LOCUS       NM_014003               4323 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens DEAH-box helicase 38 (DHX38), mRNA.
ACCESSION   NM_014003
VERSION     NM_014003.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4323)
  AUTHORS   Mi,K., Zeng,L., Chen,Y., Ning,J., Zhang,S., Zhao,P. and Yang,S.
  TITLE     DHX38 enhances proliferation, metastasis, and EMT progression in
            NSCLC through the G3BP1-mediated MAPK pathway
  JOURNAL   Cell Signal 113, 110962 (2024)
   PUBMED   37931691
  REMARK    GeneRIF: DHX38 enhances proliferation, metastasis, and EMT
            progression in NSCLC through the G3BP1-mediated MAPK pathway.
REFERENCE   2  (bases 1 to 4323)
  AUTHORS   Li,Z., Qin,C., Zhao,B., Wang,Y., Li,T., Zhao,Y. and Wang,W.
  TITLE     DHX38 restricts chemoresistance by regulating the alternative
            pre-mRNA splicing of RELL2 in pancreatic ductal adenocarcinoma
  JOURNAL   PLoS Genet 19 (7), e1010847 (2023)
   PUBMED   37506056
  REMARK    GeneRIF: DHX38 restricts chemoresistance by regulating the
            alternative pre-mRNA splicing of RELL2 in pancreatic ductal
            adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4323)
  AUTHORS   Obuca,M., Cvackova,Z., Kubovciak,J., Kolar,M. and Stanek,D.
  TITLE     Retinitis pigmentosa-linked mutation in DHX38 modulates its
            splicing activity
  JOURNAL   PLoS One 17 (4), e0265742 (2022)
   PUBMED   35385551
  REMARK    GeneRIF: Retinitis pigmentosa-linked mutation in DHX38 modulates
            its splicing activity.
            Erratum:[PLoS One. 2023 Jan 20;18(1):e0280904. doi:
            10.1371/journal.pone.0280904.. PMID: 36662708]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4323)
  AUTHORS   Cona,B., Hayashi,T., Yamada,A., Shimizu,N., Yokota,N., Nakato,R.,
            Shirahige,K. and Akiyama,T.
  TITLE     The splicing factor DHX38/PRP16 is required for ovarian clear cell
            carcinoma tumorigenesis, as revealed by a CRISPR-Cas9 screen
  JOURNAL   FEBS Open Bio 12 (3), 582-593 (2022)
   PUBMED   34965029
  REMARK    GeneRIF: The splicing factor DHX38/PRP16 is required for ovarian
            clear cell carcinoma tumorigenesis, as revealed by a CRISPR-Cas9
            screen.
REFERENCE   5  (bases 1 to 4323)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 4323)
  AUTHORS   Wang,Y. and Guthrie,C.
  TITLE     PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome
            primarily via its nonconserved N-terminal domain
  JOURNAL   RNA 4 (10), 1216-1229 (1998)
   PUBMED   9769096
REFERENCE   7  (bases 1 to 4323)
  AUTHORS   Zhou,Z. and Reed,R.
  TITLE     Human homologs of yeast prp16 and prp17 reveal conservation of the
            mechanism for catalytic step II of pre-mRNA splicing
  JOURNAL   EMBO J 17 (7), 2095-2106 (1998)
   PUBMED   9524131
REFERENCE   8  (bases 1 to 4323)
  AUTHORS   Gee,S., Krauss,S.W., Miller,E., Aoyagi,K., Arenas,J. and
            Conboy,J.G.
  TITLE     Cloning of mDEAH9, a putative RNA helicase and mammalian homologue
            of Saccharomyces cerevisiae splicing factor Prp43
  JOURNAL   Proc Natl Acad Sci U S A 94 (22), 11803-11807 (1997)
   PUBMED   9342318
REFERENCE   9  (bases 1 to 4323)
  AUTHORS   Fahim,A.T., Daiger,S.P. and Weleber,R.G.
  TITLE     Nonsyndromic Retinitis Pigmentosa Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301590
REFERENCE   10 (bases 1 to 4323)
  AUTHORS   Schwer,B. and Guthrie,C.
  TITLE     PRP16 is an RNA-dependent ATPase that interacts transiently with
            the spliceosome
  JOURNAL   Nature 349 (6309), 494-499 (1991)
   PUBMED   1825134
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG719187.1, BM473438.1,
            BC008340.1 and AA126451.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014003.3.
            
            Summary: DEAD box proteins, characterized by the conserved motif
            Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are
            implicated in a number of cellular processes involving alteration
            of RNA secondary structure such as translation initiation, nuclear
            and mitochondrial splicing, and ribosome and spliceosome assembly.
            Based on their distribution patterns, some members of this family
            are believed to be involved in embryogenesis, spermatogenesis, and
            cellular growth and division. The protein encoded by this gene is a
            member of the DEAD/H box family of splicing factors. This protein
            resembles yeast Prp16 more closely than other DEAD/H family
            members. It is an ATPase and essential for the catalytic step II in
            pre-mRNA splicing process. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.261139.1,
                                           SRR1660809.36002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000268482.8/ ENSP00000268482.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BG719187.1         139-150
            13-370              BM473438.1         44-401
            371-4149            BC008340.1         278-4056
            4150-4323           AA126451.1         7-180               c
FEATURES             Location/Qualifiers
     source          1..4323
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.2"
     gene            1..4323
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /note="DEAH-box helicase 38"
                     /db_xref="GeneID:9785"
                     /db_xref="HGNC:HGNC:17211"
                     /db_xref="MIM:605584"
     exon            1..205
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            206..547
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..3908
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38;
                     PRP16 homolog of S.cerevisiae; DEAH box protein 38;
                     ATP-dependent RNA helicase DHX38; DEAH (Asp-Glu-Ala-His)
                     box polypeptide 38; pre-mRNA processing factor 16"
                     /codon_start=1
                     /product="pre-mRNA-splicing factor ATP-dependent RNA
                     helicase PRP16"
                     /protein_id="NP_054722.2"
                     /db_xref="CCDS:CCDS10907.1"
                     /db_xref="GeneID:9785"
                     /db_xref="HGNC:HGNC:17211"
                     /db_xref="MIM:605584"
                     /translation="MGDTSEDASIHRLEGTDLDCQVGGLICKSKSAASEQHVFKAPAP
                     RPSLLGLDLLASLKRREREEKDDGEDKKKSKVSSYKDWEESKDDQKDAEEEGGDQAGQ
                     NIRKDRHYRSARVETPSHPGGVSEEFWERSRQRERERREHGVYASSKEEKDWKKEKSR
                     DRDYDRKRDRDERDRSRHSSRSERDGGSERSSRRNEPESPRHRPKDAATPSRSTWEEE
                     DSGYGSSRRSQWESPSPTPSYRDSERSHRLSTRDRDRSVRGKYSDDTPLPTPSYKYNE
                     WADDRRHLGSTPRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYMMDEGYD
                     EFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLE
                     VDEDFEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQT
                     VRKHREQKERKKAQHKHWELAGTKLGDIMGVKKEEEPDKAVTEDGKVDYRTEQKFADH
                     MKRKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLT
                     QYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTL
                     IKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIV
                     TSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAP
                     GDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGV
                     RKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGR
                     AGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDP
                     PPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEIL
                     LIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCND
                     HFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGIG
                     EYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGP
                     MFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVRSTKI
                     YTPGRKEQGEPMTPRRTPARFGL"
     exon            548..735
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            736..840
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            841..988
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1107
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1184
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1340
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1502
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1610
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1723
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1861
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            1862..2048
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2234
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2375
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2486
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2487..2603
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2711
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2712..2824
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            2825..3033
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3034..3188
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3344
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3345..3479
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3605
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3606..3701
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3702..3823
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..4323
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4297..4302
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /note="hexamer: AATAAA"
     polyA_site      4323
                     /gene="DHX38"
                     /gene_synonym="DDX38; PRP16; PRPF16; RP84"
                     /note="major polyA site"
ORIGIN      
        1 acttggatcc aggaatcggg cgtgttccag gctgctctct atggtagctt tgggcggata
       61 gagggggcgc gcaaagtatt aagggacaat aatggccgct ttcaaggtgt ggattttggc
      121 tccttgagcc tgtctgagcg aggggtggca gcgccggcgc cccagaatcc gggacagaag
      181 ggtcccaaga gtcgcgcttg gtgagagaaa tcccagatcc tgtgatgggg gacaccagtg
      241 aggatgcctc gatccatcga ttggaaggca ctgatctgga ctgtcaggtt ggtggtctta
      301 tttgcaagtc caaaagtgcg gccagcgagc agcatgtctt caaggctcct gctccccgcc
      361 cttcattact cggactggac ttgctggctt ccctgaaacg gagagagcga gaggagaagg
      421 acgatgggga ggacaagaag aagtccaaag tctcctccta caaggactgg gaagagagca
      481 aggatgacca gaaggatgct gaggaagagg gcggtgacca ggctggccaa aatatccgga
      541 aagacagaca ttatcggtct gctcgggtag agactccatc ccatccgggt ggtgtgagcg
      601 aagagttttg ggaacgcagt cggcagagag agcgggagcg gcgggaacat ggtgtctatg
      661 cctcgtccaa agaagaaaag gattggaaga aggagaaatc gcgggatcga gactatgacc
      721 gcaagaggga cagagatgag cgggatagaa gtaggcacag cagcagatca gagcgagatg
      781 gagggtcaga gcgtagcagc agaagaaatg aacccgagag cccacgacat cgacctaaag
      841 atgcagccac cccttcaagg tctacctggg aggaagagga cagtggctat ggctcctcaa
      901 ggcgctcaca gtgggaatcg ccctccccga cgccttccta tcgggattct gagcggagcc
      961 atcggctgtc cactcgagat cgagacaggt ctgtgagggg caagtactcg gatgacacgc
     1021 ctctgccaac tccctcctac aaatataacg agtgggccga tgacagaaga cacttggggt
     1081 ccaccccgcg tctgtccagg ggccgaggaa gacgtgagga gggcgaagaa ggaatttcat
     1141 ttgacacgga ggaggagcgg cagcagtggg aagatgacca gaggcaagcc gatcgggatt
     1201 ggtacatgat ggacgagggc tatgacgagt tccacaaccc gctggcctac tcctccgagg
     1261 actacgtgag gaggcgggag cagcacctgc ataaacagaa gcagaagcgc atttcagctc
     1321 agcggagaca gatcaatgag gataacgagc gctgggagac aaaccgcatg ctcaccagtg
     1381 gggtggtcca tcggctggag gtggatgagg actttgaaga ggacaacgcg gccaaggtgc
     1441 atctgatggt gcacaatctg gtgcctccct ttctggatgg gcgcattgtc ttcaccaagc
     1501 agccggagcc ggtgattcca gtgaaggatg ctacttctga cctggccatc attgctcgga
     1561 aaggcagcca gacagtgcgg aagcacaggg agcagaagga gcgcaagaag gctcagcaca
     1621 aacactggga actggcgggg accaaactgg gagatataat gggcgtcaag aaggaggaag
     1681 agccagataa agctgtgacg gaggatggga aggtggacta caggacagag cagaagtttg
     1741 cagatcacat gaagagaaag agcgaagcca gcagtgaatt tgcaaagaag aagtccatcc
     1801 tggagcagag gcagtacctg cccatctttg cagtgcagca ggagctgctc actattatca
     1861 gagacaacag catcgtgatc gtggttgggg agacggggag tggtaagacc actcagctga
     1921 cgcagtacct gcatgaagat ggttacacgg actatgggat gattgggtgt acccagcccc
     1981 ggcgtgtagc tgccatgtca gtggccaaga gagtcagtga agagatgggg ggaaaccttg
     2041 gcgaggaggt gggctatgcc atccgctttg aagactgcac ttcagagaac accttgatca
     2101 aatacatgac tgacgggatc ctgctccgag agtccctccg ggaagccgac ctggatcact
     2161 acagtgccat catcatggac gaggcccacg agcgctccct caacactgac gtgctctttg
     2221 ggctgctccg ggaggtagtg gctcggcgct cagacctgaa gctcatcgtc acatcagcca
     2281 cgatggatgc ggagaagttt gctgcctttt ttgggaatgt ccccatcttc cacatccctg
     2341 gccgtacctt ccctgttgac atcctcttca gcaagacccc acaggaggat tacgtggagg
     2401 ctgcagtgaa gcagtccttg caggtgcacc tgtcgggggc ccctggagac atccttatct
     2461 tcatgcctgg ccaagaggac attgaggtga cctcagacca gattgtggag catctggagg
     2521 aactggagaa cgcgcctgcc ctggctgtgc tgcccatcta ctctcagctg ccttctgacc
     2581 tccaggccaa aatcttccag aaggctccag atggcgttcg gaagtgcatc gttgccacca
     2641 atattgccga gacgtctctc actgttgacg gcatcatgtt tgttatcgat tctggttatt
     2701 gcaaattaaa ggtcttcaac cccaggattg gcatggatgc tctgcagatc tatcccatta
     2761 gccaggccaa tgccaaccag cggtcagggc gagccggcag gacgggccca ggtcagtgtt
     2821 tcaggctcta cacccagagc gcctacaaga atgagctcct gaccaccaca gtgcccgaga
     2881 tccagaggac taacctggcc aacgtggtgc tgctgctcaa gtccctcggg gtgcaggacc
     2941 tgctgcagtt ccacttcatg gacccgcccc cggaggacaa catgctcaac tctatgtatc
     3001 agctctggat cctcggggcc ctggacaaca caggtggtct gacctctacc gggcggctga
     3061 tggtggagtt cccgctggac cctgccctgt ccaagatgct catcgtgtcc tgtgacatgg
     3121 gctgcagctc cgagatcctg ctcatcgttt ccatgctctc ggtcccagcc atcttctaca
     3181 ggcccaaggg tcgagaggag gagagtgatc aaatccggga gaagttcgct gttcctgaga
     3241 gcgatcattt gacctacctg aatgtttacc tgcagtggaa gaacaataat tactccacca
     3301 tctggtgtaa cgatcatttc atccatgcta aggccatgcg gaaggtccgg gaggtgcgag
     3361 ctcaactcaa ggacatcatg gtgcagcagc ggatgagcct ggcctcgtgt ggcactgact
     3421 gggacatcgt caggaagtgc atctgtgctg cctatttcca ccaagcagcc aagctcaagg
     3481 gaatcgggga gtacgtgaac atccgcacag ggatgccctg ccacttgcac cccaccagct
     3541 ccctttttgg aatgggctac accccagatt acatagtgta tcacgagttg gtcatgacca
     3601 ccaaggagta tatgcagtgt gtgaccgctg tggacgggga gtggctggcg gagctgggcc
     3661 ccatgttcta tagcgtgaaa caggcgggca agtcacggca ggagaaccgt cgtcgggcca
     3721 aagaggaagc ctctgccatg gaggaggaga tggcgctggc cgaggagcag ctgcgagccc
     3781 ggcggcagga gcaggagaag cgcagccccc tgggcagtgt caggtctacg aagatctaca
     3841 ctccaggccg gaaagagcaa ggggagccca tgacccctcg ccgcacgcca gcccgctttg
     3901 gtctgtgagc tgaggctgtc cccagagagg atggcagcag gtattgggtc ctcagccttc
     3961 tggcgggagc cctgaggctg cggacaaagc cctttcatct gaggactttc atctgtgcat
     4021 atcacggccc cccagggcag ttcctgctgg accagactct ctggcagagg aggtggagtt
     4081 cttccatgca ggagcacggc atggcgggag cggggctgca gagtatccga ggtgctgccg
     4141 gggcagcggg aggtggctgg acccatcgca tctaaaactg gcccaggaca cttggtgtat
     4201 gcgtgacttg gctgtggctg tcttttttaa tccttgtgta aagcagcaaa aaagacctaa
     4261 agggaattgt aatttggtta taattcagga tttggaaata aatttattat ttgtaaaaca
     4321 tga
//
