LOCUS       NM_001042517            4745 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens diaphanous related formin 3 (DIAPH3), transcript
            variant 1, mRNA.
ACCESSION   NM_001042517
VERSION     NM_001042517.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4745)
  AUTHORS   Lin,L., Wang,L., Li,A., Li,Y. and Gu,X.
  TITLE     CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and
            inflammation through miR-338-3p/SRSF1 axis
  JOURNAL   J Bioenerg Biomembr 56 (3), 235-245 (2024)
   PUBMED   38613636
  REMARK    GeneRIF: CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis
            and inflammation through miR-338-3p/SRSF1 axis.
REFERENCE   2  (bases 1 to 4745)
  AUTHORS   Su,T., Zhang,N., Wang,T., Zeng,J., Li,W., Han,L. and Yang,M.
  TITLE     Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative
            Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis
  JOURNAL   Cancer Res 83 (24), 4080-4094 (2023)
   PUBMED   37756562
  REMARK    GeneRIF: Super Enhancer-Regulated LncRNA LINC01089 Induces
            Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma
            Metastasis.
REFERENCE   3  (bases 1 to 4745)
  AUTHORS   Zhang,K., Huang,M., Li,A., Wen,J., Yan,L., Li,Y., Guo,L.,
            Senthil,K.S., Zhou,Y., Chen,G., Liu,Y., Zhang,X., Yao,X., Qin,D.
            and Su,H.
  TITLE     DIAPH3 condensates formed by liquid-liquid phase separation act as
            a regulatory hub for stress-induced actin cytoskeleton remodeling
  JOURNAL   Cell Rep 42 (1), 111986 (2023)
   PUBMED   36640348
  REMARK    GeneRIF: DIAPH3 condensates formed by liquid-liquid phase
            separation act as a regulatory hub for stress-induced actin
            cytoskeleton remodeling.
REFERENCE   4  (bases 1 to 4745)
  AUTHORS   Chen,X., Xie,L., Qiao,K., Zhu,X., Ren,J. and Tan,Y.
  TITLE     The pan-cancer analysis identified DIAPH3 as a diagnostic biomarker
            of clinical cancer
  JOURNAL   Aging (Albany NY) 15 (3), 689-704 (2023)
   PUBMED   36750200
  REMARK    GeneRIF: The pan-cancer analysis identified DIAPH3 as a diagnostic
            biomarker of clinical cancer.
REFERENCE   5  (bases 1 to 4745)
  AUTHORS   Huang,R., Wu,C., Wen,J., Yu,J., Zhu,H., Yu,J. and Zou,Z.
  TITLE     DIAPH3 is a prognostic biomarker and inhibit colorectal cancer
            progression through maintaining EGFR degradation
  JOURNAL   Cancer Med 11 (23), 4688-4702 (2022)
   PUBMED   35538918
  REMARK    GeneRIF: DIAPH3 is a prognostic biomarker and inhibit colorectal
            cancer progression through maintaining EGFR degradation.
REFERENCE   6  (bases 1 to 4745)
  AUTHORS   Stastna,J., Pan,X., Wang,H., Kollmannsperger,A., Kutscheidt,S.,
            Lohmann,V., Grosse,R. and Fackler,O.T.
  TITLE     Differing and isoform-specific roles for the formin DIAPH3 in
            plasma membrane blebbing and filopodia formation
  JOURNAL   Cell Res 22 (4), 728-745 (2012)
   PUBMED   22184005
  REMARK    GeneRIF: isoform-selective actin assembly by DIAPH3 exerts specific
            and differentially regulated functions during cell adhesion and
            motility.
REFERENCE   7  (bases 1 to 4745)
  AUTHORS   Wallar,B.J., Deward,A.D., Resau,J.H. and Alberts,A.S.
  TITLE     RhoB and the mammalian Diaphanous-related formin mDia2 in endosome
            trafficking
  JOURNAL   Exp Cell Res 313 (3), 560-571 (2007)
   PUBMED   17198702
  REMARK    GeneRIF: These studies further suggest that Rho GTPases
            significantly influence the activity of mDia family formins in
            driving cellular membrane remodeling through the regulation of
            actin dynamics.
REFERENCE   8  (bases 1 to 4745)
  AUTHORS   Kim,T.B., Isaacson,B., Sivakumaran,T.A., Starr,A., Keats,B.J. and
            Lesperance,M.M.
  TITLE     A gene responsible for autosomal dominant auditory neuropathy
            (AUNA1) maps to 13q14-21
  JOURNAL   J Med Genet 41 (11), 872-876 (2004)
   PUBMED   15520414
REFERENCE   9  (bases 1 to 4745)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human DIAPH3 gene in silico
  JOURNAL   Int J Mol Med 13 (3), 473-478 (2004)
   PUBMED   14767582
REFERENCE   10 (bases 1 to 4745)
  AUTHORS   Fisher,R.A., Edwards,Y.H., Putt,W., Potter,J. and Hopkinson,D.A.
  TITLE     An interpretation of human diaphorase isozymes in terms of three
            gene loci DIA1, DIA2 and DIA3
  JOURNAL   Ann Hum Genet 41 (2), 139-149 (1977)
   PUBMED   563699
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356502.21, AK298509.1,
            AL390878.6, AY750055.1, AL359266.14 and CA310418.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_001042517.1.
            
            Summary: This gene encodes a member of the diaphanous subfamily of
            the formin family. Members of this family are involved in actin
            remodeling and regulate cell movement and adhesion. Mutations in
            this gene are associated with autosomal dominant auditory
            neuropathy 1. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Apr
            2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY750055.1, SRR7346977.1912237.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400324.9/ ENSP00000383178.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AL356502.21        37185-37341         c
            158-1924            AK298509.1         1-1767
            1925-1925           AL390878.6         54155-54155         c
            1926-3210           AK298509.1         1769-3053
            3211-3500           AY750055.1         3141-3430
            3501-3501           AL359266.14        135013-135013       c
            3502-3600           AY750055.1         3432-3530
            3601-4101           AL359266.14        134413-134913       c
            4102-4745           CA310418.1         11-654              c
FEATURES             Location/Qualifiers
     source          1..4745
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q21.2"
     gene            1..4745
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /note="diaphanous related formin 3"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
     exon            1..342
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..3744
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /note="isoform a is encoded by transcript variant 1;
                     diaphanous homolog 3"
                     /codon_start=1
                     /product="protein diaphanous homolog 3 isoform a"
                     /protein_id="NP_001035982.1"
                     /db_xref="CCDS:CCDS41898.1"
                     /db_xref="GeneID:81624"
                     /db_xref="HGNC:HGNC:15480"
                     /db_xref="MIM:614567"
                     /translation="MERHQPRLHHPAQGSAAGTPYPSSASLRGCRESKMPRRKGPQHP
                     PPPSGPEEPGEKRPKFHLNIRTLTDDMLDKFASIRIPGSKKERPPLPNLKTAFASSDC
                     SAAPLEMMENFPKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYIN
                     TASKTGSLKRSRQISPQEFIHELKMGSADERLVTCLESLRVSLTSNPVSWVESFGHEG
                     LGLLLDILEKLISGKIQEKVVKKNQHKVIQCLKALMNTQYGLERIMSEERSLSLLAKA
                     VDPRHPNMMTDVVKLLSAVCIVGEESILEEVLEALTSAGEEKKIDRFFCIVEGLRHNS
                     VQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILPNLKCIKNDGLDIQLKVF
                     DEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISILQHLLLIRND
                     YFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEFEEK
                     ASELYKKFEKEFTDHQETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSK
                     EGGTGHSALPPPPPLPSGGGVPPPPPPPPPPPLPGMRMPFSGPVPPPPPLGFLGGQNS
                     PPLPILPFGLKPKKEFKPEISMRRLNWLKIRPHEMTENCFWIKVNENKYENVDLLCKL
                     ENTFCCQQKERREEEDIEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMM
                     ILEVDETRLAESMIQNLIKHLPDQEQLNSLSQFKSEYSNLCEPEQFVVVMSNVKRLRP
                     RLSAILFKLQFEEQVNNIKPDIMAVSTACEEIKKSKSFSKLLELVLLMGNYMNAGSRN
                     AQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEICEEKYPDILNFVDDLEPLDKASKVS
                     VETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSRFVISAKEQYETLSKLHE
                     NMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKREAEEKEKRVRI
                     AKELAERERLERQQKKKRLLEMKTEGDETGVMDNLLEALQSGAAFRDRRKRTPMPKDV
                     RQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTST
                     GRIKAAEKKEACNVESNRKKETELLGSFSKNESVPEVEALLARLRAL"
     exon            343..375
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            376..552
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            553..657
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            658..788
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            789..863
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            864..933
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1070
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1176
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1287
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1406
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1523
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1642
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1707
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1812
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..2121
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2236
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2332
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2427
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2529
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2769
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2899
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..3024
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3025..3189
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3190..3325
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3421
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3481
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     exon            3482..4745
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3872..3877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /note="hexamer: AATAAA"
     polyA_site      3896
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /note="major polyA site"
     regulatory      4566..4571
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /note="hexamer: AATAAA"
     polyA_site      4588
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
     polyA_site      4618
                     /gene="DIAPH3"
                     /gene_synonym="AN; AUNA1; DIA2; diap3; DRF3; mDia2; NSDAN"
                     /note="major polyA site"
ORIGIN      
        1 agatgtgttg gctgcggccc cgacttcagc ggttgggcta ggctgtgctg actgtttggg
       61 tggcggaccc cgggagtaaa acctgttgtc gatccctcag cttccagctt gcggcttgct
      121 gagtggccac cttctttccg gtccccggag ctgcggggaa agatggaacg gcaccagccg
      181 cggctgcacc acccggccca aggctcagcc gctgggactc cctacccttc ctcagcctct
      241 ctccgcggct gccgggaaag caagatgccg cgcaggaagg gcccccaaca ccctccgccg
      301 cccagtggcc ccgaggagcc tggggagaag cgccccaagt ttcatttaaa tattaggaca
      361 ctgacggatg atatgctgga caaatttgcc agcataagaa ttccagggag caagaaagag
      421 agacctccac ttcccaacct gaagactgca tttgcaagca gtgattgctc agcagcacct
      481 ttagagatga tggagaactt tccaaagcca ctgtcagaga atgaactctt agaacttttt
      541 gaaaaaatga tggaagatat gaatttaaat gaagataaaa aggcaccatt gcgggaaaag
      601 gacttcagta tcaaaaaaga aatggtgatg cagtacatta atactgcttc taagacagga
      661 agtcttaaga gaagccgaca gatctcacct caggaattca ttcatgagct gaaaatgggg
      721 tctgcagatg agagacttgt cacatgcctg gagtctctcc gagtgtcttt gaccagcaat
      781 cctgtgagtt gggtggaaag ctttggacat gaagggcttg gattattatt agacattttg
      841 gaaaaactga ttagtggaaa aatccaagaa aaagttgtaa agaaaaatca acataaagtc
      901 atacagtgtc taaaagccct gatgaatacg cagtatggct tggaaagaat tatgagtgag
      961 gagaggagcc tttccttatt ggccaaagcc gtggatccca gacaccccaa tatgatgaca
     1021 gatgtggtta aacttctctc tgcggtatgc attgtagggg aagaaagcat ccttgaagaa
     1081 gttttagaag ctttaacttc agctggtgaa gaaaaaaaaa ttgacagatt tttttgtatt
     1141 gtggaaggcc tccggcacaa ttcagttcaa ctgcaagtag cttgtatgca gctcatcaat
     1201 gccctggtta catctcctga tgatttggat ttcaggcttc acatcagaaa tgaatttatg
     1261 cgttgtggat tgaaagagat attgccaaat ttaaaatgca ttaagaatga tggcctggat
     1321 atccaactta aagtctttga tgagcataaa gaagaagatt tgtttgagtt atcccatcgc
     1381 cttgaagata ttagagctga acttgatgaa gcatatgatg tttacaacat ggtgtggagc
     1441 acagttaaag aaactagagc agagggatat tttatttcta ttcttcagca tcttttgctg
     1501 attcgaaatg attattttat aaggcaacaa tacttcaaat taattgatga gtgtgtatcc
     1561 cagattgtat tgcatagaga tggaatggat ccagacttca catatcgaaa aagactagat
     1621 ttagatttaa cccagtttgt agacatttgc atagatcaag caaaactaga agagtttgaa
     1681 gagaaagcat cagaacttta caagaaattt gaaaaagagt ttaccgacca ccaagaaact
     1741 caggctgaat tgcagaaaaa agaggcaaag attaatgagc ttcaagcaga gctacaagct
     1801 tttaagtctc agtttggtgc cttgccagct gattgtaata ttcctttgcc tccctctaaa
     1861 gaaggtggaa ctggccactc agcacttcct cctccgcctc cactgccttc tggtggaggg
     1921 gtgccgcctc cacctcctcc cccaccacct cctccacttc caggaatgcg gatgccattc
     1981 agtggtcctg tgcctccacc acctcccctg ggattccttg gaggacaaaa ttctcctcct
     2041 ctaccaatcc tgccatttgg gttgaaacca aagaaagaat ttaaacctga aatcagcatg
     2101 agaagattga attggttaaa gatcagacct catgaaatga ctgaaaactg tttctggata
     2161 aaagtaaatg aaaataagta tgaaaacgtg gatttgcttt gtaaacttga gaatacattt
     2221 tgttgccaac aaaaagagag aagagaagag gaagatattg aagagaagaa atcgattaag
     2281 aaaaaaatta aagaacttaa gtttttagat tctaaaattg cccagaacct ttcaatcttc
     2341 ctgagctctt ttcgggtgcc atatgaggaa atcagaatga tgatattgga agtagatgaa
     2401 acacggttgg cagagtctat gattcagaac ttaataaagc atcttcctga tcaagagcaa
     2461 ttaaattcat tgtctcagtt caagagtgaa tatagcaact tatgtgaacc tgagcagttt
     2521 gtggttgtga tgagcaatgt gaagagacta cggccacggc tcagtgctat tctctttaag
     2581 cttcagtttg aagagcaggt gaacaacatc aaacctgaca tcatggctgt cagtactgcc
     2641 tgcgaagaga taaagaagag caaaagcttt agcaagttgc tggaacttgt attgctaatg
     2701 ggaaactaca tgaatgctgg ctcccggaat gctcaaacct tcggatttaa ccttagctct
     2761 ctctgtaaac taaaggacac aaaatcagca gatcagaaaa caacgctact tcatttcctg
     2821 gtagaaatat gtgaagagaa gtaccctgat atactgaatt ttgtggatga tttggaacct
     2881 ttagacaaag ctagtaaagt ctctgtagaa acgctggaaa agaatttgag gcagatggga
     2941 aggcagcttc aacagcttga gaaggaattg gaaacctttc cccctcctga ggacttgcat
     3001 gacaagtttg tgacaaagat gtccagattt gttatcagtg caaaagaaca atatgagaca
     3061 ctttcgaagt tacacgaaaa catggaaaag ttataccaga gtataatagg atactatgcc
     3121 attgatgtga agaaggtgtc tgtggaagac tttcttactg acctgaataa cttcagaacc
     3181 acattcatgc aagcaataaa ggagaatatc aaaaaaagag aagcagagga aaaagaaaaa
     3241 cgtgtcagaa tagctaaaga attagcagag cgagaaagac tcgaacgcca acaaaagaaa
     3301 aagcgtttat tagaaatgaa gactgagggt gatgagacag gagtgatgga taatctgctg
     3361 gaggccttgc agtccggggc tgccttccgc gacagaagaa aaaggacacc gatgccaaaa
     3421 gatgttcggc agagtctcag tccaatgtct cagaggcctg ttctgaaagt ttgtaaccat
     3481 gaaaatcaga aagtgcagtt gacagaaggg tcacgttcac actacaatat caattgcaac
     3541 tcaacaagga ctccagtcgc caaggagctt aattataatc tagacactca tacgtctact
     3601 gggaggatca aggcagctga gaagaaggaa gcgtgtaatg tagaaagcaa cagaaaaaag
     3661 gaaacggaac ttcttggctc tttttctaaa aatgaatcag ttcccgaagt tgaagccctg
     3721 ctggcaagat tacgagcttt ataagttaaa ctggttttta aaaaaaatga ttaagccaaa
     3781 tataaagcca tgctctaaac tataacactt gaaaaaattg cttttatgta agtgacttta
     3841 tatagtttta aattatgata tatattagaa aaataaagct aaatatatga ttgcaatgct
     3901 ttttctatgt actggaggtt ttggtttatt caagattgta ccgggcttta atcctttttt
     3961 tttttttttt gtctcctggt attcctcagt tctttatttg gtggttaaat tatacatatt
     4021 gctttagaga gcaggtaggt ggccatgtgt tcagcagtgt gtccttaaga aaataccatc
     4081 tttctaagcc actggaattt ttactttact atttttaaca ttaatggatg tcaggtcatc
     4141 aacctcaagt ctttacatat ccatgtatat tccatatata ttgtttatat aggcccaagt
     4201 ttctccttaa ttgggatcta tatactacca gcacaacatc aaaaacatgt aattgaatac
     4261 atcagagcta tatatgtaag gaaatgactg gtgaccccat tatcatcatt gttgaattca
     4321 tgttaagtag accctctagg ggaccataag gcaattgagc acataacgaa aaatgatgca
     4381 ataagaatgt atgcactctc tttgccaaat gcatgtgctt ttgtgtaacg tggatgtaaa
     4441 cagaattgca gtgctgccga aattcttgat cttggctaag agagtatttt tccccttgta
     4501 attatgactc tgagataaaa ttgccatttt gaaatttcca aagtaacaac tttttttatt
     4561 ttatgaataa acttgggatt gcaatttctc tgatctgaca atcaataact ttaacaaaga
     4621 tctaaataag tgtttcaagg aaagttttcc taagcaaatg taatattacc tcatttgggc
     4681 atcattactc tgttaattct atatcaaagg aaataaactt gctacttgca ctaaatgaaa
     4741 aaaaa
//
