LOCUS       NM_198963               4885 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens DExH-box helicase 57 (DHX57), transcript variant 1,
            mRNA.
ACCESSION   NM_198963
VERSION     NM_198963.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4885)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4885)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4885)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 4885)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB211450.1, BC131534.1, AC018693.8 and AF070590.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198963.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131534.1, ERR3218374.640107.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000457308.6/ ENSP00000405111.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                DB211450.1         1-83
            84-1913             BC131534.1         1-1830
            1914-1914           AC018693.8         90706-90706         c
            1915-3438           BC131534.1         1832-3355
            3439-3439           AC018693.8         58503-58503         c
            3440-4200           BC131534.1         3357-4117
            4201-4711           AF070590.1         1159-1669
            4712-4712           AC018693.8         33406-33406         c
            4713-4885           AF070590.1         1670-1842
FEATURES             Location/Qualifiers
     source          1..4885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p22.1"
     gene            1..4885
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /note="DExH-box helicase 57"
                     /db_xref="GeneID:90957"
                     /db_xref="HGNC:HGNC:20086"
     exon            1..148
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            149..378
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..4315
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAH-box RNA/DNA helicase AAM73547; putative ATP-dependent
                     RNA helicase DHX57; DEAH box protein 57; DEAH
                     (Asp-Glu-Ala-Asp/His) box polypeptide 57; DEAH-box
                     helicase 57"
                     /codon_start=1
                     /product="putative ATP-dependent RNA helicase DHX57
                     isoform 1"
                     /protein_id="NP_945314.1"
                     /db_xref="CCDS:CCDS1800.1"
                     /db_xref="GeneID:90957"
                     /db_xref="HGNC:HGNC:20086"
                     /translation="MSSSVRRKGKPGKGGGKGSSRGGRGGRSHASKSHGSGGGGGGGG
                     GGGGGNRKASSRIWDDGDDFCIFSESRRPSRPSNSNISKGESRPKWKPKAKVPLQTLH
                     MTSENQEKVKALLRDLQEQDADAGSERGLSGEEEDDEPDCCNDERYWPAGQEPSLVPD
                     LDPLEYAGLASVEPYVPEFTVSPFAVQKLSRYGFNTERCQAVLRMCDGDVGASLEHLL
                     TQCFSETFGERMKISEAVNQISLDECMEQRQEEAFALKSICGEKFIERIQNRVWTIGL
                     ELEYLTSRFRKSKPKESTKNVQENSLEICKFYLKGNCKFGSKCRFKHEVPPNQIVGRI
                     ERSVDDSHLNAIEDASFLYELEIRFSKDHKYPYQAPLVAFYSTNENLPLACRLHISEF
                     LYDKALTFAETSEPVVYSLITLLEEESEIVKLLTNTHHKYSDPPVNFLPVPSRTRINN
                     PACHKTVIPNNSFVSNQIPEVEKASESEESDEDDGPAPVIVENESYVNLKKKISKRYD
                     WQAKSVHAENGKICKQFRMKQASRQFQSILQERQSLPAWEERETILNLLRKHQVVVIS
                     GMTGCGKTTQIPQFILDDSLNGPPEKVANIICTQPRRISAISVAERVAKERAERVGLT
                     VGYQIRLESVKSSATRLLYCTTGVLLRRLEGDTALQGVSHIIVDEVHERTEESDFLLL
                     VLKDIVSQRPGLQVILMSATLNAELFSDYFNSCPVITIPGRTFPVDQFFLEDAIAVTR
                     YVLQDGSPYMRSMKQISKEKLKARRNRTAFEEVEEDLRLSLHLQDQDSVKDAVPDQQL
                     DFKQLLARYKGVSKSVIKTMSIMDFEKVNLELIEALLEWIVDGKHSYPPGAILVFLPG
                     LAEIKMLYEQLQSNSLFNNRRSNRCVIHPLHSSLSSEEQQAVFVKPPAGVTKIIISTN
                     IAETSITIDDVVYVIDSGKMKEKRYDASKGMESLEDTFVSQANALQRKGRAGRVASGV
                     CFHLFTSHHYNHQLLKQQLPEIQRVPLEQLCLRIKILEMFSAHNLQSVFSRLIEPPHT
                     DSLRASKIRLRDLGALTPDERLTPLGYHLASLPVDVRIGKLMLFGSIFRCLDPALTIA
                     ASLAFKSPFVSPWDKKEEANQKKLEFAFANSDYLALLQAYKGWQLSTKEGVRASYNYC
                     RQNFLSGRVLQEMASLKRQFTELLSDIGFAREGLRAREIEKRAQGGDGVLDATGEEAN
                     SNAENPKLISAMLCAALYPNVVQVKSPEGKFQKTSTGAVRMQPKSAELKFVTKNDGYV
                     HIHPSSVNYQVRHFDSPYLLYHEKIKTSRVFIRDCSMVSVYPLVLFGGGQVNVQLQRG
                     EFVVSLDDGWIRFVAASHQVAELVKELRCELDQLLQDKIKNPSIDLCTCPRGSRIIST
                     IVKLVTTQ"
     exon            379..537
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            538..726
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            727..1565
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1741
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1863
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2059
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2184
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2318
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2373
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2579
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2696
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2793
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2967
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            2968..3168
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3169..3445
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3446..3541
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3542..3625
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3626..3760
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..3835
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3836..3970
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            3971..4171
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     exon            4172..4885
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4864..4869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /note="hexamer: ATTAAA"
     polyA_site      4885
                     /gene="DHX57"
                     /gene_synonym="DDX57"
                     /note="major polyA site"
ORIGIN      
        1 agaaggcgcc gggactgtgc cgctgcagct gggccaccgc agggctgctc caagtgagaa
       61 tcgtgagggt ggccaagtcc agtttggacc tctgaccctt gggcagcacc tcccgacagc
      121 cggctcggga cccaactctg cgagccaggt gaaaatgagt tcttcagtaa gaagaaaagg
      181 caagccaggc aaaggaggtg gaaaagggtc ttctagagga ggaagaggag gcaggagtca
      241 cgccagtaaa tctcatggga gtggtggcgg tggcggtggt ggtggtggtg gaggtggcgg
      301 caacagaaag gcctccagta gaatatggga tgatggagat gacttttgta tcttcagtga
      361 atcaaggcgc ccttccagac ctagcaacag taacataagc aaaggagagt cacgcccaaa
      421 atggaaaccc aaagccaaag taccccttca gactctacat atgacttctg agaatcaaga
      481 gaaagtgaaa gctcttctcc gagacctgca agaacaagat gctgatgctg gatctgaaag
      541 aggcctttct ggggaggagg aagatgatga gcctgattgc tgtaacgatg agcggtactg
      601 gccagctgga caggaacctt ccctcgttcc cgacttggat cctttggaat atgctggctt
      661 agcctcagtg gagccttatg ttccagaatt tacagtctcc ccatttgcag tgcaaaaact
      721 ttccaggtat ggtttcaata ctgaacgctg tcaagcggtc ctgaggatgt gtgatggaga
      781 tgtgggagca tcactagagc atctccttac ccagtgtttt tcagagacat ttggagagag
      841 gatgaagatc tctgaggcag tcaaccagat aagcttggat gagtgtatgg aacagcgaca
      901 ggaagaggca tttgctctca agtccatctg tggagaaaaa tttatagaaa gaattcagaa
      961 cagagtctgg accattgggt tagaactgga gtatctgaca agtagattcc gcaaatccaa
     1021 gccaaaagaa agtaccaaaa atgtacaaga gaattcactt gaaatctgta aattttacct
     1081 caaaggaaat tgtaaatttg gatcaaaatg cagattcaaa catgaagtgc ccccaaatca
     1141 aattgttgga agaatagaaa gaagtgtaga tgattctcat cttaatgcta ttgaagatgc
     1201 atctttttta tatgaacttg aaattcgatt ttctaaagac cacaaatatc cctaccaagc
     1261 tccgctcgtg gcattttatt ccaccaatga gaacctacct ctggcttgtc gtttacatat
     1321 ttctgagttt ctttatgaca aggccttgac atttgcggaa acttcggaac ctgtcgtata
     1381 ttctttgata acccttttag aggaagagtc ggaaatagtc aagttactaa cgaataccca
     1441 ccacaagtat agtgaccctc ctgtgaactt tctgccagta ccctctagga ccagaataaa
     1501 taatcctgcc tgtcataaaa cagtgattcc aaataattct tttgtttcta atcaaattcc
     1561 agaagttgaa aaagcatcag aatctgagga gtcagatgag gatgacggtc ctgcacctgt
     1621 tatagtagag aatgaaagct atgtgaacct taagaaaaag atttccaaaa gatatgactg
     1681 gcaggcaaag tcagtacatg ctgaaaatgg taaaatctgc aagcagttcc gaatgaaaca
     1741 ggcttccaga cagttccagt ccattctgca agagaggcaa tcactccctg cttgggaaga
     1801 aagagaaacc attcttaact tattgcgtaa gcaccaggtg gttgtcataa gtggtatgac
     1861 tggatgtggg aaaaccacac aaattccgca gtttattctg gatgattctc tgaatggacc
     1921 acctgagaag gtagccaaca tcatctgtac ccaaccccga cgaatctctg caatctctgt
     1981 tgctgaacgc gttgctaaag aaagagcaga gagggtgggt ctgaccgtgg gataccagat
     2041 tcggttagaa agtgtcaagt cctcagccac cagactgtta tactgcacca cgggagtgct
     2101 gctgagaagg ctagaaggag atacagctct acaaggagtt tcccatatca ttgttgatga
     2161 agttcatgag aggacagaag aaagtgactt cttgctgcta gttttgaagg acattgtatc
     2221 gcagaggcca ggtcttcaag ttattttaat gagtgcaact ctaaacgctg agcttttttc
     2281 agactatttt aattcctgcc ccgttattac tataccaggt cgtacatttc ctgttgatca
     2341 attttttttg gaagatgcaa ttgctgtgac aaggtatgta ttacaggatg ggagcccata
     2401 tatgcggtcc atgaaacaga tttcaaagga aaagcttaaa gcaaggcgga acagaactgc
     2461 atttgaagaa gtggaagaag acctaaggct ctcccttcac ctccaggatc aggattctgt
     2521 caaagatgca gtgccagatc aacagttaga ttttaagcag ctcctggccc gctataaagg
     2581 ggttagcaag tcagtcatca aaacaatgtc catcatggat tttgaaaagg tgaatcttga
     2641 attaatagag gccttattag agtggattgt ggatggaaag cactcctacc ctccaggtgc
     2701 tatacttgta tttttaccag gactagcaga aatcaaaatg ctttatgaac agctacagtc
     2761 taattctctt ttcaacaaca gacgtagtaa tcgatgtgtt attcacccac ttcattcatc
     2821 tttatccagt gaagagcagc aggctgtgtt tgtaaaacct cctgcaggag taactaagat
     2881 tataatttcc accaacattg ctgagacatc cataaccatc gatgatgttg tctatgttat
     2941 cgattctggg aaaatgaaag aaaagagata tgatgccagc aaagggatgg aaagtctaga
     3001 ggacaccttt gtatctcaag ctaatgctct acaaaggaaa ggccgagcag gccgtgttgc
     3061 atctggggtc tgcttccatt tattcactag ccatcactac aatcaccagc ttttaaaaca
     3121 acagctacca gaaatacaaa gagtgccatt ggaacagctg tgtctaagaa ttaaaatttt
     3181 agagatgttt agtgctcata atctccagtc tgtgttctct cggctcattg aacctccaca
     3241 caccgattct cttcgtgcct caaaaatacg attacgagac ttaggagcat taactccaga
     3301 tgaaagattg acccctcttg ggtatcattt ggcctctctg cccgtggatg tgagaattgg
     3361 caaactaatg ttgtttgggt ctatcttccg ctgtttggat cctgctctca ccattgctgc
     3421 cagtttggct tttaagtctc cgtttgtatc tccctgggat aaaaaagaag aagctaacca
     3481 gaaaaagctg gaatttgcat tcgcaaacag tgattatctg gcccttctac aagcgtataa
     3541 gggatggcag ctaagtacaa aagaaggcgt gcgtgcaagt tataattact gcagacaaaa
     3601 cttcttgtct ggaagagttc tgcaggaaat ggccagcctc aaacgacaat tcacggaact
     3661 gttatcggat atagggtttg caagggaagg gctcagagca agggaaattg agaaaagggc
     3721 ccaaggagga gatggtgtct tagatgccac aggagaagag gcaaactcaa atgctgagaa
     3781 ccccaagctg atatcagcaa tgctgtgtgc tgctttgtat ccaaatgtag tgcaggtgaa
     3841 aagcccagaa ggaaaatttc agaagaccag tactggagct gtcagaatgc aaccaaaatc
     3901 agctgagttg aagtttgtca ccaagaacga tggatatgta cacattcacc cttcatcagt
     3961 gaactatcag gtgagacact ttgacagccc ctacctgttg taccacgaga agataaaaac
     4021 tagtcgagta ttcatccgag actgcagcat ggtgtctgtg tacccgctgg tcttgtttgg
     4081 aggaggccaa gtgaatgtgc agcttcaaag aggagagttc gttgtctccc tggatgatgg
     4141 ttggatccgt tttgtagctg cttcccatca ggtggctgaa ctggtaaagg agcttcgttg
     4201 cgaacttgat cagcttctcc aggataaaat taaaaaccca agcattgatc tgtgtacgtg
     4261 tcctcgagga tcccggatca tcagcacaat tgtgaaactt gtcaccacac aataaaaagc
     4321 agtcttagag agtgcttgct actcacctgc ttctagctca cctgggaaat aacagcagaa
     4381 cctctacctc gaactaaaga cctattgggg ctggccctgg tggaggagcc cagggcatga
     4441 agcccaaggc agctgaggca gtgtatatac ccttagggcc atttctaaca aagccttggc
     4501 cactcccagc acaatttgga gtgtcaaggg tgagagccta aaacccagct tgcctgtctt
     4561 tgtctctgtg attgttctgg agtgaattaa gttcacctga taactcaaaa gtgaatgtat
     4621 aatacaattc tgttttaatc tgtgtattct ttttctccta ctttttactg gggtgagagg
     4681 ggcatgaaga gaaatacgcc tttttttttt ttcttttcct gtcgccaagg ctcgactgag
     4741 agaagtcaga acagagaagg ggaaaaaaaa cccaaaatta tgtgaacaag caaaattaaa
     4801 atttcatttt aggctattgg ctactgagta aacttgactt gtgaggggtt tttattttta
     4861 ctcattaaaa gtcaacttaa aaaaa
//
