGDSHLGEIWVNSPHTASGYYTIYDSETLQADHFNTRLSFGDAAQTLWARTG
                     YLGFVRRTELTAATGERHDALYVVGALDETLELRGLRYHPIDIETSVSRIHRSIAECA
                     VFTWTNLLVVVVELCGSEQEALDLVPLVTNVVLEEHYLIVGVVVVVDPGVIPINSRGE
                     KQRMHLRDSFLADQLDPIYVAYNM"
     exon            257..328
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            329..457
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            458..583
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            584..796
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            797..952
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1072
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1270
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1362
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1473
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1597
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1707
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1810
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1875
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1969
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2089
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2204
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2344
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2481
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2562
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2690
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2805
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            2806..3007
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3117
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3198
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3199..3322
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3323..3444
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3445..3556
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3557..3666
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3667..3797
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3798..3966
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            3967..4137
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4138..4199
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4257
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4332
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4333..4510
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4634
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     exon            4635..8705
                     /gene="DIP2B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8687..8692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIP2B"
                     /note="hexamer: AATAAA"
     polyA_site      8705
                     /gene="DIP2B"
                     /note="major polyA site"
ORIGIN      
        1 acgtgacctt tgctcatggc ggcggcggcg gcggcggcgg tgctggtggt gctcggcggc
       61 cggagccgga tcctgtagcc gggtgtgggc ccgtgtctgt ccgtccctcc ttcggccccc
      121 tctcttgtct tccggagtgt ggctggcgga gctgggatgg cggaacgagg cctggagccg
      181 tcgccggccg cggtggcggc gctgccgcct gaagtgcggg cgcagctggc ggagctggag
      241 ctggagctct cggaggggga catcacccag aagggctatg aaaagaaaag gtccaaactc
      301 ctatctcctt acagcccgca gacacaagaa actgattcag cagtacagaa agaacttaga
      361 aaccagacac ctgctccatc tgcagctcaa acttctgctc cctctaagta ccaccgaact
      421 cgatctgggg gagccaggga tgaacgatat cgatcagata tccacacaga agcagttcag
      481 gctgcactgg caaagcataa agaacagaag atggctttgc ccatgccaac caaaaggcga
      541 tccacatttg ttcagtctcc tgcagatgcc tgcacacctc ctgacacatc ttcggcctct
      601 gaggatgagg gctctctgag acgccaagct gcgctctctg ctgccttgca acagagctta
      661 cagaatgctg agtcctggat caaccgttca attcagggat cgtccacttc ttcatccgca
      721 tcttctacgc tgtcccacgg agaggtcaaa ggaaccagtg ggtctctagc tgatgtattt
      781 gccaatactc gaatagagaa tttctctgct cctcctgatg tcactacaac tacctcttcc
      841 tcctcatcat cttcctcaat tcgcccagca aacattgacc tgcccccctc ggggatagtt
      901 aaaggcatgc acaaaggatc caacaggtcc agccttatgg atacagctga tggtgttcct
      961 gtcagtagca gagtatctac aaaaatccag cagcttctga acactctgaa acgacccaaa
     1021 aggcctccct taaaggaatt ttttgtggat gactctgaag aaattgtgga agtacctcag
     1081 ccagacccca accagcccaa gccggaggga cggcagatga cccctgtgaa aggagagcct
     1141 ttaggagtca tctgtaactg gcctcctgct cttgaatctg ccctgcagcg ctggggtacc
     1201 actcaagcaa aatgctcctg tctgactgca ctggacatga cagggaaacc agtttacact
     1261 cttacatatg gaaagttgtg gagcagaagt ttaaagttgg cctacacact tcttaataaa
     1321 ctggggacca aaaatgaacc tgtgttaaaa cctggagaca gggtagccct ggtttacccc
     1381 aacaatgatc cagtcatgtt tatggtggct ttctatggat gcctcctggc agaagtgatt
     1441 ccagtgccta tagaggtacc tcttaccaga aaggatgctg gaggtcagca gattggcttc
     1501 ttgctaggaa gctgtggtat tgccttagct cttaccagtg aagtttgtct aaaaggactg
     1561 ccaaaaaccc agaatggaga aattgtacag tttaaaggtt ggccccggct caaatgggtt
     1621 gtaacagatt ccaagtacct ttcaaagcca ccgaaagact ggcagccaca catctcacct
     1681 gctgggacag aaccggcata cattgagtat aaaacaagca aagaagggag tgtaatggga
     1741 gttacagtat cccggcttgc aatgttgtct cactgccaag ctctgtcgca ggcctgcaat
     1801 tattctgaag gggaaacaat agtaaatgtc ttagacttta agaaggatgc tgggctgtgg
     1861 cacggcatgt ttgcgaatgt aatgaataag atgcacacaa tcagcgtacc ctactctgtt
     1921 atgaaaacct gtcctctctc ttgggtccaa agagtacatg ctcacaaagc caaggtagct
     1981 ttagtaaaat gtcgggactt gcactgggct atgatggcac atcgggacca aagagacgtg
     2041 agcttgagtt ccctccgaat gttaattgtg actgatggag ctaacccctg gtccgtgtca
     2101 tcctgtgatg ccttcctgag tctgttccaa agtcatggac tgaagcctga ggccatctgt
     2161 ccgtgcgcca cgtctgctga agccatgact gtagcaatcc gcaggcctgg agttccagga
     2221 gcccctttgc caggaagagc cattctctca atgaatggat tgagctatgg ggtaatacgg
     2281 gtcaatactg aagataaaaa ttcagcactg acggtccagg atgtagggca tgtaatgcct
     2341 ggtgggatga tgtgcattgt gaaaccagat ggacctcccc agctctgcaa aacagatgaa
     2401 attggagaaa tctgtgttag ctccagaact ggaggcatga tgtactttgg gcttgctggt
     2461 gtgacaaaaa atacatttga ggtaattcca gtgaattctg caggctctcc tgttggggat
     2521 gtgccattca tccgatcagg attgctgggg tttgtagggc cgggtagttt ggtgttcgtg
     2581 gttgggaaaa tggatggctt actgatggtt agtggtcgaa gacataatgc tgatgacatt
     2641 gttgctactg gattggctgt agaatcaata aagactgttt atagaggaag aattgctgtg
     2701 ttttctgtgt ctgtatttta tgatgagcgc attgtggtgg ttgcggaaca aagacctgat
     2761 gcttctgagg aagatagttt ccagtggatg agccgcgtgc tgcaggcgat cgatagcatt
     2821 catcaagtgg gggtttattg tcttgctctg gtgccagcca atacattgcc aaaaactcca
     2881 ctaggaggaa tccatatatc tcagacgaaa caactctttc tggagggatc actgcatcct
     2941 tgcaacatcc tcatgtgccc ccatacatgt gtgacaaact tgccaaagcc ccggcaaaaa
     3001 caaccaggtg taggccctgc ttccgtgatg gttgggaatc tggttgctgg aaaacgtata
     3061 gcacaagctg ctggaaggga tctgggacaa atagaagaga atgatttggt gaggaagcac
     3121 cagtttctgg cagagatcct acagtggcga gcccaggcga ctcctgacca tgtactcttc
     3181 atgctgttaa atgccaaggg aaccactgta tgcacagcca gctgccttca gcttcataag
     3241 cgagcagaga ggattgcatc tgttcttggt gataagggac atctaaatgc aggagataat
     3301 gtggtgttgc tctatccacc tggcattgag ttaatcgccg ccttctatgg ctgcctgtat
     3361 gcgggctgta tacctgtgac cgtcagacct ccacatgctc agaacctcac ggccacgctg
     3421 cccactgtcc gaatgattgt tgatgtcagc aaagcagcct gtattctcac cagtcagacc
     3481 ctaatgaggc tactgaggtc ccgagaggca gcagcagctg tggatgtgaa aacctggcca
     3541 accatcattg acacagatga tttacccagg aaaaggttac ctcagctgta taaaccgccc
     3601 actcctgaga tgttggcata tcttgatttt agtgtctcca caactggcat gcttacagga
     3661 gtgaagatgt cccactctgc agtgaacgct ctgtgtcgag ccatcaagct ccagtgtgag
     3721 ttgtactctt ctcggcagat cgccatctgc cttgaccctt actgtggact tggcttcgcg
     3781 ctctggtgtc tctgcagtgt ctattcaggc caccagtctg tcttaattcc tcctatggag
     3841 ttagagaaca accttttcct ctggctctcc acagtcaacc agtacaaaat aagggacact
     3901 ttctgctcct attcagtgat ggagctctgc accaaaggtc ttgggaacca agtggaagtg
     3961 ctaaagacca gagggatcaa cctctcctgc gtccggacct gtgtggtggt ggcggaggag
     4021 aggccccgcg ttgcactcca gcagtccttc tctaagctct tcaaagacat cgggctgtcc
     4081 ccgcgggctg tcagcaccac ttttggatca agagtcaatg tagcaatatg tttacaggga
     4141 acctcagggc ctgatccgac tactgtgtat gtggatctga aatcactaag acatgacagg
     4201 gttcgtctcg tggaacgtgg cgcccctcag agtttgcttc tctcagagtc tggaaagatt
     4261 ttacctggag tgaaagtggt tattgttaat cctgagacca aagggccggt tggagactct
     4321 caccttggag agatttgggt gaacagtccc catacagcca gcggctacta caccatctat
     4381 gatagcgaga ctcttcaagc tgatcatttc aacactcgcc tcagctttgg agatgcagct
     4441 cagacactct gggctcggac aggatacctt ggttttgtcc gccggaccga gctcacagcg
     4501 gccactggag agcgtcatga tgcattgtat gtggtgggag cgctggatga aacactggag
     4561 ctgagaggat tacgatacca cccaattgat attgagacct cggtgtcccg gatccacaga
     4621 agcattgctg aatgtgccgt gttcacatgg accaacttgc ttgtggtggt tgtggaactg
     4681 tgcggctctg aacaggaagc cctagatctg gtcccattag tgaccaacgt ggtcctggaa
     4741 gagcattacc tcatcgttgg cgtcgtggtt gtggtggacc caggtgtcat cccgatcaac
     4801 tccagaggag agaagcagag gatgcacctc cgtgatagct tcctagctga ccagttagac
     4861 cccatctacg tggcttataa catgtaacca gccttgtggg gactgcagtg ggccattctg
     4921 aagaatcaca aagacagaag acctctggct aagagcaggc ttcaaacgat gtgaaataag
     4981 ctgagatggc tacatgatat tcttcatctc atcctgtggg attctgcaat cataaaacac
     5041 aggaaagggg aattctgtga tggcaaatga aaaaaatgtt aacatttggt agacatgtgc
     5101 tttgacatag cgtgagcagc acattactaa agcaattaca tgcatgttgc atttttttca
     5161 tctgttgtac atagttgtat ttttatctaa tgccatttta gaattttcta agggaattta
     5221 atgaattcac atgaaagggg tagtctgagt gacacagttc cccactccgt actgtatttt
     5281 gccattctgc cgtagctaga tgttctgtgg ggtttgttaa catggaacta ctcagctttc
     5341 tttcagtcaa cccataagca aatcagataa cccactgact atgagaatta ctttatatag
     5401 ataattcttg actgtaaaac attttgacca gtgttttaca acatgtacat aagaatacac
     5461 ataattcaac tagagatttg aagaattggc ttgtatagtt ataacaacca cagtagaaac
     5521 atttctactt tgagagaatt tcaatattct cttaatgttg tgtaattgat taggtaacta
     5581 aaaagcgcaa attgttggca ggttttgctg cacattgttc tatgtctttg ttggctggtg
     5641 tattttataa actaaagctg cctatgtttc tttttaaagc tcgcattccc agaatcagct
     5701 taggcttcta tgaattcagc ctgtttctaa aagctgaaaa tctcagttta aaaatcaaaa
     5761 tgttaacaca aagctaagat tcatcagagc ccaccctatt ctaaggaacc acaataactt
     5821 actctggccc cagtgttaaa acgatctttc agatttagag tgactatgta agaatttagg
     5881 atttcctctt ttccaggcac attgtaaact gtgtctacag tttatccata taacttctct
     5941 tctgaaaact gaggagtgtc ctctgttctt ccagttcacg agggcagggg gtttaaaaca
     6001 agaatgatag gccaggaagg cagtggggat ccaccatcac atggaactgt aaggccatat
     6061 aactacacaa aactgaccaa tctgggttgc caaagcagcc aggcttatgc tgaaaccggg
     6121 gaagtctgac atatgcagga aactcttttg aaataacttt ggtgcccagg ccaagtagaa
     6181 tgagatgaga ctgagtttgg cctctggctc ggtttccttt ctttggtctg atacttcatg
     6241 tatttgaata tagttaaatc gtattatttt tttcttaaca gaaatatttt taaaaatgaa
     6301 aaagtactca aaagtgagaa gagttaactt gtcaaagcag aatggttctc tttgacccac
     6361 tctggtctat tgtgtaaata tttatttaga ctattttaat aatacatatt atttacccca
     6421 ctgtaacatc atgtaaacta agtatgtttt taaacaattt ttaagacttg taattaccct
     6481 gaaaataagg tttataatgc aaagaccagc tcctttgcgg tggcagtgct ctagggctgc
     6541 cattacacgg tcttgtgatg tgactaaaag ccactttgtg actcccttca tgtaatcctc
     6601 ttttcctccc cactcctcca cagagggcag agctcaggac atttgccagt tccagatctc
     6661 tttttcagca ttttcatgga attaatttac acgtaatgag ggaagtccta ggatggatag
     6721 aaaaaaagca cttacattgg ggcacacagg aaatcccagt gtctagcaat ggtttggttt
     6781 gcagagaaca cagcctgata cttaattttc ttaaaactat ttttaatgat ccactaaaca
     6841 aagcagggga tcctgaagct gatataaata agtctagctc tataatcccc aagttctaaa
     6901 agttatggtt agatgctatt ctgtgggttg ctttgataat tcttactaac acagattagg
     6961 gtataggcat ctagagatgc actgtccact gtaaatacta taatgagagc cacatctgta
     7021 atttaaatgt ttctagtaac cacatttttt taaaagtaaa aagaaaccca tggtattgat
     7081 ttaaatatat tttatttaac ccaatagctc aaaaacacta tcatttcaac ataggatcaa
     7141 tataaaaatt attaatgagt tattttactt tttttcatat taggcctttg aaattcagtg
     7201 tgtattaaac acatctcaat tcaaaccatc accatatttc aagtctttgt agccaaatgt
     7261 gactagtggc taccatatta gacagtgcag atctatactc attccttcaa atacattact
     7321 ctgttaatct caaagtgtgg ccaactccca tttacttaga ggctgattat ctagttttgt
     7381 agttcctcag gcctctaatt tattttttgc tttctgcttt attgatcttt tgcatgtccc
     7441 ccaaagccag aatctgctca tggaggaagg aaggctaaga actgtccttg aggaacttca
     7501 tcagtaactc tggtaaagca tcctgtggag ggagaggaga gcccagtcat ttgcttagat
     7561 ggtgtttgtg ggatcacctg cagatttaaa gcctactctg ccacagactc gagtaagaaa
     7621 atgttctctt gatgacacag tgctcctact ctatccacat taagtagcac ttttgtggta
     7681 gaactgattc ttaaggcagg cctgaaaggc cattactaat agaaacacag cctttccaat
     7741 cctctggaac atattctgtc tgggttttta atgtctgtgg aaaaaaacta aacaagtctc
     7801 tgtctcagtt aagagaaatc tattggtctg aaggtttctg aacctctttc tggttctcag
     7861 cagaagtaac tgaagtagat caggaagggg ctgcctcagg aaaattccta gatcctagga
     7921 attcagtgag accctgggaa ggaccagcat gctaatcagt gtcagtgaat ccacagtctt
     7981 tacttcctgc ctcataaagg gccaggtctc cccagtacca agtcctttcc tcatgaagtt
     8041 gtgttgcctc aggctgttta gggaccattg cctgtcttgg tcacatgagt ctgtctcctt
     8101 actttagtcc ctgggcaatc cttgcttaat gcttttgttg actcaacaag ggcccgaggc
     8161 cttaggtttt ctattaaggt ctctgcccca ggcatggtgc tctatatctt ggccaaataa
     8221 attactttcc ttgaatatcc aggaatcttt tagtctaaag caatgaggag ttatcacctc
     8281 atcctcaaac tccaacaaga tctatgcctt agtgttgttt ttgttgtctg ctttgatgta
     8341 aaagcaagag tatttggagc aagaagctgc aatgcgccaa atacacaata ggccttttct
     8401 ttatcattca tacgacattt ctggtttagg tgtatgtagt tgggccatgt tacttgtcca
     8461 gaggaagaga ctaaagatat aagaataatt ttttagtcct aaatgctgtt ttgtttactt
     8521 tctgtcaaga tatttacccg tgtcaaattc aaactacagt actgtgtaat tatgtataaa
     8581 gtttttttat ttatttgaag ttagactaga tatacgtttt taaatttaac atctggctgg
     8641 acagtgttct attaactcat tgaatgtgtt tcctttgtct tgtgttaata aatattgatg
     8701 cctga
//
