LOCUS       NM_024119               2591 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens DExH-box helicase 58 (DHX58), mRNA.
ACCESSION   NM_024119
VERSION     NM_024119.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2591)
  AUTHORS   Singh,R., Wu,Y., Herrero Del Valle,A., Leigh,K.E., Mong,S.,
            Cheng,M.T.K., Ferguson,B.J. and Modis,Y.
  TITLE     Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral
            RNA sensing
  JOURNAL   J Biol Chem 300 (3), 105711 (2024)
   PUBMED   38309507
  REMARK    GeneRIF: Contrasting functions of ATP hydrolysis by MDA5 and LGP2
            in viral RNA sensing.
REFERENCE   2  (bases 1 to 2591)
  AUTHORS   Lee,K.Y., Craig,C. and Patel,S.S.
  TITLE     Unraveling blunt-end RNA binding and ATPase-driven translocation
            activities of the RIG-I family helicase LGP2
  JOURNAL   Nucleic Acids Res 52 (1), 355-369 (2024)
   PUBMED   38015453
  REMARK    GeneRIF: Unraveling blunt-end RNA binding and ATPase-driven
            translocation activities of the RIG-I family helicase LGP2.
REFERENCE   3  (bases 1 to 2591)
  AUTHORS   Novosad,V.O. and Maltseva,D.V.
  TITLE     The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are Involved in
            the Regulation of CD44 mRNA Splicing in Colorectal Cancer Cells
  JOURNAL   Bull Exp Biol Med 175 (1), 144-149 (2023)
   PUBMED   37336810
  REMARK    GeneRIF: The RNA-Binding Proteins OAS1, ZFP36L2, and DHX58 Are
            Involved in the Regulation of CD44 mRNA Splicing in Colorectal
            Cancer Cells.
REFERENCE   4  (bases 1 to 2591)
  AUTHORS   Kouwaki,T., Nishimura,T., Wang,G., Nakagawa,R. and Oshiumi,H.
  TITLE     K63-linked polyubiquitination of LGP2 by Riplet regulates
            RIG-I-dependent innate immune response
  JOURNAL   EMBO Rep 24 (2), e54844 (2023)
   PUBMED   36515138
  REMARK    GeneRIF: K63-linked polyubiquitination of LGP2 by Riplet regulates
            RIG-I-dependent innate immune response.
REFERENCE   5  (bases 1 to 2591)
  AUTHORS   Huang,P., Wu,J.J., Zhang,J.W., Hou,Y.Q., Zhu,P., Yin,R., Yu,R.B.,
            Zhang,Y., Yue,M. and Hou,W.
  TITLE     Genetic variants of IFIH1 and DHX58 affect the chronicity of
            hepatitis C in the Chinese Han population
  JOURNAL   PeerJ 11, e14740 (2023)
   PUBMED   36743960
  REMARK    GeneRIF: Genetic variants of IFIH1 and DHX58 affect the chronicity
            of hepatitis C in the Chinese Han population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2591)
  AUTHORS   Murali,A., Li,X., Ranjith-Kumar,C.T., Bhardwaj,K., Holzenburg,A.,
            Li,P. and Kao,C.C.
  TITLE     Structure and function of LGP2, a DEX(D/H) helicase that regulates
            the innate immunity response
  JOURNAL   J Biol Chem 283 (23), 15825-15833 (2008)
   PUBMED   18411269
  REMARK    GeneRIF: LGP2 can be coexpressed with RIG-I to inhibit activation
            of the NF-kappaB reporter expression and that LGP2 protein produced
            in insect cells can bind both single- and double-stranded RNA
            (dsRNA), with higher affinity and cooperativity for dsRNA.
REFERENCE   7  (bases 1 to 2591)
  AUTHORS   Saito,T., Hirai,R., Loo,Y.M., Owen,D., Johnson,C.L., Sinha,S.C.,
            Akira,S., Fujita,T. and Gale,M. Jr.
  TITLE     Regulation of innate antiviral defenses through a shared repressor
            domain in RIG-I and LGP2
  JOURNAL   Proc Natl Acad Sci U S A 104 (2), 582-587 (2007)
   PUBMED   17190814
REFERENCE   8  (bases 1 to 2591)
  AUTHORS   Komuro,A. and Horvath,C.M.
  TITLE     RNA- and virus-independent inhibition of antiviral signaling by RNA
            helicase LGP2
  JOURNAL   J Virol 80 (24), 12332-12342 (2006)
   PUBMED   17020950
  REMARK    GeneRIF: LGP2 competes with the kinase IKKi for a common
            interaction site on IPS-1, as an element of negative-feedback
            regulation of intracellular antiviral signaling.
REFERENCE   9  (bases 1 to 2591)
  AUTHORS   Yoneyama,M., Kikuchi,M., Matsumoto,K., Imaizumi,T., Miyagishi,M.,
            Taira,K., Foy,E., Loo,Y.M., Gale,M. Jr., Akira,S., Yonehara,S.,
            Kato,A. and Fujita,T.
  TITLE     Shared and unique functions of the DExD/H-box helicases RIG-I,
            MDA5, and LGP2 in antiviral innate immunity
  JOURNAL   J Immunol 175 (5), 2851-2858 (2005)
   PUBMED   16116171
  REMARK    GeneRIF: Shared and unique functions of the DExD/H-box helicases
            RIG-I, MDA5, and LGP2 in antiviral innate immunity.
REFERENCE   10 (bases 1 to 2591)
  AUTHORS   Cui,Y., Li,M., Walton,K.D., Sun,K., Hanover,J.A., Furth,P.A. and
            Hennighausen,L.
  TITLE     The Stat3/5 locus encodes novel endoplasmic reticulum and
            helicase-like proteins that are preferentially expressed in normal
            and neoplastic mammary tissue
  JOURNAL   Genomics 78 (3), 129-134 (2001)
   PUBMED   11735219
  REMARK    GeneRIF: Cloning and expression of the mouse Lpg2 mRNA, and
            comparison of the ORF to that of human LPG2 mRNA.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK021416.1 and BC014949.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024119.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014949.1, AK021416.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251642.8/ ENSP00000251642.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK021416.1         20-63
            45-2591             BC014949.1         1-2547
FEATURES             Location/Qualifiers
     source          1..2591
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.2"
     gene            1..2591
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /note="DExH-box helicase 58"
                     /db_xref="GeneID:79132"
                     /db_xref="HGNC:HGNC:29517"
                     /db_xref="MIM:608588"
     exon            1..110
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            111..203
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            204..372
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            373..574
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            575..765
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..882
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1009
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1201
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1455
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1605
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1767
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..1958
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1959..2055
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     exon            2056..2591
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2573..2578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /note="hexamer: AATAAA"
     polyA_site      2591
                     /gene="DHX58"
                     /gene_synonym="D11LGP2; D11lgp2e; LGP2; RLR-3"
                     /note="major polyA site"
ORIGIN      
        1 gatttctgct ctctgcgctg agcacagcgg caccaggctg agctaagcag ggccgccttg
       61 ggcaggccta cgtggtggtg caggcgagac ccaggctggg caaggcgcag tttcagtttc
      121 catcttgggt ctctgagctg agcagagtgg caccaggctg agttaagtgg gactgccctg
      181 ggcagaccta cctactagag cagaatggag cttcggtcct accaatggga ggtgatcatg
      241 cctgccctgg agggcaagaa tatcatcatc tggctgccca cgggtgccgg gaagacccgg
      301 gcggctgctt atgtggccaa gcggcaccta gagactgtgg atggagccaa ggtggttgta
      361 ttggtcaaca gggtgcacct ggtgacccag catggtgaag agttcaggcg catgctggat
      421 ggacgctgga ccgtgacaac cctgagtggg gacatgggac cacgtgctgg ctttggccac
      481 ctggcccggt gccatgacct gctcatctgc acagcagagc ttctgcagat ggcactgacc
      541 agccccgagg aggaggagca cgtggagctc actgtcttct ccctgatcgt ggtggatgag
      601 tgccaccaca cgcacaagga caccgtctac aacgtcatca tgagccagta cctagaactt
      661 aaactccaga gggcacagcc gctaccccag gtgctgggtc tcacagcctc cccaggcact
      721 ggcggggcct ccaaactcga tggggccatc aaccacgtcc tgcagctctg tgccaacttg
      781 gacacgtggt gcatcatgtc accccagaac tgctgccccc agctgcagga gcacagccaa
      841 cagccttgca aacagtacaa cctctgccac aggcgcagcc aggatccgtt tggggacttg
      901 ctgaagaagc tcatggacca aatccatgac cacctggaga tgcctgagtt gagccggaaa
      961 tttgggacgc aaatgtatga gcagcaggtg gtgaagctga gtgaggctgc ggctttggct
     1021 gggcttcagg agcaacgggt gtatgcgctt cacctgaggc gctacaatga cgcgctgctc
     1081 atccatgaca ccgtccgcgc cgtggatgcc ttggctgcgc tgcaggattt ctatcacagg
     1141 gagcacgtca ctaaaaccca gatcctgtgt gccgagcgcc ggctgctggc cctgttcgat
     1201 gaccgcaaga atgagctggc ccacttggca actcatggcc cagagaatcc aaaactggag
     1261 atgctggaaa agatcctgca aaggcagttc agtagctcta acagccctcg gggtatcatc
     1321 ttcacccgca cccgccaaag cgcacactcc ctcctgctct ggctccagca gcagcagggc
     1381 ctgcagactg tggacatccg ggcccagcta ctgattgggg ctgggaacag cagccagagc
     1441 acccacatga cccagaggga ccagcaagaa gtgatccaga agttccaaga tggaaccctg
     1501 aaccttctgg tggccacgag tgtggcggag gaggggctgg acatcccaca ttgcaatgtg
     1561 gtggtgcgtt atgggctctt gaccaatgaa atctccatgg tccaggccag gggccgtgcc
     1621 cgggccgatc agagtgtata cgcgtttgta gcaactgaag gtagccggga gctgaagcgg
     1681 gagctgatca acgaggcgct ggagacgctg atggagcagg cagtggctgc tgtgcagaaa
     1741 atggaccagg ccgagtacca ggccaagatc cgggatctgc agcaggcagc cttgaccaag
     1801 cgggcggccc aggcagccca gcgggagaac cagcggcagc agttcccagt ggagcacgtg
     1861 cagctactct gcatcaactg catggtggct gtgggccatg gcagcgacct gcggaaggtg
     1921 gagggcaccc accatgtcaa tgtgaacccc aacttctcga actactataa tgtctccagg
     1981 gatcctgtgg tcatcaacaa agtcttcaag gactggaagc ctgggggtgt catcagctgc
     2041 aggaactgtg gggaggtctg gggtctgcag atgatctaca agtcagtgaa gctgccagtg
     2101 ctcaaagtcc gcagcatgct gctggagacc cctcaggggc ggatccaggc caaaaagtgg
     2161 tcccgcgtgc ccttctccgt gcctgacttt gacttcctgc agcattgtgc cgagaacttg
     2221 tcggacctct ccctggactg accacctcat tgctgcagtg cccggtttgg gctgtagggg
     2281 gcgggagagt ctgcagcaga ctccaggccc ctccttcctg aatcatcagc tgtgggcatc
     2341 aggcccacca gccacacagg agtcctgggc accctggctt aggctcccgc aatgggaaaa
     2401 caaccggagg gccagagctt agtccagacc taccttgtac gcacatagac attttcatat
     2461 gcactggatg gagttaggga aactgaggca aaagaatttg ccatactgta ctcagaatca
     2521 cgacattcct tccctaccaa ggccacttct attttttgag gctcctcata aaaataaatg
     2581 aaaaaatggg a
//
