LOCUS       NM_032656               4559 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens DEAH-box helicase 37 (DHX37), mRNA.
ACCESSION   NM_032656
VERSION     NM_032656.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4559)
  AUTHORS   de Oliveira,F.R., Guaragna,M.S., Maciel-Guerra,A.T., Barros,B.A.,
            de Mello,M.P., Guerra-Junior,G. and Fabbri-Scallet,H.
  TITLE     DHX37 and the Implications in Disorders of Sex Development: An
            Update Review
  JOURNAL   Horm Res Paediatr 97 (5), 433-444 (2024)
   PUBMED   38142677
  REMARK    GeneRIF: DHX37 and the Implications in Disorders of Sex
            Development: An Update Review.
            Review article
REFERENCE   2  (bases 1 to 4559)
  AUTHORS   Liu,Z., Ye,Y., Liu,Y., Liu,Y., Chen,H., Shen,M., Wang,Z., Huang,S.,
            Han,L., Chen,Z. and He,X.
  TITLE     RNA Helicase DHX37 Facilitates Liver Cancer Progression by
            Cooperating with PLRG1 to Drive Superenhancer-Mediated
            Transcription of Cyclin D1
  JOURNAL   Cancer Res 82 (10), 1937-1952 (2022)
   PUBMED   35290436
  REMARK    GeneRIF: RNA Helicase DHX37 Facilitates Liver Cancer Progression by
            Cooperating with PLRG1 to Drive Superenhancer-Mediated
            Transcription of Cyclin D1.
REFERENCE   3  (bases 1 to 4559)
  AUTHORS   McElreavey,K., Pailhoux,E. and Bashamboo,A.
  TITLE     DHX37 and 46,XY DSD: A New Ribosomopathy?
  JOURNAL   Sex Dev 16 (2-3), 194-206 (2022)
   PUBMED   35835064
  REMARK    GeneRIF: DHX37 and 46,XY DSD: A New Ribosomopathy?
            Review article
REFERENCE   4  (bases 1 to 4559)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   5  (bases 1 to 4559)
  AUTHORS   Zidoune,H., Martinerie,L., Tan,D.S., Askari,M., Rezgoune,D.,
            Ladjouze,A., Boukri,A., Benelmadani,Y., Sifi,K., Abadi,N.,
            Satta,D., Rastari,M., Seresht-Ahmadi,M., Bignon-Topalovic,J.,
            Mazen,I., Leger,J., Simon,D., Brauner,R., Totonchi,M., Jauch,R.,
            Bashamboo,A. and McElreavey,K.
  TITLE     Expanding DSD Phenotypes Associated with Variants in the DEAH-Box
            RNA Helicase DHX37
  JOURNAL   Sex Dev 15 (4), 244-252 (2021)
   PUBMED   34293745
  REMARK    GeneRIF: Expanding DSD Phenotypes Associated with Variants in the
            DEAH-Box RNA Helicase DHX37.
REFERENCE   6  (bases 1 to 4559)
  AUTHORS   McElreavey,K., Jorgensen,A., Eozenou,C., Merel,T.,
            Bignon-Topalovic,J., Tan,D.S., Houzelstein,D., Buonocore,F.,
            Warr,N., Kay,R.G.G., Peycelon,M., Siffroi,J.P., Mazen,I.,
            Achermann,J.C., Shcherbak,Y., Leger,J., Sallai,A., Carel,J.C.,
            Martinerie,L., Le Ru,R., Conway,G.S., Mignot,B., Van Maldergem,L.,
            Bertalan,R., Globa,E., Brauner,R., Jauch,R., Nef,S., Greenfield,A.
            and Bashamboo,A.
  TITLE     Pathogenic variants in the DEAH-box RNA helicase DHX37 are a
            frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular
            regression syndrome
  JOURNAL   Genet Med 22 (1), 150-159 (2020)
   PUBMED   31337883
  REMARK    GeneRIF: Results identified heterozygous missense pathogenic
            variants involving DHX37 gene as a new cause of an autosomal
            dominant form of 46,XY DSD, including gonadal dysgenesis and
            testicular regression syndrome (TRS), showing that these conditions
            are part of a clinical spectrum. Some of the variants are clustered
            in two highly conserved functional domains.
REFERENCE   7  (bases 1 to 4559)
  AUTHORS   da Silva,T.E., Gomes,N.L., Lerario,A.M., Keegan,C.E., Nishi,M.Y.,
            Carvalho,F.M., Vilain,E., Barseghyan,H., Martinez-Aguayo,A.,
            Forclaz,M.V., Papazian,R., Pedroso de Paula,L.C., Costa,E.C.,
            Carvalho,L.R., Jorge,A.A.L., Elias,F.M., Mitchell,R., Costa,E.M.F.,
            Mendonca,B.B. and Domenice,S.
  TITLE     Genetic Evidence of the Association of DEAH-Box Helicase 37 Defects
            With 46,XY Gonadal Dysgenesis Spectrum
  JOURNAL   J Clin Endocrinol Metab 104 (12), 5923-5934 (2019)
   PUBMED   31287541
  REMARK    GeneRIF: In 46,XY Gonadal dysgenesis, we identified four
            heterozygous missense rare variants, classified as pathogenic or
            likely pathogenic in the Asp-Glu-Ala-His-box (DHX) helicase 37
            (DHX37) gene.Two variants were recurrent: p.Arg308Gln and
            p.Arg674Trp. The variants were specifically associated with
            embryonic testicular regression syndrome. DHX37 is a player in the
            complex cascade of male gonadal differentiation and maintenance.
REFERENCE   8  (bases 1 to 4559)
  AUTHORS   Paine,I., Posey,J.E., Grochowski,C.M., Jhangiani,S.N.,
            Rosenheck,S., Kleyner,R., Marmorale,T., Yoon,M., Wang,K.,
            Robison,R., Cappuccio,G., Pinelli,M., Magli,A., Coban Akdemir,Z.,
            Hui,J., Yeung,W.L., Wong,B.K.Y., Ortega,L., Bekheirnia,M.R.,
            Bierhals,T., Hempel,M., Johannsen,J., Santer,R., Aktas,D.,
            Alikasifoglu,M., Bozdogan,S., Aydin,H., Karaca,E., Bayram,Y.,
            Ityel,H., Dorschner,M., White,J.J., Wilichowski,E., Wortmann,S.B.,
            Casella,E.B., Kitajima,J.P., Kok,F., Monteiro,F., Muzny,D.M.,
            Bamshad,M., Gibbs,R.A., Sutton,V.R., Van Esch,H.,
            Brunetti-Pierri,N., Hildebrandt,F., Brautbar,A., Van den
            Veyver,I.B., Glass,I., Lessel,D., Lyon,G.J. and Lupski,J.R.
  CONSRTM   University of Washington Center for Mendelian Genomics,
            Baylor-Hopkins Center for Mendelian Genomics, Telethon Undiagnosed
            Diseases Program
  TITLE     Paralog Studies Augment Gene Discovery: DDX and DHX Genes
  JOURNAL   Am J Hum Genet 105 (2), 302-316 (2019)
   PUBMED   31256877
REFERENCE   9  (bases 1 to 4559)
  AUTHORS   Choudhury,P., Hackert,P., Memet,I., Sloan,K.E. and Bohnsack,M.T.
  TITLE     The human RNA helicase DHX37 is required for release of the U3
            snoRNP from pre-ribosomal particles
  JOURNAL   RNA Biol 16 (1), 54-68 (2019)
   PUBMED   30582406
REFERENCE   10 (bases 1 to 4559)
  AUTHORS   Mohnach,L., Fechner,P.Y. and Keegan,C.E.
  TITLE     Nonsyndromic Disorders of Testicular Development Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301714
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093719.26, BC037964.1 and
            BU633279.1.
            
            On Nov 22, 2018 this sequence version replaced NM_032656.3.
            
            Summary: This gene encodes a DEAD box protein. DEAD box proteins,
            characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are
            putative RNA helicases. They are implicated in a number of cellular
            processes involving alteration of RNA secondary structure such as
            translation initiation, nuclear and mitochondrial splicing, and
            ribosome and spliceosome assembly. Based on their distribution
            patterns, some members of this family are believed to be involved
            in embryogenesis, spermatogenesis, and cellular growth and
            division. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037964.1, SRR11853567.8197.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308736.7/ ENSP00000311135.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AC093719.26        18436-18474
            40-2439             BC037964.1         12-2411
            2440-2440           AC093719.26        50754-50754
            2441-2607           BC037964.1         2413-2579
            2608-2608           AC093719.26        53401-53401
            2609-4001           BC037964.1         2581-3973
            4002-4559           BU633279.1         20-577              c
FEATURES             Location/Qualifiers
     source          1..4559
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..4559
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /note="DEAH-box helicase 37"
                     /db_xref="GeneID:57647"
                     /db_xref="HGNC:HGNC:17210"
                     /db_xref="MIM:617362"
     exon            1..215
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..3583
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /EC_number="3.6.4.13"
                     /note="DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 37;
                     DEAD/DEAH box helicase DDX37; DEAH box protein 37; DEAH
                     (Asp-Glu-Ala-His) box polypeptide 37"
                     /codon_start=1
                     /product="probable ATP-dependent RNA helicase DHX37"
                     /protein_id="NP_116045.2"
                     /db_xref="CCDS:CCDS9261.1"
                     /db_xref="GeneID:57647"
                     /db_xref="HGNC:HGNC:17210"
                     /db_xref="MIM:617362"
                     /translation="MGKLRRRYNIKGRQQAGPGPSKGPPEPPPVQLELEDKDTLKGVD
                     ASNALVLPGKKKKKTKAPPLSKKEKKPLTKKEKKVLQKILEQKEKKSQRAEMLQKLSE
                     VQASEAEMRLFYTTSKLGTGNRMYHTKEKADEVVAPGQEKISSLSGAHRKRRRWPSAE
                     EEEEEEEESESELEEESELDEDPAAEPAEAGVGTTVAPLPPAPAPSSQPVPAGMTVPP
                     PPAAAPPLPRALAKPAVFIPVNRSPEMQEERLKLPILSEEQVIMEAVAEHPIVIVCGE
                     TGSGKTTQVPQFLYEAGFSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSQRVVSYQIR
                     YEGNVTEETRIKFMTDGVLLKEIQKDFLLLRYKVVIIDEAHERSVYTDILIGLLSRIV
                     TLRAKRNLPLKLLIMSATLRVEDFTQNPRLFAKPPPVIKVESRQFPVTVHFNKRTPLE
                     DYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCRRLRKAFPPSRARPQEKDDDQK
                     DSVEEMRKFKKSRARAKKARAEVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDSD
                     LDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAE
                     TSLTIPGIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHCYR
                     LYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEEL
                     LIALGALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLP
                     YAITIVASMTVRELFEELDRPAASDEELTRLKSKRARVAQMKRTWAGQGASLKLGDLM
                     VLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKM
                     QPPTESQVTYLRQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVL
                     FKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFDKPLEEPAPTYCPERG
                     RVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSP
                     GTMLKTWARLQPRTESLLRALVAEKADCHEALLAAWKKNPKYLLAEYCEWLPQAMHPD
                     IEKAWPPTTVH"
     exon            216..385
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            386..498
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            499..847
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            848..996
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1089
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1186
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1300
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1402
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1517
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1518..1613
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1699
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1844
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1921
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..2154
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2266
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2373
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2374..2562
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2687
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2688..2804
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..2977
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3092
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            3093..3230
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3325
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            3326..3399
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            3400..3497
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     exon            3498..4559
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4538..4543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /note="hexamer: AATAAA"
     polyA_site      4559
                     /gene="DHX37"
                     /gene_synonym="DDX37; Dhr1; NEDBAVC; SRXY11"
                     /note="major polyA site"
ORIGIN      
        1 aacccggaag tctcacggcc ggagttggtg gtctgggaac ccacgtgggc tgggtttcgg
       61 attgctctgc tggtccggcc gctggagcgc ccaccctggc ctagtcgcca tggggaagct
      121 gcgccggcgc tacaacatca aggggcgcca gcaggcgggc cccggaccct cgaagggccc
      181 ccccgagccg ccccccgtgc agctggaact ggaggacaag gacacgttga agggagttga
      241 tgcaagcaac gcgctcgttc taccggggaa gaagaaaaag aagaccaaag cccctcccct
      301 gtcgaagaag gagaagaagc ctctgaccaa gaaggagaag aaagtgctgc agaaaatctt
      361 agaacagaag gagaaaaaga gccagcgagc agagatgcta cagaagctga gtgaagtcca
      421 ggcttccgaa gctgagatga gactctttta taccacttcc aagctaggca ctgggaaccg
      481 catgtatcac accaaagaga aggctgacga ggtggtagcc ccgggccagg agaagatcag
      541 tagcctcagc ggtgcccacc ggaagcgtcg ccgctggccc tcagctgagg aggaggagga
      601 ggaggaggag gagtcggaat cggagctgga ggaggagtcg gagctggacg aggacccagc
      661 tgctgagccg gctgaggctg gtgtggggac caccgtggca cctctgccgc cagctccagc
      721 acccagcagt cagcccgtgc cggctgggat gactgttcct cctcctccag ctgcagcccc
      781 accactgccc agggccctgg ctaagcccgc cgtcttcatc cccgtgaacc gctccccgga
      841 aatgcaggag gaacggctga agctcccaat tctctccgaa gaacaagtaa tcatggaggc
      901 tgtggccgag caccccatcg tcatcgtgtg tggtgagacc ggcagcggga agaccacaca
      961 ggtgcctcag tttctctatg aagcaggctt cagcagtgaa gacagcatca tcggtgtcac
     1021 ggagccccgc cgagtggccg ccgtggccat gtcccagcga gtggccaagg agatgaatct
     1081 gtcccagcgg gtcgtctcct accagatccg gtatgaagga aacgtgacag aggagaccag
     1141 aatcaagttc atgacggatg gtgtgctgct taaagaaatc cagaaggact tcctgctgct
     1201 gcggtacaag gtggtgatca tcgacgaggc ccacgagagg agcgtgtaca cggacatcct
     1261 catcggcctc ctgtcccgca ttgtgactct ccgggctaag aggaacctgc cactcaagct
     1321 gctcatcatg tcggccacgc tgcgggtgga ggacttcacc cagaacccac ggctcttcgc
     1381 caagccgccg ccggtcatca aggtggaatc caggcagttc ccagtgactg tgcatttcaa
     1441 caagcggaca ccgctggaag actacagtgg cgagtgcttc cggaaggtct gcaagatcca
     1501 ccggatgctg cccgcaggtg gcatcctggt gttcctgacg gggcaggctg aggtgcatgc
     1561 gctgtgccgc aggctcagga aggctttccc accctccaga gcccggccac aagaaaagga
     1621 cgacgatcag aaagactcgg tggaggaaat gcggaagttt aagaagtcaa gggccagggc
     1681 caagaaggcg cgggctgagg tgctgcccca gatcaacttg gatcattact cggtgttacc
     1741 ggcaggcgaa ggcgatgagg acagggaggc agaagtggat gaggaagagg gggccctgga
     1801 ctccgacctc gatctggacc tgggggatgg cgggcaagat ggaggtgagc agccggatgc
     1861 ctccctcccg ctccacgtgc tcccgctgta ctctctgctg gccccagaga agcaagcaca
     1921 ggtctttaag cctccaccgg aggggactcg gttgtgtgtt gtggccacca atgtggccga
     1981 gacgtcgctt accatccctg gcatcaagta cgtggtggac tgtgggaagg tcaagaaacg
     2041 ctactacgac cgcgtcactg gcgtatcctc cttccgtgtc acctgggtct cccaggcatc
     2101 agctgaccag cgagcgggca gagcaggacg gacggagccc ggccactgct acaggctgta
     2161 ttcatctgcg gtttttggtg acttcgagca gtttcctcct ccagaaatca cccggaggcc
     2221 tgttgaagac ttaatccttc aaatgaaggc gctcaacgtt gaaaaggtca tcaacttccc
     2281 cttcccgacg cccccctccg tggaagccct tcttgccgcc gaggagctgt tgatcgcact
     2341 gggtgccctg caaccgcccc agaaagcaga aagggtgaag caactgcagg agaaccggct
     2401 gagctgcccc atcactgcgc tgggccggac aatggccaca ttccccgtgg caccccgcta
     2461 cgctaagatg ctggcactga gccgacaaca cggctgcctg ccctatgcca tcaccatcgt
     2521 ggccagcatg acggtgcggg agctgtttga ggagctggac agaccagcgg ccagtgacga
     2581 ggagctcacc aggctgaaga gcaagcgggc ccgggtggcc cagatgaaga ggacctgggc
     2641 agggcagggg gcttctctga agctcggcga cctcatggtg ctgctgggcg ccgtgggagc
     2701 ctgtgagtat gccagctgca caccccagtt ttgcgaagcc aacgggctgc ggtacaaagc
     2761 catgatggag atccggcgcc tgcggggcca gctgaccacc gcagtcaatg ccgtgtgccc
     2821 cgaggctgag ctcttcgtgg atcccaagat gcagccgccc accgagagcc aggtgaccta
     2881 cctgcgacag atcgtgacgg caggcctggg ggaccacttg gcccgcaggg tccagagcga
     2941 ggagatgctg gaggacaagt ggaggaacgc ctacaagacc cctctcctcg acgaccctgt
     3001 cttcatccac cccagctccg tccttttcaa agagctcccc gagtttgtgg tctaccagga
     3061 aatcgtggag accactaaga tgtacatgaa aggcgtctct agcgtggagg tccagtggat
     3121 cccggccctg ctgccctctt actgccagtt tgacaagccc ctggaggaac cagcccctac
     3181 atactgcccc gagcgggggc gggtgctgtg tcaccgggcc agcgtgttct atcgcgtggg
     3241 ctggccgctc cccgccatcg aggtggattt tccagagggg attgaccgct acaagcactt
     3301 tgcccggttc ctgctggaag ggcaggtctt ccgcaagctg gcctcatacc ggagctgtct
     3361 gctgtccagc cccggcacca tgctgaagac gtgggccagg ctgcagcccc gtacggagag
     3421 ccttctgcga gccctggttg cagagaaggc tgactgccat gaagccttgc tggctgcttg
     3481 gaagaaaaac cccaaatacc tgctggctga gtactgtgag tggcttccac aggccatgca
     3541 ccccgatatc gagaaagcct ggccccccac cactgtccac tgaccagaaa cctggctgca
     3601 gggccgagga ctggtttggg gactggaggg ctggcagcag cctgtcaccg tgcgaccgtg
     3661 accacctggc atgggcttcg tggcctgctc tcaggaagtg ggtcaagccc tgggaaccct
     3721 catccatgag agctcgatcc cgtatgaagg gtgctgccgc ccgtgccatc tggcccgggg
     3781 gtgacttttt gaactgttta ttatatggtg gatgatgatt tcatctcacg tgctggacgc
     3841 tgttctgttc agtgtgctct ttggactaca ttagtcccct gtggagcagc agggctggag
     3901 atctctgcag tcccttcccc gcccgccctg ccagaaggcc gaggaggcac gtggagggcc
     3961 tccttcctgc aattcttccc tctccagagt cagggagggc tgcccagccc tggcctcaca
     4021 gccgtcccag atgttaggtg agccactgag ctctgtgttg accttgaggg gcctggctgg
     4081 gggcccccag gctccatgcc ttcttgggag ggtggccgcc aacgcctttc ctgtgttatg
     4141 gcaacaggga gtgggcatct catctgcctg tggtcagctc tcagacggca gggagcggag
     4201 ctgacgttgg ctgtgcttgg tcaccgctgc catgccgcag aggatgcgcc tagctgggct
     4261 ggggccacac gactattatg ttggccttga acggggactg cagagccctc agtttgtctc
     4321 ccttgttcct ctgtggctga ggtgggaggg ggagggtggg gtaggtcccc cagcaagaaa
     4381 gagggacagg agcaccccag gcaggaccaa ggagtcggga ggcccctgcc ttctgtcctc
     4441 catggtgagg gcacagatgt ctccccagag cccagcgctg gcagaatgga ttctgctcct
     4501 ggctttgctt ctgcggcttc ggtggagaca gttatggaat aaaatgttcc ttgcaccca
//
