LOCUS       NM_014473               2831 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens DIM1 rRNA methyltransferase and ribosome maturation
            factor (DIMT1), transcript variant 1, mRNA.
ACCESSION   NM_014473
VERSION     NM_014473.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2831)
  AUTHORS   Gonskikh,Y., Stoute,J., Shen,H., Budinich,K., Pingul,B.,
            Schultz,K., Elashal,H., Marmorstein,R., Shi,J. and Liu,K.F.
  TITLE     Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in
            acute myeloid leukemia
  JOURNAL   Genes Dev 37 (7-8), 321-335 (2023)
   PUBMED   37024283
  REMARK    GeneRIF: Noncatalytic regulation of 18S rRNA methyltransferase
            DIMT1 in acute myeloid leukemia.
REFERENCE   2  (bases 1 to 2831)
  AUTHORS   Verma,G., Bowen,A., Gheibi,S., Hamilton,A., Muthukumar,S.,
            Cataldo,L.R., Asplund,O., Esguerra,J., Karagiannopoulos,A.,
            Lyons,C., Cowan,E., Bellodi,C., Prasad,R., Fex,M. and Mulder,H.
  TITLE     Ribosomal biogenesis regulator DIMT1 controls beta-cell protein
            synthesis, mitochondrial function, and insulin secretion
  JOURNAL   J Biol Chem 298 (3), 101692 (2022)
   PUBMED   35148993
  REMARK    GeneRIF: Ribosomal biogenesis regulator DIMT1 controls beta-cell
            protein synthesis, mitochondrial function, and insulin secretion.
REFERENCE   3  (bases 1 to 2831)
  AUTHORS   Shen,H., Gonskikh,Y., Stoute,J. and Liu,K.F.
  TITLE     Human DIMT1 generates N26,6A-dimethylation-containing small RNAs
  JOURNAL   J Biol Chem 297 (4), 101146 (2021)
   PUBMED   34473991
  REMARK    GeneRIF: Human DIMT1 generates N2(6,6)A-dimethylation-containing
            small RNAs.
REFERENCE   4  (bases 1 to 2831)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 2831)
  AUTHORS   Shen,H., Stoute,J. and Liu,K.F.
  TITLE     Structural and catalytic roles of the human 18S rRNA
            methyltransferases DIMT1 in ribosome assembly and translation
  JOURNAL   J Biol Chem 295 (34), 12058-12070 (2020)
   PUBMED   32616653
  REMARK    GeneRIF: Structural and catalytic roles of the human 18S rRNA
            methyltransferases DIMT1 in ribosome assembly and translation.
REFERENCE   6  (bases 1 to 2831)
  AUTHORS   Ikeda,S., Kitadate,A., Abe,F., Saitoh,H., Michishita,Y., Hatano,Y.,
            Kawabata,Y., Kitabayashi,A., Teshima,K., Kume,M., Takahashi,N. and
            Tagawa,H.
  TITLE     Hypoxia-inducible microRNA-210 regulates the DIMT1-IRF4 oncogenic
            axis in multiple myeloma
  JOURNAL   Cancer Sci 108 (4), 641-652 (2017)
   PUBMED   28164410
  REMARK    GeneRIF: Studies show that miroRNA miR-210 acts as a tumor
            suppressor in hypoxic conditions by downregulating the 18S rRNA
            base methyltransferase (DIMT1)-interferon regulatory factor 4
            (IRF4) axis.
REFERENCE   7  (bases 1 to 2831)
  AUTHORS   Zorbas,C., Nicolas,E., Wacheul,L., Huvelle,E., Heurgue-Hamard,V.
            and Lafontaine,D.L.
  TITLE     The human 18S rRNA base methyltransferases DIMT1L and
            WBSCR22-TRMT112 but not rRNA modification are required for ribosome
            biogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2080-2095 (2015)
   PUBMED   25851604
  REMARK    GeneRIF: DIMT1L and WBSCR22-TRMT112 are required for distinct
            pre-rRNA processing reactions leading to synthesis of 18S rRNA.
            Ribosome biogenesis requires the presence of the modification
            enzyme rather than its RNA-modifying catalytic activity.
REFERENCE   8  (bases 1 to 2831)
  AUTHORS   Kiga,K., Mimuro,H., Suzuki,M., Shinozaki-Ushiku,A., Kobayashi,T.,
            Sanada,T., Kim,M., Ogawa,M., Iwasaki,Y.W., Kayo,H.,
            Fukuda-Yuzawa,Y., Yashiro,M., Fukayama,M., Fukao,T. and Sasakawa,C.
  TITLE     Epigenetic silencing of miR-210 increases the proliferation of
            gastric epithelium during chronic Helicobacter pylori infection
  JOURNAL   Nat Commun 5, 4497 (2014)
   PUBMED   25187177
  REMARK    GeneRIF: Epigenetic silencing of miR-210 increases the
            proliferation of gastric epithelium during chronic Helicobacter
            pylori infection by activating STMN1 and DIMT1.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2831)
  AUTHORS   Stanchi,F., Bertocco,E., Toppo,S., Dioguardi,R., Simionati,B.,
            Cannata,N., Zimbello,R., Lanfranchi,G. and Valle,G.
  TITLE     Characterization of 16 novel human genes showing high similarity to
            yeast sequences
  JOURNAL   Yeast 18 (1), 69-80 (2001)
   PUBMED   11124703
REFERENCE   10 (bases 1 to 2831)
  AUTHORS   Law,S.F., Zhang,Y.Z., Klein-Szanto,A.J. and Golemis,E.A.
  TITLE     Cell cycle-regulated processing of HEF1 to multiple protein forms
            differentially targeted to multiple subcellular compartments
  JOURNAL   Mol Cell Biol 18 (6), 3540-3551 (1998)
   PUBMED   9584194
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292723.1, AC016637.7 and
            BQ009563.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014473.3.
            
            Summary: The protein encoded by this gene is a methyltransferase
            that is responsible for dimethylation of adjacent adenosines near
            the 18S rRNA decoding site. The encoded protein is essential for
            ribosome biogenesis, although its catalytic activity is not
            involved in the process. The yeast ortholog of this protein
            functions in the cytoplasm while this protein functions in the
            nucleus. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.450841.1,
                                           SRR1660805.29519.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000199320.9/ ENSP00000199320.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-370               AK292723.1         25-394
            371-371             AC016637.7         74050-74050         c
            372-1515            AK292723.1         396-1539
            1516-2132           BQ009563.1         18-634              c
            2133-2831           AC016637.7         59266-59964         c
FEATURES             Location/Qualifiers
     source          1..2831
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q12.1"
     gene            1..2831
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="DIM1 rRNA methyltransferase and ribosome maturation
                     factor"
                     /db_xref="GeneID:27292"
                     /db_xref="HGNC:HGNC:30217"
                     /db_xref="MIM:612499"
     exon            1..212
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..1075
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /EC_number="2.1.1.183"
                     /note="isoform 1 is encoded by transcript variant 1;
                     dimethyladenosine transferase; DIM1 dimethyladenosine
                     transferase 1-like; DIMT1 rRNA methyltransferase and
                     ribosome maturation factor; probable dimethyladenosine
                     transferase; 18S rRNA dimethylase;
                     S-adenosylmethionine-6-N',N'-adenosyl(rRNA)
                     dimethyltransferase; 18S rRNA
                     (adenine(1779)-N(6)/adenine(1780)-N(6))-
                     dimethyltransferase; probable 18S rRNA dimethylase;
                     probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA)
                     dimethyltransferase; probable 18S rRNA
                     (adenine(1779)-N(6)/adenine(1780)-N(6))-
                     dimethyltransferase; DIM1 dimethyladenosine transferase 1
                     homolog"
                     /codon_start=1
                     /product="dimethyladenosine transferase isoform 1"
                     /protein_id="NP_055288.1"
                     /db_xref="CCDS:CCDS3981.1"
                     /db_xref="GeneID:27292"
                     /db_xref="HGNC:HGNC:30217"
                     /db_xref="MIM:612499"
                     /translation="MPKVKSGAIGRRRGRQEQRRELKSAGGLMFNTGIGQHILKNPLI
                     INSIIDKAALRPTDVVLEVGPGTGNMTVKLLEKAKKVVACELDPRLVAELHKRVQGTP
                     VASKLQVLVGDVLKTDLPFFDTCVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFA
                     LRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPI
                     NFQEWDGLVRITFVRKNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFSIADKI
                     QQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHFS"
     exon            213..286
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            287..373
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            374..435
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            436..529
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            530..579
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            580..703
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            704..796
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..861
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            862..925
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1032
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..2831
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="hexamer: AATAAA"
     polyA_site      1459
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="major polyA site"
     regulatory      1537..1542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="hexamer: AGTAAA"
     polyA_site      1561
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="hexamer: AATAAA"
     polyA_site      2132
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="hexamer: AGTAAA"
     polyA_site      2418
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
     regulatory      2811..2816
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
                     /note="hexamer: AATAAA"
     polyA_site      2831
                     /gene="DIMT1"
                     /gene_synonym="DIM1; DIMT1L; HSA9761; HUSSY5"
ORIGIN      
        1 cttgcccctc cggcgcttgg gccagagtgg tgcgggcggc gcgtggcggc gatccccacg
       61 tggtggcttt ctcacgctag ccctctttgg tcctccttga cgtcccgggc ctgtgggccc
      121 gctttctgcc gagatgccga aggtcaagtc gggggccatc ggccgccgcc gcgggcggca
      181 ggagcagcgc cgggagctga agagcgctgg aggactcatg ttcaacacgg ggattgggca
      241 gcacattttg aaaaatcctc tcattattaa cagcattatc gataaggctg ccttaagacc
      301 aactgatgta gtgctggaag ttggacctgg aactggcaac atgactgtaa agttgttaga
      361 aaaggcaaaa aaggttgttg cttgtgaact tgacccaagg ctagtagctg aacttcacaa
      421 aagagttcag ggcacgcctg tggccagcaa acttcaagta ctggtgggtg atgtgctgaa
      481 aacagatttg ccattctttg atacttgtgt ggcaaatttg ccttatcaga tctcttcacc
      541 ttttgtcttc aagctgttgc tacatcgacc ttttttcagg tgtgctatac ttatgtttca
      601 aagagaattt gccctccgac tggttgcaaa acctggagat aagttatact gcagactctc
      661 aattaataca cagctgttgg cacgtgtgga ccatctaatg aaagtgggaa agaataactt
      721 cagaccaccg cccaaggtgg aatccagtgt tgtaaggata gaacctaaga atccaccacc
      781 acccatcaat tttcaggaat gggatggtct agtaaggata acctttgtta ggaaaaacaa
      841 gacactctct gctgcattta aatcaagtgc agtgcaacaa ctcttggaaa aaaactacag
      901 aattcactgt tcagtccata atattataat accagaagat ttcagcatag cagataaaat
      961 acagcaaatc ctaaccagca caggttttag tgacaaacgg gcccgttcca tggacataga
     1021 tgacttcatc agattgctac atggattcaa cgcagaaggt attcattttt cctaggtatt
     1081 tggaaaacag aaattttcaa ggtcaagaaa agaaatgaat tttgtatttt ttgtatttga
     1141 gaagataatg cttttgcttt actgagacat tatttacttg actatttttg gttcaatact
     1201 actactgttg tcaccattta tgattctgaa ttttaaagtt ggaaagttct aagtatcaaa
     1261 gtttttaata tataatgctg gtccaatcta ttcataataa tcttcaagtt caggagccgc
     1321 agagacgcac aactttacac ttatcatttc taacagttta ttgtataaag atgttactct
     1381 tctatttact gttatatact gtaaggcctt ctttaggcct ttagctctgt tcctccagta
     1441 ataaaaaagt taaaatatgc ttcactagtc acacattccc cataccattt cgtgttattc
     1501 acattccccg taccatttct tgttattcac atgtacagta aaacaattgt ttcttaaatt
     1561 atttttattt tggttctctc attctcttcc ctatttatcc tatacagtgt ctgttacgat
     1621 tgcctacctc tttcgctatc ctatagcgtc agagacttag ggttctgggt aagcccaagt
     1681 ctgctactgc caccgtgcag tgccaggcat attaaagggc atgactccca acatgtaaaa
     1741 tgaggaagct aaactggaat gaaattaaca ataaaattat ctttttttat ggttcttagg
     1801 gagataacta taggcttagc aaaatttcag agggttttgt aattgaaact ggtttcaact
     1861 tcagaaaaac agccatttcc cataactaca ggttcccagt attcctatga tttctggaca
     1921 attaaaattt ccagttcctt tttcatatac ctggtgctta gttttaagct attttaaaac
     1981 tgtcagactg agaatttcaa tagatgtcat aaactagttt tattagctac tatgtttaag
     2041 tcaatataat actaagtgct gttaatatac tataatagag ttatagtagc tattttgttt
     2101 ctataaaaaa ttaataaaaa tatctttatt gatatttggc tttttttaat acctaactta
     2161 atagaagagt gtttccaatt aatttaacaa agccagattt tgaaatctgg cttcaaagtc
     2221 atagtaaatg ttactacata attaaaataa tgcttgttct taatgtataa tccagaacaa
     2281 aggcatcaag ctgcttttgt taaacaaata tgaaataata tacattaaga gtagattttt
     2341 ttgtttaatt tcacaaaact attttgcaga gttcacttgt atcatctcta tccttatagt
     2401 aaaaatttta agatttaact cggctttctc aggttatttc cctctacccc tatgaactgc
     2461 tgagttttag ttccttttct ggccttcagt tttcactatc tgtaaagctg aaggactgta
     2521 ttatattacc tccagtatct tttctggtac taatttttaa aatacctgat cagaatgaag
     2581 ccatcatagt gtaaggcagc atatttgtct ataaggagac tttccaaaga cagtacccat
     2641 ccaatgcaaa taataaattt gaagctaatc atctgttgtg ctttaaaatg agcaaattca
     2701 catgtcttta ttgccctttg aaagttggtt aatctcaaaa actacctttt ttttaaatat
     2761 cctttgcaag gtcaattgta acagttctcc atccttcctc ttccctttga aataaacaca
     2821 aatagaatat a
//
