LOCUS       NM_015151               7350 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens disco interacting protein 2 homolog A (DIP2A),
            transcript variant 1, mRNA.
ACCESSION   NM_015151
VERSION     NM_015151.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7350)
  AUTHORS   Zhang,B., Zhang,X., Omorou,M., Zhao,K., Ruan,Y. and Luan,H.
  TITLE     Disco interacting protein 2 homolog A (DIP2A): A key component in
            the regulation of brain disorders
  JOURNAL   Biomed Pharmacother 168, 115771 (2023)
   PUBMED   37897975
  REMARK    GeneRIF: Disco interacting protein 2 homolog A (DIP2A): A key
            component in the regulation of brain disorders.
            Review article
REFERENCE   2  (bases 1 to 7350)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 7350)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 7350)
  AUTHORS   Nie,E., Miao,F., Jin,X., Wu,W., Zhou,X., Zeng,A., Yu,T., Zhi,T.,
            Shi,Z., Wang,Y., Zhang,J., Liu,N. and You,Y.
  TITLE     Fstl1/DIP2A/MGMT signaling pathway plays important roles in
            temozolomide resistance in glioblastoma
  JOURNAL   Oncogene 38 (15), 2706-2721 (2019)
   PUBMED   30542120
  REMARK    GeneRIF: An important role of Fstl1 in the regulation of
            temozolomide resistance by modulation of DIP2A/MGMT signaling.
REFERENCE   5  (bases 1 to 7350)
  AUTHORS   Kudo-Saito,C., Ishida,A., Shouya,Y., Teramoto,K., Igarashi,T.,
            Kon,R., Saito,K., Awada,C., Ogiwara,Y. and Toyoura,M.
  TITLE     Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity
  JOURNAL   Cell Rep 24 (7), 1790-1801 (2018)
   PUBMED   30110636
  REMARK    GeneRIF: Expression of DIP2A (the receptor of FSTL1) in tumor cells
            is critical for FSTL1-induced neoplastic immune resistance;
            FSTL1/DIP2A co-positivity in non-small-cell lung tumor (NSCLC)
            tissues correlates with poor prognosis in NSCLC patients.
REFERENCE   6  (bases 1 to 7350)
  AUTHORS   Winnepenninckx,B., Debacker,K., Ramsay,J., Smeets,D., Smits,A.,
            FitzPatrick,D.R. and Kooy,R.F.
  TITLE     CGG-repeat expansion in the DIP2B gene is associated with the
            fragile site FRA12A on chromosome 12q13.1
  JOURNAL   Am J Hum Genet 80 (2), 221-231 (2007)
   PUBMED   17236128
REFERENCE   7  (bases 1 to 7350)
  AUTHORS   Casadei,R., Strippoli,P., D'Addabbo,P., Canaider,S., Lenzi,L.,
            Vitale,L., Giannone,S., Frabetti,F., Facchin,F., Carinci,P. and
            Zannotti,M.
  TITLE     mRNA 5' region sequence incompleteness: a potential source of
            systematic errors in translation initiation codon assignment in
            human mRNAs
  JOURNAL   Gene 321, 185-193 (2003)
   PUBMED   14637006
REFERENCE   8  (bases 1 to 7350)
  AUTHORS   Mukhopadhyay,M., Pelka,P., DeSousa,D., Kablar,B., Schindler,A.,
            Rudnicki,M.A. and Campos,A.R.
  TITLE     Cloning, genomic organization and expression pattern of a novel
            Drosophila gene, the disco-interacting protein 2 (dip2), and its
            murine homolog
  JOURNAL   Gene 293 (1-2), 59-65 (2002)
   PUBMED   12137943
REFERENCE   9  (bases 1 to 7350)
  AUTHORS   Gardiner,K., Slavov,D., Bechtel,L. and Davisson,M.
  TITLE     Annotation of human chromosome 21 for relevance to Down syndrome:
            gene structure and expression analysis
  JOURNAL   Genomics 79 (6), 833-843 (2002)
   PUBMED   12036298
REFERENCE   10 (bases 1 to 7350)
  AUTHORS   Wang,Z., Tseng,C.P., Pong,R.C., Chen,H., McConnell,J.D., Navone,N.
            and Hsieh,J.T.
  TITLE     The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate
            cancer. Characterization of a novel GTPase-activating protein
            associated with N-terminal domain of DOC-2/DAB2
  JOURNAL   J Biol Chem 277 (15), 12622-12631 (2002)
   PUBMED   11812785
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000337.1, DA326960.1,
            AB273729.1, AF490768.1 and AP000338.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015151.3.
            
            Summary: The protein encoded by this gene may be involved in axon
            patterning in the central nervous system. This gene is not highly
            expressed. Several transcript variants encoding different isoforms
            have been found for this gene. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1), as well as variant 9, encodes
            isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.140916.1, AB273729.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000417564.3/ ENSP00000392066.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AP000337.1         15889-15946
            59-220              DA326960.1         2-163
            221-3003            AB273729.1         1-2783
            3004-5643           AF490768.1         2839-5478
            5644-7350           AP000338.3         72460-74166
FEATURES             Location/Qualifiers
     source          1..7350
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..7350
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /note="disco interacting protein 2 homolog A"
                     /db_xref="GeneID:23181"
                     /db_xref="HGNC:HGNC:17217"
                     /db_xref="MIM:607711"
     exon            1..332
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..4957
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /EC_number="6.2.1.1"
                     /note="isoform a is encoded by transcript variant 1;
                     disco-interacting protein 2A; DIP2 homolog A; DIP2
                     disco-interacting protein 2 homolog A"
                     /codon_start=1
                     /product="disco-interacting protein 2 homolog A isoform a"
                     /protein_id="NP_055966.2"
                     /db_xref="CCDS:CCDS46655.1"
                     /db_xref="GeneID:23181"
                     /db_xref="HGNC:HGNC:17217"
                     /db_xref="MIM:607711"
                     /translation="MADRGCPLEAAPLPAEVRESLAELELELSEGDITQKGYEKKRAK
                     LLARYIPLIQGIDPSLQAENRIPGPSQTTAAAPKQQKSRPTASRDERFRSDVHTEAVQ
                     AALAKYKERKMPMPSKRRSVLVHSSVETYTPPDTSSASEDEGSLRRPGRLTSTPLQSH
                     SSVEPWLDRVIQGSSTSSSASSTSSHPGGRPTTAPSAAATPGAAATTALAGLEAHTHI
                     DLHSAPPDVTTGLVEHSYFERPQVASVRSVPRGCSGSMLETADGVPVNSRVSSKIQQL
                     LNTLKRPKRPPLKEFFVDDFEELLEVQQPDPNQPKPEGSETSVLRGEPLTAGVPRPPS
                     LLATLQRWGTTQPKSPCLTALDTTGKAVYTLTYGKLWSRSLKLAYTLLNKLTSKNEPL
                     LKPGDRVALVFPNSDPVMFMVAFYGCLLAELVPVPIEVPLTRKDAGSQQVGFLLGSCG
                     VFLALTTDACQKGLPKAQTGEVAAFKGWPPLSWLVIDGKHLAKPPKDWHPLAQDTGTG
                     TAYIEYKTSKEGSTVGVTVSHASLLAQCRALTQACGYSEAETLTNVLDFKRDAGLWHG
                     VLTSVMNRMHVVSVPYALMKANPLSWIQKVCFYKARAALVKSRDMHWSLLAQRGQRDV
                     SLSSLRMLIVADGANPWSISSCDAFLNVFQSRGLRPEVICPCASSPEALTVAIRRPPD
                     LGGPPPRKAVLSMNGLSYGVIRVDTEEKLSVLTVQDVGQVMPGANVCVVKLEGTPYLC
                     KTDEVGEICVSSSATGTAYYGLLGITKNVFEAVPVTTGGAPIFDRPFTRTGLLGFIGP
                     DNLVFIVGKLDGLMVTGVRRHNADDVVATALAVEPMKFVYRGRIAVFSVTVLHDDRIV
                     LVAEQRPDASEEDSFQWMSRVLQAIDSIHQVGVYCLALVPANTLPKAPLGGIHISETK
                     QRFLEGTLHPCNVLMCPHTCVTNLPKPRQKQPEVGPASMIVGNLVAGKRIAQASGREL
                     AHLEDSDQARKFLFLADVLQWRAHTTPDHPLFLLLNAKGTVTSTATCVQLHKRAERVA
                     AALMEKGRLSVGDHVALVYPPGVDLIAAFYGCLYCGCVPVTVRPPHPQNLGTTLPTVK
                     MIVEVSKSACVLTTQAVTRLLRSKEAAAAVDIRTWPTILDTDDIPKKKIASVFRPPSP
                     DVLAYLDFSVSTTGILAGVKMSHAATSALCRSIKLQCELYPSRQIAICLDPYCGLGFA
                     LWCLCSVYSGHQSVLVPPLELESNVSLWLSAVSQYKARVTFCSYSVMEMCTKGLGAQT
                     GVLRMKGVNLSCVRTCMVVAEERPRIALTQSFSKLFKDLGLPARAVSTTFGCRVNVAI
                     CLQGTAGPDPTTVYVDMRALRHDRVRLVERGSPHSLPLMESGKILPGVKVIIAHTETK
                     GPLGDSHLGEIWVSSPHNATGYYTVYGEEALHADHFSARLSFGDTQTIWARTGYLGFL
                     RRTELTDASGGRHDALYVVGSLDETLELRGMRYHPIDIETSVIRAHRSIAECAVFTWT
                     NLLVVVVELDGLEQDALDLVALVTNVVLEEHYLVVGVVVIVDPGVIPINSRGEKQRMH
                     LRDGFLADQLDPIYVAYNM"
     exon            333..404
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..524
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..644
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            645..896
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            897..1025
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1145
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1343
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1435
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1546
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1670
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1780
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1883
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1948
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2042
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2043..2162
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2277
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2417
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..2554
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2555..2635
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2763
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2764..2878
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2879..3080
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3081..3190
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3191..3271
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3395
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3517
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..3629
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..3739
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3870
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4039
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4040..4210
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4211..4272
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4273..4330
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4331..4405
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4406..4580
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4581..4704
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            4705..7350
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7021..7026
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /note="hexamer: AATAAA"
     polyA_site      7043
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /note="major polyA site"
     regulatory      7181..7186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /note="hexamer: ATTAAA"
     polyA_site      7202
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
     regulatory      7326..7331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
                     /note="hexamer: AATAAA"
     polyA_site      7350
                     /gene="DIP2A"
                     /gene_synonym="C21orf106; DIP2"
ORIGIN      
        1 gtgtagggcc ggccgggcgc tcaggagcgc gcggggcagc ggcggcgcgg cggagccatc
       61 cgcgctcgtg cccgcgcggg tgcgttgctg tcctggccgc gcccctgtcc cgccgcctcc
      121 cgctcctcgc ctggcggatg taggttgttg gcctgagggg agctacgtag ccgaggtttg
      181 cgctgccgcc gccaggcccg gtccggttcc agcctctgcc cggacgctag ccggcctggc
      241 catggctgac cgcgggtgcc cgctggaggc ggcgccgctg cctgccgagg tgcgggagag
      301 cctggctgag ctggagctgg agctgtcgga aggtgacatc actcaaaaag gatatgaaaa
      361 gaaaagggca aagctgcttg cacgttatat accgcttatt caaggaatag acccatctct
      421 gcaagcagag aatagaattc ctgggccctc acaaaccacg gccgctgcac ccaagcagca
      481 gaagtctcgg cccaccgcct cgagggatga gcgcttccgg tcagatgtcc acactgaagc
      541 cgtgcaagca gctttggcca aatacaaaga gaggaagatg cctatgcctt cgaagagacg
      601 ttctgtcctt gtgcattcgt ctgtggaaac ctacacccct ccagacacgt cgtctgcctc
      661 agaagatgag ggctctttac ggcgacccgg gcgactcacc tccactccgc tccagagcca
      721 ttccagcgtc gagccctggc tcgaccgggt cattcagggc tcgtccacct catcctctgc
      781 atcctccacc tcatctcacc cgggagggag acccaccact gctcccagtg ctgcagccac
      841 gccgggggcc gccgctacca ctgcactcgc aggcctcgag gcccacaccc acatagatct
      901 gcattctgcc cctcctgatg tcaccacggg cctcgtggag cattcgtact ttgagcgtcc
      961 acaggtggct tctgtgagaa gtgttcctcg ggggtgcagc gggagcatgc tggaaacagc
     1021 agatggtgtc cctgtgaaca gcagagtgtc ctccaaaatc cagcagcttc tgaacaccct
     1081 gaagaggcca aagcgccctc cactgaagga gttctttgtg gatgattttg aggaattgtt
     1141 ggaagttcag caaccagatc caaatcagcc aaagcctgag ggaagcgaga cgagtgtgct
     1201 gagaggggag cctctcactg caggtgtccc ccgaccgccg tcgctgttgg ccaccttgca
     1261 gcgctggggc acaacacagc ccaaatcccc ctgtctgact gccttggata caactgggaa
     1321 agccgtctac actctcacct atggtaaact ttggagtcgg agtttaaaac tagcttatac
     1381 tctacttaat aaactgacaa gtaagaatga acctctactt aaacctggag acagagtggc
     1441 gctcgtgttt ccgaatagtg accctgtgat gttcatggtt gcattttatg ggtgtctcct
     1501 ggcagagctg gttcctgtcc ccatagaagt gccattaaca agaaaggatg caggcagcca
     1561 gcaggttggg tttctgctgg gcagctgtgg agtcttcttg gccctgacca cagacgcttg
     1621 tcagaaaggc ctccccaagg cacagacagg agaggtggca gctttcaaag gttggccccc
     1681 gctctcctgg ctagtgattg atgggaagca tctagccaag cccccaaagg actggcaccc
     1741 tctggcccag gacacaggga ctgggactgc ctacattgag tataaaacca gcaaagaagg
     1801 cagtacggtg ggggtcacag tgtcccacgc atccctgctg gcacagtgcc gggctctgac
     1861 ccaggcgtgc gggtactcag aagctgaaac attaacaaac gtgctggatt tcaaaaggga
     1921 tgctggtctg tggcatggcg tgttaacaag cgtcatgaac aggatgcacg tggtcagcgt
     1981 cccctacgcg ctgatgaagg cgaacccact ctcctggatc cagaaagtgt gcttctataa
     2041 agctcgggcc gcgctggtga agtcgcgaga catgcactgg tctctcctag ctcagcgggg
     2101 ccagagggac gtcagcctca gctcactgcg catgctgatt gtggccgatg gtgccaaccc
     2161 gtggtcgatc tcctcctgtg acgccttcct caacgtcttc cagtccagag gtctgaggcc
     2221 agaggtcatc tgtccttgtg caagttctcc tgaggcgctg actgtcgcca tccgcaggcc
     2281 acctgatctg ggaggaccac ctccaagaaa agcagtcctg tcgatgaacg gtctaagtta
     2341 tggtgttatc agagtggata ctgaagaaaa gttgtcagtc cttactgttc aggacgttgg
     2401 tcaggtgatg cctggagcta atgtatgtgt tgtgaagtta gaaggtaccc cttatctttg
     2461 taaaactgat gaagtgggag aaatatgcgt cagttccagt gcaactggca cagcgtacta
     2521 tggattgctt ggaatcacga agaatgtgtt tgaggcagtt ccggtcacca caggaggagc
     2581 acccatcttt gacaggccat tcaccaggac aggcctgctg ggcttcatcg ggcctgacaa
     2641 cctggtcttc atcgtgggca aactggacgg gctgatggtc actggagttc gcagacacaa
     2701 tgcagatgac gttgtggcca ccgcactggc cgtggagccc atgaagtttg tctacagagg
     2761 caggatcgct gtgttctctg tgaccgtgct gcacgacgac cggattgtcc tggtggctga
     2821 gcagcggccg gatgcctcgg aggaggacag cttccagtgg atgagccgtg tgctgcaggc
     2881 cattgatagc atccaccagg tgggcgtgta ctgtctggcc ctggttcctg ccaacacctt
     2941 gcccaaggct cctctcggag ggattcacat ttctgaaacc aaacagcgct ttctggaagg
     3001 gacgctgcac ccgtgtaatg tgctgatgtg ccctcacacc tgtgttacca acctccccaa
     3061 acctcgtcag aaacaaccag aggttggacc agcctcaatg atcgtgggga acctggttgc
     3121 tgggaagaga atcgctcagg cttccgggag agagctcgcc cacctggagg acagcgacca
     3181 ggcacggaag ttcctgttcc tggctgacgt gctgcagtgg cgtgcccaca ccactcctga
     3241 ccacccgctg ttcttgctgc tgaacgccaa gggcaccgtc acaagcactg caacctgtgt
     3301 ccagctgcac aaaagggctg agagagtggc cgcggctctg atggagaagg gaagactgag
     3361 tgttggggac catgtggctc tggtctaccc accaggggtg gacctcattg ccgcgttcta
     3421 tggctgcttg tactgtggct gcgtgcctgt caccgtgcgg cccccgcacc ctcagaacct
     3481 cggcaccaca ctgcccaccg tcaagatgat cgtggaggtc agcaagtctg catgcgtcct
     3541 caccacgcag gctgtcacac ggctgctcag gtccaaggag gctgctgctg ccgtggacat
     3601 caggacctgg cccaccatcc tagacacaga tgacatccca aaaaagaaga tagcaagcgt
     3661 tttcaggccc ccctcccccg atgtcctcgc atacttggac ttcagcgtgt caaccactgg
     3721 gatattagcg ggagtgaaga tgtcgcacgc ggccacaagc gccttatgcc gctccataaa
     3781 gctgcagtgt gagctgtacc cctcgcggca gatcgccatc tgcctcgacc cctactgtgg
     3841 ccttggtttt gccctgtggt gtctgtgcag tgtctactcg ggacaccaat cagtgctggt
     3901 gcccccgctg gagctggaga gcaacgtgtc cctgtggctg tcggccgtca gccagtacaa
     3961 ggcccgcgtc accttctgct cctactctgt gatggagatg tgcaccaagg gcctaggcgc
     4021 acagacgggt gtcctcagga tgaagggggt gaacctgtca tgtgtgcgca cgtgcatggt
     4081 ggtcgccgag gagcggccca ggattgcgct gacccagtcc ttctccaagc tcttcaagga
     4141 cctgggcctg ccggcccgcg ccgtaagcac cacgttcggg tgcagggtca acgtggccat
     4201 ctgcctccag ggcacagctg gcccggaccc cacaaccgtc tacgtggaca tgcgggcact
     4261 gcgccatgac agggttcgtt tggtagaacg gggttctccg cacagcctgc cattgatgga
     4321 gtctggaaag atcctccccg gcgtgaaggt catcatcgca cacaccgaga ccaaaggacc
     4381 cttgggagac tcacacctgg gagagatctg ggtaagcagc ccccacaatg ccaccgggta
     4441 ctacaccgtt tacggggagg aggcgcttca tgccgaccac ttcagtgccc ggctgagttt
     4501 tggagacaca cagaccatct gggcaaggac cggctacctt ggcttccttc ggcgaacaga
     4561 gctcactgat gccagtggag ggcggcacga tgcactgtat gtggttgggt ctctggatga
     4621 aactctggag ctcagaggca tgcggtacca ccccatcgac attgagacct ctgtcatccg
     4681 agcacacagg agcatcgctg agtgtgccgt attcacctgg accaacctgc tggtggtggt
     4741 ggtggagctg gatgggctag agcaggatgc cctggacctg gtggccctgg tgaccaacgt
     4801 ggtgctggag gagcactacc tggtcgtggg agtggtggtc atcgtggacc caggggtgat
     4861 ccctatcaac tctcggggtg agaagcagcg catgcacctg cgggacggct tcctggctga
     4921 ccagctggac cccatctatg tcgcctacaa catgtgagcg cagcacaccg gcccaggtgc
     4981 cggagatgaa tgagccccag cagtccaagg tgtgatgtgg gaagacaccg cagagctcac
     5041 tcaccgggac tcgcccttcc tgtgctctta cagatccctc tcaacaatcc ccgcatctcc
     5101 ttttagaaag cacttcctga attatttaaa gaaatatttt gaatctgcca agtacattta
     5161 caaaaacacg gatgctggta ttttaacaga tggagagaca aggaaaggaa aggaaaggcc
     5221 tggcatgggc attgtgagga atcacaggca ccgaggttgt tctctgctgt actgcaagtt
     5281 tgcactttct ttaggctaaa aatatagttc ctgattttta aaattcagtt atttattccc
     5341 acttcaaatg acaagttcat atatagaatt tacgggagaa acttgagacc atttacgggg
     5401 agaaacttga ttctgggaag atagcagagt acaaaccagc tgcctcactt ctgtttcaca
     5461 gggaggctga tggaaaaagg aagcaagctg gacccatcct ccctgctcac agagggcact
     5521 gtggtcacac acagtgcctc ctctgccagt tcctttattg aaagaggtgt gctggctggc
     5581 cacggtggct tacacctgta atcccagcac tttgggaggc cgaggcgagc agatcacgag
     5641 gtcaggagac cgagaccatc ctggctaaca tggtgaaacc ctgtctctac taaaaataca
     5701 aaaaattagc cgggtgtggt ggtgggcgcc tgtagtccca gctacttggg aggctgaggc
     5761 aggagaatgg tatgaaccag ggaggcggag cttgcagtga gccgagatca cgctactgca
     5821 ctccagcctg ggtgacagca cgagatgccg tcttaaaaaa acaaaaaaga ggtgtgctgc
     5881 ttgtcagcat gtattgtcac ggacactcaa taagtgccat tttggactgt caaatttaga
     5941 tgctttgttt cagaaagata agccagcatt tagttttaaa tcactttcct ggtttgtaac
     6001 ttgatgctgt ttagttaaat tgctagtttt cctaacacta caatattaat tcttctcgtg
     6061 gaagtgtact gatttattat ttttattcca agtcagcaga tttggaagca ttgtggtaaa
     6121 gtctaaggtt ttcatatcca tagtgctgtt tggtgagtac cggcagtaca gttgagggga
     6181 gcagggaaca gcattgcccc gtattgaagg tggagatggt tacattcttc actgcttttt
     6241 gcattttgag ttgtgtgcct ataaaatttg gccaaaccat tttattattt tgttcaaact
     6301 tgactaagct gagtgatcta aaattataca gaacctaaat caaagaagag aatgtaaagt
     6361 cctttagtta cttctaagaa tttgaagtca agcacgaatc taagacatag attattttta
     6421 tatagctaat gaagagtatg ttacgaaatt gttgggtttt tggggtattg agggtggcaa
     6481 attttgtgaa tcatgcatgc ttcacagaaa caaccaggtt tttccagaat tagtctggat
     6541 cagtgcctaa caaagctgtt attaattctc cacacatgag tctggctaac tgggccagct
     6601 ctcatgtttt actcctgtct ggctacaaat agcactgtgc atagtagccc tgtttcccca
     6661 tggtgttgga ctgtggtaaa gtatgttgtg acatactgga attctaataa tcctgttgta
     6721 agtatgtaca gaatctatgt aacttattgt tgacatacag aggtttggga agtagtctaa
     6781 tggacattcc ttacaataga atggctggga agggaaagaa aaaaaaaaaa aaactaccta
     6841 actccaatct taatgttgta gttttatagc aaacaaaaat tgtcagcttt ttgtattgaa
     6901 aggtcagtgg tggtaagaca aggtgtcttg taaattaaga ttttaagaag tgcattaaaa
     6961 tgttttagaa ttactctggg aattctgtat atcacactaa aatttttata tcattatgtt
     7021 aataaaagtt attgactttg taattctgca ttttgaaatg tgtgaaaagg gtctttaaat
     7081 taccccgaat aggttgtatc ttattttgct ttttttctga ctataaaagc agttatgctt
     7141 atagcataaa atctagaaag cacattaaag tataaagaaa attaaaattt cttataattc
     7201 tacctctgag taaacagcag cattcgtatg taacataaac cctctcaggg atttattttt
     7261 tctttttaaa aattttttac aaaattagga tcaagtgctt ttttaaataa tttgcttttg
     7321 tacttaataa attatagact ttaaaatcta
//
