LOCUS       NM_024612               3575 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens DEAH-box helicase 40 (DHX40), transcript variant 1,
            mRNA.
ACCESSION   NM_024612 XM_372677
VERSION     NM_024612.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3575)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3575)
  AUTHORS   Xu,J., Wu,H., Zhang,C., Cao,Y., Wang,L., Zeng,L., Ye,X., Wu,Q.,
            Dai,J., Xie,Y. and Mao,Y.
  TITLE     Identification of a novel human DDX40gene, a new member of the
            DEAH-box protein family
  JOURNAL   J Hum Genet 47 (12), 681-683 (2002)
   PUBMED   12522690
REFERENCE   3  (bases 1 to 3575)
  AUTHORS   Hu,T., Guan,T. and Gerace,L.
  TITLE     Molecular and functional characterization of the p62 complex, an
            assembly of nuclear pore complex glycoproteins
  JOURNAL   J Cell Biol 134 (3), 589-601 (1996)
   PUBMED   8707840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC024187.2 and AF319521.1.
            
            On Nov 23, 2018 this sequence version replaced NM_024612.4.
            
            Summary: This gene encodes a member of the DExH/D box family of
            ATP-dependent RNA helicases that have an essential role in RNA
            metabolism. Alternate splicing results in multiple transcript
            variants. A pseudogene of this gene is found on chromosome
            17.[provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024187.2, SRR1660807.119076.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000251241.9/ ENSP00000251241.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3130              BC024187.2         1-3130
            3131-3575           AF319521.1         2338-2782
FEATURES             Location/Qualifiers
     source          1..3575
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.1"
     gene            1..3575
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /note="DEAH-box helicase 40"
                     /db_xref="GeneID:79665"
                     /db_xref="HGNC:HGNC:18018"
                     /db_xref="MIM:607570"
     exon            1..174
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..2402
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /EC_number="3.6.4.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 40 (RNA
                     helicase); probable ATP-dependent RNA helicase DHX40; DEAH
                     box protein 40; DEAH (Asp-Glu-Ala-His) box polypeptide 40"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DHX40
                     isoform 1"
                     /protein_id="NP_078888.4"
                     /db_xref="CCDS:CCDS11617.1"
                     /db_xref="GeneID:79665"
                     /db_xref="HGNC:HGNC:18018"
                     /db_xref="MIM:607570"
                     /translation="MSRFPAVAGRAPRRQEEGERSRDLQEERLSAVCIADREEKGCTS
                     QEGGTTPTFPIQKQRKKIIQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMIG
                     VTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILG
                     DPNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKL
                     SAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENTAYIQAIVKVTMDIHLNEMAGDIL
                     VFLTGQFEIEKSCELLFQMAESVDYDYDVQDTTLDGLLILPCYGSMTTDQQRRIFLPP
                     PPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQ
                     RSGRAGRTSSGKCFRIYSKDFWNQCMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFP
                     YLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCE
                     DLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRELAAKAGGFNDFATLAVIFEQCKSS
                     GAPASWCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQSDFPKETFEGPKHEVLRRCLC
                     AGYFKNVARRSVGRTFCTMDGRGSPVHIHPSSALHEQETKLEWIIFHEVLVTTKVYAR
                     IVCPIRYEWVRDLLPKLHEFNAHDLSSVARREVREDARRRWTNKENVKQLKDGISKDV
                     LKKMQRRNDDKSISDARARFLERKQQRTQDHSDTRKETG"
     exon            175..342
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            343..488
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            489..608
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            609..836
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            837..903
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1035
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1135
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1222
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1405
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1486
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1644
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1759
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1868
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..1963
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1964..2033
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2262
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..3575
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3544..3549
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /note="hexamer: AATAAA"
     polyA_site      3575
                     /gene="DHX40"
                     /gene_synonym="ARG147; DDX40; PAD"
                     /note="major polyA site"
ORIGIN      
        1 gtctttcccc tcccatctcc tcagatcggt ggacgtgctc gcctccactc ggggccaggt
       61 ctatgtcccg gtttcccgca gtcgcgggca gggcgccaag gcggcaggag gagggtgagc
      121 ggtcaagaga cctccaggaa gagcggctct cggctgtttg catcgccgat agagaagaga
      181 aaggatgcac gtcccaggag ggaggaacta ctccaacttt tcctattcag aaacaaagaa
      241 aaaagattat tcaagctgtg agggacaatt cattccttat tgttactgga aatacaggaa
      301 gtggtaaaac aactcaactc ccaaaatatc tatatgaagc agggttttca caacatggta
      361 tgattggtgt aactcaacca cgaaaagtag ctgctatatc agttgctcag agagtagctg
      421 aagaaatgaa atgcactttg ggatccaaag taggatacca agttcgtttt gatgattgca
      481 gttctaagga gacagcaatc aaatatatga ctgatggatg tttactgaaa catattctgg
      541 gagacccaaa tcttaccaaa ttcagtgtca ttattttgga tgaagcccat gaaagaactc
      601 taactacaga tatcttattt ggtttattga agaagctatt tcaggagaag tctcctaata
      661 ggaaggagca tttaaaagtg gtggtaatgt cagcaactat ggaattagcc aagctctctg
      721 cattctttgg aaattgtcca atatttgata tacctggaag gctttatcca gtcagagaga
      781 aattctgcaa tttgattggt ccacgagaca gagaaaatac tgcgtatatt caagcgattg
      841 tgaaagtcac catggatatc catttgaatg aaatggctgg agacatcttg gtttttctga
      901 ctggccagtt tgaaatagaa aaaagttgtg agttactttt tcagatggca gagtctgttg
      961 attatgatta tgatgttcaa gataccaccc tcgatggctt gttaatattg ccgtgttatg
     1021 gatcaatgac aacagatcaa cagaggagga tatttttgcc accaccacct ggaattagaa
     1081 aatgtgtcat atccaccaat atttctgcaa cgtctttgac aatagatgga atcagatatg
     1141 tggtagatgg tggcttcgtg aagcagttaa atcacaaccc cagattaggg ttggacatcc
     1201 tggaggtggt tccaatttca aagagcgagg cattacagcg aagtggccga gctggcagga
     1261 cttcttcagg aaaatgcttt cggatctata gtaaagattt ttggaaccag tgtatgcctg
     1321 accatgtgat ccctgaaatt aagagaacta gtttgacatc tgtagttctg accttaaagt
     1381 gccttgccat acacgatgtc ataaggtttc cctatttgga tccacctaat gagagactta
     1441 ttttagaagc tcttaaacaa ctttaccagt gtgatgctat tgacaggagt ggccatgtca
     1501 ccagattggg tttgtctatg gtggagtttc ctttgcctcc acatctgaca tgtgcagtaa
     1561 taaaagctgc ttccctggat tgtgaagatc tactacttcc aatagcagca atgttgtctg
     1621 tggaaaacgt cttcattaga cctgttgatc cagagtacca gaaggaagca gaacagagac
     1681 atcgagaatt ggcagctaaa gctggaggat ttaatgactt tgcaacttta gctgtcatct
     1741 ttgaacaatg caaatcaagt ggagctccag cttcatggtg ccaaaaacac tggattcatt
     1801 ggaggtgctt attttctgca tttcgtgtgg aagctcaact tcgagaacta atcaggaagc
     1861 ttaaacagca aagtgatttc ccaaaagaga cctttgaagg ccctaaacat gaagtactac
     1921 gaagatgtct ttgtgcgggc tatttcaaaa atgtagctcg aagatctgtt gggagaacgt
     1981 tttgcacaat ggatggtcgt ggaagcccag ttcacattca tccttcctca gcacttcatg
     2041 aacaggaaac caaacttgaa tggatcattt ttcatgaggt attggttacc accaaagtct
     2101 acgcaagaat tgtatgccca atccgttatg aatgggtaag agacttgtta cccaagttgc
     2161 atgaatttaa tgcacatgat ttgagcagtg tggcccgacg tgaagtgaga gaagatgcaa
     2221 gaaggagatg gacaaataag gaaaatgtaa agcagctaaa ggatggaata tcgaaagacg
     2281 tcttaaagaa aatgcaaaga agaaatgatg acaaatccat atctgatgca cgggctcgtt
     2341 tccttgagag aaagcagcag aggacccagg accacagtga cacacgaaag gaaacaggct
     2401 aaggtggtga accctccaat tcaggaagtg ggaaaaggag ccaggaaatg tgcttctact
     2461 ttgccagtta tttcagacag cactaccaag aggaggtggt cagcacttgt tattggccta
     2521 tgaactaaaa gcaaatcaaa gctcataaat caaagctcat cagttcccat aaatgcagtt
     2581 gtcaaagaaa agatttggtt gccatagtca taagcaatga tacatgaaac caatgaaaga
     2641 cagtacatgt aataatattt tcctcagtac aattttgctg gccttaactg gtatcaaacg
     2701 ctgtcattga gatgttttca aagaacattg agttgtattt aatcagcgtg tactccattt
     2761 gcattgaagc attaaaaatt atttttctta aaatctcttt aaggccttct tgttgctgtt
     2821 agaatagtgc tatatatcag gtatgtgacc atttatttca gaaggctgaa cataagaggt
     2881 ttctactcag caatacttag atgtctaact gtttaattgc tacagagctt tatagatatt
     2941 tagagaaaag acttaatcaa ttagtaaata aaattgccta tggcaggatt ctttcttgaa
     3001 ttaatattaa tccttaaatt gatttttctg ggattataca aattcctttt tatataaaag
     3061 tatattgttt aaaacagtag ctatagccat taaccaaagg acagatgata tatatatata
     3121 tgatatatat atatatataa gttctttttt agctgtacct acgtacttat atcagcacca
     3181 tgtatgtagg tgtgatagta ctttcaaaca gcgcctccac ctggcctact ctgttatttc
     3241 cacctgtttg ggtagggcca tttaacttcc attatgccaa acttgggatg ggattttcga
     3301 agcagacaac actatttcat cgtgtttcaa attggaacct tgaggctagt tagtatcaca
     3361 ctcaggccac actcagcact tgcccactct tgtttactgc cttgtattct agttatttgt
     3421 gtatttgtct ccctcactag attatacgct ccttgtgggc agggactgtg tcttttttca
     3481 tctttgtatc tttcatgcac ctagcatagt gctttgcaca tagtagtcac tcagtgtttg
     3541 ttaaataaag ctattagtgt cattaaaatt caaaa
//
